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Choi Hey-Ran,Yang Hong Seuk,Choi Jae-Moon,Park Chungon,인준용,김용범 대한마취통증의학회 2022 Anesthesia and pain medicine Vol.17 No.2
Background: Sugammadex is a specific antagonist of aminosteroidal neuromuscular blocking agents with 1:1 binding to guest molecules. Sugammadex can also bind to other drugs having a steroid component in its chemical structure. In this in vivo experiment, we investigated the differences in the recovery of rocuronium-induced neuromuscular blockade using sugammadex pre-exposed with two different concentrations of hydrocortisone.Methods: The sciatic nerves and tibialis anterior muscles of 30 adult Sprague–Dawley rats were prepared for the experiment. The sciatic nerves were stimulated using a train-of-four (TOF) pattern with indirect supramaximal stimulation at 20 s intervals. After 15 min of stabilization, a 250 μg loading dose and 125 μg booster doses of rocuronium were serially administered until > 95% depression of the first twitch tension of TOF stimulation (T1) was confirmed. The study drugs were prepared by mixing sugamadex with the same volume of three different stock solutions (0.9% normal saline, 10 mg/ml hydrocortisone, and 100 mg/ml hydrocortisone). The recovery of rats from neuromuscular blockade was monitored by assessing T1 and the TOF ratio (TOFR) simultaneously until T1 was recovered to > 95% and TOFR to > 0.9.Results: In the group injected with sugammadex premixed with a high concentration of hydrocortisone, statistically significant intergroup differences were observed in the recovery progression of T1 and TOFR (P < 0.050).Conclusions: When sugammadex was pre-exposed to a high dose of hydrocortisone only, recovery from neuromuscular blockade was delayed. Delayed recovery from neuromuscular blockade is not always plausible when sugammadex is pre-exposed to steroidal drugs.
Hey-Ran Choi,Jae Keun Cho,이상석,Byung Hoon Yoo,Jun Heum Yon,김계민 대한마취통증의학회 2011 Korean Journal of Anesthesiology Vol.61 No.2
Background: Remifentanil can be an alternative to N_2O in general anesthesia. Intraoperative remifentanil may lead to acute opioid tolerance. This study aims to assess the effect of remifentanil substituted for 70% N_2O on postoperative pain in children undergoing tonsillectomy/adenoidectomy. In addition, we evaluated the effect of remifentanil infusion on incidence of emergence agitation in these patients. Methods: Eighty children, aged 2-12 years, undergoing tonsillectomy/adenoidectomy were randomly allocated to the N_2O group (Group N; n = 40, sevoflurane and 70% N_2O) or remifentanil group (Group R; n = 40, sevoflurane with remifentanil infusion at the rate of 0.17 μg/kg/min). In the recovery room, severity of pain and agitation were assessed by an investigator blinded to the assigned group. Time to eye opening and incidence of severe pain and agitation were compared between groups. Logistic regression was used to identify factors related to occurrence of severe pain and agitation. Results: Number of patients with severe postoperative pain was 6 and 16 in groups N and R, respectively (P = 0.012). Incidence of emergence agitation was not significantly different between groups. Remifentanil infusion was a significant factor related to the occurrence of severe postoperative pain (P = 0.015), and age was inversely related to occurrence of emergence agitation (P = 0.001). Conclusions: In children undergoing tonsillectomy/adenoidectomy, intraoperative remifentanil infusion may increase incidence of severe postoperative pain compared to N_2O, but it may not affect incidence of emergence agitation.
