http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Cui, Xiangx2010,Dan,Lee, Mix2010,Jin,Kim, Jongx2010,Hyun,Hao, Peix2010,Pei,Liu, Lan,Yu, Goungx2010,Ran,Kim, Daex2010,Ghon Wiley Subscription Services, Inc., A Wiley Company 2013 Hepatology Vol.57 No.6
<P><B>Abstract</B></P><P>Eph receptor 2 (EphA2) overexpression is frequently accompanied by the loss of its cognate ligand during tumor progression. However, the molecular mechanism of this ligand‐independent promotion of tumor by EphA2 remains unclear in highly malignant and fatal cholangiocarcinoma (CC). We examined the biological role of EphA2 in tumor growth and metastasis in CC tissues and cells according to the degree of differentiation and we explored the downstream signaling pathways of EphA2. Growth factor‐mediated EphA2 overexpression itself leads to the activation of the mammalian target of rapamycin complex 1 (mTORC1) and extracellular signal‐regulated kinase (ERK) pathways through ligand‐independent activation of EphA2 (phosphorylation of S897). An <I>in vitro</I> soft agar assay and <I>in vivo</I> orthotopic or subcutaneous tumor model showed that EphA2 enhanced colony formation and accelerated tumor growth, and which seemed to be mainly associated with Akt (T308)/mTORC1 activation. Aberrant expression and activation of EphA2 was also associated with poorer differentiation and higher metastatic ability. Enhanced metastatic ability was also observed in an orthotopic tumor model or lung metastasis model, correlating with Pyk2(Y402)/c‐Src/ERK activation in addition to activation of the canonical Raf/MEK/ERK pathway. The mTORC1 and Raf/Pyk2 pathways also appeared to affect each other. These results suggest that growth factor‐mediated EphA2 might be involved in tumor growth and metastasis through activation of the mTORC1 and Raf/Pyk2 pathways. Therapeutic strategies that target EphA2 and its downstream effectors may be useful to control CC. (H<SMALL>EPATOLOGY</SMALL> 2013;57:2248–2260)</P>
Tachikawa, Takashi,Wangx2009,, Nan,Yamashita, Soichiro,Cui, Shix2010,Cong,Majima, Tetsuro WILEY‐VCH Verlag 2010 Angewandte Chemie Vol.122 No.46
<P><B>Einzelmolekül‐Fluoreszenzsonde</B>: Über die Bildung der stark fluoreszierenden 4‐NHOH‐Form eines 3,4‐dinitrophenylsubstituierten Bor‐Dipyrromethan‐Farbstoff wird der Elektronentransfer an einzelnen TiO<SUB>2</SUB>‐Partikeln untersucht (siehe Bild; B gelb, C grau, F grün, H weiß, O rot). Kinetische und optische Analysen der Fluoreszenzereignisse geben Aufschluss über die Dynamik der molekularen Wechselwirkungen und die Verteilung der reaktiven Zentren.</P>
A Self-Sampling-and-Flow Biosensor for Continuous Monitoring
Zhang, Fenghua,Kim, Jongx2005,Sik,Cui, Gang,Cha, Geunx2005,Sig,Nam, Hakhyun WILEY-VCH Verlag 2005 Electroanalysis Vol.17 No.8
<P>A self-sampling-and-flow biosensor was fabricated by sandwiching a nitrocellulose strip on the working electrode side of the double-sided microporous gold electrodes and a wicking pad on the counter electrode side. The double-sided microporous electrodes were formed by plasma sputtering of gold on a porous nylon substrate. Sample was taken up to the enzyme-immobilized working electrode by the capillary action of the front nitrocellulose strip dipped into the sample solution, analyzed electrochemically at the enzyme-immobilized electrode, and diffuses out to the backside wicking pad through the micropores of the electrodes, constituting a complete flow cell device with no mechanical liquid-transporting device. Biosensor was formed by co-immobilizing the glucose oxidase and electron transfer mediator (ferrocene acetic acid) on the thioctic acid self-assembled monolayer-modified working electrode. A typical response time of the biosensor was about 5 min with the sensitivity of 2.98 nA/mM glucose, providing linear response up to 22.5 mM. To demonstrate the use of self-sampling-and-flow biosensor, the consumption rate of glucose in the presence of yeast was monitored for five days. </P>
Tailoring the Impact Toughness of Sintered NdFeB Magnets via Surface Coating
X. G. Cui,J. X. Pan,C. Y. Cui,P. Mei,X. H. Wang,C. Fang,T. Y. Ma,C. Wang,X. C. Peng 한국자기학회 2018 Journal of Magnetics Vol.23 No.1
Metallic coating by electroplating is commonly attractive for improving the corrosion resistance of sintered NdFeB magnets. However, its tailoring of mechanical characteristics for sintered NdFeB magnets has been seldom concerned. Herein, the impact toughnesses of sintered NdFeB magnets with various metallic coatings (Ni or Ni/Sn) were comparatively investigated. The results indicate that the impact toughnesses of sintered NdFeB magnets are both improved by Ni coating and Ni/Sn bilayer coating. And Ni/Sn bilayer coating exhibits more enhancement of the impact toughness, increased by 41.6% compared with the original magnet. Moreover, the microstructural observations of the metallic coatings and the fracture were conducted, and the enhanced mechanism of impact toughness for the magnet is analyzed. These findings may provide a reference for toughening the brittle materials.
Thermodynamic Analysis of Intergranular Additives in Sintered Nd-Fe-B Magnet
X. G. Cui,X. H. Wang,C. Y. Cui,G. C. Yin,C. D. Xia,X. N. Cheng,X. J. Xu 한국자기학회 2017 Journal of Magnetics Vol.22 No.2
To get deeper insight into the effect of intergranular additives in sintered Nd-Fe-B magnet and consequently improve the properties better, the interaction between additives (oxide, nitride, and carbide) and Nd-rich phase in the temperature range of 298.15-1400 K was analyzed thermodynamically. It can be found that the oxide additives became less stable than nitrides and carbides. Except for calcium oxide, almost all oxides could react with Nd from Nd-rich phase. To be different from oxide additives, the mechanism of nitrides and carbides was defined with various elements, either reaction with Nd from Nd-rich phase or not. The two different mechanisms would show different effects on the microstructure and hence properties of magnet. The thermodynamic analysis had a better agreement with the experimental information.
In Vitro Endothelialization on CNx Films Deposited on PTFE
X. L. Qing,F. Z. Cui,C. L. Zheng 한국물리학회 2005 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.46 No.1
Endothelial cells were successfully seeded onto carbon nitride (CNx) ¯lms deposited on poly-tetra°uoroethylene (PTFE) by using the ion beam-assisted deposition (IBAD) technique. X-ray photoelectron spectroscopy and, Raman characterization of the resulting ¯lms showed that IBAD was e±cient in fabricating CNx ¯lms with controllable nitrogen content and sp2=sp3 fraction. The 48 hr cell culture indicated the endothelial cells grew best on CNx ¯lm with greatest nitrogen content. The CNx-coated PTFE may be a promising vascular prosthesis in vascular reconstruction.