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유비쿼터스 환경을 위한 임베디드 정보표시 장치 시스템 구현
이병권,김석일,전중남 충북대학교 컴퓨터정보통신 연구소 2004 컴퓨터정보통신연구 Vol.12 No.1
가전제품 및 생활도구에 운영체제가 내장됨으로써 네트워크 및 파일시스템을 사용할 수 있게 되었고, 그 결과로 제품이 지능화되고 소형화되고 있다. 본 논문에서는 ARM, x86, 그리고 XScale기반으로 임베디드 플랫폼에서 동작하는 임베디드형 정보표시장치를 설계하고 구현 과정을 설명한다. 각 플랫폼에 대한 커널 포팅, 파일시스템 구성 과정을 설명하고, 서버 클라이언트 환경에서 동작하는 정보 표시 소프트웨어에 대하여 설명한다. 서버는 화면에 여러 종류의 데이터와 및 제어정보를 클라이언트에게 보내고, 클라이언트는 수신된 데이터를 재조립하여 지정된 영역에 표시한다. With the help of embedded operating system, the electric home appliances have been able to access the network and file system, and become intelligent and miniaturized. In this paper, we explain an information display system operating on three embedded platforms: ARM, x86, and XScale. For each platform, we describe the process of kernel porting and file system construction. And we also explain the information display software based on the server-client environment. The server sends various kinds of display data and control data to the clients. A client reassembles the received data and displays them in the appropriate location of its screen
거대 점오염원이 주변 대기질에 미치는 영향에 관한 연구
김유근,이화운,전병일,장은숙,홍정혜,문윤섭,원경미,송정희 부산대학교 환경문제연구소 1996 環境硏究報 Vol.14 No.1
In order to show the effect of a vast point pollutant source on air quality of Pusan Thermoeletric Power Plant and its surrounding area, air quality around Pusan Thermoeletric Power Plant was simulated by ISCLT-2 which was supplied by EPA. For this purpose the emission amount of SO_2, NO_2 and TSP was calculated and atmospheric stability was classified for a recent decade(1985~1994) in Pusan. A result of the emission amount showed that much amount of NO_2, NO_2 and TSP are emitted from industrial area. It was clear that NO_2 is much emitted from line source and industrial area. And as a result of classification of atmospheric stability, neutral, stable and unstable state were 58%, 24.1% and 17.9%, respectivly. The result of ai quality simulation by ISCLT-2 showed that Pusan Thermoeletric Power Plant is affecting on the increse of 2.0ppb, 3.0ppb and 5.0㎍/㎥, SO_2, NO_2, and TSP respectively at its surrounding area, site A-3 which was located westward 2.2㎞ distance from Plant
The Development of a Korean Drug Dosing Database
Byung Koo, Lee,Sun Ah, Kim,Jung Hoon, Kim,Yoo Jin, Jang,Young Mi Jeong,Joong Un, Hwang,Kyung Suk, Choi,Iyn Hyang, Lee,Jin Ok, Jeon,Hong Bin, Kim,Ho Jun, Chin,Ji Hye, Ha 이화여자대학교 약학연구소 2012 藥學硏究論文集 Vol.- No.22
OBJECTIVES: This report describes the development process of a drug dosing database for ethical drugs approved by the Korea Food & Drug Administration (KFDA). The goal of this study was to develop a computerized system that supports physicians' prescribing decisions, particularly in regards to medication dosing. METHODS: The advisory committee, comprised of doctors, pharmacists, and nurses from the Seoul National University Bundang Hospital, pharmacists familiar with drug databases, KFDA officials, and software developers from the BIT Computer Co. Ltd. analyzed approved KFDA drug dosing information, defined the fields and properties of the information structure, and designed a management program used to enter dosing information. The management program was developed using a web based system that allows multiple researchers to input drug dosing information in an organized manner. The whole process was improved by adding additional input fields and eliminating the unnecessary existing fields used when the dosing information was entered, resulting in an improved field structure. RESULTS: A total of 16,994 drugs sold in the Korean market in July 2009, excluding the exclusion criteria (e.g., radioactivity drugs, X-ray contrast medium), usage and dosing information were made into a database. CONCLUSIONS: The drug dosing database was successfully developed and the dosing information for new drugs can be continually maintained through the management mode. This database will be used to develop the drug utilization review standards and to provide appropriate dosing information.
Cytochrome P450 enzyme levels in HepG2 cells and iPSC-derived hepatocytes
Byung-Suk Jeon,Nam-Ju Kim,Hee Yi,Ji-Hyun Bang,Moon Her,Hyun-Ok Ku 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
Hepatocyte cell systems for in vitro assessment include hepatoma cell lines and normal hepatocyte cultures used in toxicity and metabolism of drugs. However, each cell line has its own characteristics. Induced pluripotent stem cells(iPSC), which can be differentiated to hepatocytes and providing a limitless supply of cells with hepatocyte characteristics that can mimic the physiology of liver, has been one of the best ways to portray the in vivo system. Thus, the objective of the present study was to compare between HepG2 cell line and iPSC-derived hepatocytes to conclude which is the good model for preclinical in vitro drug screening studies. We evaluated cytotoxicity and induction of CYP1A2 and 3A4 with treated acetaminophen, aminodarone, orphenadrine or lovastatin. The levels of CYPs was measured with luminometric assay. The cytotoxicity and induction of CYPs was increased in a concentration-dependent manner, and the CYPs level was higher in iPSC-derived hepatocytes than in HepG2. The results showed that in vitro studies on cytotoxicity and drug metabolism using iPSC-derived hepatocytes can be potential application as cost effective substitutes in drug screening. We will cover how iPSC technology is being used to develop predictive models and how information gained from in vitro screening experiments using this model.
