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Jin’e Wan,Jian Yang,Cuixia Qiao,Xiaomei Sun,Aiting Di,Lize Zhang,Dandan Wang,Gang Zhao 연세대학교의과대학 2019 Yonsei medical journal Vol.60 No.5
Purpose: Colorectal cancer (CRC) is the third most common cancer in China and poses high morbidity and mortality. In recentyears, increasing evidence has indicated that microRNAs played important functions in the occurrence and development of tumors. The purpose of this study was to identify the biological mechanisms of miR-362 in CRC. Materials and Methods: Quantitative real-time PCR was carried out to assess the expression of miR-362 and SIX1. The Kaplan-Meier method was employed to evaluate the 5-year overall survival of CRC patients. The proliferative and invasive abilities of CRCcells were assessed by MTT and transwell assays. Results: miR-362 was significantly decreased in CRC tissues and cell lines, compared to the normal tissues and normal cells. Asignificant connection was confirmed between the overall survival of 53 CRC patients and low expression of miR-362. Downregulationof miR-362 inhibited the proliferation and invasion through binding to the 3'-UTR of SIX1 mRNA in CRC. Additionally, wediscovered that SIX1 was a direct target gene of miR-362 and that the expression of miR-362 had a negative connection with SIX1expression in CRC. SIX1 could reverse partial functions in the proliferation and invasion in CRC cells. Conclusion: miR-362 may be a prognostic marker in CRC and suppress CRC cell proliferation and invasion in part through targetingthe 3'-UTR of SIX1 mRNA. The newly identified miR-362/SIX1 axis provides insight into the progression of CRC.
아몬드와 대두의 혼합비율과 가공공정을 달리하여 제조한 아몬드 청국장의 품질 특성
Wen-Di Jin,어지현,황수정,범희주,은종방 全南大學校 農業科學技術硏究所 2012 農業科學技術硏究 Vol.47 No.-
Almond cheonggukjang was made and evaluated in order to improve nutritional value and quality of cheonggukjang with different addition levels of almond and soybean, 4:6, 5:5 and 6:4 (w/w). To make almond cheonggukjang, Bacillus subtilis was added to mixture of almond and soybean then fermented at 42℃ for 48 hours. Physicochemical, microbiological properties and sensory evaluation for almond cheonggukjang were conducted. In color, L* and b* values of almond cheonggukjang increased with increasing addition levels of almond. As addition levels of almond increased, there was no change in pH value of almond cheonggukjang. Slime production of almond cheonggukjang with 5:5 (w/w) ratio of almond and soybean was the highest among all samples. These results showed that the almond cheonggukjang exhibited effective growth of microorganisms with increasing addition levels of soybean. The amino nitrogen contents of almond cheonggukjang ranged from 164.85±1.12 mg% to 173.25±1.16 mg%. Almond cheonggukjang with 6:4 (w/w) ratio of almond and soybean and prepared by steaming showed the best results in sensory evaluation, compared to those prepared by steaming with 4:6 (w/w) and 5:5 (w/w) ratios. In conclusion, almond cheonggukjang added with 6:4 (w/w) ratio of almond and soybean and prepared by steaming was the best formula to improve nutritional value and quality of cheonggukjang.
Identification and expression analysis of grape LRK10L-2 genes during grape fruit development
Ma Jin-Ping,Yin Xue-Ren,Wei Tong-Lu,Liu Hai-Nan,Pei Mao-Song,Yang Sheng-Di,Jin Hui-Ying,He Guang-Qi,Guo Da-Long 한국식물생명공학회 2022 Plant biotechnology reports Vol.16 No.1
LRK10L-2 is known to be related to the plant disease response, little information is available about the relationship of LRK10L-2 and fruit ripening. The protein physicochemical properties, conserved domains, gene structures, subcellular locali- zation, expression patterns during grape fruit development and promoter activity of the members of grape LRK10L-2 gene family were explored in this study. A total of 109 LRK10L-2 family gene members were identified, and mainly distributed on chromosome 16. Almost all of them were located in the plasma membrane. Most of the LRK10L-2 genes contain four or five motifs, ranging from 0 to 5 introns and have the cis-acting elements related to hormones in their promoter regions. There were 20 pairs of tandem duplicates and 293 pairs of segmental duplication in LRK10L-2 family genes. It was proved that the expression of LRK10L-2 gene varied at the different fruit development stages of 'Kyoho' and its early-ripening bud mutant, ‘Fengzao’. The subcellular localization of VIT_16s0098g00160 and VIT_16s0098g00400 were in the plasma membrane, and had a significant enrichment of the GUS signal in N.benthamiana leaves for the promoter. The results lay a solid basis for the further functional researches of the LRK10L-2 genes for grape fruit ripening.
