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- 검색키워드
- 저자 : Choi Kyung-Un (검색결과 304 건)
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Choi, Jaemyung,Huh, Sung Un,Kojima, Mikiko,Sakakibara, Hitoshi,Paek, Kyung-Hee,Hwang, Ildoo Elsevier 2010 DEVELOPMENTAL CELL Vol.19 No.2
<P><B>Summary</B></P><P>Cytokinins affect plant immunity to various pathogens; however, the mechanisms coupling plant-derived cytokinins to pathogen responses have been elusive. Here, we found that plant-derived cytokinins promote resistance of <I>Arabidopsis</I> to <I>Pseudomonas syringae pv. tomato DC3000</I> (<I>Pst</I>). Modulated cytokinin levels or signaling activity in CKX- or IPT-overexpressing plants or in <I>ahk2 ahk3</I> mutants correlated with altered resistance. In fact, the cytokinin-activated transcription factor ARR2 contributes specifically to <I>Pst</I> resistance. The salicylic acid (SA) response factor TGA3 binds ARR2, and mutation of TGA-binding <I>cis</I>-elements in the <I>Pr1</I> promoter abolished cytokinin- and ARR2-dependent <I>Pr1</I> activation. Cytokinin treatment did not increase pathogen resistance in <I>tga3</I> plants, as the cytokinin-dependent induction of <I>Pr1</I> was eliminated. Moreover, SA signaling enhanced binding of ARR2/TGA3 to the <I>Pr1</I> promoter. Taken together, these results show that cytokinins modulate the SA signaling to augment resistance against <I>Pst</I>, a process in which the interaction between TGA3 and ARR2 is important.</P> <P><B>Graphical Abstract</B></P><P><ce:figure></ce:figure></P><P><B>Highlights</B></P><P>► Cytokinin promotes plant resistance against a bacterial pathogen, <I>Pst</I> DC3000 ► Cytokinin-activated transcription factor ARR2 interacts with TGA3 ► Salicylic acid signaling activates TGA3 to recruit ARR2 to the <I>PR1</I> promoter</P>
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( Kyung Hee Lee ),( Jang Hee Cho ),( Owen Kwon ),( Sang Un Kim ),( Ryang Hi Kim ),( Young Wook Cho ),( Hee Yeon Jung ),( Ji Young Choi ),( Chan Duck Kim ),( Yong Lim Kim ),( Sun Hee Park ) 대한신장학회 2016 Kidney Research and Clinical Practice Vol.35 No.3
Background: Prealbumin, a sensitive marker for proteineenergy status, is also known as an independent risk factor for mortality in hemodialysis patients. We investigated the impact of prealbumin on survival in incident peritoneal dialysis (PD) patients. Methods: In total, 136 incident PD patients (mean age, 53.0 ± 15.8 years) between 2002 and 2007 were enrolled in the study. Laboratory data, dialysis adequacy, and nutritional parameters were assessed 3 months after PD initiation. Patients were classified into 2 groups according to prealbumin level: high prealbumin ( 40 mg/dL) and low prealbumin (< 40 mg/dL). Results: The patients in the low-prealbumin group were older and had more comorbidities such as diabetes and cardiovascular diseases compared with the patients in the high-prealbumin group. Mean subjective global assessment scores were lower, and the high-sensitivity C-reactive protein levels were higher in the low-prealbumin group. Serum creatinine, albumin, and transferrin levels; percent lean body mass; and normalized protein catabolic rate were positively associated, whereas subjective global assessment scores and high-sensitivity C-reactive protein levels were negatively associated with prealbumin concentration. During the median follow-up of 49 months, patients in the lower prealbumin group had a higher mortality rate. Multivariate analysis revealed that prealbumin < 40 mg/dL (hazard ratio, 2.30; 95% confidence interval, 1.14e4.64) was an independent risk factor for mortality. In receiver operating characteristic curves, the area under the curve of prealbumin for mortality was the largest among the parameters. Conclusion: Prealbumin levels were an independent and sensitive predictor for mortality in incident PD patients, showing a good correlation with nutritional and inflammatory markers.
