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A Functionalised Macrobicycle Complex Available for Surface Immobilisation and Protein Grafting
Bernhardt, Paul V.,Harrowfield, Jack M.,Kim, Yang,Lee, Young-Hoon,Park, Yu-Cheol,Sujandi, Sujandi Korean Chemical Society 2007 Bulletin of the Korean Chemical Society Vol.28 No.4
The conversion of both the racemic and resolved forms of the Co(III) complex of an hydroxymethyl-substituted tripodal hexamine to macrobicycles via reaction with formaldehyde and nitromethane (and subsequent reduction of the product) has been conducted. The prospect is that it will provide cage complexes in which the hydroxyl substituent is sufficiently remote from the metal ion centre for its nucelophilicity to be largely unaffected. X-ray structure determinations have been used to characterise these new cage species as well as some complexes of the precursor hexamine and its mono-aminal. The electrochemistry and optical activity of the complexes have also been studied in detail.
Simulate Reality - Deliver Certainty Through the Virtual Weld
Bernhardt, Ralph,Schafstall, Hendrik,Hwang, Inhyuck The Korean Welding and Joining Society 2016 대한용접·접합학회지 Vol.34 No.5
Welding is an absolutely essential component of industries such as the automotive industry, the construction industry and even the aviation industry. Although it is a widespread technology it is still characterized by lots of uncertainties. This still requires well experienced and highly skilled workforce to design and perform safe welding processes. The early knowledge of distortion and residual stresses is almost an issue which is influenced mainly by the welding parameters and the fixture design. But more and more engineers want to know as well final properties of the assembled components. With the beginning of the computer age in the 1970s and 1980s last century, the numerical prediction of manufacturing processes using FEM was gradually getting better and has established itself in the industry since the 1990s as a standard tool. Unlike in metal casting and forming industry, however, the everyday use of FEM- simulation tools for welding processes eked out a shadowy existence for a long time. This paper will give a short classification of welding simulation types and a structured overview on the technical questions. Selected case studies and the benefits achieved through simulations with the software Simufact welding are discussed. Finally an outlook on future developments will be given.
Simulate Reality - Deliver Certainty Through the Virtual Weld
Ralph Bernhardt,Hendrik Schafstall,Inhyuck Hwang 대한용접·접합학회 2016 대한용접·접합학회지 Vol.34 No.5
Welding is an absolutely essential component of industries such as the automotive industry, the construction industry and even the aviation industry. Although it is a widespread technology it is still characterized by lots of uncertainties. This still requires well experienced and highly skilled workforce to design and perform safe welding processes. The early knowledge of distortion and residual stresses is almost an issue which is influenced mainly by the welding parameters and the fixture design. But more and more engineers want to know as well final properties of the assembled components. With the beginning of the computer age in the 1970s and 1980s last century, the numerical prediction of manufacturing processes using FEM was gradually getting better and has established itself in the industry since the 1990s as a standard tool. Unlike in metal casting and forming industry, however, the everyday use of FEM- simulation tools for welding processes eked out a shadowy existence for a long time. This paper will give a short classification of welding simulation types and a structured overview on the technical questions. Selected case studies and the benefits achieved through simulations with the software Simufact.welding are discussed. Finally an outlook on future developments will be given.
Self-assembling transfer RNA has potential for nanoparticle arrays
Harold S. Bernhardt,Warren P. Tate 한국물리학회 2008 Current Applied Physics Vol.8 No.3,4
Transfer RNAs (tRNAs) are small, stable, L-shaped RNA molecules that transfer amino acids to the growing polypeptide chain dur-ing protein synthesis. Exploiting the similarity in shape between tRNA and H₂O molecules, our aim has been to produce a tRNA build-ing block that will self-assemble into higher aggregates, with a goal of 3D arrays, for possible application as molecular sieves or scaolds. Some tRNAs can form dimers by intermolecular base-pairing of their single-stranded loops. The glycine tRNA (GCC) gene fromEsch-erichia coliwith additional complementarity in a specic loop (T loop). Initial aggregation studies showed two of ve variant tRNAs tested formdimers at neutral pH in the presence of spermine and magnesium and sodium chloride ions, in contrast to the starting tRNA. One formsdimers rapidly, the other more slowly, possibly due to the need for structural rearrangement to disruptintramolecular interactions beforedimerization can occur. Surprisingly, with the variant where arrays were possible there was a lack of higher aggregates, which may be dueto steric hindrance around the elbow region formed from the 3D folding of this tRNA.
A Functionalised Macrobicycle Complex Available for Surface Immobilisation and Protein Grafting
Paul V. Bernhardt,Jack M. Harrowfield,김양,이영훈,Yu Cheol Park,Sujandi 대한화학회 2007 Bulletin of the Korean Chemical Society Vol.28 No.4
The conversion of both the racemic and resolved forms of the Co(III) complex of an hydroxymethyl-substituted tripodal hexamine to macrobicycles via reaction with formaldehyde and nitromethane (and subsequent reduction of the product) has been conducted. The prospect is that it will provide cage complexes in which the hydroxyl substituent is sufficiently remote from the metal ion centre for its nucelophilicity to be largely unaffected. X-ray structure determinations have been used to characterise these new cage species as well as some complexes of the precursor hexamine and its mono-aminal. The electrochemistry and optical activity of the complexes have also been studied in detail.
Posavec, Damir,Muller, Rainer,Bogner, Udo,Bernhardt, Gunther,Knor, Gunther Techno-Press 2014 Biomaterials and Biomechanics in Bioengineering Vol.1 No.2
Covalent attachment of 1, 4-dimethylnaphthalene (DMN) based endoperoxide forming subunits to a polyvinyl butyral (PVB) backbone has been achieved. The functionalized polymer materials prepared and characterized here can serve as biocompatible carrier systems for studying cellular uptake, intermediate storage and delayed release of singlet oxygen, which opens up new doors for optimizing a variety of medical applications of photogenerated DMN-endoperoxides such as antiviral, antibacterial, antiplasmodial and antitumor activity.