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Xiliang Liu,Song Liu,Youkun Fan,Jin Qi,Xin Wang,Wei Bai,Dongliang Chen,Chengdong Xiong,Lifang Zhang 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.104 No.-
The poly(L-lactide-co-e-caprolactone) (PLCL) ureteral stent creeps and loses shape stability, increasingthe risk of stent tube dislocation. The rubbery biodegradable cross-linked PLCL networks were preparedthrough gamma irradiation under vacuum in the presence of trimethylolpropane triacrylate (TMPTA),pentaerythritol tetraacrylate (PET4A), and pentaerythritol triacrylate (PETA). At a standard sterilizationdose of 25 kGy, the gel content and network density of PLCL networks increased with increasingcrosslinking agent content (1, 3, 5, 7 wt%), and crosslinking efficiency decreased in the order ofPETA > PET4A > TMPTA. The average molecular weight (Mc ) between two crosslinks ranged from 2000to 105 g/mol. To perform the beneficial semi-interpenetrated polymer network and characterized bythe principle, the networks were processed in several doses (25, 50, 75, 100, and 125 kGy). In place ofthe Charlesby-Pinner equation, the irradiation cross-linking followed the Chen-Liu-Tang equation. ThePLCL network with 7 wt% PETA had a gel fraction of 83%, tensile strength of 34.7 MPa, and tensile setvalue as low as 5%. Furthermore, degradation in vitro was slowed down. Thus, PLCL networks with appropriateelasticity and flexibility, inherent biodegradability, and excellent biocompatibility can provide apromising alternative method for soft tissue repair engineering, such as ureteral stents.
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Manjing Deng,Qian Xu,Zhihua Liu1,Ling Guo,Rui Liu,Rulei Li,Xiang Chu,Jiajia Yang,Jia Luo,Faming Chen 한국분자세포생물학회 2019 Molecules and cells Vol.42 No.11
Periodontitis is characterized by the loss of periodontal tissues, especially alveolar bone. Common therapies cannot satisfactorily recover lost alveolar bone. Periodontal ligament stem cells (PDLSCs) possess the capacity of self-renewal and multilineage differentiation and are likely to recover lost alveolar bone. In addition, periodontitis is accompanied by hypoxia, and hypoxia-inducible factor-1α (HIF-1α) is a master transcription factor in the response to hypoxia. Thus, we aimed to ascertain how hypoxia affects runt-related transcription factor 2 (RUNX2), a key osteogenic marker, in the osteogenesis of PDLSCs. In this study, we found that hypoxia enhanced the protein expression of HIF-1α, vascular endothelial growth factor (VEGF), and RUNX2 ex vivo and in situ. VEGF is a target gene of HIF-1α, and the increased expression of VEGF and RUNX2 proteins was enhanced by cobalt chloride (CoCl2, 100 μmol/L), an agonist of HIF-1α, and suppressed by 3-(5′-hydroxymethyl-2′-furyl)-1-benzyl indazole (YC-1, 10 μmol/L), an antagonist of HIF-1α. In addition, VEGF could regulate the expression of RUNX2, as RUNX2 expression was enhanced by human VEGF (hVEGF165) and suppressed by VEGF siRNA. In addition, knocking down VEGF could decrease the expression of osteogenesis-related genes, i.e., RUNX2, alkaline phosphatase (ALP), and type I collagen (COL1), and hypoxia could enhance the expression of ALP, COL1, and osteocalcin (OCN) in the early stage of osteogenesis of PDLSCs. Taken together, our results showed that hypoxia could mediate the expression of RUNX2 in PDLSCs via HIF-1α-induced VEGF and play a positive role in the early stage of osteogenesis of PDLSCs
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Liu Jianjian,Liu Jinhui,Cui Miaomiao,Chen Xiao,Liu Junli,Chen Jiadong,Chen Aiqun,Xu Guohua 한국식물학회 2022 Journal of Plant Biology Vol.65 No.6
Leguminous plants form root nodule organs with soil rhizobia bacteria, which can fix atmospheric nitrogen (N2) and supply ammonia to the host plant. It is established that the symbiotic N fixation efficiency is substantially influenced by plant nutrients, such as molybdenum (Mo), phosphorus (P), copper (Cu), and zinc (Zn). Potassium (K+) is the most abundant cation in plant cells; however, little evidence regarding the potential link between K nutrition and symbiotic N fixation efficiency is available to date. Here, we showed that K+ deficiency reduced the efficiency of symbiotic nitrogen fixation, and inoculated with rhizobia strain USDA110 could improve plant K+ acquisition. Furthermore, we identified a potassium transporter gene (GmHAK5) that was highly expressed in the root steles and in the vasculature cells of nodules. The GmHAK5 protein was localized at the plasma membrane and could rescue the growth phenotype of yeast K+ uptake-defective mutant. The results obtained from this study provides new insights for the understanding of the potential role of K+ nutrition in modulating symbiotic N fixation in soybean.
