Fertility and prognosis assessment between bleomycin/etoposide/cisplatin and paclitaxel/carboplatin chemotherapy regimens in the conservative treatment of malignant ovarian germ cell tumors: a multicenter and retrospective study

Ran Chu,Penglin Liu,Jingying Chen,Xiaodong Cheng,Kezhen Li,Yanci Che,Jianliu Wang,Li Li,Xi Zhang,Shu Yao,Li Song,Ying Zhao,Changzhen Huang,Ying Xue,Xiyu Pan,Junting Li,Zhongshao Chen,Jie Jiang,Beihua 대한부인종양학회 2023 Journal of Gynecologic Oncology Vol.34 No.2

Objective: To evaluate the impact of bleomycin/etoposide/cisplatin (BEP) and paclitaxel/carboplatin (PC) chemotherapy regimens on the fertility and prognostic outcomes in malignant ovarian germ cell tumor (MOGCT) patients who underwent fertility-sparing surgery (FSS). Methods: A propensity score matching algorithm was performed between the BEP and PC groups. The χ2 test and the Kaplan-Meier method were used to compare the fertility outcome, disease-free survival (DFS) and overall survival (OS). The Cox proportional hazards regression analysis was used to identify risk factor of DFS. Results: We included 213 patients, 185 (86.9%) underwent BEP chemotherapy, and 28 (13.1%) underwent PC chemotherapy. The median age was 22 years (range, 8–44 years), and the median follow-up period was 63 months (range, 2–191 months). Fifty-one (29.3%) patients had a pregnancy plan, and 35 (85.4%) delivered successfully. In the before and after propensity score matching cohorts, there were no significant differences in spontaneous abortion, selective termination of pregnancy, during-pregnancy status, and live birth between the BEP and PC groups (p>0.05). Fourteen (6.6%) patients experienced recurrence, including 11 (5.9%) in the BEP group and 3 (10.7%) in the PC group. Four (1.9%) patients in the BEP group died. Kaplan-Meier analysis revealed no significant differences in DFS (p=0.328) and OS (p=0.446) between the BEP and PC groups, and the same survival results were observed in the after matching cohort. Conclusion: The PC regimen is as safe as the BEP regimen for MOGCT patients with fertility preservation treatment, and no differences were observed in fertility and clinical prognosis.

Synthesis of Rod-Like Porous MgFe2O4 Architectures as a Catalyst for Ammonium Perchlorate Thermal Decomposition

Run Chen,Gang Li,Weiyang Bai,Shuang Bao,Zhiliang Cheng 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2018 NANO Vol.13 No.6

The development of highly active catalysts for the pyrolysis of ammonium perchlorate (AP) is of considerable importance for AP-based composite solid propellant. In the present study, we produced porous MgFe2O4 architectures by using a facile two-step strategy. A rod-like precursor of MgFe2(C2O4)3 · nH2O (diameter: 0.5–2.5 μm; length: 2–15 μm) was fabricated under solvothermal conditions using metal sulfates as raw materials and oxalic acid as the precipitant. Subsequently, porous MgFe2O4 architectures were obtained by the thermal treatment of the as-prepared oxalate precursor, during which the mesopores were formed in situ via the liberation of volatile gases, while the rod-like morphology was well preserved. The catalytic performances of the as-synthesized porous rod-like MgFe2O4 architectures with respect to the AP pyrolysis were assessed using differential scanning calorimetry (DSC) techniques. The results indicated that the high thermal decomposition temperature and the apparent activation energy of AP with 2 wt.% MgFe2O4 addition decreased from 445.4 ℃ to 386.7 ℃ and from 280.5ffi11.8 to 147.6ffi4.8 kJ mol-1, respectively. Meanwhile, the decomposition heat of AP with MgFe2O4 as the additive reached up to 1230.6 J g-1, which was considerably higher than that of its neat counterpart (695.8 J g-1). Thus, porous rod-like MgFe2O4 architectures could be served as the catalyst for the AP pyrolysis.

