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Pasireotide treatment for severe congenital hyperinsulinism due to a homozygous ABCC8 mutation
Mooij Christiaan F.,Tacke Carline E.,van Albada Mirjam E.,Barthlen Winfried,Bikker Hennie,Mohnike Klaus,Oomen Matthijs W.N.,van Trotsenburg A.S. Paul,Zwaveling-Soonawala Nitash 대한소아내분비학회 2021 Annals of Pediatirc Endocrinology & Metabolism Vol.26 No.4
ABCC8 and KCJN11 mutations cause the most severe diazoxide-resistant forms of congenital hyperinsulinism (CHI). Somatostatin analogues are considered as secondline treatment in diazoxide-unresponsive cases. Current treatment protocols include the first-generation somatostatin analogue octreotide, although pasireotide, a second-generation somatostatin analogue, might be more effective in reducing insulin secretion. Herein we report the first off-label use of pasireotide in a boy with a severe therapy-resistant form of CHI due to a homozygous ABCC8 mutation. After partial pancreatectomy, hyperinsulinism persisted; in an attempt to prevent further surgery, off-label treatment with pasireotide was initiated. Short-acting pasireotide treatment caused high blood glucose level shortly after injection. Long-acting pasireotide treatment resulted in more stable glycemic control. No side effects (e.g., central adrenal insufficiency) were noticed during a 2-month treatment period. Because of recurrent hypoglycemia despite a rather high carbohydrate intake, the boy underwent near-total pancreatectomy at the age of 11 months. In conclusion, pasireotide treatment slightly improved glycemic control without side effects in a boy with severe CHI. However, the effect of pasireotide was not sufficient to prevent near-total pancreatectomy in this case of severe CHI.
진의덕(E. D. Jin),최진승(J. S. Choi),탁계래(G. R. Tack),이봉수(B. S. Lee),이법이(B. Y. Lee) 한국정밀공학회 2006 한국정밀공학회 학술발표대회 논문집 Vol.2006 No.5월
Recently intradiscal electrothermal therapy is introduced, which is a new and minimally invasive technique for the treatment of discogenic low back pain. This procedure involves the percutaneous threading of a flexible catheter into the disc under fluoroscopic guidance. The catheter, composed of thermal resistive coil, heats the posterior annulus of the disc, causing contraction of collagen fibers and destruction of afferent nociceptors. This study tries to investigate the effects of the important factors of this procedure such as heat source temperature and heat applying time on the temperature distribution within the intervertebral disc. This study utilized both computer simulation and the experiment for the verification of finite element analysis. FE analysis was carried out with ANSYS v7.0 (ANSYS Inc, USA) using 10,980 number of brick element and 12,551 number of node. The functional spinal units of 5 month old swine were used for the experiment and the temperature was monitored using 10 channel temperature measurement device MV200. Through this study, it was able to analyze the temperature range of inner intervertebral disc by two mechanisms which are known to alleviate pain clinically. The results showed that when the heat source temperature was kept up 80 degree for 1,020 seconds, the temperature of inner annulus reached at 45 degree up to the distance of 15.6㎜ from heat source, which explains coagulation of inner annulus by heat. When the same heat source was used, the temperature of inner nucleus reached at 60 degree up to the distance of 9㎜ from heat source, which explains contraction of inner nucleus by heat.
Egene, C.E.,Van Poucke, R.,Ok, Y.S.,Meers, E.,Tack, F.M.G. Elsevier 2018 Science of the Total Environment Vol.626 No.-
<P><B>Abstract</B></P> <P>To determine the long-term impact of organic amendments on metal (Cd and Zn) immobilization, soil from the Campine region was amended with holm oak-derived biochar, compost, and peat, and monitored over a 3-year period. Pot experiments were conducted by mixing the amendments independently at 2% and 4% (g/g) with the soil. The mobility and solubility of metals in the treatments were assessed by means of rhizon soil moisture samplers, sequential BCR extractions, and diffusive gradient in thin films (DGT).</P> <P>Over the three-year period, the 2% biochar addition resulted in an average decrease in pore water concentration of 40% for Cd and 48% for Zn whereas the 4% addition led to an average decrease of 66% for Cd and 77% for Zn. The immobilization effect in the biochar treatments was attributed to the consistently higher pH and lower concentrations of dissolved organic carbon (DOC) in the soil. The latter may have been caused by sorption of DOC onto the surface of biochar thereby increasing its negatively charged functional groups that are able to sorb cations. On the other hand, compost and peat had the unwanted effect of significantly increasing the concentrations of Cd and Zn in the soil pore water. This was partly due to the formation of soluble organo-metallic complexes as significantly higher DOC concentrations were found in the compost and peat treatments.