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Sohn, Bo Hwa,Hwang, Jun-Eul,Jang, Hee-Jin,Lee, Hyun-Sung,Oh, Sang Cheul,Shim, Jae-Jun,Lee, Keun-Wook,Kim, Eui Hyun,Yim, Sun Young,Lee, Sang Ho,Cheong, Jae-Ho,Jeong, Woojin,Cho, Jae Yong,Kim, Joohee,Ch American Association for Cancer Research 2017 Clinical Cancer Research Vol.23 No.15
<P><B>Purpose:</B> The Cancer Genome Atlas (TCGA) project recently uncovered four molecular subtypes of gastric cancer: Epstein–Barr virus (EBV), microsatellite instability (MSI), genomically stable (GS), and chromosomal instability (CIN). However, their clinical significances are currently unknown. We aimed to investigate the relationship between subtypes and prognosis of patients with gastric cancer.</P><P><B>Experimental Design:</B> Gene expression data from a TCGA cohort (<I>n</I> = 262) were used to develop a subtype prediction model, and the association of each subtype with survival and benefit from adjuvant chemotherapy was tested in 2 other cohorts (<I>n</I> = 267 and 432). An integrated risk assessment model (TCGA risk score) was also developed.</P><P><B>Results:</B> EBV subtype was associated with the best prognosis, and GS subtype was associated with the worst prognosis. Patients with MSI and CIN subtypes had poorer overall survival than those with EBV subtype but better overall survival than those with GS subtype (<I>P</I> = 0.004 and 0.03 in two cohorts, respectively). In multivariate Cox regression analyses, TCGA risk score was an independent prognostic factor [HR, 1.5; 95% confidence interval (CI), 1.2–1.9; <I>P</I> = 0.001]. Patients with the CIN subtype experienced the greatest benefit from adjuvant chemotherapy (HR, 0.39; 95% CI, 0.16–0.94; <I>P</I> = 0.03) and those with the GS subtype had the least benefit from adjuvant chemotherapy (HR, 0.83; 95% CI, 0.36–1.89; <I>P</I> = 0.65).</P><P><B>Conclusions:</B> Our prediction model successfully stratified patients by survival and adjuvant chemotherapy outcomes. Further development of the prediction model is warranted. <I>Clin Cancer Res; 23(15); 4441–9. ©2017 AACR</I>.</P>
고교 생물의 오버헤드 프로젝터용 필름 제작 및 전달 매체로서의 CD - ROM과 홈페이지의 설계
정화숙,송방호,최미숙,박창보,권덕기,손종경,양홍준,박성호,안나영,서혜애,신연욱,강재석,김정현 한국과학교육학회 1999 한국과학교육학회지 Vol.19 No.3
고등학교 생물교육의 강의 및 학습의 효율증진을 위한 영상매체로써 오버헤드 프로젝터 필름(OHP)을 제작하였으며 이의 전달매체로써 CD-ROM및 웹용 홈페이지를 설계하였다. 본 필름은 제6차 교육과정에 의해 개정된 공통과학 및 생물교과서에 수록된 내용을 총 망라하는 방향에서 천연색으로 제작하였으며 도안의 선명도, 수려성, 청정성, 색상, 명암, 인지도 등에서 내용의 질적 우월성을 시도하였고 교수-학생-내용 상호간의 관련성을 감안하여 학습항진효과를 극대화하는 측면에서 설계되고 제작되었다. 제6차 교육 과정에 의해 개정된 공통과학 및 생물 교과서 7 종에 수록된 내용을 총 망라하는 방향에서 교재를 분석한 후 가장 다빈도로 출현하는 내용을 우선적으로 제작하였다. CD-ROM은 로고(logo), 초기 메인(main), 학습목록, 내용, 종료 등의 화면으로 구성되어 있고 초기 메인 화면은 공통과학, 생물I, 생물II 교과서에 수록된 단원의 내용(장)목록을 제시한 후 내용세부 문항, 실제내용화면으로 하이퍼링크 시켰다. 내용화면은 교과서 내용의 요약, 그림 및 사진과 그 해설, 실험과정 및 결과의 요약, 표에 의한 내용의 정리 등 4가지 형식으로 제작된 필름 화면이 우선적으로 수록되어 있으나, 비디오 영상수취(video capture)에 의한 화면이나 인쇄 버턴, 자료의 설명 또는 해설, 용어해설 등의 버턴과 연결시킨 경우도 있다. OHP파일은 제작시 포토상(Adobe Photoshop) 일러스터레이터(Adobe Illustrator), 클레리스 오피스(Claris Office)를, CD-ROM 은 MM 디렉터(Macromedia Director)를 웹용 홈페이지는 html 에디터(editor)를 주된 소프트웨어로 사용하였다. OHP파일은 스케닝, 그림, 배경, 문자의 입력, 그림의 수식, PICT 또는 PSD 파일로의 저장, JPG 파일로의 변환 등의 순서로 진행되었다. 공통과학 14점, 생물I 80점, 생물II 142점, 총 236점이 제작되었으며 이들의 전달매체로써 CD-ROM 및 웹 홈페이지를 제작하여 이들을 이미 공개된 중학생물과 동일한 주소 즉 http : //gic.kyungpook.ac.kr /biocosmos에 공개하였다. The colorful overhead projector films, named as Bio-cosmos II, including photographs, pictures, concept maps, and diagrams, were developed and manufactured as audio-visual teaching aids and teaching resources for students' biology learning in high school, and the CD-ROM and web sites for their application to the school were also constructed. The content of the films was organized based upon the analysis of seven different biology textbooks approved by the Ministry of Education. The films were designated based on various instructional strategies and manufactured using multimedia with various educational softwares. The CD-ROM was composed of the scenes as logo, initial main, chapters list, contents, and quit. Initial main scene