Synthesis of g-C3N4/diatomite/MnO2 composites and their enhanced photo-catalytic activity driven by visible light

Chen Ran-Ran,Ren Qi-Fang,Liu Yu-Xin,Ding Yi,Zhu Hai-Tao,Xiong Chun-Yu,Jin Zhen,오원춘 한국세라믹학회 2021 한국세라믹학회지 Vol.58 No.5

Herein, a novel visible-light-responsive g-C 3 N 4 /diatomite/MnO 2 composite was successfully fabricated through a simple redox reaction method. The structure and morphology of the sample are mainly characterized by X-ray diff raction (XRD), photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), energy-dispersive spectroscopy (EDS), transmis- sion electron microscopy (TEM), and ultraviolet–visible spectroscopy (UV–Vis). In this paper, the photo-catalytic activity of the sample was evaluated by degradation RhB under visible-light irradiation. The results shown that, compared with g-C 3 N 4 /diatomite composite, MnO 2 , g-C 3 N 4 , diatomite, the prepared g-C 3 N 4 /diatomite/2.5%MnO 2 composite exhibits bet- ter photo-catalytic activity and stability. At the same time, the eff ect of diff erent MnO 2 additions on the photo-catalytic activity of the composite material was further analyzed. The results indicated that the g-C 3 N 4 /MnO 2 /diatomite composites exhibit highest photo-catalytic activity when the adding amount of MnO 2 reached 2.5%. The degradation rate of the g-C 3 N 4 / diatomite/2.5%MnO 2 is 93% after recycling for three times, showing good stability and reusability. Moreover, the mechanism of catalytic performance enhancement also has been discussed.

An Optimized Iterative Semantic Compression Algorithm And Parallel Processing for Large Scale Data

( Ran Jin ),( Gang Chen ),( Anthony K H Tung ),( Lidan Shou ),( Beng Chin Ooi ) 한국인터넷정보학회 2018 KSII Transactions on Internet and Information Syst Vol.12 No.6

With the continuous growth of data size and the use of compression technology, data reduction has great research value and practical significance. Aiming at the shortcomings of the existing semantic compression algorithm, this paper is based on the analysis of ItCompress algorithm, and designs a method of bidirectional order selection based on interval partitioning, which named An Optimized Iterative Semantic Compression Algorithm (Optimized ItCompress Algorithm). In order to further improve the speed of the algorithm, we propose a parallel optimization iterative semantic compression algorithm using GPU (POICAG) and an optimized iterative semantic compression algorithm using Spark (DOICAS). A lot of valid experiments are carried out on four kinds of datasets, which fully verified the efficiency of the proposed algorithm.

Finite-element analysis and design of aluminum alloy RHSs and SHSs with through-openings in bending

Ran Feng,Tao Yang,Zhenming Chen,Krishanu Roy,Boshan Chen,James B. P. Lim 국제구조공학회 2023 Steel and Composite Structures, An International J Vol.46 No.3

This paper presents a finite-element analysis (FEA) of aluminum alloy rectangular hollow sections (RHSs) and square hollow sections (SHSs) with circular through-openings under three-point and four-point bending. First, a finite-element model (FEM) was developed and validated against the corresponding test results available in the literature. Next, using the validated FE models, a parametric study comprising 180 FE models was conducted. The cross-section width-to-thickness ratio (b/t) ranged from 2 to 5, the hole size ratio (d/h) ranged from 0.2 to 0.8 and the quantity of holes (n) ranged from 2 to 6, respectively. Third, results obtained from laboratory test and FEA were compared with current design strengths calculated in accordance with the North American Specifications (NAS), the modified direct strength method (DSM) and the modified Continuous strength method (CSM). The comparison shows that the modified CSM are conservative by 15% on average for aluminum alloy RHSs and SHSs with circular through-openings subject to bending. Finally, a new design equation is proposed based on the modified CSM after being validated with results obtained from laboratory test and FEA. The proposed design equation can provide accurate predictions of flexural capacities for aluminum alloy RHSs and SHSs with circular throughopenings.

An Improved Method of Maximum Power Point Tracking Strategy for Wind Power Conversion System

CHEN Ran,CHEN Jie,CHEN Jia-wei,CHEN Zhi-hui,GONG Chun-ying,YAN Yang-guang 전력전자학회 2011 ICPE(ISPE)논문집 Vol.2011 No.5

The turbine speed loop adjustment is the key link of the designing of the controller for the fixed pitch variable speed wind energy conversion systems (WECS). Because of the strong nonlinear, big inertia and mechanical damping characteristics, it’s difficult to designing the controller of the wind power systems. In this paper, a small signal model is present, and based on the analyzing; a wind turbine speed loop regulator is designed. Then, a method of tracking the peak power conversion system is proposed, which is independent of the turbine parameters and air density. At last, simulation system is built, and the results of the simulation experiments show that, the performance of the controller algorithm meet the requirements of the MPPT without wind measurement.