Altered Expression of Cellular Bcl-2 in the Progression of Hamster Cholangiocarcinogenesis
Jeon, Byung-suk,Yoon, Byung-IL The Scientific World Journal 2012 The Scientific World Journal Vol.2012 No.-
<P>Bcl-2 is an intracytoplasmic and membrane-associated apoptosis suppressor, and its overexpression is closely associated with survival of malignant tumors, in particular their aggressive behavior and poor prognosis. The role of Bcl-2 is, however, still controversial in cholangiocarcinogenesis because of the discrepancies in the expression of the protein. In the present study, alteration in the expression of Bcl-2 in cholangiocarcinogenesis was investigated by studying the immunoreactivities of this protein in normal, hyperplastic bile ducts with or without dysplastic changes, and neoplastic bile duct cells from a hamster cholangiocarcinoma (ChC) model. Cytoplasmic staining, which reflects high-Bcl-2 immunoreactivity, was negative to very weak in normal and hyperplastic bile ducts without dysplastic changes, while hyperplastic bile ducts with dysplasia indicated heterogeneously strong expression. On the other hand, most of the neoplastic cells of invasive cholangiocarcinomas were negative to weak as much as the level of normal bile ducts. The results suggest that the antiapoptotic factor Bcl-2 plays a limited role in the survival of highly proliferative, potentially dysplastic bile duct cells. However, the role of Bcl-2 in biliary cancer cells was not significant.</P>
Prevalence of Bacterial Contaminations of Chicken Meat in South Korea 2014 - 2015
( Byung-kook Choi ),( Ok-mi Jeong ),( Chun-tae Lim ),( So-youn Youn ),( Na-young Kim ),( Byung-woo Jeon ),( Shin-ae Kim ),( Suk-chan Jung ),( Min-su Kang ) 대한인수공통전염병학회 2016 창립총회 및 학술대회 초록집 Vol.2016 No.1
Introduction: Food borne diseases are considered to begin from animal meat and meat products which are sometimes resulting to serious health problems due to the consumption of them. A two years study about bacteriological condition of chicken meat in South Korea, was carried out to investigate the occurrence of Salmonella spp., Staphylococcus aureus, Clostridium perfringens, Campylobacter coli, Campylobacter jejuni, Escherichia coli, Yersinia enterocolitica, and Listeria moncytogenes. Methods: Each solution of a hundred eighty samples of chicken carcasses was collected from the slaughter houses throughout the South Korea during 2014 -2015. The samples were analyzed for the presence of bacterial contaminations using Korean Food Standard Codex for meat and meat products. Results: In one hundred eighty chicken samples, Staphylococcus aureus (36.1%) is the most frequent pathogen in chicken meat for two years followed by Clostridium perfringens (31.7%), Campylobacter coli (23.3%), Salmonella spp. (13.3%), Campylobacter jejuni (10.0%), Escherichia coli: 0111 (3.9%), Escherichia coli: 0145 (2.2%), Escherichia coli: 026 (1.7%), Yersinia enterocolitica (1.1%), and Listeria monocytogenes (1.1%). Minor pathogens are Escherichia coli spp. (O45, O103, O104, O121 and O128). Conclusion: The bacteriological status of chicken meats from the slaughter houses showed that a variety of pathogens were able to transmit diseases to people especially high level of Staphylococcus aureus and Clostridium perfringens. Our findings suggest that farms and slaughter houses should more enforce hygiene system to reduce pathogens which are harmful for public health.
How useful are liver function tests in vitro in human hepatoma cell line (HepG2)?
Byung-Suk Jeon,Seong-Yun Hwang,So-Ryeon Hwang,Nam-Ju Kim,Hee Yi,Ji-Hyun Bang,Moon Her,Hyun-Ok Ku 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
In preclinical hepatotoxicity testing cell based are frequently relevant. However, prediction of drug induced liver injury remains a major challenge. Here we addressed the usefulness of frequently relevant markers of hepatocellular injury in human hepatocarcinoma cell line (HepG2) in response to treatment with either acetaminophen, amiodarone, etoposide, orphenadrine and/or lovastatin. The change in the cellular injury (AST, ALT and LDH) were determined toxicity and above drug concentrations as to evaluate the utility of these markers in vitro systems. Initially, treatment of HepG2 with any of the drugs caused a statistically significant reduction in enzyme activities to suggest a switch from basic amino acid metabolism towards induced detoxification. However, treatment for prolonged periods of time caused cytolysis, as evidenced by the significant rise in extracellular LDH and the concomitant increase in ALT and AST activity. Notably, among the various endpoints studied, LDH was best to determined dose dependent cytotoxicity, while other markers of hepatocellular injury were variable. Taken collectively, LDH measurement proofed to be robust in predicting hepatocellular toxicity; therefore, it should be included in preclinical testing strategies for an improved prediction of hepatotoxicity.