이종접합 Gate 구조를 갖는 수평형 NiO/Ga₂O₃ FET의 전기적 특성 연구

이건희 ( Geon-hee Lee ),문수영 ( Soo-young Moon ),이형진 ( Hyung-jin Lee ),신명철 ( Myeong-cheol Shin ),김예진 ( Ye-jin Kim ),전가연 ( Ga-yeon Jeon ),오종민 ( Jong-min Oh ),신원호 ( Weon-ho Shin ),김민경 ( Min-kyung Kim ),박철환 ( 한국전기전자재료학회 2023 전기전자재료학회논문지 Vol.36 No.4

Gallium Oxide (Ga₂O₃) is preferred as a material for next generation power semiconductors. The Ga₂O₃ should solve the disadvantages of low thermal resistance characteristics and difficulty in forming an inversion layer through p-type ion implantation. However, Ga₂O₃ is difficult to inject p-type ions, so it is being studied in a heterojunction structure using p-type oxides, such as NiO, SnO, and Cu₂O. Research the lateral-type FET structure of NiO/Ga₂O₃ heterojunction under the Gate contact using the Sentaurus TCAD simulation. At this time, the VG-ID and VD-ID curves were identified by the thickness of the Epi-region (channel) and the doping concentration of NiO of 1 × 10¹⁷ to 1 × 10¹⁹ cm^-3. The increase in Epi region thickness has a lower threshold voltage from -4.4 V to -9.3 V at I_D = 1 × 10^-8 mA/mm, as current does not flow only when the depletion of the PN junction extends to the Epi/Sub interface. As an increase of NiO doping concentration, increases the depletion area in Ga₂O₃ region and a high electric field distribution on PN junction, and thus the breakdown voltage increases from 512 V to 636 V at I_D =1 × 10^-3 A/mm.

Total vaginal necrosis after radiation for recurrent cervical cancer: A case report

( Young Shin Chung ),( Sang Wun Kim ),( Young Tae Kim ),( Sunghoon Kim ),( Eun Ji Nam ),( Ga Won Yim ) 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-

Total vaginal necrosis (TVN) is a rare, late complication after radiation treatment that requires prolonged management. A 75-year-old woman with a history of whole pelvis and intracavitary radiotherapy (ICR) for squamous cell carcinoma stage IIB in 1981 (complete remission) and another 6th cycles of chemotherapy due to cervical recurrence in 2009 developed second local recurrence confirmed by cervical biopsy in 2012. The vaginal length had been extremely shortened due to atrophy. The patient received ICR (3000 cGy) for a month. Seven months after radiation, the patient suffered pelvic pain, foul-odored vaginal discharge and urinary leakage. Pelvic examination showed total necrotic change of vagina. Vaginal biopsy showed no evidence of malignancy. Despite a month of conservative treatment, symptoms aggravated and thus necessitated intensive inpatient treatment. Therapies included daily vaginal irrigation, dressing with chlorohexidine gluconate and saline, intravenous antibiotics, and pain control with oral opioid and NSAIDs. Only minimal surgical debridement was possible due to diffusely necrotic and friable epithelium. Two kinds of vaginal suppositories (estradiol/ lyophilized lactobacilli, and neomycin sulfate / nystatin / polymyxin B sulfate) were inserted daily alternatively. Medication dosage was tapered gradually after 3 months. Five months after treatment, the vaginal wall was significantly improved with pinkish normal-looking epithelium. Although no definitive treatment is proven optimal for TVN so far, several conservative options may help alleviate symptoms.

Poster Session : PS 1489 ; Allergy : A Case of Eosinophilic Gastroenteritis Which Led to Malabsorption and Iron Defl ciency Anemia Associated with Multiple Food Allergies

( Young Soo Lee ),( Ga Young Ban ),( Ji Hye Kim ),( Dae Hong Seo ),( Young Min Ye ),( Yoo Seob Shin ),( Dong Ho Nahm ),( Hae Sim Park ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1

