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Brain Neuroplasticity after Treatment with Antiseizure: A Review
Débora Lopes Silva de Souza,Hosana Mirelle Goes e Silva Costa,Francisca Idalina Neta,Paulo Leonardo Araujo de Gois Morais,Luís Marcos de Medeiros Guerra,Fausto Pierdoná Guzen,Lucídio Clebeson de Olive 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.4
Epilepsy is a disease characterized by the periodic occurrence of seizures. Seizures can be controlled by antiseizure medications, which can improve the lives of individuals with epilepsy when given proper treatment. Therefore, this study aimed to review the scientific literature on brain neuroplasticity after treatment with antiseizure drugs in different regions of the brain. According to the findings, that several antiseizure, such as lamotrigine, diazepam, levetiracetam, and valproic acid, in addition to controlling seizures, can also act on neuroplasticity in different brain regions. The study of this topic becomes important, as it will help to understand the neuroplastic mechanisms of these drugs, in addition to helping to improve the effectiveness of these drugs in controlling the disease.
Tinku Casper D’ Silva,Srishti Verma,Rinku Mary Magdaline,Ram Chandra,Abid Ali Khan 대한환경공학회 2022 Environmental Engineering Research Vol.27 No.5
Rural coastal regions in developing countries are generally neglected with respect to environmental issues. The present study examined the feasibility of green technologies such as rainwater harvesting (RWH), sand filtration (SF), and composting (in-vessel and pit) to recover from the environmental issues in the coastal rural regions using survey and geographic information systems considering a rural Indian case study. According to the results, RWH yielded 0.140 million litres per 100 m² rooftop in the area, while a maximum total dissolved solids removal of 52% was achieved using the SF alleviating the water concerns. Meanwhile, with a solid waste generation of 0.207 kg d<SUP>-1</SUP> capita<SUP>-1</SUP> comprising 79.81% organic fraction, composting becomes the best waste resource recovery option in the area. Pilot-scale studies of composting transformed organic wastes into compost manure rich in nutrients improving the soil quality. Further analysis using a multi-criteria decision-making approach revealed that the public interest in applying these technologies depends on investment costs, additional resources requirements, and governmental policies. With the scope of improved lifestyle and quality, the study proposes more future research over green technologies and their implementation and is also directed towards developing decentralized site-specific rural governmental policies to achieve sustainability goals.
R. D. A. Pinto,L. D. R. Ferreira,R. A. G. Silva 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.8
Cu–Al alloys have been used for marine applications due to their corrosion resistance and smart materials based on the shapememory effect. A technological tendency for Cu–Al alloys is the development of increasingly complex formulations, althoughthe role of alloying elements still unclear in comparison to other metallurgical systems, such as steels. In the present study,2 at% Cu were substituted by equal quantities of Ni and Ga in the Cu81Al19alloy, which are elements from the same periodand similar in size to the Cu atom. The obtained alloys were analyzed by several characterization techniques. The resultsshowed that the Ni addition increases the critical temperatures and decreases the microhardness values. The Ga additionhas the opposite effect. Both alloying elements produce new phases in the microstructures, hamper the α phase ordering,accelerate the β phase decomposition, and increase the conductivity of the Cu81Al19alloy. From this study, it is possible torealize that small changes in atomic features (electronic structure, atomic radius, valence, electronegativity) from a portionof atoms are enough to obtain distinctive materials, which turns the design of new Cu–Al alloys and the prediction of theirproperties a challenging task.
Dávalos Enrique,Enciso José-Luis,Silva Nicolás,Pinto-Ríos Juan,Leiva Ariel 한국통신학회 2023 ICT Express Vol.9 No.5
Bandwidth fragmentation is a critical problem for Elastic Optical Networks (EON), and spectrum defragmentation is the most important strategy to mitigate this phenomenon. In this work we propose a Machine Learning (ML) based method for estimating the Blocking Rate, which, when exceeding a threshold, triggers a defragmentation process. This is done in order to achieve better results in terms of the number of blocking demands and the number of re-routed connections. The performance of the proposed method was compared with two other known strategies: fixed-time (FT) defragmentation, and triggering based on one fragmentation metric (BFR). Simulation results were evaluated using two multi-objective metrics. Experimental results show that the proposed method is more efficient than the other two, being the best method in 85.7% of comparisons using the Pareto Coverage metric, and obtaining 47.4% of non-dominated solutions in the Pareto Front.
