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황기환,고대식,전계석 慶熙大學校 材料科學技術硏究所 1992 材料科學技術硏究論集 Vol.5 No.-
In this paper, using the spectra and the reflection coefficient of surface acoustic wave:SAW, the surface breaking crack-depth is estimated by computer simulation and the experiment. In order to perform this experiment, two type shaped flows half-penny and rectangular of line-crack have been made in the surface of aluminium. Measuring results, for half-penny type, the reflection coefficient have been in proportion to the surface breaking crack-depth. When the spectrum analyzer was used, the spectra analysis method for line crack of rectangular type was measured the average deviation 8.7% to the surface breaking crack-depth.
황기현,문경준,김문수,원태현 동의공업대학 1998 論文集 Vol.24 No.1
In this paper, a reference model following control system using a fuzzy logic controller (FLC) is proposed. A reference model whose response does not overshoot and has a fast rise time is designed. A FLC is designed to follow as close as possible the response of the reference model. The proposed design method has the robustness and the optimal tracking property under modeling error, disturbance and parameter perturbations. The proposed designing method is compared using a PD controller throughout the experiment. The effectiveness of the proposed designing method is verified through computer simulation and experiments for the second-order and the first-order reference model.
Hwang, Ji Sun,Kim, Gi-Cheon,Park, EunBee,Kim, Jung-Eun,Chae, Chang-Suk,Hwang, Won,Lee, Changhon,Hwang, Sung-Min,Wang, Hui Sun,Jun, Chang-Duk,Rudra, Dipayan,Im, Sin-Hyeog The American Association of Immunologists, Inc. 2015 JOURNAL OF IMMUNOLOGY Vol.194 No.4
<P>IL-31 is a key mediator of itching in atopic dermatitis (AD) and is preferentially produced by activated CD4<SUP>+</SUP> T cells and Th2 cells. Although pathophysiological functions of IL-31 have been suggested in diverse immune disorders, the molecular events underlying <I>IL-31</I> gene regulation are still unclear. In this study we identified the transcription start site and functional promoter involved in <I>IL-31</I> gene regulation in mouse CD4<SUP>+</SUP> T cells. TCR stimulation–dependent IL-31 expression was found to be closely linked with in vivo binding of NFAT1 and JunB to the <I>IL-31</I> promoter. Although NFAT1 alone enhanced <I>IL-31</I> promoter activity, it was further enhanced in the presence of JunB. Conversely, knockdown of either NFAT1 or JunB resulted in reduced <I>IL-31</I> expression. NFAT1-deficient CD4<SUP>+</SUP> T cells showed a significant defect in <I>IL-31</I> expression compared with wild-type CD4<SUP>+</SUP> T cells. In agreement with these findings, mice subjected to atopic conditions showed much higher levels of IL-31, which were closely correlated with a significant increase in the number of infiltrated NFAT1<SUP>+</SUP>CD4<SUP>+</SUP> T cells into the AD ears. Amelioration of AD progression by cyclosporin A treatment was well correlated with downregulation of IL-31 expressions in CD4<SUP>+</SUP> T cells and total ear residual cells. In summary, our results suggest a functional cooperation between NFAT1 and JunB in mediating <I>IL-31</I> gene expression in CD4<SUP>+</SUP> T cells and indicate that interference with this interaction or their activity has the potential of reducing IL-31–mediated AD symptoms.</P>
Common ABCB1 SNP, C3435T could affect systemic exposure of dapagliflozin in healthy subject
Jun Gi Hwang,Sae Im Jeong,Yu Kyong Kim,Yujin Lee,Sang Chun Ji,SeungHwan Lee,Min Kyu Park 대한임상약리학회 2022 Translational and Clinical Pharmacology Vol.30 No.4
P-glycoprotein (P-gp) is a transporter that plays an excretory role in epithelial cells. It is encoded by ABCB1, and single nucleotide polymorphisms (SNPs) in this gene can affect systemic drug exposure. Dapagliflozin and sitagliptin, used in type 2 diabetes treatment, are P-gp substrates. Here, we aimed to investigate whether ABCB1 polymorphisms affect dapagliflozin and sitagliptin pharmacokinetics (PK) in healthy Korean subjects. The study population consisted of 100 healthy Korean subjects (94 men and 6 women) who participated in four different clinical trials and received dapagliflozin and sitagliptin doses of 10 and 100 mg, respectively. We determined ABCB1 genotypes for the C3435T, C1236T, and G2677T/A SNPs. The relationship between the genotypes and dapagliflozin PKs was examined. Dapagliflozin and sitagliptin PK parameters were not statistically significantly affected by ABCB1 SNP genotypes. However, homozygous 3435TT subjects showed higher dapagliflozin PK parameters than CT and CC subjects. In subjects with the 3435TT and those with 3435CC and 3435CT genotypes, mean C max , AUC inf , and AUC 0-1 values of dapagliflozin were 223.06 ng/ mL and 194.81 ng /mL (p = 0.2767), 673.58 ng*h/mL and 573.96 ng*h/mL (p = 0.0492), and 128.53 ng*h/mL and 104.61 ng*h/mL (p = 0.2678), respectively. In summary, dapagliflozin and sitagliptin PK parameters were not significantly different between individuals with C1236T and C2677T/A ABCB1 genetic polymorphisms. Dapagliflozin exhibited higher systemic exposure in 3435TT subjects than in CC/CT subjects.