Eosinophilic gastroenteritis (EG) is a rare disease characterized by massive eosinophilic infiltration of gastrointestinal tissue, increased peripheral eosinophilia and nonspecific gastrointestinal symptoms. EG have no known causes for eosinophilia such as drug, parasite, or malignancy. About 50% of EG patients have allergic diseases suggesting EG may be associated with allergic status since some EG patients exhibit elevated serum immunoglobulin E (IgE) levels. We report a case of EG which led to severe malabsorption and iron deficiency anemia associated with multiple food allergies. A 28-yearold Caucasian male patient visited emergency room complaining general weakness and leg swelling for 2 months. He had allergic rhinitis and vomiting whenever eating eggs, steaks, and salmons. He looked chronically-ill and conjunctivae were pale. In laboratory findings, hemoglobin level and WBC count were 6.4g/dL and 7,400/uL with 24.4% of eosinophil fraction as well as serum total protein and albumin levels were 3.9g/dL and 2.8g/dL, respectively. Serum iron level (12μg/dL), total iron binding capacity (247μg/ dL), and ferritin level (2.2μg/L) were all decreased. Serum eosinophil cationic protein level was increased (30.0μg/L) whereas serum total IgE level was within normal reference value (77KU/L). Serologic tests for parasite were all negative. Endoscopic studies were performed to exclude gastrointestinal bleeding and multiple nodular lesions were seen on gastric antrum with increased eosinophil in. ltration in lamina propria. High serum specific IgE levels to offending foods (beef: 0.82kU/L, pork: 0.83kU/L, egg white: 0.40kU/L, egg yolk: 0.54kU/L, and milk: 0.81kU/L) were noted. He was recommended avoiding offending foods with oral prednisolone therapy. Six months after food restriction, eosinophil count was 400/uL and hemoglobin level was restored to 11.5g/dL with 4.1g/dL of serum albumin level. We report a rare case of eosinophilic gastroenteritis associated with multiple food allergies.

Multifunctional Anti-alzheimer’s Disease (AD) Activities of Organic Solvents Extracts of Propolis

Ga Young Shin,Byoung Wook Choi,Bong Ho Lee 한국양봉학회 2015 한국양봉학회 학술대회 자료집 Vol.2015 No.3

Clinical features of elderly chronic urticaria

( Ga Young Ban ),( Mi Yea Kim ),( Hye Soo Yoo ),( Dong Ho Nahm ),( Young Min Ye ),( Yoo Seob Shin ),( Hae Sim Park ) 대한내과학회 2013 대한내과학회 추계학술발표논문집 Vol.2013 No.1

Background: Chronic urticaria (CU) is defined as itchy wheals lasting for at least 6 weeks, with or without angioedema. It is a common disabling disorder occurring in about 0.5-1% of the population. Recently, the aged population is increasing worldwide, and this group responds differently to environmental stimuli. Therefore, it is essential to identify the specific features of disease in aged group. Nevertheless, there have been few studies reporting the features about CU in the elderly population. We investigated the prevalence and clinical features of elderly CU in comparison with non-elderly CU in this country. Method: We retrospectively analyzed the medical records of 827 CU patients who were followed in the outpatient Allergy Clinic of Ajou University Hospital, South Korea. According to the EAACI/GA2LEN/EDF/WAO guideline, physical or other secondary types of urticarial patients were excluded, and chronic spontaneous urticarial patients were included. Elderly CU was defined as the CU patients older than 60 years old. Severe CU was defined when urticaria activity score was ≥13 at initial visit. Results: Of the total 827 patients, 37 (4.5%) were elderly. Among co-morbid conditions, atopic dermatitis (AD) was significantly higher (37.8% vs. 21.7%, p=0.022), while prevalence of aspirin intolerance was lower (18.9% vs. 43.6%, p=0.003) in elderly CU. However, prevalence of severe CU was not significantly different between the two groups. Other clinical parameters such as sex, atopy and laboratory findings including anti-thyroid antibodies and serum specific IgE to staphylococcal superantigens were found to have no significant differences between the two groups. However the prevalences of serum specific IgE to staphylococcal enterotoxin A (SEA) and staphylococcal enterotoxin B (SEB) were significantly higher in elderly CU with AD than in those without AD (37.5% vs. 0%, respectively). Conclusion: Considering the higher prevalence of AD in elderly CU, it is needed to observe the coexistence of AD in elderly CU. Specific IgE to SEA/SEB may play a role in the pathogenesis of elderly CU, especially who are accompanied by AD.

Genetic Effects on Leukotriene Production in Aspirin Exacerbated Respiratory Disease

( Ga-young Ban ),( Kumsun Cho ),( Seung-hyun Kim ),( Moon Kyung Yoon ),( Ji-hye Kim ),( Yoo-seob Shin ),( Young-min Ye ),( Dong-ho Nahm ),( Hae-sim Park ) 대한내과학회 2015 대한내과학회 추계학술발표논문집 Vol.2015 No.1

