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Choi Min Joo,Choi Won Suk,Seong Hye,최준용,Kim Jong-Hyun,Kim Yae-Jean,Cho Eun Young,김동현,Park Hyesook,Lee Heeyoung,Kim Nam Joong,Song Joon Young,Cheong Hee Jin,Kim Sang Il,Peck Kyong Ran 대한의학회 2021 Journal of Korean medical science Vol.36 No.23
Background: This study presents a framework for determining the allocation and distribution of the limited amount of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Methods: After analyzing the pandemic strategies of the major organizations and countries and with a literature review conducted by a core panel, a modified Delphi survey was administered to 13 experts in the fields of vaccination, infectious disease, and public health in the Republic of Korea. The following topics were discussed: 1) identifying the objectives of the vaccination strategy, 2) identifying allocation criteria, and 3) establishing a step-by-step vaccination framework and prioritization strategy based on the allocation criteria. Two rounds of surveys were conducted for each topic, with a structured questionnaire provided via e-mail in the first round. After analyzing the responses, a meeting with the experts was held to obtain consensus on how to prioritize the population groups. Results: The first objective of the vaccination strategy was maintenance of the integrity of the healthcare system and critical infrastructure, followed by reduction of morbidity and mortality and reduction of community transmission. In the initial phase, older adult residents in care homes, high-risk health and social care workers, and personal support workers who work in direct contact with coronavirus disease 2019 (COVID-19) patients would be prioritized. Expansion of vaccine supply would allow immunization of older adults not included in phase 1, followed by healthcare workers not previously included and individuals with comorbidities. Further widespread vaccine supply would ensure availability to the extended adult age groups (50–64 years old), critical workers outside the health sector, residents who cannot socially distance, and, eventually, the remaining populations. Conclusion: This survey provides the much needed insight into the decision-making process for vaccine allocation at the national level. However, flexibility in adapting to strategies will be essential, as new information is constantly emerging.
Ran Joo Choi,Eun Myoung Shin,Tran Minh Ngoc,Ki Hwan Bae,Yeong Shik Kim 한국당과학회 2011 한국당과학회 학술대회 Vol.2011 No.1
This study investigates the anti-inflammatory effects of several components isolated from Rheum tanguticum Maxim. (Polygonaceae). Previously, we found that 70 % ethanol extracts of Rheum Rhizoma (Rheum tanguticum, R. undulatum, R. palmatum, R. officinale, Rumex crispus) had anti-inflammatory properties on LPS-stimulated RAW 264.7 macrophages and carrageenan-induced paw edema model. Thus, we studied five anthraquinone derivatives isolated from Rheum tanguticum, including chrysophanol, chrysophanol-8-O-Glc, 2-methoxy-4-hydroxyanthraquinone-5-O-Glc, emodin, and physcion. Chrysophanol, chrysophanol-8-O-Glc, physcion and emodin inhibited nitric oxide (NO) production at micromolar concentrations in LPS-induced RAW 264.7 macrophages. Among these anthraquinones, emodin was found to be a potent inhibitor with its IC50 (the half maximal inhibitory concentration) value of 57.23 μM. In addition, these four compounds dose-dependently reduced inducible nitricoxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein expression conducted by Western blotting analysis. Taken together, our data suggest that chrysophanol, chrysophanol-8-O-Glc, physcion and emodin from R. tanguticum showed anti-inflammatory activities through their inhibition of iNOS and COX-2 expression. Emodin was already reported to exhibit anti-inflammatory effects especially on acute pacreatitis animal model (1-3). Therefore, the further study is required to clarify anti-inflammatory mechanism of emodin in detail.
Protective role of DAX-1 deficiency against acetaminophen-induced liver injury in animal model
Young Joo Suh,Hyo Jeong Yun,Yu bin Kim,Eun Jung Kang,Dong Hee Choi,Jung Hyeon Choi,Young Keun Choi,In Bok Lee,Yun Jeong Seo,Jung Ran Noh,Yong Hoon Kim,Jong Soo Lee,Chul Ho Lee 한국실험동물학회 2022 한국실험동물학회 학술발표대회 논문집 Vol.2022 No.7
Rapid Dissemination of Newly Introduced Plasmodium vivax Genotypes in South Korea
Kim, Yeon-Joo,Kim, Jung-Yeon,Lee, Eun-Gyu,Lee, Byeong-Chul,Cho, Shin-Hyung,Yu, Jae-Ran,Rhie, Ho-Gun,Choi, Yien-Kyoung,Lee, Ho-Sa,Lee, Joo-Shil,Kim, Tong-Soo,Choi, Kyung-Mi,Park, Mi-Hyun American Society of Tropical Medicine and Hygiene 2010 The American journal of tropical medicine and hygi Vol.82 No.3
<P>Reemerged Plasmodium vivax malaria in South Korea has not yet been eradicated despite continuous governmental efforts. It has rather become an endemic disease. Our study aimed to determine the genetic diversity in P. vivax merozoite surface protein-1 (PvMSP-1) and circumsporozoite protein (PvCSP) genes over an extended period after its reemergence to its current status. Sequence analysis of PvMSP-1 gene sequences from the 632 P. vivax isolates during 1996-2007 indicates that most isolates recently obtained were different from isolates obtained in the initial reemergence period. There was initially only one subtype (recombinant) present but its subtypes have varied since 2000; six MSP-1 subtypes were recently found. A similar variation was observed by CSP gene analysis; a new CSP subtype was found. Understanding genetic variation patterns of the parasite may help to analyze trends and assess extent of endemic malaria in South Korea.</P>