α-2,3 Sialylation on Neural Cell Surface N-Glycans Increases during Glucose Deprivation
Ha Na Choi,Yoon Hee Lee,Doo Jin Choi,Hey Ran Moon,Young-Kug Choo,Su-Il Do,Yong Il Park 한국당과학회 2010 한국당과학회 학술대회 Vol.2010 No.1
Sialic acids are typically found as terminal monosaccharides attached to the cell surface glycoconjugates and play important roles in many physiological and pathological processes, including microbe binding that leads to infections, regulation of the immune response, the progression and spread of human malignancies, differentiation, development, canceration, and degenerative diseases (1-3). UDP-GlcNAc is a metabolic precursor of sialic acids. Thus, glucose metabolism and regulation of metabolic flux of UDT-GlcNAc critically affect the expression of cell surface sialic acid and nervous system function (4,5). Here, we investigated the expression of sialic acid in human neuroblastoma cell, SK-N-SH, in response to glucose deprivation. When subjected to a glucose-free environment for 24 h, SK-N-SH cells showed severe defects in neurite development and eventually died. During glucose limitation, the expression level of sialic acid of total cellular proteins was examined by lectin blotting using Maackia amunrensis(MAA) lectin and Sambucus nigra(SNA) lectin, which are specific for α-2,3 sialic acid and α-2,6 sialic acid, respectively. Glucose deprivation caused increase in MAA binding to several major proteins (especially, 45 and 75 kDa), suggesting an increased α-2,3 sialylation on these proteins. Lectin histochemistry using MAA lectin also showed a significant increase in surface α,2-3 sialylation upon glucose deprivation. In addition, glucose deprivation resulted in a dose-dependant increase in the mRNA level of ST3GAL4 sialyltransferase by 2.3 folds comparing to that cultured in 2 mg/ml glucose medium, whereas expressions of other sialyltransferases (ST3GAL3, ST3GAL6, and ST6GAL1) were not significantly influenced. These results suggest that glucose deprivation upregulates the α,2-3 sialylation on several cell surface glycoproteins and this phenomenon may be involved in neural cell death by glucose deprivation.
Dissection of Korean landrace chamoe (Cucumis melo var. makuwa) genome
Inkyu Park,Jae-Pil Choi,Jungeun Kim,Jeongyeo Lee,Soohwan Lim,Mi-Ye Lee,Hey-Ran Kim 한국육종학회 2015 한국육종학회 심포지엄 Vol.2015 No.07
The oriental melon (C. melo var. makuwa), called ‘Chamoe’ in Korean, is a popular fruit crop cultivated mainly in Asia and a high–market value crop in Korea. To provide a genomic resource as a reference genome for the Cucurbitaceae crop improvement, we performed whole genome sequencing of Korean landrace, Gotgam chamoe. We used Illumina HiSeq2000 sequencing platform to generate 89 Gb (205X) of paired and mate pair sequence reads. The pre-processed reads were de novo assembled resulting in 4,764 scaffolds with a N50 scaffold length of 249kb. This assembly represented 379.8Mb which was 84.7% of the 448Mb of the whole genome. The assembled draft was predicted 26,634 genes of which 80% were predicted by known protein or C. melo unigene homology. Approximately 20% of predicted genes were hypothetical. A total of 1,885 non-coding RNA was detected including rRNA. The transposable elements were accounted for 21% (71.6Mb) of the total assembly. All the marker candidates including SSR, INDEL, SNP were mined and presented. The draft genome will provide a useful platform for genomic research and improvement for Cucurbitacea crops.
Impact of coronavirus disease 2019 on patients with chronic pain: multicenter study in Korea
( Hyunji John ),( Yun Hee Lim ),( Sung Jun Hong ),( Jae Hun Jeong ),( Hey Ran Choi ),( Sun Kyung Park ),( Jung Eun Kim ),( Byung-soo Kim ),( Jae Hun Kim ) 대한통증학회 2022 The Korean Journal of Pain Vol.35 No.2
Background: The coronavirus disease 2019 (COVID-19) pandemic has caused significant changes. This study aimed to investigate the impact of COVID-19 on patients with chronic pain. Methods: Patients with chronic pain from 23 university hospitals in South Korea participated in this study. The anonymous survey questionnaire consisted of 25 questions regarding the following: demographic data, diagnosis, hospital visit frequency, exercise duration, time outside, sleep duration, weight change, nervousness and anxiety, depression, interest or pleasure, fatigue, daily life difficulties, and self-harm thoughts. Depression severity was evaluated using the Patient Health Questionnaire-9 (PHQ-9). Logistic regression analysis was used to investigate the relationship between increased pain and patient factors. Results: A total of 914 patients completed the survey, 35.9% of whom had decreased their number of visits to the hospital, mostly due to COVID-19. The pain level of 200 patients has worsened since the COVID-19 outbreak, which was more prominent in complex regional pain syndrome (CRPS). Noticeable post-COVID-19 changes such as exercise duration, time spent outside, sleep patterns, mood, and weight affected patients with chronic pain. Depression severity was more significant in patients with CRPS. The total PHQ-9 average score of patients with CRPS was 15.5, corresponding to major depressive orders. The patients’ decreased exercise duration, decreased sleep duration, and increased depression were significantly associated with increased pain. Conclusions: COVID-19 has caused several changes in patients with chronic pain. During the pandemic, decreased exercise and sleep duration and increased depression were associated with patients’ increasing pain.