indicated various chapters according to the texts of biology areas in General Science, Biology I, and II. Each chapters linked with the scenes for detailed concept maps, the downstream real subjects, and contents. The subject screens were composed of various types of summarized diagrams including lesson contents, figures, pictures, photographs, and their explanation, experimental procedures and results, tables for summarized contents, and additional animation with video captures, explanations, glossary, etc. Most files were manufactured in software Adobe Photoshop by scanning the pictures, figures and photographs, and then the explanation, modification, storing with PICT or PSD files, and transformation with JPG files, were processed in the aspect of high quality in terms of instructional strategies and graphic skills on gracefulness, clearness, colorfulness, brightness, and distinctness. A 14 films for biology areas in General Science, 80 for Biology I, and 142 for Biology II were manufactured and loaded to the CD-ROM and web site, and the files had been attempted to opened with an Internet home-page of http://gic.kyungpook.ac.kr/biocosmos.
손용만 ( Sohn Yong Man ),김현태 ( Kim Hyun Tae ),김영화 ( Kim Youug Hwa ),박지성 ( Park Ji Sung ),이재황 ( Lee Jae Hwang ),이경보 ( Lee Kyeong Bo ),이경도 ( Lee Kyung Do ) 한국농공학회 2007 한국농공학회 학술대회초록집 Vol.2007 No.-
This study was carried out to analyze the effect of different desalinating treatments on Seamangeum soil. Four treatments (full-time flooding, 3day interval flooding and drain, Tillage and ground leveling) were tested at Seamangeum tidal land of Gwanghwal-myeon, Gimje-si, Jeollabuk-do, Korea for two months. By full-time flooding and 3 day interval flooding treatment, desalinating rate of top (0-20cm) and mid-soil (20-40cm) was more than 95%, which the salinity of these soils was lowered to below 1dS/m. In addition, desalinating rate of lower-soil (50-80cm) was more than 70%. Desalinating rate of top-soil caused by ground leveling and tillage treatment was more than 70%. Besides, 64% of desalinating rate was also observed in mid-soil. Desalinating treatment did not affect top-soil of either control or the outer area of experimental plots. On the contrary, these area was resalinized and soil salinity became higher.
A New Monoterpene Glycoside and Antibacterial Monoterpene Glycosides from Paeonia suffruticosa
Ren-Bo An,Hyun-Chul Kim,이성희,정길생,Dong-Hwan Sohn,Hyun Park,권동렬,John Hwa Lee,김윤철 대한약학회 2006 Archives of Pharmacal Research Vol.29 No.10
Antibacterial activity-guided fractionation of the CHCl3-MeOH (1:1) extract of Paeonia suffruticosa root bark furnished three monoterpene glycosides, 6-O-vanillyoxypaeoniflorin (1), mudanpioside-H (2), and galloyl-oxypaeoniflorin (3). Of the isolated compounds, compound 1 is a new compound. All isolated compounds showed broad, but moderate, antibacterial activity with minimum inhibitory concentration (MIC) values in the range of 100 to 500 μg/mL against eighteen pathogenic microorganisms of concern for public health or zoonosis.
Kim, Hwa-Min,Seo, Sung Bo,Kim, Dong Young,Bae, Kang,Sohn, Sun Young The Korean Institute of Electrical and Electronic 2013 Transactions on Electrical and Electronic Material Vol.14 No.3
$TiO_2$ films were deposited on glass substrates with and without $O_2$ plasma etching by using the RF-magnetron sputtering method. We focused on the effect of surface structure on the photoinduced hydrophilic properties of $TiO_2$ films, fabricated on different surface conditions according to the presence or absence of the $O_2$ plasma treatment on glass substrates. The wettability and photoinduced hydrophilic properties of the $TiO_2$ films were investigated according to the changes in water contact angles under UV light irradiations with a very low intensity of 0.1 $mW/cm^2$. The photoinduced hydrophilic properties on the $TiO_2$ formed above the plasma treated glass were also superior to those on the $TiO_2$ formed above the bare glass. This enhanced $TiO_2$ film has been used practically for self cleaning and anti-fogging glasses.
