The Moderated Mediating Effects of Nutrition and Physical Activity Between Fatigue and Quality of Life in Childhood Cancer Survivors

Wu Wei-Wen,Shiu Cheng-Shi,Tang Chia-Chun,Jou Shiann-Tang,Chen Huey-Ling 한국간호과학회 2023 Asian Nursing Research Vol.17 No.1

Purpose: The aim of this study was to investigate the associations between nutrition, physical activity, fatigue, and quality of life (QoL) among childhood cancer survivors. The specific purpose was to examine whether nutrition mediated and physical activity moderated the relationship between fatigue and QoL in this population. Methods: A pooled sample of 120 childhood cancer survivors was recruited at pediatric oncology wards and ambulatory settings between August 2020 and May 2021. We collected data on participants’ demographic characteristics, fatigue, nutritional status, physical activity, and QoL. We then adapted Hayes Process Macro to examine the mediating and moderating effects of nutrition and physical activity on the relationship between fatigue and QoL. Results: In models adjusted for age and sex, (1) the simple mediation analysis identified the mediating effect of nutrition on the relationship between fatigue and QoL; and (2) the mediation and moderation analysis identified that the direct effect of nutrition between fatigue and QoL was significant when adding (a) physical activity and (b) fatigue physical activity. There were significantly decreasing trends in physical activity at 1 standard deviation below the mean and at the mean, but not at 1 standard deviation above the mean. Conclusions: Our findings demonstrate that nutrition mediated and physical activity moderated the relationship between fatigue and QoL. This highlights an opportunity to enhance QoL among childhood cancer survivors through healthy lifestyle interventions. To ensure that future interventions address children's needs and promote the greatest impact, such interventions should include nutrition and physical activity components that involve nurses, pediatric oncology physicians, nutritionists, and physical therapists.

Advances in Understanding the “Perfect Monsoon-influenced Typhoon”: Summary from International Conference on Typhoon Morakot (2009)

Cheng-Shang Lee,Chun-Chieh Wu,Tai-Chi Chen Wang,Russell L. Elsberry 한국기상학회 2011 Asia-Pacific Journal of Atmospheric Sciences Vol.47 No.3

Typhoon Morakot (2009) produced 2855 mm of rain and was the deadliest typhoon to impact Taiwan with 619 deaths and 76missing persons, including a landslide that wiped out an entire village. While Morakot did not exceed the heaviest 24-h rain record,the combination of heavy rain and long duration that led to the record accumulation is attributed to the southwest summer monsoon influence on the typhoon. Thus, a special combination of factors was involved in the Morakot disaster: (i) Strong southwesterly monsoon winds; (ii) Convergence between the typhoon circulation and monsoon flow to form an east-west oriented convective band over the Taiwan Strait that was quasi-stationary and long-lasting; (iii) A typhoon in a specific location relative to the Central Mountain Range and moving slowly; and (iv) Steep topography that provided rapid lifting of the moist air stream. The contributions of each of these four factors in leading to the Morakot disaster are reviewed primarily based on new research presented at the International Conference on Typhoon Morakot (2009). Historical data sets, new Doppler radar observations, and numerical modeling have advanced the understanding of the special conditions of monsoon-influenced typhoons such as Morakot. This research is also leading to modifications of existing and development of new forecasting tools. Gaps in scientific understanding, limits to the predictability, and requirements for advanced forecast guidance tools are described that are challenges to improved warnings of these extreme precipitation and flooding events in monsoon-influenced typhoons.

Inhibiting the Growth of Cu3Sn and Kirkendall Voids in the Cu/Sn-Ag-Cu System by Minor Pd Alloying

Cheng En Ho,,Tsai Tung Kuo,Chun Chien Wang,Wei Hsiang Wu 대한금속·재료학회 2012 ELECTRONIC MATERIALS LETTERS Vol.8 No.5

In this study, the metallurgical reaction between Cu substrates (electrolytic type) and a Sn3Ag0.5Cu-xPd alloy at 180°C was examined using a scanning electron microscope (SEM), electron probe microanalyzer (EPMA),focused ion beam (FIB) microscope, and transmission electron microscope (TEM). The results showed that the growth of Cu3Sn in the Cu/Sn-Ag-Cu solder joints was substantially suppressed by doping with a minor quantity of Pd (0.1-0.7 wt. %) in the solder alloy. The sluggish growth of Cu3Sn reduced the formation of Kirkendall voids at the Cu/Cu3Sn interface and significantly improved the mechanical reliability of the joint interface. It was argued that a minor addition of Pd into the solder stabilized the Cu6Sn5 phase and enlarged the interdiffusion coefficient of Cu6Sn5 but diminished that of the neighboring phase (Cu3Sn), thereby decreasing the Kirkendall effect in the Cu/Sn-Ag-Cu reactive system.

