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抗癌 化學療法을 施行한 末期 胃癌患者 에 對한 抗癌調理方과 AC 2 시럽의 效果에 關한 臨床的 考察
방대건,최서영 대한한방성인병학회 2000 韓方成人病學會誌 Vol.6 No.1
Objectives : This study was performed to evaluate the efficiency of Hangamjori-bang and ACⅡsyrup on the decrease side effects of chemotherapy in Stomach cancer patients. Methods : From September 1999 to June 2000, 9 stomach cancer patients were treated with chemotherapy in other hospital and treated with herb medicine (Hangamjori-bang and AC Ⅱsyrup) in Hana Oriental Hospital. Symptoms of patients were evaluated by symptom numeral scale at ① before chemotherapy ② during chemotherapy ③ treated by Herb medicine for 2 weeks after chemotherapy, and Blood analysis were performed. Results : After chemotherapy, Symptom numeral scale were significantly increased on the nausea/ vomitting and Total point compared to before chemotherapy. After Herb medicine (Hangamjori-bang and AC Ⅱsyrup) treated, symptom numeral scale was significantly decreased on the nausea/vomitting, indigestion, abdominal pain and total point compared to after chemotherapy. After herb medicine treatment, symptom numeral scale was significantly decreased on the abdominal pain compared to before chemotherapy and after chemotherapy. The changes of tumor marker (CA 72-4 and CEA) was not significant between before chemotherapy and chemotherapy + herb medcine combine treatment. In blool analysis blood, liver and kidney toxicity caused by western-oriental combine treatment were not seen. Conclusions : This result revealed that Hangamjori-bang and AC Ⅱsyrup were useful to decrease side effects of chemotherapy and symptoms of stomach cancer patients.
Seo, Dae-Bang,Jeong, Hyun Woo,Cho, Donghyun,Lee, Bum Jin,Lee, Ji Hae,Choi, Jae Young,Bae, Il-Hong,Lee, Sung-Joon Mary Ann Liebert 2015 Journal of medicinal food Vol.18 No.5
<P>Obesity is caused by an imbalance between caloric intake and energy expenditure and accumulation of excess lipids in adipose tissues. Recent studies have demonstrated that green tea and its processed products (e.g., oolong and black tea) are introduced to exert beneficial effects on lipid metabolism. Here, we propose that fermented green tea (FGT) extract, as a novel processed green tea, exhibits antiobesity effects. FGT reduced body weight gain and fat mass without modifying food intake. mRNA expression levels of lipogenic and inflammatory genes were downregulated in white adipose tissue of FGT-administered mice. FGT treatment alleviated glucose intolerance and fatty liver symptoms, common complications of obesity. Notably, FGT restored the changes in gut microbiota composition (e.g., the Firmicutes/Bacteroidetes and Bacteroides/Prevotella ratios), which is reported to be closely related with the development of obesity and insulin resistance, induced by high-fat diets. Collectively, FGT improves obesity and its associated symptoms and modulates composition of gut microbiota; thus, it could be used as a novel dietary component to control obesity and related symptoms.</P>
Seo, Dae-Bang,Jeong, Hyun Woo,Kim, Yeon-Ji,Kim, Sukyung,Kim, Jeongkee,Lee, Ji Hae,Joo, Kyungmi,Choi, Jin Kyu,Shin, Song Seok,Lee, Sung-Joon Cambridge University Press 2017 The British journal of nutrition Vol.117 No.2
<B>Abstract</B><P>Hyperlipidaemia is a major cause of atherosclerosis and related CVD and can be prevented with natural substances. Previously, we reported that a novel <I>Bacillus</I>-fermented green tea (FGT) exerts anti-obesity and hypolipidaemic effects. This study further investigated the hypotriglyceridaemic and anti-obesogenic effects of FGT and its underlying mechanisms. FGT effectively inhibited pancreatic lipase activity <I>in vitro</I> (IC50, 0·48 mg/ml) and ameliorated postprandial lipaemia in rats (26 % reduction with 500 mg/kg FGT). In hypertriglyceridaemic hamsters, FGT administration significantly reduced plasma TAG levels. In mice, FGT administration (500 mg/kg) for 2 weeks augmented energy expenditure by 22 % through the induction of plasma serotonin, a neurotransmitter that modulates energy expenditure and mRNA expressions of lipid metabolism genes in peripheral tissues. Analysis of the gut microbiota showed that FGT reduced the proportion of the phylum Firmicutes in hamsters, which could further contribute to its anti-obesity effects. Collectively, these data demonstrate that FGT decreases plasma TAG levels via multiple mechanisms including inhibition of pancreatic lipase, augmentation of energy expenditure, induction of serotonin secretion and alteration of gut microbiota. These results suggest that FGT may be a useful natural agent for preventing hypertriglyceridaemia and obesity.</P>