The Relationship of Society, Company and Consumers in Product Service System : The case study of laundry service

Chen Kui-ran,Lee Sung-pil,Lim Beak-vin 한국디자인학회 2011 시그포럼 Vol.1 No.-

Product service system is a sustainable concept aimed at providing sustainability of both consumption and production. It focuses on providing a combination of products and services to meet specific customers need promoting higher profit than products alone. However, since the environmental problem has become one of the most serious issues of the world, the majority of the PSS's researches are now focused on sustainable design, using PSS as an effective way to improve the material utilization. These researches are biased to the original definition of this system. This paper is devoted to evaluate the relationship between the PPS's social demands, consumer demands and company demands, providing a possible way to balance demands of these factors. This article exhibits a discussion upon a case study of laundry service. Previous researches in this field have suggested that the laundromat(self-service laundry place) is more sustainable than the home-based washing service in consumers' homes in both consumptions and productions. However, this situation may only make sense amongst crowded residential areas, where in small towns domestic washing machines might be more sustainable in terms of development and fulfiiling customers' needs. In order to balance different demands in the laundry service, they could be combined into a new service type, and provided customized services for different clients.

Characterization of proteolysis in muscle tissues of sea cucumber Stichopus japonicus

Chen-Chen Zhao,Yang Yang,Hai-tao Wu,Zhi-Mo Zhu,Yue Tang,Cui-Ping Yu,Na Sun,Qiang Lv,Jia-Run Han,Ao-Ting Li,Jia-Nan Yan,Yue Cha 한국식품과학회 2016 Food Science and Biotechnology Vol.25 No.6

The proteolysis in muscle tissues of sea cucumber Stichopus japonicus (sjMTs) was characterized. The proteins from sjMTs were primarily myosin heavy chains (MHCs), paramyosin (Pm), and actin (Ac) having a molecular mass of approximately 200, 98, and 42 kDa, respectively. Based on SDS-PAGE analysis and quantification of trichloroacetic acid (TCA)-soluble peptides released, degradation of muscle proteins from sjMTs was favorable at pH 5 and 50°C. Proteolysis of MHCs was mostly inhibited by cysteine protease inhibitors, including trans-epoxysuccinyl-L-leucyl-amido (4- guanidino) butane (E-64) and antipain (AP). E-64 and AP completely inhibited the degradation of Pm and Ac, while iodoacetic acid showed a partially inhibitory effect. These results indicated that the proteolysis of sjMTs was mainly attributed to cysteine proteases. Avoidance of setting the tissues at 40–50oC and slightly acidic condition and inhibition of cysteine proteases are helpful for decreasing sea cucumber autolysis.

Multi-Dimensional CFD Analysis for the Prediction of Transient Wellbore Circulating Temperature Profile to Guide Offshore Cementing Job

Ran Wang,Yanfang Wang,Mayank Tyagi,Yuanhang Chen,Seung Ihl Kam 한국자원공학회 2019 한국자원공학회지 Vol.56 No.4

This study investigates how temperature profile changes with time during fluid circulation through the wellbore and annulus by using ANSYS Fluent, to help designing offshore cementing job in the petroleum industry. The use of two-dimensional nature of transient computational-fluid-dynamics (CFD) simulations shows that both flow rheology and fluid distribution in the well affect heat transfer calculations and such an effect is more pronounced at the bottom hole where the flow direction changes from downward to upward. When compared with one-dimensional (1D) simulation, multi-dimensional simulation results predict a longer time for heat transfer consistently, implying that simple 1D simulation techniques tend to under-predict the amount of time associated with cementing job. How fluid distribution within the well changes with time and how the resulting pressure and temperature calculations are affected at different times and locations are also visualized in this study.

Alternating-Projection-Based Channel Estimation for Multicell Massive MIMO Systems

Chen, Yi Liang,Ran, Rong,Oh, Hayoung The Korea Institute of Information and Commucation 2018 Journal of information and communication convergen Vol.16 No.1

In massive multiple-input multiple-output (MIMO) systems, linear channel estimation algorithms are widely applied owing to their simple structures. However, they may cause pilot contamination, which affects the subsequent data detection performance. Therefore, herein, for an uplink multicell massive multiuser MIMO system, we consider using an alternating projection (AP) for channel estimation to eliminate the effect of pilot contamination and improve the performance of data detection in terms of the bit error rates as well. Even though the AP is nonlinear, it iteratively searches the best solution in only one dimension, and the computational complexity is thus modest. We have analyzed the mean square error with respect to the signal-to-interference ratios for both the cooperative and non-cooperative multicell scenarios. From the simulation results, we observed that the channel estimation results via the AP benefit the following signal detection more than that via the least squares for both the cooperative and non-cooperative multicell scenarios.