안구 마우스를 이용한 전신마비 환자용 홈 네트워크 시스템
황기현 ( Ki-hyun Hwang ),김범준 ( Beom-jun Kim ),송준 ( Jun Song ),유우종 ( Woo-jong Yoo ),황성현 ( Sung-hyun Hwang ),이수원 ( Soowon Lee ),김병기 ( Byung-gi Kim ) 한국정보처리학회 2014 한국정보처리학회 학술대회논문집 Vol.21 No.2
본 연구에서는 전신마비 환자들이 안구 마우스를 사용하여 전등,선풍기,창문 제어 및 침대 각도 조절을 할 수 있고,보호자에게 소변통 알림과 응급메시지 알림을 보낼 수 있는 홈 네트워크 시스템을 설계하고 구현한다. 또한 전신마비 환자들뿐만 아니라 일반 사용자들도 이용할 수 있도록 동일한 기능을 모바일 어플리케이션으로 구현한다. 본 연구의 입력장치인 안구 마우스는 삼성전자 창의개발연구소에서 개발한 eyeCm을 사용하였다. 전체적인 시스템은 Arduino를 사용하여 제어하고,무선 통신은 Xbee모듈을 사용하여 구현하였다. 기존의 홈 네트워크 시스템은 일반 사용자들만 이용할 수 있지만, 본 연구에서는 루게릭 환자처럼 전신을 움직이지 못하는 환자들에게 최적화된 홈 네트워크 시스템을 구축하여 소외계층의 스마트 기기에 대한 접근성을 높이고,자립심을 키울 수 있도록 도와준다는 점에서 의의가 있다.
Jun Sang Ahn,정기용,Sun-Sick Jang,Ui-Hyung Kim,So-Mi Hwang,Shil Jin,Bo-Hye Park,Dong-Hun Kang,Eung Gi Kwon 한국축산학회 2020 한국축산학회지 Vol.62 No.6
This study was conducted to compare the mRNA expression levels of myogenic-adipogenic makers in the skeletal muscle and adipocytes formation, body weight, rumen weight, and papilla length on Hanwoo calves at newborn and 6 months of age. Animals used three newborn Hanwoo calves (NC) and three Hanwoo calves 6 months of age (SC). Body weight and rumen weight were significantly increased in SC compared to NC (p < 0.01), and papilla length was longer about 10-fold in SC than NC. Adipocytes was possible to visually identify more adipocytes in SC compared to NC, and were mainly formed around the blood vessels. mRNA expression of myogenin, myosin heavy chain 1 and myosin heavy chain 2A in both longissimus dorsi (LD) and semimembranosus (SM) was found to increase with calves growth (p < 0.01), and it was confirmed that have higher levels of mRNA expression in SM than LD. In LD tissues, the mRNA expression of stearoyl-CoA desaturase (SCD, p < 0.03) and peroxisome proliferator activated receptor γ (PPARγ, p < 0.04) was significantly higher in SC than NC. In SM tissues, mRNA expression levels of SCD (p < 0.02) and CCAAT/enhancer binding protein β (C/EBPβ, p < 0.01) were higher in SC than NC, and also mRNA expression levels of PPARγ increased, but there was no significant difference. Thus, the calves period suggests that it is an important step in the development of the rumen and the myogenesis and adipogenesis.
Hwang, Ji-Min,Kim, Jun-Yeon,Kim, Ha-Na,Park, Kyeong-Ju,Jo, Min-Gi,Jang, Jun-Yeong,Nam, Sang-Soo,Goo, Bon Hyuk,Kim, Jung-Hyun,Ko, Min Jung,Chae, Sang Yeup,Park, Young Jae Korean AcupunctureMoxibustion Medicine Society 2021 대한침구의학회지 Vol.38 No.3
Background: In this retrospective study, we aimed to determine which diagnostic tests were associated with an improvement in Bell's palsy symptoms. Methods: There were 30 patients who visited Kyung Hee University Korean Medicine Hospital from April 1, 2017 to February 29, 2020, and who received East-West collaboration treatment for Bell's palsy. The tests included electroneurography (ENoG), electromyography (EMG), hematology, and heart rate variability (HRV) results which were used to determine if any test correlated with improvement of Bell's palsy symptoms. Results: The initial severity of symptoms did not correlate with the tests performed, with the exception of mean corpuscular hemoglobin concentration (p = 0.013). For both ENoG for oculi degeneration and mean EMG tests, the rate of nerve degeneration showed a significant negative correlation with the improvement of Bell's palsy symptoms. Amongst the HRV test indicators, the square root of the mean of the sum of the squares of differences between the adjacent normal R-R wave interval, the standard deviation of intervals, total power, very low frequency, and high frequency of the wave was negatively correlated with improvement of Bell's palsy symptoms. Similarly, glycosylated hemoglobin Type A1c (HbA1c) and erythrocyte sedimentation rate (ESR) showed a negative correlation with improvement of symptoms of Bell's palsy. With the exception of HbA1c and ESR, the remaining hematology test results showed no significant difference when comparing before and after treatment. Conclusion: ENoG, EMG, HRV test, HbA1c, and ESR negatively correlated with improvements in Bell's palsy symptoms and may determine the prognosis of Bell's palsy.