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Dasom Jung,Seulgi Kang,Heesoo Lee,Keunbae Park,Ke Li,Jin Hak Kim,Jeong Ho Geum,Jeongmi Lee 한국분석과학회 2019 분석과학 Vol.32 No.4
A simple and reliable analytical method based on high-performance liquid chromatography-ultraviolet detection was established for the analysis of the flowers of Chrysanthemum morifolium (CM). Luteolin-7-Oglucoside (LU7G) was chosen as a target analyte considering its content, availability, and ease of analysis. Chromatographic separation of LU7G was achieved using a Phenomenex Gemini C18 column (250 × 4.6 mm, 5 μm) run with a mobile phase consisting of 0.5 % acetic acid in water and 0.5 % acetic acid in acetonitrile at a flow rate of 1.0 mL min−1. The detection wavelength and column temperature were set at 350 nm and 40 oC, respectively. Method validation was performed according to the AOAC guidelines and the method was specific, linear (R2 = 0.9991 for 50–300 μg mL−1), precise (≤ 3.91 % RSD), and accurate (100.1–105.7 %). The limits of detection and quantification were 3.62 and 10.96 μg mL−1, respectively. The established method was successfully applied to determine the contents of LU7G in various batches of bulk CM extracts and labscale CM extract. The developed method is a readily applicable method for the quality assessment of CM and its related products.
Jung, Dasom,Jin, Yan,Kang, Seulgi,Lee, Heesoo,Park, Keunbae,Li, Ke,Kim, Jin Hak,Geum, Jeong Ho,Lee, Jeongmi The Korean Society of Analytical Science 2019 분석과학 Vol.32 No.4
A simple and reliable analytical method based on high-performance liquid chromatography-ultraviolet detection was established for the analysis of the flowers of Chrysanthemum morifolium (CM). Luteolin-7-O-glucoside (LU7G) was chosen as a target analyte considering its content, availability, and ease of analysis. Chromatographic separation of LU7G was achieved using a Phenomenex Gemini $C_{18}$ column ($250{\times}4.6mm$, $5{\mu}m$) run with a mobile phase consisting of 0.5 % acetic acid in water and 0.5 % acetic acid in acetonitrile at a flow rate of $1.0mL\;min^{-1}$. The detection wavelength and column temperature were set at 350 nm and $40^{\circ}C$, respectively. Method validation was performed according to the AOAC guidelines and the method was specific, linear ($R^2=0.9991$ for $50-300{\mu}g\;mL^{-1}$), precise (${\leq}3.91%$RSD), and accurate (100.1-105.7 %). The limits of detection and quantification were 3.62 and $10.96{\mu}g\;mL^{-1}$, respectively. The established method was successfully applied to determine the contents of LU7G in various batches of bulk CM extracts and labscale CM extract. The developed method is a readily applicable method for the quality assessment of CM and its related products.
Dasom Jung,Jae Back Jung,Seulgi Kang,Ke Li,Inseon Hwang,Ji Hoon Jeong,Hyung Sik Kim,Jeongmi Lee(이정미) 한국분석과학회 2021 학술대회논문집 Vol.2021 No.11
Deep eutectic solvents (DESs) are formed from two or more components that are capable of hydrogen bonding. Because many constituents of DESs are naturally occurring and of low toxicity, the resulting DESs are often regarded safe. Recent studies reporting DES toxicity led us to systematically investigate the potential toxicity of a variety of DESs of which components are GRAS by FDA. The hydrogen bond donor was varied among organic acids (lactic acid and malic acid), polyols (glycerol, xylitol, and sorbitol), sugars (glucose and fructose), and urea, while the hydrogen bond acceptor was fixed as choline chloride (ChCl). The eight DESs were tested on HepG2 and HEK293T cell lines, and their IC50 values were compared with those of the aqueous solutions of individual components and mixtures. The aqueous mixtures of DES components generally showed lower IC50 than those of the individual components. Moreover, DESs usually exhibited similar to or higher cytotoxicities than the aqueous mixtures. For further in vivo toxico-metabolomics investigation, a DES, namely CU (1:2) consisting of ChCl and urea at 1:2 molar ratio was selected, because it is one of the most commonly applied DESs in diverse areas. Mice were grouped into five classes, each of which underwent oral administration of saline, ChCl, urea, aqueous solution of ChCl and urea, and CU (1:2). The acute oral toxicity was examined from serum, kidney, and liver by gas chromatography-mass spectrometry- and liquid chromatography-tandem mass spectrometry-based analysis. Metabolic profiles of the DES-treated mice were generally distinct from those of the other groups. Orthogonal projection to latent structure discriminant analysis allowed us to identify numerous differential metabolites, which imply the association of DES toxicity with oxidative and ammonia stresses. DES-induced oxidative stress was confirmed by superoxide dismutase activity, catalase activity, and malondialdehyde assays. Ammonia stress was evidenced by significantly increased ammonia levels in serum of the DES-treated mice. Ammonia could be produced from heating ChCl and urea and from heating ChCl and organic acids. Taken together, our study suggests that ChCl-based DESs may not be simply considered as pure and safe mixtures. The current presentation is based on our recent publication in Green Chemistry (2021).
