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Chae Hyun Park,강재희,Hwa Yeon Ryu,Ga Hyeon Jung,Yong Ho Ku,이현 대한침구의학회 2021 대한침구의학회지 Vol.38 No.1
Miller Fisher syndrome (MFS) is a rare variant of Guillain–Barré syndrome characterized by ocular paralysis, ataxia, and insensitivity. This report describes the effect of Complex Korean Medicine Treatment (CKMT) on a patient previously diagnosed with MFS presenting with diplopia and facial palsy. The distance at which diplopia occurs, the diplopia questionnaire, the range of diplopia, the degree of facial paralysis, and the degree of ptosis were evaluated at the time of admission and weekly for 1 month. After receiving CKMT for 4 weeks the 62-year-old female had improved symptoms of diplopia, bilateral facial palsy and ptosis caused by MFS. These results show the significant association of MFS with facial paralysis and the improvement achieved with CKMT.
Synthesis and Antifungal Activity of 5,8-Quinazolinedione Derivatives Modified at Positions 6 and 7
Ryu, Chung-Kyu,Shim, Ju-Yeon,Yi, You-Jin,Choi, Ik Hwa,Chae, Mi-Jin,Han, Ja-Young,Jung , Ok-Jai The Pharmaceutical Society of Korea 2004 Archives of Pharmacal Research Vol.27 No.10
5,8-Quinazolinediones modified at positions 6 and 7 were synthesized and tested for in vitro antifungal activities against Candida species and Aspergillus niger. Most of 5,8-quinazolinediones 3-5 generally exhibited potent antifungal activity. 6-Arylamino-7-chloro-5,8-quinazolinediones (3) generally showed more potent antifungal activity than 7-arylthio-5,8-quinzolinediones (4) and 6,7-bis-(arylthio)-5,8-quinazolinediones (5).
Synthesis and Antifungal Activity of 2,5-Disubstituted-6-arylamino-4,7-benzimidazolediones
Ryu, Chung-Kyu,Song, Eun-Ha,Shim, Ju-Yeon,You, Hea-Jung,Choi, Ko Un,Choi, Ik Hwa,Lee, Eun Young,Chae, Mi Jin 梨花女子大學校 藥學硏究所 2002 藥學硏究論文集 Vol.- No.11
2,5-Disubstituted-6-arylamino-4,7-benzimidazolediones were synthesized and tested for in vitro antifungal activity against pathogenic fungi. Among them, 6-arylamino-5-chloro-2-(2-pyridyl)-4,7-benzimidazolediones exhibited potent antifungal activity against Candida specis and Aspergillus niger.
Synthesis and Antifungal Activity of 2,5-Disubstituted-6-arylamino-4,7-benzimidazolediones
Ryu, Chung-Kyu,Song, Eun-Ha,Shim, Ju-Yeon,You, Hea-Jung,Choi, Ko Un,Choi, Ik Hwa,Lee, Eun Young,Chae, Mi Jin 梨花女子大學校 藥學硏究所 2003 藥學硏究論文集 Vol.- No.12
2,5-Disubstituted-6-arylamino-4,7-benzimidazolediones were synthesized and tested for in vitro antifungal activity against pathogenic fungi. Among them, 6-arylamino-5-chloro-2-(2-pyridyl)-4,7-benzimidazolediones exhibited potent antifungal activity against Candida species and Aspergillus niger.
Synthesis and Antifungal Activity of 6-Arylthio-/6-Arylamino-4,7-dioxobenzothiazoles
Ryu, Chung-Kyu,Choi, Ko Un,Shim, Ju-Yeon,You, Hea-Jung,Choi, Ik Hwa,Chae, Mi Jin 梨花女子大學校 藥學硏究所 2003 藥學硏究論文集 Vol.- No.12
6-Arylthio-/6-arylamino-4,7-dioxobenzothiazoles were synthesized and tested for in vitro antifungal activity against Candida species and Aspergillus niger. 6-Arylamino-4,7-dioxobenzothiazoles 5 and 6 showed, in general, more potent antifungal activity than 6-arylthio-4,7-dioxobenzothiazoles 3 and 4. The 6-arylamino-substituted compounds 5 and 6 exhibited the greatest activity. In contrast, 6-arylthio-, 2-/5-methyl- or 5-methoxy-moieties of compounds 3-4 did not improve their antifungal activity significantly. The results of this study suggest that 6-arylamino-4,7-dioxobenzothiazoles would be potent antifungal agents.
Prenatal Diagnosis of Chromosome 22q11.2 Deletions: Experiences in a Single Institution
Chae, Yong Hwa,Kwak, Dong Wook,Kim, Moon Young,Park, So Yeon,Lee, Bom Yi,Lee, Yeon Woo,Lee, Young Ho,Song, Mi Jin,Ryu, Hyun Mee Korean Society of Medical Genetics and Genomics 2013 대한의학유전학회지 Vol.10 No.2
Purpose: This study was designed to determine the frequency and echocardiographic findings of 22q11.2 deletions in fetuses with cardiac defects on fetal ultrasound or familial backgrounds of 22q11.2 deletions. Materials and methods: We retrospectively reviewed the medical and ultrasonographic records of 170 fetuses that underwent fluorescence in situ hybridization (FISH) analysis for chromosome 22q11.2 deletions between February 2001 and April 2013. Results: Among 145 fetuses with cardiac defects, six (4.1%) had 22q11.2 deletions. Deletions of 22q11.2 were detected in 6 (5%) of the 120 fetuses with conotruncal defects: 5 (8.9%) of 56 with tetralogy of Fallot (TOF) and 1 (5.9%) of 17 with double outlet right ventricle (DORV). No deletions were found in cases of pulmonary atresia, truncus arteriosus, right aortic arch, or transposition of the great arteries. No 22q11.2 deletions were found in non-conotruncal cardiac malformations. Among 25 fetuses with familial backgrounds of 22q11.2 deletions, one (4%) had a maternally inherited 22q11.2 deletion with no cardiac findings. Conclusion: Knowledge of the frequency and echocardiographic findings of 22q11.2 deletions might be helpful for prenatal genetic counseling. It is advisable to perform FISH analysis for 22q11.2 deletions in pregnancies exhibiting conotruncal cardiac defects such as TOF or DORV.