연구보문 : 토양환경 ; 셀레늄 처리가 4가지 채소종자 발아와 싹의 생장 및 셀레늄 흡수 특성에 미치는 영향
정용화 ( Yong Hwa Cheong ),한명자 ( Myung Ja Han ),성선진 ( Sun Jin Sung ),서동철 ( Dong Cheol Seo ),강종구 ( Jong Gu Kang ),손보균 ( Bo Kyoon Sohn ),허종수 ( Jong Soo Heo ),조주식 ( Ju Sik Cho ) 한국환경농학회 2009 한국환경농학회지 Vol.28 No.2
새싹채소의 종자발아와 생장에 미치는 셀레늄 농도 처리(삽입) 효과와 흡수특성을 구명하기 위하여, 대표적인 채소류인 배추, 상추, 청경채 및 갓을 이용하여 다양한 셀레늄 농도 (0, 1, 5, 10, 25, 50, 100 mg L-1를 처리하였다. 종자발아는 배추, 청경채 및 갓에서 처리 농도가 증가함에 따라 억제되었지만, 상추의 경우 큰 영향을 받지 않았다. 싹의 생장에 미치는 셀레늄의 효과는 배추, 상추, 청경채 및 갓의 경우, 지상부 길이, 뿌리 길이, 생체중 및 엽록소 함량 등의 생육특성에 있어서 낮은 처리 농도 (1 mg L-1)에서 오히려 약간의 생장 촉진 효과를 보이거나 거의 차이가 없었다. 5 mg L-1 이상의 농도 처리 시에는 농도가 높아짐에 따라 심각한 생육 억제 현상을 보였다. 식물체내의 셀레늄의 흡수 특성은 셀레늄을 각각 1~25 mg L-1 처리 시 배추는 0.11~1.15, 상추는 0.16~0.61, 청경채는 0.13~1.31 그리고 갓은 0.14~1.13 mg g-1dw 범위에서 셀레늄 처리농도가 높아짐에 따라 점진적으로 증가하였다. 따라서 본 연구의 결과에 의하여 1~5 mg L-1 범위의 낮은 농도의 셀레늄 처리가 셀레늄 함유된 기능성 새싹채소의 생산을 위한 기초 자료로 활용 될 것으로 판단된다. This study was carried out to investigate the effect of selenium treatment on the growth of vegetables sprout. Four vegetables, such as cabbage, lettuce, pak-choi and leaf mustard were examined under various selenium treatments (0, 1, 5, 10, 25, 50, 100 mg L-1). Seed germinations in cabbage, pak-choi and leaf mustard were significantly inhibited at high concentration of selenium treatment. However, seed germination in lettuce was not much inhibited. Growth characteristics, such as soot length, root length, fresh weight and chlorophyll contents, were not much decreased at 1 mg L-1 of selenium and then significantly inhibited with the increase of selenium concentration at above 5 mg L-1 in all four vegetables. The selenium content increased linearly with the increase of selenium concentration. At the range of 1 to 25 mg L-1 of selenium treatment, selenium contents in vegetables were 0.11 to 1.15 of cabbage, 0.16 to 0.61 of lettuce, 0.13 to 1.31 of pak-choi and 0.14 to 1.13 mg g-1dw of leaf mustard, respectively. These results showed that treatment of selenium with the range of 1 to 5 mg L-1 could be used to produce the selenium enriched vegetable sprouts.
A New Monoterpene Glycoside and Antibacterial Monoterpene Glycosides from Paeonia suffruticosa
An, Ren-Bo,Kim, Hyun-Chul,Lee, Sung-Hee,Jeong, Gil-Saeng,Sohn, Dong-Hwan,Park, Hyun,Kwon, Dong-Yeul,Lee, John-Hwa,Kim, Youn-Chul The Pharmaceutical Society of Korea 2006 Archives of Pharmacal Research Vol.29 No.10
Antibacterial activity-guided fractionation of the $CHCl_3-MeOH$ (1:1) extract of Paeonia suffruticosa root bark furnished three monoterpene glycosides, 6-O-vanillyoxypaeoniflorin (1), mudanpioside-H (2), and galloyl-oxypaeoniflorin (3). Of the isolated compounds, compound 1 is a new compound. All isolated compounds showed broad, but moderate, antibacterial activity with minimum inhibitory concentration (MIC) values in the range of 100 to $500\;{\mu}g/mL$ against eighteen pathogenic microorganisms of concern for public health or zoonosis.