Coumestrol Induces Mitochondrial Biogenesis by Activating Sirt1 in Cultured Skeletal Muscle Cells
Seo, Dae-Bang,Jeong, Hyun Woo,Lee, Sang-Jun,Lee, Sung-Joon American Chemical Society 2014 Journal of agricultural and food chemistry Vol.62 No.19
<P>The mitochondrion is a central organelle in cellular energy homeostasis; thus, reduced mitochondrial activity has been associated with aging and metabolic disorders. This paper provides biological evidence that coumestrol, which is a natural isoflavone, activates mitochondrial biogenesis. In cultured myocytes, coumestrol activated the silent information regulator two ortholog 1 (Sirt1) through the elevation of the intracellular NAD<SUP>+</SUP>/NADH ratio. Coumestrol also increased the mitochondrial contents and induced the expression of key proteins in the mitochondrial electron transfer chain in cultured myocytes. A Sirt1 inhibitor and Sirt1-targeting siRNAs abolished the effect of coumestrol on mitochondrial biogenesis. Similar to an increase in mitochondrial content, coumestrol improved myocyte function with increased ATP concentration. Taken together, the data suggest that coumestrol is a novel inducer of mitochondrial biogenesis through the activation of Sirt1.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jafcau/2014/jafcau.2014.62.issue-19/jf404882w/production/images/medium/jf-2013-04882w_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jf404882w'>ACS Electronic Supporting Info</A></P>
Dae Yun Seo,Hyo Bum Kwak,Sung Ryul Lee,Yeun Suk Cho,In-Sung Song,Nari Kim,Hyun Seok Bang,Byoung Doo Rhee,Kyung Soo Ko,Byung Joo Park,Jin Han 한국영양학회 2014 Nutrition Research and Practice Vol.8 No.2
BACKGROUND/OBJECTIVES: Irisin, a newly identified hormone, is associated with energy homeostasis. We investigated whether aged garlic extract (AGE) and exercise training intervention could improve body weight, insulin sensitivity, skeletal muscle fibronectin domain containing protein 5 (FNDC-5) levels, and plasma irisin in high-fat diet (HFD). MATERIALS/METHODS: Male Sprague Dawley rats were fed a ND (normal diet, n = 5) or HFD (n = 28) for 6 weeks. After 6 weeks, all rats were divided into 5 groups for the next 4 weeks: ND, (normal diet, n = 5), HFD (high-fat diet, n = 7), HFDA (high-fat diet + aged garlic extract, n = 7), HFDE (high-fat diet + exercise, n = 7), and HFDEA (high-fat diet + exercise + aged garlic extract, n = 7). Exercise groups performed treadmill exercises for 15-60 min, 5 days/week, and AGE groups received AGE (2.86 g/kg, orally injected) for 4 weeks. RESULTS: Significant decreases in body weight were observed in the ND, HFDE, and HFDEA groups, as compared with the HFD group. Neither intervention affected the masses of the gastrocnemius muscle or liver. There were no significant differences in glucose levels across the groups. The homeostatic model assessments of insulin resistance were significantly higher in the HFD group, as compared with the ND, HFDA, HFDE, and HFDEA groups. However, skeletal muscle FNDC-5 levels and plasma irisin concentrations were unaffected by AGE or exercise in obese rats. AGE supplementation and exercise training did not affect skeletal muscle FNDC-5 or plasma irisin, which are associated with insulin sensitivity in obese rats. CONCLUSION: Our results suggest that the protection against HFD-induced increases in body fat/weight and insulin resistance that are provided by AGE supplementation and exercise training may not be mediated by the regulation of FNDC-5 or irisin.