Muscular and collagenous cerebellar choristoma in a dog
Angel Ripplinger,Stella Maris Pereira de Melo,Dênis Antonio Ferrarin,Marcelo Luís Schwab,Mathias Reginatto Wrzesinski,Júlia da Silva Rauber,Mariana Martins Flores,Glaucia Denise Kommers,Alexandre Mazz 대한수의학회 2022 Journal of Veterinary Science Vol.23 No.2
This report aims to describe the first case of muscular and collagenous choristoma in a dog. A 10-yr-old female mixed-breed dog presented with lateral recumbence, vocalization, positional vertical nystagmus, divergent strabismus, anisocoria, and status epilepticus. The clinical condition evolved to stupor and ultimately, death. Necropsy revealed a white mass causing an irregular increase in the volume of the cerebellar vermis. In histological analysis, a well circumscribed, unencapsulated mass was observed in the cerebellum, consisting of fibers of striated skeletal muscle and collagen fibers, mostly mineralized. Based on the histopathological and histochemical findings, a diagnosis of muscular and collagenous cerebellar choristoma was made.
José Maria Renata,Ortega Jéssica da Silva,Baran Jordana Batista Correia,Lüders Débora,Gonçalves Claudia Giglio de Oliveira,Zeigelboim Bianca Simone,Taveira Karinna Veríssimo Meira,Polanski José Fernan 대한청각학회 2024 Journal of Audiology & Otology Vol.28 No.2
Background and Objectives: Chloroquine and its analog hydroxychloroquine are derivatives of 4-aminoquinoline and are regularly used in the treatment of malaria and autoimmune diseases. Among the side effects of these drugs, alterations associated with the auditory system are frequently mentioned. Thus, the aim of this systematic review is to systematically review publications on hearing disorders and chloroquine or hydroxychloroquine use.Materials and Methods: Inclusion criteria were observational or interventional studies on audiological assessment in participants who were using chloroquine or hydroxychloroquine. The methodological quality was independently assessed by two reviewers using the Meta-Analysis of Statistics: assessment and review Instrument. The certainty of the evidence was assessed using the GRADE tool.Results: A total of 1,372 non-duplicate papers were screened, out of which 17 were included in the final qualitative synthesis, and 5 studies in the meta-analysis. The odds ratio for the two subgroups evaluated did not show significance with no heterogeneity between the effects observed between the different diseases (I<sup>2</sup>=0%) and obtaining the global estimate of 0.76 (95% confidence interval [CI]=0.41–1.39; <i>p</i>>0.05). Despite the inclusion of papers with different disease samples, the heterogeneity observed in the analysis was low (I<sup>2</sup>= 0%) and prediction interval (95% PI=0.32–1.80; p>0.05) remained close to that estimated by the CI (95% CI=0.41–1.39; <i>p</i>>0.05). The certainty of the evidence assessed by the GRADE tool was considered very low due to the risk of bias, indirect evidence, and imprecision.Conclusions: The findings of this study suggest that the use of chloroquine/hydroxychloroquine is not associated with hearing disorders.
Impact of Zinc Stress on Biochemical and Biophysical Parameters in Coffea Arabica Seedlings
Jacqueline Oliveira dos Santos,Cinthia Aparecida Andrade,Kamila Rezende Dázio de Souza,Meline de Oliveira Santos,Isabel Rodrigues Brandão,Jose Donizeti Alves,Iasminy Silva Santos 한국작물학회 2019 Journal of crop science and biotechnology Vol.22 No.3
Zinc is an essential micronutrient for the healthy development of plants, since its insufficient and supraoptimal doses can disrupt the metabolism and biomass production. We aimed to investigate the physiological responses of coffee seedlings to Zn deficiency and excess. Six-month-old seedlings were transferred to plastic pots containing a nutrient solution. The treatments were control (0.03 ppm), zinc deficiency (0.00 ppm), and zinc excess (0.12 ppm). The evaluations were performed in leaves and roots at the beginning of the treatments and after 30 and 60 d of treatments. Zn deficiency and excess increased the production of hydrogen peroxide, antioxidant enzymes activity, ascorbate, and lipid peroxidation contents. The imbalance in zinc nutrition reduced total chlorophyll content and increased carotenoids content throughout the experimental period. Lower biomass and proline accumulation were observed only for deficient seedlings at the end of the experiment. The characteristics analyzed showed that zinc deficiency caused greater damage to the Coffea arabica plants of (Catuai cultivar) than zinc excess.