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${\alpha}$-Glucosidase Inhibitiors from Seed Extract of Paeonia lactiflora
Choi, Chun-Whan,Choi, Yeon-Hee,Cha, Mi-Ran,Park, Jee-Hee,Kim, Young-Sup,Kim, Young-Kyoon,Choi, Sang-Un,Yon, Gyu-Hwan,Hong, Kyung-Sik,Kim, Young-Ho,Ryu, Shi-Yong The Korean Society for Applied Biological Chemistr 2009 Applied Biological Chemistry (Appl Biol Chem) Vol.52 No.6
Alpha-glucosidase inhibitors are oral antihyperglycemic agents that act on alpha-glucosidase competitively, delaying intestinal carbohydrate absorption and lessening postprandial increases in glucose levels. In the search for new classes of ${\alpha}$-glucosidase inhibitors extracted from natural resources, 420 different plant extracts were evaluated for their inhibitory effect on ${\alpha}$-glucosidase, in vitro. Amongst the tested extracts, the seed extract of Paeonia lactiflora (Paeoniaceae) demonstrated a significant degree of inhibition on the enzyme, according to dose. Extensive bioassay-guided fractionation of the extract resulted in the isolation of six materials, luteolin (1), resveratrol (2), trans-${\varepsilon}$-viniferin (3), gnetin H (4), suffruticosol A (5) and suffruticosol B (6), that are active agents for ${\alpha}$-glucosidase inhibition. Resveratrol (2) is a well-known naturally occurring hydroxystilbene, particularly abundant in wine and some related stilbene oligomers. Materials (3-6) exhibited relatively strong inhibition of ${\alpha}$-glucosidase and their $IC_{50}$ values were calculated as: 0.92mM (2), 3.15mM (3), 1.15 mM (4), 2.53mM (5) and 3.15mM (6). In contrast, the ($IC_{50}$) value of the reference drug, acarbose, was estimated as 8.28mM in vitro.
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Hematological Aspects in A Endotoxemic Young Rabbit Model
Choi, Seok-Cheol,Kwon, Heun-Young,Kim, Jai-Young,Hwang, Soo-Myung,Kim, Tae-Un,Seong, Hee-Kyung,Kim, Yang-Weon,Lee, Won-Jae 대한의생명과학회 2002 Biomedical Science Letters Vol.8 No.3
Gram-negaive septicemia, which continues to be a serious clinical problem, is one of the major causes of morbidity and mortality in hospitalized patients. Endotoxin of gram-negative bacteria is a pivotal pathogen of sepsis. To understand the effect of endotoxin on hematological aspect and the time course in early childhood, this study was designed with experimental septic model of young rabbits (8 week-old). Rabbits were divided into control (n=7) and endotoxin group (0.50 mg/kg of endotoxin). The endotoxin group was subdivided into six groups by the sampling times: 3,6,12,24,48 and 72 hr-group (E-G_3, E-G_6, E-G_12, E-G_24, E-G_48 and E-G_72hrs, each n=7). The evaluation of CBC, activated partial thromboplastin time (APTT), prothrombin time (PT),fibrinogen concentration, coagulation factors and D-dimer were taken from the bloods. The number of leukocytes was lower in E-G_3and E-G_6hrs (due to pantocytopenia), whereas it was higher in E-G_24 and E-G_48hrs (due to neutrophilia and/or lymphophilia) than in control group (p<0.05). Platelet counts in E-G_3, E-G_6, E-G_12, E-G_24 and E-G_48hrs were lover than those of control group (p<0.05). Normoblast counts in E-G_3, E-G_6, E-G_12 and E-G_48hrs were higher than those of control group (p<0.01). APTT in E-G_3, E-G_6, E-G_12, E-G_24 and E-G_72hrs were longer while PT in E-G_3, E-G_6, E-G_48 and E-G_72hrs were higher than those of control group (p<0.05). Fibrinogen concentrations were lover in E-G_3, E-G_6 and E-G_12hrs but higher in E-G_48 and E-G_72hrs than those of control (P<0.05). Intrinsic coagulation factors (XII, XI, IX, VIII) in all endotoxin groups were significantly lower than those of control group (P<0.05). Extrinsic coagulation factors (X, VII, V, II) were lower in E-G_3, E-G_6, E-G_12 and E-G_24hrs whereas they were higher in E-G_48 and E-G_72hrs than in controlgroup (p<0.05). D-dimer concentrations in E-G_48 and E-G_72hrs were higher than those of control group (p<0.001). We concluded that endotoxin led to extensive hematological disturbances including disseminated intravascular coagulation in the young rabbits and that this pathologic condition in the infant and childhood groups will cause the grave results.