Generation of Selenoprotein with Glutathione Peroxidase Activity by Chemical Modification of the Single-chain Variable Fragment Expressed in a Single-protein Production System and Its Antioxidant Ability

Cheng Wang,Gang-Lin Yan,Shao-Wu Lü,Chun-Hong Sui,Yang Zhao,Ya-Wei Xu,Gang Zhao,Jun-jie Xu,Ping-Sheng Gong,Gui-Min Luo,Ying Mu 한국생물공학회 2013 Biotechnology and Bioprocess Engineering Vol.18 No.1

Glutathione peroxidase (GPX) is one of the important members of the antioxidant enzyme family. It can catalyze the reduction of hydroperoxides with glutathione to protect cells against oxidative damage. Single-chain variable fragment (scFv) can be converted into seleniumcontaining single-chain variable fragment (Se-scFv) by chemical modification of the hydroxyl groups in scFv, thus Se-scFv possesses GPX activity and becomes a prodrug. To improve the expression of scFv and simplify its purification steps, Single-protein production (SPP) system was used to express scFv and chemical modification was used to synthesize Se-scFv. Therefore, we must construct a new scFv-WCD1-lessACA gene, which can express its mRNA not containing any ACA sequences and express its amino acid sequence of target protein (scFv) being same to scFv-WCD1. In this way, the scFv-WCD1-lessACA can be only expressed in SPP system and no other background proteins in the cells could be expressed. The expression results showed that high level of scFv-WCD1-lessACA synthesis was at least sustained for 96 h in the virtual absence of background protein synthesis. Then, selenocysteine (Sec) was incorporated into the scFv-WCD1-lessACA by chemical modification and resulted in Se-scFv-WCD1-lessACA. The enzymatic characteristics of Se-scFv-WCD1-lessACA were determined. GPX activity was 2,563 U/μmol,its binding constant for GSH was 0.687 ×105/mol. Moreover,Se-scFv-WCD1-lessACA was confirmed to have a strong antioxidant ability to protect mitochondria against oxidative damage induced by Vc/Fe2+ (mitochondrial damage model),suggesting that Se-scFv-WCD1-lessACA has potential application for protection of mitochondrial damage induced by reactive oxygen species (ROS).

Potential of a combination of entomopathogenic fungal strains and a non-ionic surfactant to control the fall armyworm (Spodoptera frugiperda)

Wu Sing-Shan,Tseng Ching-Tzu,Yang Yu-Hung,Liu Yao-Chia,Chang Ju-Chun,Gyawali Purushottam,Li Yi-Hsuan,Yang Tzu-Hao,Tsai Yi-Fang,Tang Li-Cheng,Nai Yu-Shin 한국응용곤충학회 2022 Journal of Asia-Pacific Entomology Vol.25 No.4

The fall armyworm, Spodoptera frugiperda, is an emerging invasive pest in Taiwan that feeds on a wide range of crops and causes serious damage. Herein, an entomopathogenic fungal library (EFLib) was constructed to identify potential microbes to control FAW. Twenty-eight indigenous entomopathogenic fungi (EPF) were iso lated and investigated for their potential pathogenicity, with Metarhizium pinghaense (Mp-NCHU-124) and Beauveria bassiana (Bb-NCHU-157) exerting dose-dependent effects on the 4th instar FAW larvae. The non-ionic surfactant Silwet L-77 rapidly killed FAW larvae after spraying at a concentration of 300 mg/kg and the toxic effect of Silwet L-77 on FAW larvae was dose-dependent. When the EPF isolates (10 6 conidia/mL) were applied to FAW larvae in combination with the non-ionic surfactant Silwet L-77 (30–90 mg/kg), the mortality rate dramatically increased and the LT 50 reduced, with increased fungal mycosis (Mp-NCHU-124: 38% to 72% and Bb-NCHU-157: 20 to 62%), indicating the high compatibility of EPF with the non-ionic surfactant. Thus, the Silwet L-77+EPF combined formulation has potential for practical field application for FAW pest control and sustainable agriculture in the future.

Robust design on the arrangement of a sail and control planes for improvement of underwater Vehicle's maneuverability

Wu, Sheng-Ju,Lin, Chun-Cheng,Liu, Tsung-Lung,Su, I-Hsuan The Society of Naval Architects of Korea 2020 International Journal of Naval Architecture and Oc Vol.12 No.1

The purpose of this study is to discuss how to improve the maneuverability of lifting and diving for underwater vehicle's vertical motion. Therefore, to solve these problems, applied the 3-D numerical simulation, Taguchi's Design of Experiment (DOE), and intelligent parameter design methods, etc. We planned four steps as follows: firstly, we applied the 2-D flow simulation with NACA series, and then through the Taguchi's dynamic method to analyze the sensitivity (β). Secondly, take the data of pitching torque and total resistance from the Taguchi orthogonal array (L9), the ignal-to-noise ratio (SNR), and analysis each factorial contribution by ANOVA. Thirdly, used Radial Basis Function Network (RBFN) method to train the non-linear meta-modeling and found out the best factorial combination by Particle Swarm Optimization (PSO) and Weighted Percentage Reduction of Quality Loss (WPRQL). Finally, the application of the above methods gives the global optimum for multi-quality characteristics and the robust design configuration, including L/D is 9.4:1, the foreplane on the hull (Bow-2), and position of the sail is 0.25 Ls from the bow. The result shows that the total quality is improved by 86.03% in comparison with the original design.