Sungjin Jung,Dasom Kim,Gunyoung Lee,Sang Soon Yun,Ho Soo Lim,Young Rim Jung,Hekap Kim 한국식품과학회 2017 한국식품과학회지 Vol.49 No.6
This study aimed to evaluate the measurement uncertainty for the quantitative determination of chlorite and chlorate in ready-to-eat fresh-cut vegetables using ion chromatography with a hydroxide-selective column. One gram of the homogenized sample in deionized water was sonicated and centrifuged at 8,500 rpm. The supernatant was purified by passing it through a Sep-Pak tC18 cartridge, followed by chromatographic determination using a Dionex IonPac AS27 column. The linearity of the calibration curves, recovery, repeatability, and reproducibility of the method were satisfactory. The method detection limit was estimated to be approximately 0.5 mg/kg. Each uncertainty component was evaluated separately, and the combined and expanded uncertainty values were calculated at the 95% confidence level. The measured concentrations for 3 mg/kg of chlorite and chlorate standard materials were 3.18±0.32 and 3.10±0.42 mg/kg, respectively. These results confirmed the reliability of the developed method for measuring the two chlorine-based oxyanions in freshcut vegetables.
Dasom Lee,Boung-Chul Lee,최수희,Do-Hyung Kang,전덕인,Myung Hun Jung 대한정신약물학회 2020 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.18 No.2
Objective: Long-acting injectable (LAI) antipsychotics, such as paliperidone palmitate (PP), are known to improve treatment adherence in patients with schizophrenia, which can lead to reductions in relapse and hospitalization rates. However, relatively few studies have demonstrated the economic impact of LAIs, especially in Asian populations. Methods: We conducted a claim-based mirror-image study to explore changes in healthcare utilization and associated costs, among 1,272 South Korean patients with schizophrenia (ICD-10-CM code F20), between the 1-year periods before and after the initiation of PP treatment. Results: Patients accessed outpatient services more frequently after versus before starting PP treatment, with the number of prescription days increasing by 133.45 (p < 0.0001) and the associated costs increasing by USD 1,497.15 (p < 0.0001). The number of admission days was reduced by 11.33 after starting PP treatment (p < 0.0001) and the associated costs were reduced by USD 1,220.75 (p < 0.0001). However, admission cost savings were different according to patients’ oral drug compliance. The daily dosages for benztropine, procyclidine, and propranolol decreased, showing that there were fewer side-effects after PP-treatment (p < 0.0001). Conclusion: Although the high acquisition cost of PP has been regarded as an obstacle to its clinical use, our results imply that the high prescription costs for PP may be counterbalanced by the reduced admission costs associated with its use. Economic outcomes for patients treated with LAIs should be investigated further to help healthcare decision-makers and providers to determine the value of LAIs relative to other treatment medications.
Updating Korean Disability Weights for Causes of Disease: Adopting an Add-on Study Method
Dasom Im,Noor Afif Mahmudah,Seok-Jun Yoon,Young-Eun Kim,Don-Hyung Lee,Yeon-hee Kim,Yoon-Sun Jung,Minsu Ock The Korean Society for Preventive Medicine 2023 예방의학회지 Vol.56 No.4
Objectives: Disability weights require regular updates, as they are influenced by both diseases and societal perceptions. Consequently, it is necessary to develop an up-to-date list of the causes of diseases and establish a survey panel for estimating disability weights. Accordingly, this study was conducted to calculate, assess, modify, and validate disability weights suitable for Korea, accounting for its cultural and social characteristics. Methods: The 380 causes of disease used in the survey were derived from the 2019 Global Burden of Disease Collaborative Network and from 2019 and 2020 Korean studies on disability weights for causes of disease. Disability weights were reanalyzed by integrating the findings of an earlier survey on disability weights in Korea with those of the additional survey conducted in this study. The responses were transformed into paired comparisons and analyzed using probit regression analysis. Coefficients for the causes of disease were converted into predicted probabilities, and disability weights in 2 models (model 1 and 2) were rescaled using a normal distribution and the natural logarithm, respectively. Results: The mean values for the 380 causes of disease in models 1 and 2 were 0.488 and 0.369, respectively. Both models exhibited the same order of disability weights. The disability weights for the 300 causes of disease present in both the current and 2019 studies demonstrated a Pearson correlation coefficient of 0.994 (p=0.001 for both models). This study presents a detailed add-on approach for calculating disability weights. Conclusions: This method can be employed in other countries to obtain timely disability weight estimations.