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Choi, Myung-Sook,Jung, Un-Ju,Kim, Myung-Joo,Kim, Jong-Yeon,Park, So-Young,Jang, Joo-Yeum,Lee, Mi-Kyung The Korean Society of Food Science and Nutrition 2005 Preventive Nutrition and Food Science Vol.10 No.1
Soy and soy foods are a rich source of isoflavones, which possess several biological activities. The effect of soy isoflavones, genistin and diadzin and their respective aglycones, on glucose uptake in adipocytes isolated from normal or high-fat fed rats was examined. As expected, insulin stimulated glucose uptake in a concentration-dependent manner. However, genistin and daidzin and their aglycones inhibited glucose uptake in a concentration-dependent (25-100μM) manner. In a time-course response, the aglycones significantly inhibited glucose uptake throughout 3 hr (after 30, 60, 120, 180 min), whereas the glycones only significantly inhibited the glucose uptake after 120 min and 180 min in the isolated rat adipocytes. Thus, the glucosides of genistein and daidzein, i.e. genistin and daidzin, were much less effective in inhibiting glucose uptake than their aglycones. In addition, genistin and daidzin did not significantly affect the insulin-stimulated glucose uptake, whereas genistein and daidzein did significantly inhibited glucose uptake compared to the vehicle control group by 47.5% and 24.8%, respectively (p < 0.05). The isoflavones also significantly inhibited glucose uptake in adipocytes isolated from rats fed a high-fat diet (50% of total calorie intake) when compared to the vehicle control. Finally, the isoflavones were found to enhance lipolysis in adipocytes isolated from high-fat fed rats, where the glycerol released by the aglycones was also higher than that released by the glycones. The current results showed that the inhibitory effect of daidzein on glucose uptake was very similar to that of genistein. The aglycones were more potent in inhibiting the uptake of glucose and a more potent stimulator of lypolysis than the glycones in adipocytes isolated from high-fat fed rats.
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Choi, Ji Soo,Leem, Joong Woo,Lee, Kyung Hee,Kim, Sung-Soo,SuhKim, Haeyoung,Jung, Se Jung,Kim, Un Jeng,Lee, Bae Hwan The Korean Society of Pharmacology 2012 The Korean Journal of Physiology & Pharmacology Vol.16 No.6
The spontaneous axon regeneration of damaged neurons is limited after spinal cord injury (SCI). Recently, mesenchymal stem cell (MSC) transplantation was proposed as a potential approach for enhancing nerve regeneration that avoids the ethical issues associated with embryonic stem cell transplantation. As SCI is a complex pathological entity, the treatment of SCI requires a multipronged approach. The purpose of the present study was to investigate the functional recovery and therapeutic potential of human MSCs (hMSCs) and polymer in a spinal cord hemisection injury model. Rats were subjected to hemisection injuries and then divided into three groups. Two groups of rats underwent partial thoracic hemisection injury followed by implantation of either polymer only or polymer with hMSCs. Another hemisection-only group was used as a control. Behavioral, electrophysiological and immunohistochemical studies were performed on all rats. The functional recovery was significantly improved in the polymer with hMSC-transplanted group as compared with control at five weeks after transplantation. The results of electrophysiologic study demonstrated that the latency of somatosensory-evoked potentials (SSEPs) in the polymer with hMSC-transplanted group was significantly shorter than in the hemisection-only control group. In the results of immunohistochemical study, ${\beta}$-gal-positive cells were observed in the injured and adjacent sites after hMSC transplantation. Surviving hMSCs differentiated into various cell types such as neurons, astrocytes and oligodendrocytes. These data suggest that hMSC transplantation with polymer may play an important role in functional recovery and axonal regeneration after SCI, and may be a potential therapeutic strategy for SCI.