( Jae Yun Kim ),( Jae Hang Shim ),( Sung Jun Hong ),( Jong Yeun Yang ),( Hey Ran Choi ),( Yun Hee Lim ),( Ho Sik Moon ),( Jaemoon Lee ),( Jae Hun Kim ) 대한통증학회 2017 The Korean Journal of Pain Vol.30 No.2
Background: Spinal pain is most common symptom in pain clinic. In most cases, before the treatment of spinal pain, physician explains the patient`s disease and treatment. We investigated patient`s satisfaction and physician`s explanation related to treatments in spinal pain patients by questionnaires.Methods: Anonymous questionnaires about physician`s explanation and patient`s satisfaction in each treatment and post-treatment management were asked to individuals suffering from spinal pain. Patients who have spinal pain were participated in our survey of nationwide university hospitals in Korea. The relationships between patient`s satisfaction and other factors were analyzed.Results: Between June 2016 and August 2016, 1007 patients in 37 university hospitals completed the questionnaire. In the statistical analysis, patient`s satisfaction of treatment increased when pain severity was low or received sufficient preceding explanation about nerve block and medication (P < 0.01). Sufficient explanation increased patient`s necessity of a post-treatment management and patients` performance rate of post-treatment management (P < 0.01).Conclusions: These results show that sufficient explanation increased patients` satisfaction after nerve block and medication. Sufficient explanation also increased the practice of patients` post-treatment management. (Korean J Pain 2017; 30: 116-25)
( Jaemoon Lee ),( Yun Hee Lim ),( Sung Jun Hong ),( Jae Hun Jeong ),( Hey Ran Choi ),( Sun Kyung Park ),( Jung Eun Kim ),( Eun Hi Park ),( Jae Hun Kim ) 대한통증학회 2021 The Korean Journal of Pain Vol.34 No.3
Background: Complex regional pain syndrome (CRPS) is an intractable pain disease with various symptoms. Here, we investigated the disease status, work life, sleep problems, medical insurance, economic status, psychological problems, and quality of life (QOL) of CRPS patients. Methods: CRPS patients from 37 university hospitals in South Korea were surveyed. The survey questionnaire consisted of 24 questions on the following aspects of CRPS patients: sex, age, occupation, cause of injury, activities of daily living (ADL), pain severity, sleep disturbance, level of education, economic status, therapeutic effect, and suicidal ideation. Additionally, the abbreviated World Health Organization Quality of Life (WHOQOL-BREF) questionnaire, consisting of 26 questions, was used to identify the status of QOL. Results: A total of 251 patients completed the questionnaire. According to the survey, 54.2% patients could not perform ADL on their own. Over the previous week, the mean pain score was 7.15 ± 1.78 (out of a total of 10 points); 92.1% of patients had sleep disorders and 80.5% had suicidal ideation, with most patients suffering from psychological problems. The average for each domain of WHOQOL-BREF was as follows: 21.74 ± 14.77 for physical, 25.22 ± 17.66 for psychological, 32.02 ± 22.36 for social relationship, and 30.69 ± 15.83 for environmental (out of a total of 100 points each). Occupation, ADL, sleep time, therapeutic effect, and suicidal ideation were statistically correlated with multiple domains. Conclusions: Most patients had moderate to severe pain, economic problems, limitations of their ADL, sleep problems, psychological problems, and a low QOL score.