Background: It is widely known that there have been strong genetic associations with aspirin exacerbated respiratory diseas (AERD) development. Leukotriene overproduction is the major feature of AERD. Genetic polymorphisms of CysLTR1 and HLA-DPB1*0301 were associated with the phenotypes of AERD. Objective: To investigate the genetic effects on leukotriene production in AERD. Subjects and Methods: A total of 95 AERD and 94 aspirin tolerant asthma (ATA) patients were enrolled. Serum samples were collected from all of the study subjects whereas urine samples were collected from 45 AERD and 44 ATA patients when the asthma was stable. The metabolites of LTE4 were analyzed using liquid chromatography with mass spectrometry. HLA-DPB1 high-resolution genotyping wasobtained from direct sequencing method and polymorphism of CysLTR1 was genotyped using SNaP shot ddNTP primer extension kit. Results: The frequency of HLA-DPB1*0301 allele was significantly higher in AERD compared with ATA (p=0.004, OR=4.178). The TT genotype frequency at CysLTR1 -634C>T is significantly higher in AERD compared to ATA (p 0.006, OR= 2.891). Serum and urine LTE4 levels were significantly higher in AERD than in ATA (19.10 ± 14.14 pg/mL vs. 13.59 ± 10.10 pg/mL, p=0.002; 7.36 ±13.19 pmol/mg creatinine vs. 2.69 ±3.62 pmol/mg creatinine, p=0.047, respectively). The levels of urine LTE4 were significantly higher in patients carrying HLA-DPB1*0301 (p=0.041), while no differences were found in serum LTE4. The asthmatic patients with the TTgenotype at -634C>T had a significantly higher levels of urine LTE4 (p=0.015), but no differences were found in serum LTE4 levels. The levels of urine LTE4 correlated significantly with fall of FEV1% after lysine aspirin bronchoprovocation test (r=0.463, p=0.008). Conclusions: HLA-DPB1*0301 and genetic polymorphisms of CysLTR1 -634C>T affect cysteinyl leukotriene overproduction which can contribute to develop the phenotypes of AERD.

Poster Session : PS 0944 ; Liver : Factors Predicting Hepatocellular Carcinoma Progression after Transarterial Chemoembolization

( Ga Won Song ),( Sun Young Shin ),( Kyu Hyun Han ),( Suk Pyo Shin ),( Seong Gyu Hwang ),( Kyu Sung Rim ),( Hana Park ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1

Background/Aim: Transarterial chemoembolization (TACE) is one of the locolesional treatment modalities for hepatocellular carcinoma (HCC). However, disease progression after TACE is often developed. The aim of our study was to determine the predictors of progression after TACE in patients with HCC. Method: We retrospectively reviewed a total of 374 patients who had diagnosed as HCC and performed the fi rst TACE in our institution, Bundang CHA hospital, from 2004 January to 2013 September. Tumor response was estimated as CR (complete response), PR (partial response), SD (stable disease) and PD (progressive disease) based on the results of computed tomography 4 weeks after TACE with modifi ed RECIST criteria.Results: Among a total 374 patients, 13 patients(3.5%) had experienced previous TACE, and 361 patients(96.5%) were TACE naive. Most patients(n=370, 98.9%) had liver cirrhosis, 289 patients(77.3%) were classifi ed as Child-Pugh class A and 85 patients( 22.2%) as Child-Pugh class B. After 4 weeks after TACE, tumor response was as follows: CR 146(39.0%), PR 124(3.2%), SD 16(4.3%) and PD 88(23.5%). In patients with PD, there was a signifi cantly greater portion of TACE experienced patients compared to those with CR, PR, and SD(8.0 vs. 2.1%, p=0.016). The mean size of largest tumor and total sum of tumor sizes were signifi cantly greater in patients with PD(6.4 vs. 3.6 cm of largest tumor size, p<0.001; 7.0 vs 4.1 cm of total sum of tumor sizes, p=0.001, respectively). In multivariate analysis, previous TACE experience[Odds ratio (OR) 8.746, p=0.002] and a total sum of tumor sizes( = 3cm; OR 4.022, p=0.016, = 10cm; OR 9.153, p=0.008) were predictors of progression after TACE.Conclusion: Progression of HCC after TACE is associated with history of previous TACE experience and the total sum of tumor sizes. * Ga Won Song and Sun Young Shin contributed equally.

Clinical features of elderly chronic urticaria

( Ga Young Ban ),( Mi Yea Kim ),( Hye Soo Yoo ),( Dong Ho Nahm ),( Young Min Ye ),( Yoo Seob Shin ),( Hae Sim Park ) 대한내과학회 2014 The Korean Journal of Internal Medicine Vol.29 No.6

Background/Aims: Chronic urticaria (CU) is defined as itchy wheals lasting 6 weeks or more. As the aged population increases worldwide, it is essential to identify the specific features of this disease in the elderly population. Methods: We investigated the prevalence and clinical features of CU in elderly patients. Medical records of 837 CU patients from the outpatient Allergy Clinic of Ajou University Hospital, Korea were analyzed retrospectively. Patients with chronic spontaneous urticaria according to the EAACI/GA2LEN/EDF/WAO guidelines were included. Patients older than 60 years were defined as elderly. Results: Of the 837 patients, 37 (4.5%) were elderly. In elderly versus nonelderly CU patients, the prevalence of atopic dermatitis (AD) was significantly higher (37.8% vs. 21.7%, respectively; p = 0.022), while that of aspirin intolerance was lower (18.9% vs. 43.6%, respectively; p = 0.003) in terms of comorbid conditions. The prevalences of serum specific immunoglobulin E antibodies to staphylococcal enterotoxin A and staphylococcal enterotoxin B were considerably higher in elderly CU patients with AD than in those without AD (37.5% vs. 0%, respectively). Conclusions: Elderly patients with CU had a higher prevalence of AD. Therefore, there is a need to recognize the existence of AD in elderly CU patients.