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Choi, Kyung Un,Yun, Jeong Sup,Lee, Il Hwan,Heo, Soon Chul,Shin, Sang Hun,Jeon, Eun Su,Choi, Yoon Ji,Suh, Dong‐,Soo,Yoon, Man‐,Soo,Kim, Jae Ho Wiley Subscription Services, Inc., A Wiley Company 2011 International journal of cancer: Journal internati Vol.128 No.2
<P><B>Abstract</B></P><P>Lysophosphatidic acid (LPA) is a bioactive lipid crucial for the initiation and progression of ovarian cancer. Identification of LPA‐induced biomarkers is necessary for predicting prognosis of ovarian cancer patients. Here we report periostin, an extracellular matrix protein, as an LPA‐induced protein in stromal cells and as a prognostic marker in patients with epithelial ovarian cancer (EOC). In human EOC tissues, periostin was mainly expressed in cancer‐associated stromal fibroblasts, but not in cancer cells. The expression levels of periostin highly correlated with poor survival and tumor recurrence of ovarian cancer patients. Treatment of human adipose tissue‐derived stromal cells with LPA or conditioned media from human ovarian adenocarcinoma cell lines, such as SK‐OV‐3 and OVCAR‐3, induced expression of periostin. The periostin expression induced by cancer‐conditioned media was abrogated by silencing of the LPA receptor 1 expression using small hairpin RNA lentivirus. Recombinant periostin stimulated adhesion and invasion of SK‐OV‐3 human ovarian adenocarcinoma cells and induced expression of matrix metalloprotease‐2 in the cancer cells. These results suggest that LPA is associated with the expression of periostin in cancer‐associated fibroblasts of EOC.</P>
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Choi Seon-Ah,Kim Kyung Hyun,Choi Un Yong,Park Jeong Yoon,Kuh Sung-Uk,Chin Dong Kyu,Kim Keun Su,Cho Yong Eun 대한말초신경학회 2019 The Nerve Vol.5 No.2
Objective Trans-oral approach or occipitocervical/atlantoaxial fusion with/without posterior decompression has been considered to be an appropriate surgical strategy for craniovertebral junction (CVJ) stenosis with myelopathy. However, decompressive C1 laminectomy without posterior stabilization was reported recently for treating retro-odontoid pseudotumor. This study aimed to evaluate surgical outcomes of the patients treated with decompressive C1 laminectomy without posterior stabilization for CVJ stenosis with myelopathy. Methods Ten patients underwent decompressive C1 laminectomy without posterior stabilization for CVJ stenosis with myelopathy from August 2007 to December 2016. All patients were evaluated preoperatively for spinal canal stenosis, cord signal changes, and instability based on preoperative computed tomography, magnetic resonance imaging, and plain dynamogram. We retrospectively reviewed the clinic charts and radiographs for investigating clinical outcomes such as the visual analog scale (VAS), and Ranawat grade scale and complications. Radiographic parameters including pre- and postoperative atlas-dens interval change in flexion and extension, O-C2 angle, C2-C7 Cobb angle, and C2-C7 sagittal vertical axis were measured. Results The mean follow-up time was 41 months. Eight men and 2 women with a mean age of 58 years (range, 45-69 years) were enrolled. Preoperative neck pain by the VAS was improved significantly in all patients (p<0.01). Nine of 10 patients showed improvement on the Ranawat grading scale, but 1 patient who required a Halo-vest due to aggravated instability after surgery remained unchanged. The statistical results of the preoperative and postoperative radiographic measurements were not significant. Conclusion In select patients with certain indications, decompressive C1 laminectomy could be a viable option, especially in the elderly, patients with comorbidity, and patients with poor bone quality.
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