Tazarotene-Induced Gene 1 Interacts with DNAJC8 and Regulates Glycolysis in Cervical Cancer Cells

Chun-Hua Wang,Rong-Yaun Shyu,Chang-Chieh Wu,Mao-Liang Chen,Ming-Cheng Lee,Yi-Yin Lin,Lu-Kai Wang,Shun-Yuan Jiang,Fu-Ming Tsai 한국분자세포생물학회 2018 Molecules and cells Vol.41 No.6

The tazarotene-induced gene 1 (TIG1) protein is a retinoid-inducible growth regulator and is considered a tumor suppressor. Here, we show that DnaJ heat shock protein family member C8 (DNAJC8) is a TIG1 target that regulates glycolysis. Ectopic DNAJC8 expression induced the translocation of pyruvate kinase M2 (PKM2) into the nucleus, subsequently inducing glucose transporter 1 (GLUT1) expression to promote glucose uptake. Silencing either DNAJC8 or PKM2 alleviated the upregulation of GLUT1 expression and glucose uptake induced by ectopic DNAJC8 expression. TIG1 interacted with DNAJC8 in the cytosol, and this interaction completely blocked DNAJC8-mediated PKM2 translocation and inhibited glucose uptake. Furthermore, increased glycose uptake was observed in cells in which TIG1 was silenced. In conclusion, TIG1 acts as a pivotal repressor of DNAJC8 to enhance glucose uptake by partially regulating PKM2 translocation.

Robust design on the arrangement of a sail and control planes for improvement of underwater Vehicle's maneuverability

Wu, Sheng-Ju,Lin, Chun-Cheng,Liu, Tsung-Lung,Su, I-Hsuan The Society of Naval Architects of Korea 2020 International Journal of Naval Architecture and Oc Vol.12 No.-

The purpose of this study is to discuss how to improve the maneuverability of lifting and diving for underwater vehicle's vertical motion. Therefore, to solve these problems, applied the 3-D numerical simulation, Taguchi's Design of Experiment (DOE), and intelligent parameter design methods, etc. We planned four steps as follows: firstly, we applied the 2-D flow simulation with NACA series, and then through the Taguchi's dynamic method to analyze the sensitivity (β). Secondly, take the data of pitching torque and total resistance from the Taguchi orthogonal array (L9), the ignal-to-noise ratio (SNR), and analysis each factorial contribution by ANOVA. Thirdly, used Radial Basis Function Network (RBFN) method to train the non-linear meta-modeling and found out the best factorial combination by Particle Swarm Optimization (PSO) and Weighted Percentage Reduction of Quality Loss (WPRQL). Finally, the application of the above methods gives the global optimum for multi-quality characteristics and the robust design configuration, including L/D is 9.4:1, the foreplane on the hull (Bow-2), and position of the sail is 0.25 Ls from the bow. The result shows that the total quality is improved by 86.03% in comparison with the original design.

Synthesis of 2-(3' azido- and 3'-amino-3'-deoxy-β-D-ribofuranosyl)-thiazole-4-carboxamide

Chun Moon-Woo,Liang Cheng-Wu,Shin Ji-Hye 大韓藥學會 2003 大韓藥學會 總會 및 學術大會 Vol.2003 No.2

Phenotypes and Prognostic Factors of Syringomyelia in Single-Center Patients With Chiari I Malformation: Moniliform Type as a Special Configuration

Chunli Lu,Longbing Ma,Chenghua Yuan,Lei Cheng,Xinyu Wang,Wanru Duan,Kai Wang,Zan Chen,Hao Wu,Gao Zeng,Fengzeng Jian 대한척추신경외과학회 2022 Neurospine Vol.19 No.3

Objective: The specific association between morphometric characteristics of the syrinx and the prognosis of Chiari malformation type I (CM-I) with syringomyelia following surgical procedure seems to have not been fully elaborated. This study focused on the preoperative clinical and radiologic parameters in CM-I patients with syringomyelia to find out the relationship between the patients’ clinical status and the phenotypes of the syrinx with surgical outcome. Methods: A continuous series of pediatric and adult patients with CM-I and syringomyelia from a prospectively maintained database in a single center were included, and we explored the related factors affecting the prognosis following decompression surgery through retrospective analysis of clinical presentations, imaging characteristics, and the morphological features of syringomyelia, to provide a clinical reference for the treatment of syringomyelia. Results: There were 28 pediatric patients (13.8%), and 174 adults (86.2%) included in our study. The average Chicago Chiari Outcome Scale score was 14.56 ± 1.78. The overall prognosis after surgery was good in our series, among them 152 cases (75.25%) with a favorable prognosis, and syrinx was resolved effectively in 172 cases (85.15%). According to the univariate and multivariate analyses, the preoperative symptom duration, observation time, and with/without moniliform type were independent factors affecting the prognosis in adults. The most obvious difference between moniliform type and nonmoniliform type lies in the preoperative symptom duration, ventral subarachnoid space at the foramen magnum, and with/without straightened cervical physio-curve. Conclusion: Timely decompression surgery could achieve a better outcome in CM-I patients with syringomyelia. Moniliform syringomyelia may suggest a relatively better prognosis.