Dae-Hyuk Heo,Yu Min Kang,송경호,Jun-Won Seo,Jeong-Han Kim,June Young Chun,전강일,강창경,Song Mi Moon,Pyoeng Gyun Choe,Wan Beom Park,Ji Hwan Bang,Eu Suk Kim,Hong Bin Kim,Sang-Won Park,Won Sup Oh,Nam Joong Kim,M 대한의학회 2020 Journal of Korean medical science Vol.35 No.11
Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease with high mortality in East Asia. This study aimed to develop, for primary care providers, a prediction score using initial symptoms and basic laboratory blood tests to differentiate between SFTS and other endemic zoonoses in Korea. Methods: Patients aged ≥ 18 years diagnosed with endemic zoonoses during a 3-year period (between January 2015 and December 2017) were retrospectively enrolled from 4 tertiary university hospitals. A prediction score was built based on multivariate logistic regression analyses. Results: Of 84 patients, 35 with SFTS and 49 with other endemic zoonoses were enrolled. In multivariate logistic regression analysis, independent predictors of SFTS included neurologic symptoms (odds ratio [OR], 12.915; 95% confidence interval [CI], 2.173–76.747), diarrhea (OR, 10.306; 95% CI, 1.588–66.895), leukopenia (< 4,000/mm3 ) (OR, 19.400; 95% CI, 3.290– 114.408), and normal C-reactive protein (< 0.5 mg/dL) (OR, 24.739; 95% CI, 1.812–337.742). We set up a prediction score by assigning one point to each of these four predictors. A score of ≥ 2 had 82.9% sensitivity (95% CI, 71.7%–87.5%) and 95.9% specificity (95% CI, 88.0%–99.2%). The area under the curve of the clinical prediction score was 0.950 (95% CI, 0.903–0.997). Conclusion: This study finding suggests a simple and useful scoring system to predict SFTS in patients with endemic zoonoses. We expect this strategic approach to facilitate early differentiation of SFTS from other endemic zoonoses, especially by primary care providers, and to improve the clinical outcomes.
Dae Yun Seo,SungRyul Lee,Arturo Figueroa,Yi Sub Kwak,Nari Kim,Byoung Doo Rhee,Kyung Soo Ko,Hyun Seok Bang,Yeong Ho Baek,Jin Han 한국영양학회 2012 Nutrition Research and Practice Vol.6 No.6
Aged garlic extract (AGE) is known to have a protective effect against immune system, endothelial function, oxidative stress and inflammation. We examined the effects of exercise with and without aged garlic extract administration on body weight, lipid profiles, inflammatory cytokines, and oxidative stress marker in high-fat diet (HFD)-induced obese rats. Forty-five Sprague-Dawley rats were fed either a HFD (HFD, n = 40) or a normal diet (ND, n = 5) for 6 weeks and thereafter randomized into ND (n = 5), HFD (n = 10), HFD with AGE (n = 10), HFD with Exercise (n = 10), or HFD with Exercise+AGE (n = 10) for 4 weeks. AGE groups were administered at a dose of 2.86 g/kg·body weight, orally. Exercise consisted of running 15-60 min 5 days/week with gradually increasing intensity. AGE (P < 0.01), Exercise, and Exercise+AGE (P < 0.001) attenuated body weight gain and food efficiency ratio compared to HFD. Visceral fat and liver weight gain were attenuated (P < 0.05) with all three interventions with a greater effect on visceral fat in the Exercise+AGE than AGE (P < 0.001). In reducing visceral fat (P < 0.001), epididymal fat (P < 0.01) and liver weight (P < 0.001), Exercise+AGE was effective, but exercise showed a stronger suppressive effect than AGE. Exercise+AGE showed further additive effects on reducing visceral fat and liver weight (P < 0.001). AGE significantly attenuated the increase in total cholesterol and low-density lipoprotein-cholesterol compared with HFD (P < 0.05). Exercise+AGE attenuated the increase in triglycerides compared with HFD (P < 0.05). Exercise group significantly decrease in C-reactive protein (P < 0.001). These results suggest that AGE supplementation and exercise alone have anti-obesity, cholesterol lowering, and anti-inflammatory effects, but the combined intervention is more effective in reducing weight gain and triglycerides levels than either intervention alone.