IMPACT OF SELF-DISCLOSURE AND AUTHENTICITY OF INFLUENCER ON CONSUMER REACTION: FOCUSING ON MEDIATING EFFECT OF ENVY

Ga-Young Ahn,Shin-Young Park,Jisoo Park 글로벌지식마케팅경영학회 2017 Global Fashion Management Conference Vol.2017 No.07

In the world of SNS, once ordinary users get recognized for discriminated fashion taste, they affect other users’ choice of fashion products. Fashion companies capture the importance of these influencers and tries to take advantage of their ability. However, the benefits offered to influencers such as financial compensation may provoke negative consumer reactions. The purpose of this study is to identify what aspects of SNS influencers and how they influence other fashion consumers. We suggest that influencers’ self-disclosure and authenticity of posts are important factors which elicit positive response from consumers. We also investigate the psychological mechanism of envy which can mediate the impact of self-disclosure and authenticity on consumer response. This study was conducted by an online survey of 120 Korean women in their 20s and 30s with a 2 x 2 between-group experimental design. The data was collected from 28 November to 5 December 2016. The collected data was analyzed using SPSS 23.0 for ANOVA analysis and regression analysis. The results were as follows. The main effect of authenticity was confirmed, while self-disclosure did not play a significant role, which indicates authenticity is the main factor in exercising influence on consumer response. The interaction of authenticity and self-disclosure was also observed. The participants of high in both self-disclosure and authenticity showed the strongest consumer reaction. However, the participants of high self-disclosure and low authenticity induced the weakest consumer response. For the impacts of self-disclosure and authenticity on envy, the participants exposed to the condition of both high self-disclosure and authenticity showed benign envy. On the other hand, malicious envy was aroused when both self-disclosure and authenticity were low. In relations between authenticity and consumer response, partial mediating effect of benign envy and malicious envy was confirmed. But, there was no mediating effect between self-disclosure and consumer response. This research on consumer response to influencers’ posts will provide key implications to fashion companies in building marketing strategies. In order for influencers' posts displaying their daily lives to have a positive impact on consumer response, not only self-disclosure but authenticity has to be considered. Such posts can induce benign envy and subsequently impact consumers indirectly. Influencers’ posts which narrow the gap between daily lives and products and raise the authenticity are important keys to successful marketing.

소아 마이코플라스마 폐렴에서 흉부 방사선 소견에 따른 임상 양상의 차이

박가영 ( Ga Young Park ),이영임 ( Young Im Lee ),신미용 ( Mee Yong Shin ),박재옥 ( Jae Ock Park ),김창휘 ( Chang Hwi Kim ) 대한천식알레르기학회 2013 Allergy Asthma & Respiratory Disease Vol.1 No.4

Purpose: This study was conducted to evaluate the difference of clinical characteristics of pneumonia in children caused by Mycoplasma pneumoniae, according to their chest radiographic patterns. Methods: We analyzed medical records of 921 children who were admitted to Soonchunhyang University Buchon Hospital due to M. pneumoniae pneumonia from January 2008 to December 2011. Enrolled children were divided into 2 groups by radiological patterns: lobar/lobular pneumonia group (group 1) and broncho/interstitial pneumonia group (group 2). Results: The number of patients in group 1 was 295 (32%) and in group 2, 626 (68%). Lobar/lobular pneumonia occurred in older children compared to broncho/interstitial pneumonia (mean age, 6.4 years vs. 4.2 years; P=0.00). Group 1 had significantly longer durations of fever and hospitalization than group 2. The frequency of pleural effusion was significantly higher in group 1. Erythrocyte sedimentation rate and C-reactive protein values were higher in group 1. Coinfections with respiratory viruses were more frequent in group 2. The history of allergic diseases were more common in group 2 (P=0.006). In 2011, lobar/lobular pneumonia was more frequent and the duration of fever was longer compared with 2008.2010. Conclusion: In M. pneumoniae pneumonia, patients with lobar/lobular pneumonia were more older and had more severe clinical features and laboratory findings. Because there was an outbreak with severe clinical course in 2011, we wonder that the outbreak was related to the macrolide resistant M. pneumoniae. Careful attention about clinical course and consequences of patients with lobar/lobular pneumonia is required.