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방사선조사와 저칼슘식이가 치아형성시 Interleukin-1의 분포에 미치는 영향에 관한 연구
김일중,황의환,이상래 대한구강악안면방사선학회 2000 Imaging Science in Dentistry Vol.30 No.3
Purpose : To elucidate the effects of the irradiation and calcium-deficient diet on expression of interleukin (IL)-1 during tooth formation of rat molar Materials and Methods : The pregnant three-week-old Spague-Dawley rats were used for the study. The control group was non-irradiation/normal diet group, and the experimental groups were irradiation/normal diet group and irradiation/calcium-deficient diet group . The abdomen of the rats on the 9th day of pregnancy were irradiated with single dose of 350 cGy. The rat pups were sacrificed on the 14th day after delivery and the maxillae tooth germs were taken. The specimen were prepared to make sections for light microscopy, and some of tissue sections were stained immunohistochemically with anti-IL-1 antibody. Results : In the irradiation/normal diet group, dental follicle showed fewer blood vessels, mononuclear cells, and fusions of mononuclear cells than in non-irradiation/normal diet group. Alveolar bone showed a few osteoblasts and osteoclasts. Periodontal ligament showed collagen fibers and fibroblasts with irregularity. Weak immunoreactivity for IL-1 was shown in dental follicle, alveolar bone, and periodontal ligament, In the irradiation/calcium-deficient diet group, dental follicle showed sparse cellularity. Alveolar bone showed diminished number of osteoblasts. Periodontal ligament showed irregular collagen fibers and atrophy of cementoblasts and fibroblasts. No immunore-activity for IL-1 was shown in dental follicle, alveolar bone, and periodontal ligament. Conclusion : Irradiation and calcium-deficient diet seems to cause disturbance of the expression of interleukin-1 during tooth formation of rat molar. (Korean J Oral Maxillofac Radiol 2000; 30: 159-168)
윤여일,윤석기,김선규,김용현,남일송,차건영,황의원,김영선 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2
Background: The diabetic patients are at significantly increased risk of developing vascular disease. It's etiology may involve oxidative damage by free radiacals and protection againse such damage can be offered by antioxidants. We investigated that oxidative stress as assessed by measurement of total antioxidant status may play a role in development of diabetes mellitus. Method: We measured total antioxiant status using merchandised kit, glycated hemeglobin(HbA1c) in 46 type 2 diabetes mellitus patients and 50 healthy matched control subjects. Result: The total antioxidant status(TAS) was 2.10(±0.04) mmol/L in uncontrolled type 2 DM patients, 2.60(±0.03) in controlled type 2 DM patients and 2.70(±0.16) in healthy control subjects. TAS was significantly lower(P<0.05) in uncontrolled type 2 DM patients, but no significant association between in controlled type 2 DM patients and healthy control subjects. The TAS was 2.00(±0.17) mmol/L in complicated type 2 DM patients and 2.10(±0.29) uncomplicated type 2 DM patients. There was no significant associations between complicated type 2 DM patients and uncomplicated type 2 DM patients. Conclusion: Poor glycemic control is associated with reduced TAS in type 2 DM patients. TAS was thought indirect index that predict glycemic control of type 2 DM patients.
Hwang, Eui Il,Kim, Young Kook,Lee, Hyang Bok,Kim, Hong Gi,Kim, Sung Uk 한국미생물 · 생명공학회 2000 Journal of microbiology and biotechnology Vol.10 No.2
Chitin synthases are identified as key enzymes of chitin biosynthesis in most of the fungi. Among them, chitin synthase Ⅱ has been reported to be an essential enzyme in chitin biosynthesis, and exists as a membrane-bound form. To search and screen new antifungal agents from natural resources to inhibit chitin synthase Ⅱ, the assay conditions were established using the enzyme isolated from Saccharomyces cerevisiae ECY38-38A(pAS6) that overproduces only chitin synthase Ⅱ. This enzyme was activated only by partial proteolysis with trypsin. Its activity reached the maximum at 80㎍/ml of trypsin and was strongly stimulated by 2.0mM Co^2+, 1.0mM UDP-[^14C]-G1cNAc, and 32mM free-GlcNAc. Under these assay conditions, the highest chitin synthase Ⅱ activity was observed by incubation at 30℃ for 90min. However, an extremely narrow range of organic solvents up to as much as 25% of DMSO and 25% of MeOH was useful for determining optimal assay conditions. After a search for potent inhibitors of chitin synthase Ⅱ from natural resources, prodigiosin was isolated from Serratia marcescens and purified by solvent extraction and silica gel column chromatographies. The structure of prodigiosin was determined by UV, IR, Mass spectral, and NMR spectral analyses. Its molecular weight and formula were found to be 323 and C_20,H_25,N_3,O, respectively. Prodigiosin inhibited chitin synthase II by 50% at the concentration of 115㎍/ml.