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Chen Ting,Liu Pengfei,Liu Tianxiao,Li Xueyuan,Wang Huihui,He Tingwei,Liu Zhiyong 한국물리학회 2024 Current Applied Physics Vol.58 No.-
Electron transport layer (ETL) plays an important role in perovskite solar cells (PSCs). In this paper, a stable and cheap metal chelating agent, subnitrotriacetic acid (NTA), was used to modify SnO2 ETL in two ways:1) By incorporating NTA into SnO2 colloidal dispersion, the oxygen vacancy causing charge recombination was greatly reduced, and the recombination of psc was reduced by reducing the introduction of surface Ovs, 2) Spin-coating NTA at the SnO2/perovskite interface not only manages a large number of oxygen vacancies generated by high-temperature annealing, but also interacts with the unpaired Pb2+ in the perovskite absorption layer by interface modification of the C=O bond in NTA, passivates the surface of the perovskite layer, inhibits ion migration, stabilize the perovskite structure, and avoid its collapse, while significantly reducing the defect state density. By inhibiting the shallow interface trap and reducing the non-radiative recombination, efficient and stable perovskite solar cells were prepared. Under the condition of relative humidity greater than 40 % (RH), the efficiency of perovskite solar cells prepared by interface-anchored NTA was increased to 22.6 %, and the stability was significantly enhanced.
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Liu, Jia,Ge, Yang-Yang,Zhu, Hong-Cheng,Yang, Xi,Cai, Jing,Zhang, Chi,Lu, Jing,Zhan, Liang-Liang,Qin, Qin,Yang, Yan,Yang, Yue-Hua,Zhang, Hao,Chen, Xiao-Chen,Liu, Zhe-Ming,Ma, Jian-Xin,Cheng, Hong-Yan,S Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.16
Radiation therapy is an important treatment for head and neck squamous cell carcinoma (HNSCC). However, how to promote radiation sensitivity in HNSCC remains a challenge. This study aimed to investigate the radiosensitizing effects of fenofibrate on HNSCC and explore the underlying mechanisms. HNSCC cell lines CNE-2 and KB were subjected to ionizing radiation (IR), in the presence or absence of fenofibrate treatment. Cell growth and survival, apoptosis and cell cycle were evaluated. In addition, CNE-2 cells were xenografted into nude mice and subjected to IR and/or fenofibrate treatment. The expression of cyclinB and CDK1 was detected by Western blotting. Our results showed that fenofibrate efficiently radiosensitized HNSCC cells and xenografts in mice, and induced apoptosis and G2/M arrest via reducing the activity of the CDK1/cyclinB1 kinase complex. These data suggest that fenofibrate could be a promising radiosensitizer for HNSCC radiotherapy.
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Liu, Zhe-Ming,Ge, Xiao-Lin,Chen, Jia-Yan,Wang, Pei-Pei,Zhang, Chi,Yang, Xi,Zhu, Hong-Cheng,Liu, Jia,Qin, Qin,Xu, Li-Ping,Lu, Jing,Zhan, Liang-Liang,Cheng, Hong-Yan,Sun, Xin-Chen Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.8
Background: Radiotherapy is an important treatment of choice for breast cancer patients after breast-conserving surgery, and we compare the feasibility of using dual arc volumetric modulated arc therapy (VMAT2), single arc volumetric modulated arc therapy (VMAT1) and Multi-beam Intensity Modulated Radiotherapy (M-IMRT) on patients after breast-conserving surgery. Materials and Methods: Thirty patients with breast cancer (half right-sided and half left-sided) treated by conservative lumpectomy and requiring whole breast radiotherapy with tumor bed boost were planned with three different radiotherapy techniques: 1) VMAT1; 2) VMAT2; 3) M-IMRT. The distributions for the planning target volume (PTV) and organs at risk (OARs) were compared. Dosimetries for all the techniques were compared. Results: All three techniques satisfied the dose constraint well. VMAT2 showed no obvious difference in the homogeneity index (HI) and conformity index (CI) of the PTV with respect to M-IMRT and VMAT1. VMAT2 clearly improved the treatment efficiency and can also decrease the mean dose and V5Gy of the contralateral lung. The mean dose and maximum dose of the spinal cord and contralateral breast were lower for VMAT2 than the other two techniques. The very low dose distribution (V1Gy) of the contralateral breast also showed great reduction in VMAT2 compared with the other two techniques. For the ipsilateral lung of right-sided breast cancer, the mean dose was decreased significantly in VMAT2 compared with VMAT1 and M-IMRT. The V20Gy and V30Gy of the ipsilateral lung of the left-sided breast cancer for VMAT2 showed obvious reduction compared with the other two techniques. The heart statistics of VMAT2 also decreased considerably compared to VMAT1 and M-IMRT. Conclusions: Compared to the other two techniques, the dual arc volumetric modulated arc therapy technique reduced radiation dose exposure to the organs at risk and maintained a reasonable target dose distribution.