Cytogenotoxic study of aqueous fruit extract of Morinda citrifolia in Wistar albino rats
Germano Pinho de Moraes,Marcus Vinícius Oliveira Barros de Alencar,Lidiane da Silva Araújo,Débora Cássia Vieira Gomes,Márcia Fernanda Correia Jardim Paz,Muhammad Torequl Islam,Ana Amélia de Carvalho M 경희대학교 융합한의과학연구소 2019 Oriental Pharmacy and Experimental Medicine Vol.19 No.3
The use of herbal products and/or their derivatives as an alternative or complementary medicine becomes globally popular. To date, various biological activities have been reported in Morinda citrifolia Linn, especially antioxidants, antimicrobial, anti-infammatory and antitumor efects. This study aimed to investigate the genotoxicity and DNA repair capacity of the aqueous fruit extract of M. citrifolia (AEMC). Additionally, we checked the mutagenic capacity of AEMC by the comet assay and micronucleus tests in rats. For this, rats (n=10; 5 males and 5 females) were divided into fve groups as: negative control (distilled water); positive control (25 mg/kg of cyclophosphamide, i.p.); and three groups for AEMC (2.5, 5 and 10 mg/kg, i.p.). The results suggest that, the AEMC induced genotoxicity in white blood cells, but a DNA repair capacity was also observed after 72 h of AEMC exposure. AEMC also showed cytotoxicity and mutagenicity in liver and kidney cells of rats at 5 and 10 mg/kg doses. In conclusion, AEMC exhibited a dose-dependent cytotoxicity, genotoxicity and mutagenicity along with a time-dependent DNA repair capacity in rats. Further studies are necessary regarding the safe use of this medicinal plant for human consumption.
Léa Elias Mendes Carneiro Zaidan,Joan Manuel Rodriguez-Díaz,Daniella Carla Napoleão,Maria da Conceição Branco da Silva de Mendonça Mon,Alberto da Nova Araújo,Mohand Benachour,Valdinete Lins da Silva 한국화학공학회 2017 Korean Journal of Chemical Engineering Vol.34 No.2
We examined the photocatalytic degradation of phenol from laboratory samples under UV radiation by using BiPO4/H2O2 and TiO2/H2O2 advanced oxidation systems. Both catalysts prepared were characterized by scanning electron microscopy, Fourier transform infrared and X-ray diffraction. Surface area tests showed about 3.46 and 31.33m2·g−1, respectively, for BiPO4 and TiO2. A central composite design was developed with the following variables-- catalyst concentration, time and concentration of hydrogen peroxide--to optimize the degradation process. Removal rates of 99.99% for phenol degradation using BiPO4 and TiO2 were obtained, respectively. For mineralization of organic carbon were obtained 95,56% when using BiPO4 and 63,40% for TiO2, respectively. The lumped kinetic model represented satisfactorily the degradation of phenol process, using BiPO4/H2O2/UV (R2=0.9977) and TiO2/H2O2/UV (R2=0.9701) treatments. The toxicity tests using different seed species showed the benefits of the proposed advanced oxidation process when applied to waste waters containing these pollutants.
Antonio Miranda da Cruz-Filho,Angelo Rafael de Vito Bordin,Luis Eduardo Souza-Flamini,Débora Fernandes da Costa Guedes,Paulo César Saquy,Ricardo Gariba Silva,Jesus Djalma Pécora 대한치과보존학회 2017 Restorative Dentistry & Endodontics Vol.42 No.2
Objectives: Chitosan has been widely investigated and used. However, the literature does not refer to the shelf life of this solution. This study evaluated, through the colorimetric titration technique and an analysis of dentin micro-hardness, the shelf life of 0.2% chitosan solution. Materials and Methods: Thirty human canines were sectioned, and specimens were obtained from the second and third slices, from cemento-enamel junction to the apex. A 0.2% chitosan solution was prepared and distributed in 3 identical glass bottles (v1, v2, and v3) and 3 plastic bottles (p1, p2, and p3). At 0, 7, 15, 30, 45, 60, 90, 120, 150, and 180 days, the specimens were immersed in each solution for 5 minutes (n = 3 each). The chelating effect of the solution was assessed by micro-hardness and colorimetric analysis of the dentin specimens. 17% EDTA and distilled water were used as controls. Data were analyzed statistically by two-way and Tukey-Kramer multiple comparison (α = 0.05). Results: There was no statistically significant difference among the solutions with respect to the study time (p = 0.113) and micro-hardness/time interaction (p = 0.329). Chitosan solutions and EDTA reduced the micro-hardness in a similar manner and differed significantly from the control group (p < 0.001). Chitosan solutions chelated calcium ions throughout the entire experiment. Conclusions: Regardless of the storage form, chitosan demonstrates a chelating property for a minimum period of 6 months.