</P> <P>Results from the DGT measurements, after a 24 h deployment time, revealed a low resupply (R ≤ 0.4) of Cd and Zn from the solid phase to the soil solution in both amended and unamended soil. This suggests a case of slow metal desorption kinetics in the soil that was relatively unchanged by the presence of organic amendments.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Biochar significantly immobilized soil Cd and Zn over a 3-year period. </LI> <LI> Compost and peat increased available Cd and Zn in soil. </LI> <LI> Metal immobilization was attributed to the consistently higher pH and lower DOC concentrations in the biochar treatments. </LI> <LI> DGT measurements were used to assess the short-term metal resupply kinetics. </LI> <LI> The resupply of Cd and Zn from the solid phase to the soil solution was low (R ≤ 0.4) in all treatments. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Shaheen, Sabry M.,Kwon, Eilhann E.,Biswas, Jayanta K.,Tack, Filip M.G.,Ok, Yong Sik,Rinklebe, Jö,rg Elsevier 2017 CHEMOSPHERE - Vol.180 No.-
<P><B>Abstract</B></P> <P>The fractionation and potential mobilization of As, Cr, Mo, and Se in four floodplain soil profiles collected along the Nile (Egypt) and Wupper (Germany) Rivers were assessed using the BCR sequential extraction procedure. The concentrations of total and the geochemical fractions (acid soluble (F1), reducible (F2), oxidizable (F3), and residual (F4) fraction) of the elements were determined. The Wupper soils had the highest total concentrations (mg kg<SUP>−1</SUP>) of As (378) and Cr (2,797) while the Nile soils contained the highest total Mo (12) and Se (42). The residual fraction of As, Cr, Mo, and Se was dominant in the Nile soils suggesting the geogenic source of the elements in these soils. The residual fraction of As and Mo and the oxidizable fraction of Cr and Se were dominant in the Wupper soils. Among the non-residual fractions (potential mobile fractions; PMF = ∑F1−F3), the oxidizable fraction was dominant for Cr, Mo, and Se in the Nile soils and for Mo in the Wupper soils, while the reducible fraction was dominant for As in both soils. The PMF of As, Cr, and Se was higher in the Wupper than in the Nile soils which might reflect the anthropogenic sources of these elements in the Wupper soils, while the opposite was the case for the PMF of Mo. The high PMF of Se (87%), Cr (87%), and As (21%) in the Wupper soils suggested that a release of these toxic elements may happen which increase the potential environmental risks in the anthropogenically polluted soils.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Selenium showed the highest potential mobilization followed by Cr, Mo, and As. </LI> <LI> Potential mobilization of As, Cr, and Se was high in the Wupper soils. </LI> <LI> Potential mobilization of Mo was high in the Nile soils. </LI> <LI> Residual fraction of As, Cr, Mo, and Se was dominant in the Nile soils. </LI> <LI> Oxidizable fraction of Cr and Se was dominant in the Wupper soils. </LI> </UL> </P>
Kwon, Jung-Hoon,Lee, Dong-Hun,Swayne, David E.,Noh, Jin-Yong,Yuk, Seong-Su,Erdene-Ochir, Tseren-Ochir,Hong, Woo-Tack,Jeong, Jei-Hyun,Jeong, Sol,Gwon, Gyeong-Bin,Song, Chang-Seon Centers for Disease Control and Prevention 2016 Emerging infectious diseases Vol.22 No.3
<P>Highly pathogenic avian influenza A(H5N8) viruses were isolated from migratory waterfowl in South Korea during fall 2014–winter 2015, a recurrence after initial introduction in winter 2014. These reappeared viruses were phylogenetically distinct from isolates circulating in poultry farms in South Korea.</P>
콘크리트 구조물 안전 점검을 위한 열화상 카메라의 사례기반 응용 연구
박지섭 ( Park Ji-sup ),윤철우 ( Yun Chul-wu ),한은탁 ( Han E Un-tack ) 한국구조물진단유지관리공학회 2023 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.27 No.1
적외선 열화상은 콘크리트 구조의 결함을 찾기 위해 적외선 온도계(파기를 사용하는 효과적인 비파괴 비접촉식 점검 방법으로 이에 대한 외관조사 방안에 대한 많은 연구가 진행 중이다. 적외선은 가시광선이 가지고 있는 반사, 굴절, 회절 등의 광학적 특성을 가지며, 복사에너지를 이용하여 온도를 감지하기 때문에 기상 요인이 시험 결과에 미치는 영향이 상당히 큰 한계가 있다. 지금까지 열화상 연구는 일조시간 동안의 태양열을 이용하거나 인위적인 열원을 사용하여 시편을 가열하는 방식의 연구였다. 그러나, 실제 콘크리트 구조물에는 인위적인 열원의 공급이 불가능하고, 태양의 복사열 즉 대기 온도에 의존할 수밖에 없다. 따라서 인위적인 열원을 사용하지 않는 콘크리트 구조물에 점검 시 열화상 카메라의 실무적 도입방안을 위해 연구를 진행하였다.