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Chen Chen,Yitong Chang,Yuan Deng,Qingming Cui,Yingying Liu,Huali Li,Huibo Ren,Ji Zhu,Qi Liu,Yinglin Peng Asian Australasian Association of Animal Productio 2023 Animal Bioscience Vol.36 No.3
Objective: Daweizi (DWZ) is a famous indigenous pig breed in China and characterized by tender meat and high fat percentage. However, the expression profiles and functions of transcripts in DWZ pigs is still in infancy. The object of this study was to depict the transcript profiles in DWZ pigs and screen the potential pathway influence adipogenesis and fat deposition, Methods: Histological analysis of backfat tissue was firstly performed between DWZ and lean-type Yorkshire pigs, and then RNA sequencing technology was utilized to explore miRNAs, lncRNAs and mRNAs profiles in backfat tissue. 18 differentially expressed (DE) transcripts were randomly selected for quantitative real-time polymerase chain reaction (QPCR) to validate the reliability of the sequencing results. Finally, gene ontology (GO) and Kyoto encyclopedia of genes and genomes (KEGG) enrichment analysis were conducted to investigate the potential pathways influence adipocyte differentiation, adipogenesis and lipid metabolism, and a schematic model was further proposed. Results: A total of 1,625 differentially expressed transcripts were identified in DWZ pigs, including 27 upregulated and 45 downregulated miRNAs, 64 upregulated and 119 down-regulated lncRNA, 814 upregulated and 556 downregulated mRNAs. QPCR analysis exhibited strong consistency with the sequencing data. GO and KEGG analysis elucidated that the differentially expressed transcripts were mainly associated with cell growth and death, signal transduction, peroxisome proliferator-activated receptors (PPAR), AMP-activated protein kinase (AMPK), PI3K-Akt, adipocytokine and foxo signaling pathways, all of which are strongly involved in cell development, lipid metabolism and adipogenesis. Further analysis indicated that the BGIR9823_87926/miR-194a-5p/AQP7 network may be effective in the process of adipocyte differentiation or adipogenesis. Conclusion: Our study provides comprehensive insights into the regulatory network of backfat deposition and lipid metabolism in pigs from the point of view of miRNAs, lncRNAs and mRNAs.