Joo, Hee Kyoung,Lee, Yu Ran,Kang, Gun,Choi, Sunga,Kim, Cuk-Seong,Ryoo, Sungwoo,Park, Jin Bong,Jeon, Byeong Hwa Korean Society for Molecular and Cellular Biology 2015 Molecules and cells Vol.38 No.12
Translocator protein 18 kDa (TSPO) is a mitochondrial outer membrane protein and is abundantly expressed in a variety of organ and tissues. To date, the functional role of TSPO on vascular endothelial cell activation has yet to be fully elucidated. In the present study, the phorbol 12-myristate 13-acetate (PMA, 250 nM), an activator of protein kinase C (PKC), was used to induce vascular endothelial activation. Adenoviral TSPO overexpression (10-100 MOI) inhibited PMA-induced vascular cell adhesion molecule-1 (VCAM-1) and intracellular cell adhesion molecule-1 (ICAM-1) expression in a dose dependent manner. PMA-induced VCAM-1 expressions were inhibited by Mito-TEMPO ($0.1-0.5{\mu}m$), a specific mitochondrial antioxidants, and cyclosporin A ($1-5{\mu}m$), a mitochondrial permeability transition pore inhibitor, implying on an important role of mitochondrial reactive oxygen species (ROS) on the endothelial activation. Moreover, adenoviral TSPO overexpression inhibited mitochondrial ROS production and manganese superoxide dismutase expression. On contrasts, gene silencing of TSPO with siRNA increased PMA-induced VCAM-1 expression and mitochondrial ROS production. Midazolam ($1-50{\mu}m$), TSPO ligands, inhibited PMA-induced VCAM-1 and mitochondrial ROS production in endothelial cells. These results suggest that mitochondrial TSPO can inhibit PMA-induced endothelial inflammation via suppression of VCAM-1 and mitochondrial ROS production in endothelial cells.
Joo, Hee Kyoung,Lee, Yu Ran,Choi, Sunga,Park, Myoung Soo,Kang, Gun,Kim, Cuk-Seong,Jeon, Byeong Hwa The Korean Society of Pharmacology 2017 The Korean Journal of Physiology & Pharmacology Vol.21 No.4
Activation of protein kinase C (PKC) is closely linked with endothelial dysfunction. However, the effect of $PKC{\beta}II$ on endothelial dysfunction has not been characterized in cultured endothelial cells. Here, using adenoviral $PKC{\beta}II$ gene transfer and pharmacological inhibitors, the role of $PKC{\beta}II$ on endothelial dysfucntion was investigated in cultured endothelial cells. Phorbol 12-myristate 13-acetate (PMA) increased reactive oxygen species (ROS), p66shc phosphorylation, intracellular adhesion molecule-1, and monocyte adhesion, which were inhibited by $PKC{\beta}i$ (10 nM), a selective inhibitor of $PKC{\beta}II$. PMA increased the phosphorylation of CREB and manganese superoxide dismutase (MnSOD), which were also inhibited by $PKC{\beta}i$. Gene silencing of CREB inhibited PMA-induced MnSOD expression, suggesting that CREB plays a key role in MnSOD expression. Gene silencing of $PKC{\beta}II$ inhibited PMA-induced mitochondrial ROS, MnSOD, and ICAM-1 expression. In contrast, overexpression of $PKC{\beta}II$ using adenoviral $PKC{\beta}II$ increased mitochondrial ROS, MnSOD, ICAM-1, and p66shc phosphorylation in cultured endothelial cells. Finally, $PKC{\beta}II$-induced ICAM-1 expression was inhibited by Mito-TEMPO, a mitochondrial ROS scavenger, suggesting the involvement of mitochondrial ROS in PKC-induced vascular inflammation. Taken together, the results suggest that $PKC{\beta}II$ plays an important role in PMA-induced endothelial dysfunction, and that the inhibition of $PKC{\beta}II$-dependent p66shc signaling acts as a therapeutic target for vascular inflammatory diseases.
( Joo Ran Hong ),( Hye In Cheon ),( Min Seok Hur ),( Byung Gon Choi ),( Song Hee Han ),( Min Jung Kim ),( Hae Jeong Youn ),( Yang Won Lee ),( Yong Beom Choe ),( Kyu Joong Ahn ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2
Background: Cyclosporin A (CsA) is an immune modulating agent in treating psoriasis. Considering its nephrotoxicity, however, serum creatinine (SCr) levels should be monitored carefully. Objectives: The objective of this study is to evaluate the safety of CsA and risk factors associated with a renal impairment in treatment of psoriasis with CsA. Methods: The 284 patients with psoriasis treated with CsA between January 2011 and December 2016 were analyzed. Results: The median duration of treatment was 10 weeks (interquartile range: 4-21) and the mean dose of CsA was 3.14±0.38 mg/kg/day. Although there was a significant increase of SCr levels after CsA treatment (P = 0.01), the overall change was largely reversible on cessation of the drug. More than 25% increase of SCr above baseline was reported in 17 patients (6.0%). Comparing those with increased SCr to the others, there was no significant difference in sex, body mass index, psoriasis area and severity index, disease duration, mean dose of CsA except the age (P = 0.005). Patients older than 60 years resulted at higher risk for a rise in SCr levels when compared with younger patients (P < 0.001). The treatment duration more than a year and hypertension also found to be significantly related to the SCr elevation. Conclusion: Careful SCr monitoring is needed in patients who have factors that might increase the SCr levels, such as old age, treatment duration more than a year and the hypertension.