고등식물로부터 Chitin Synthase Ⅱ 활성 저해물질의 탐색
황의일(Eui Il Hwang),이향복(Hyang Bok Lee),김성욱(Sung Uk Kim) 대한약학회 1999 약학회지 Vol.43 No.4
Chitin is an important structural component of fungal cell wall and is synthesized by chitin synthase Ⅰ, Ⅱ, and Ⅲ. The chitin synthase Ⅱ is an essential enzyme for the formation of primary septum in Saccharomyces cereviside. Therefore, specific inhibitors of this enzyme might block the formation of fungal cell wall and could be used as effective antifungal agents. To search chitin synthase Ⅱ inhibitors from natural products, 67 plants were extracted with methanol and examined for the inhibitory activities against chitin synthase Ⅱ of S. cerevisiae by our cell free assay system. As a result, the extracts from 16 plants showed more than 70% inhibition at the concentration of 280mcg/ml. Of note, Laurus nobilis (81.4%), Lonicera maackii (81.5%), Berchemia berchemiaefolia (82.9%), Koelreuteria paniculata (87.9%), Chamaecyparis pisifera (86%) and Taxus cuspidata (83.9%) inhibited strongly the chitin synthase Ⅱ activity.
오미자에서 분리한 새로운 Chitin Synthase Ⅱ 저해제인 Gomisin N 과 Wuweizisu C
황의일(Eui Il Hwang),김미경(Mi Kyung Kim),이향복(Hyang Bok Lee),김영국(Young Kook Kim),권병목(Byoung Mog Kwon),배기환(Ki Hwan Bae),김성욱(Sung Uk Kim) 대한약학회 1999 약학회지 Vol.43 No.4
To search for new chitin biosynthesis inhibitors from natural sources, several higher plants were examined the inhibitory activity against chitin synthase Ⅱ by enzymatic assay. Among them, the extract of Schizandra chinensis strongly showed the inhibitory activity against chitin synthase Ⅱ. Gomisin N and wuweizisu C were isolated from Schizandra chinensis and showed IC50 value of 62.4mcg/ml and 19.2mcg/ml, respectively. Activities of these compounds were more stronger than that of polyoxin D. However, gomisin N and wuweizisu C showed weakly antifungal activities against various human pathogens.
척추수술시 급성 동량성 혈액희석법은 수혈요구량을 감소시킨다
황의영,고홍,도상환,김지애,최익현,곽일룡,한미애 대한마취과학회 1997 Korean Journal of Anesthesiology Vol.33 No.3
Background : Acute normovolemic hemodilution(ANH) is known as the easieat and most economical and the quality of autologous blood saved by it is the best of all methods of autotransfusion. To investigate the efficacy of ANH, we studied whether it could reduce the transfusion requirement in spinal surgery. Methods : Forty patients were randomly divided into 2 groups. In the hemodilution group(n=20), 2 or 3 units of autologous blood were procured immediately before or after anesthetic induction while Ringer's lactate and pentastarch were infused to maintain normovolemia. All patients received deliberate hypotension induced by labetalol. Perioperative changes of hemoglobin, hematocrit and platelets, the transfusion requirement and the amount of postoperative drainage were compared between each group. Results : Perioperative changes of hemoglobin, hematocrit and platelet showed no significant differences between each group. Less packed RBC were used in the hemodilution group(1.9 2.0 units) than in control group(5.9 6.8 units) (P<0.05). In the control group, 4 patients were transfused with fresh frozen plasma(mean 4.8 units), 3 patients with platelets(mean 13 units) and 1 patient with cryoprecipitate(10 units) while only one patient was transfused with 3 units of fresh frozen plasma in the hemodilution group. Postoperative drainage was significantly less in the hemodilution group(1,494 488 ml) than in the control group(2,476 1,730 ml). Conclusion : ANH seems to decrease the transfusion requirement in spinal surgery. Reduction of postoperative wound drainage appears to play an important role in that. (Korean J Anesthesiol 1997; 33: 458∼462)