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Liu, Shao-Chen,Xia, Qun-Ke,Choi, Sung Hi,Deloule, Etienne,Li, Pei,Liu, Jia Springer-Verlag 2016 Contributions to mineralogy and petrology Vol.171 No.12
<P>Various enriched recycled oceanic components in the source of Cenozoic intra-plate alkaline basalts from eastern China were identified by previous studies. Due to the existence of a stagnant subducted Pacific slab in the mantle transition zone beneath eastern China, it is logical to connect the stagnant slab to the recycled oceanic materials. However, the recycled oceanic materials could also result from ancient subduction events (e.g., Paleo-Tethyan, Paleo-Asian or Izanagi plate subduction) because enriched geochemical signatures of a recycled slab can be preserved in the mantle for longer than 1 Gyr. Investigating the temporal variations of the recycled oceanic materials in the mantle source is a useful way to trace the origin of the basalts. In this article, we have conducted a detailed geochemical study, including major and trace elements and Sr-Nd-Pb isotopes, on two alkaline basalt groups from Zhejiang, SE China, which erupted 26-17 Ma and after 11 Ma, respectively. In particular, we recovered the H2O content of the initial magmas based on the H2O content of the clinopyroxene (cpx) phenocrysts and the partition coefficients of H2O between cpx and basaltic melts. The H2O contents of the Zhejiang basalts range from 1.3 to 2.6 (wt.%), which fall within the range of back-arc basin or island arc basalts. The older basalts are more alkaline and have lower Si and Al contents; higher trace element concentrations; higher La/Yb, Ce/Pb and Nb/La ratios; lower H2O/Ce and Ba/Th ratios; and stronger negative K, Pb, Hf and Ti anomalies than the younger ones. The co-relationships between Ba/La, H2O/Ce, Nb/La, Ce/Pb and Ba/Th in the two groups of the Zhejiang basalts indicate that a recycled dehydrated oceanic alkaline basalt component is needed in the source of the older rocks, along with a depleted mantle component. Meanwhile, an additional recycled dehydrated sediment component was required in the source of the younger rocks. The temporal change in the recycled oceanic materials in the mantle sources of Zhejiang Cenozoic basalts demonstrates that the recycled components can only originate in the stagnant Pacific slab that is the only plate subducted since 100 Ma in this area.</P>
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Chen Shoucheng,Huang Zhuwei,Visalakshan Rahul Madathiparambil,Liu Haiwen,Bachhuka Akash,Wu You,Dabare Panthihage Ruvini L.,Luo Pu,Liu Runheng,Gong Zhuohong,Xiao Yin,Vasilev Krasimir,Chen Zhuofan,Chen 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Background: Transepithelial medical devices are increasing utilized in clinical practices. However, the damage of continuous natural epithelial barrier has become a major risk factor for the failure of epithelium-penetrating implants. How to increase the “epithelial barrier structures” (focal adhesions, hemidesmosomes, etc.) becomes one key research aim in overcoming this difficulty. Directly targeting the in situ “epithelial barrier structures” related proteins (such as fibronectin) absorption and functionalization can be a promising way to enhance interface-epithelial integration. Methods: Herein, we fabricated three plasma polymerized bio-interfaces possessing controllable surface chemistry. Their capacity to adsorb and functionalize fibronectin (FN) from serum protein was compared by Liquid Chromatography- Tandem Mass Spectrometry. The underlying mechanisms were revealed by molecular dynamics simulation. The response of gingival epithelial cells regarding the formation of epithelial barrier structures was tested. Results: Plasma polymerized surfaces successfully directed distinguished protein adsorption profiles from serum protein pool, in which plasma polymerized allylamine (ppAA) surface favored adsorbing adhesion related proteins and could promote FN absorption and functionalization via electrostatic interactions and hydrogen bonds, thus subsequently activating the ITG β1-FAK-mTOR signaling and promoting gingival epithelial cells adhesion. Conclusion: This study offers an effective perspective to overcome the current dilemma of the inferior interfaceepithelial integration by in situ protein absorption and functionalization, which may advance the development of functional transepithelial biointerfaces. Graphical Abstract: Tuning the surface chemistry by plasma polymerization can control the adsorption of fibronectin and functionalize it by exposing functional protein domains. The functionalized fibronectin can bind to human gingival epithelial cell membrane integrins to activate epithelial barrier structure related signaling pathway, which eventually enhances the formation of epithelial barrier structure.
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Chen, Yang,Liu, Zhong-Jing,Liu, Jia,Liu, Li-Kun,Zhang, Er-Shao,Li, Wei-Ling Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.23
Background: Rosa Roxburghii Tratt is a promising wild fruit crop in Southwest China. Its extracts have been used as traditional Chinese medicine, which benefit immune responses and cure various health disorders. However, whether Rosa Roxburghii Tratt polysaccharides could inhibit metastasis and invasion of ovarian cancer cells remains unknown. Materials and Methods: Effects of crude polysaccharides from Rosa Roxburghii Tratt on the viability of ovarian cancer A2780 cells were detected by MTT assay. Ovarian carcinoma cell migration and invasion after exposure to Rosa Roxburghii Tratt polysaccharides were quantified by wound healing and Transwell assays, respectively. Western blotting was applied to assess protein levels of MMP-9. Results: The results indicated that Rosa Roxburghii Tratt polysaccharides significantly reduced wound closure rate of A2780 cells, inhibited their migration and invasion, and suppressed the expression of MMP-9. Conclusions: Our findings indicated that Rosa Roxburghii Tratt polysaccharides have potential for develop as anti-metastatic cancer drug preparations for ovarian cancer patients.
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