Peptidoglycans Promotes Human Leukemic THP-1 Cell Apoptosis and Differentiation
Wang, Di,Xiao, Pei-Ling,Duan, Hua-Xin,Zhou, Ming,Liu, Jin,Li, Wei,Luo, Ke-Lin,Chen, Jian-Jun,Hu, Jin-Yue Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.12
The innate immune system coordinates the inflammatory response to pathogens. To do so, its cells must discriminate self from non-self utilizing receptors that identify molecules synthesized exclusively by microbes. Toll-like receptors have a crucial role in the detection of microbial infection in mammals and insects. In mammals, they have evolved to recognize conserved products unique to microbial metabolism. These include lipopolysaccharide (LPS), lipotechoic acids, and peptidoglycans (PGN). We show here that TLRs, including TLR2, are expressed on the THP-1 human leukemia cell line. Activation of TLR2 signaling in THP-1 by PGN induces the synthesis of various soluble factors and proteins including interleukin-$1{\beta}$, interleukin-8 and TNF-${\alpha}$ and apoptosis of THP-1 with PGN dose and time dependence. Moreover, in this study we show that PGN induces apoptosis of THP-1 cells in a TNF-${\alpha}$-dependent manner. These findings indicate that TLR2 signaling results in a cascade leading to tumor apoptosis and differentiation, which may suggest new clinical prospects using TLR2 agonists as cytotoxic agents in certain cancers.
High-Speed and Low-Voltage-Driven Shift Register With Self-Aligned Coplanar a-IGZO TFTs
Di Geng,Dong Han Kang,Man Ju Seok,Mativenga, M.,Jin Jang IEEE 2012 IEEE electron device letters Vol.33 No.7
<P>We report a high-speed and low-voltage-driven shift register utilizing self-aligned coplanar amorphous-indium-gallium-zinc-oxide thin-film transistors (a -IGZO TFTs). The a-IGZO TFTs exhibit field-effect mobility, threshold voltage, and gate-voltage swing of 24.7 cm<SUP>2</SUP>/V·s, 0.2 V, and 118 mV/dec, respectively. The rise and fall times of the shift register at the supply voltage (<I>V</I><SUB>DD</SUB>) of 1 V are 8 and 7 μs, respectively, and the output pulse is free from distortion or ripple. For a <I>V</I><SUB>DD</SUB> of 15 V, the clock frequency of the shift register approaches 500 kHz, making it applicable to high-resolution active-matrix displays.</P>
Di Geng,Yuan Feng Chen,Mativenga, Mallory,Jin Jang IEEE 2015 IEEE electron device letters Vol.36 No.8
<P>We report the design and fabrication of a high-yield, a high-speed, and an ultranarrow gate driver with amorphous-indium - gallium - zinc-oxide thin-film transistors (TFTs). A single stage of the gate driver consists of nine TFTs and one capacitor. For supply voltage (VDD) of 20 V, the gate driver operates with a pulsewidth of 2 μs, which is compatible with a 4k2k display operated at 240 Hz. In addition, the proposed gate driver is ultrasmall in physical size, which is only 30 μm in width (pitch) and 720 μm in length, and thus suitable for small-size, high-resolution, and narrow bezel display.</P>
Di Geng,Dong Han Kang,Jin Jang IEEE 2011 IEEE electron device letters Vol.32 No.6
<P>We report the fabrication of amorphous indium-gallium-zinc-oxide (a-IGZO) thin-film transistors (TFTs) with a bottom-gate inverted-staggered structure with an etch stopper formed by a self-aligned process using back-side UV exposure. In addition to reduction in process complexity, the gate-to-source capacitance of an a-IGZO TFT is significantly reduced, resulting in fast TFT circuits. The fabricated TFT exhibits a field-effect mobility value of 42.59 cm<SUP>2</SUP>/V·s , a threshold voltage of 6.1 V, and a gate voltage swing of 374 mV/dec. An 11-stage ring oscillator made of TFTs shows a propagation delay time of 56 ns/stage at 25 V.</P>