Relationship between BrACs and BACs of Healthy Koreans for BAIIDs

( Seunghwan Yi ),( Beomwoo Nam ),( Jeong-seok Seo ) 한국센서학회 2024 센서학회지 Vol.33 No.1

This study aims to suggest the partition ratio (Q-factor) of healthy Koreans and the comparison results of breath alcohol concentration (BAC) measurements using two methods (photoacoustic and electrochemical methods) for developing breath alcohol ignition interlock devices (BAIIDs). Given the relationship between BACs and BrACs and the Q-factor, the alcohol metabolism of healthy Koreans (96 males and 91 females) is revealed for understanding the digestion of alcohol and surveying the fundamental data of alcohol-related problems, CO₂ concentrations vs. alcohol concentrations, and the performance of alcohol sensors in the marketplace. The average Q-factor of healthy Korean males and females are 1,913 (95% confidence interval from 1,889-1,937) and 1,991 (95% confidence interval from 1,945-2,036). Photoacoustic measurements could be applied to predict the BACs of drinkers, which is confirmed by the Bland-Altman plots presented in this study. The biases based on the partition ratios (Q=1,913 and Q=1,991) in the Bland-Altman plots were -0.0004% (95% CI from -0.0011 to +0.0003% for males) and -0.0017% (95% CI from -0.020 to +0.017% for females).

Clinical Usefulness of the Geriatric Depression Scale to Identify the Elderly at Risk of Suicide

Jeong Hyunsuk,Nam Beomwoo,Jo Sun-Jin,Lee Won-Chul,Yim Hyeon Woo 대한신경정신의학회 2020 PSYCHIATRY INVESTIGATION Vol.17 No.5

Objective Population-based suicidal screening can be an important intervention method to reduce suicidal attempt rate in community. However, directly asking about suicidal behavior may be burdensome to non-mental health workers. This study aimed to evaluate the clinical usefulness of the Geriatric Depression Scale-15 (GDS-15) in identifying the elderly at risk of suicide in community. Methods Nine hundred forty-eight over 60 years of age participated in this study. All participants completed the GDS-15. A trained interviewer interviewed each participant for suicidality including suicidal ideation, plan, and prior attempt using the Structured Clinical Interview for DSM-IV. Results When the cut-off score of 10 in the GDS-15 was applied to identify the elderly at risk of suicide, the proportion of directly asking about suicidal behavior by non-mental health workers was reduced by 33.1%; however, 19.5% at risk of suicide were missed. When the cut-off was changed to 6, 100% at risk of suicide were covered by the GDS-15. Conclusion Screening for suicidality using GDS-15 is a promising way to reduce the proportion of directly asking about suicidal behavior by non-mental health workers among the high-risk suicidal elderly in a community setting.

단순 코골이 또는 폐쇄성 수면 무호흡증이 있는 후기 남자 청소년에서 다면적 인성 검사 결과

유민지 ( Minji Yu ),남범우 ( Beomwoo Nam ),서정석 ( Seo Jeong Seok ),노수림 ( Soo Rim Noh ),이종국 ( Jonggook Lee ),이제정 ( Je Jung Lee ),서희영 ( Heeyoung Seo ),김태현 ( Taehyun Kim ),오근 ( Keun Oh ) 한국정신병리진단분류학회 2021 精神病理學 Vol.25 No.2

Objectives The purpose of this study was to quantitatively assess the degree of Simple Snoring(SS) or Obstructive Sleep Apnea (OSA) affecting mental health through the results of multiphasic military personality inventory. Method We collected and analyzed the results of the military personality inventory(MPI) for healthy controls and SS or OSA patients among the 19-year-old men who visited the Military Manpower Administration from January 2008 to January 2013. MPI invented for Korean military test has similar system to Minnesota multiphasic personality inventory. Results Among demographic data, education level was lower in SS or OSA group (χ2=69.49, p<0.001). Socio-economic status and parents-relationship were not statistically different between two groups (χ2=2.94, p=0.401; χ2=2.01, p=0.570). BMI was higher in SS or OSA group (t=-8.24, p<0.001). Among validity scale, the score of faking good subscale was lower in SS or OSA group (t=3.157, p=0.002). Each score of faking bad and infrequency subscale was higher in SS or OSA group (t=-3.741, p<0.001; t=-2.766, p=0.006). Among neurosis scale, each score of anxiety, depression, somatization and personality disorder subscale was higher in SS or OSA group, respectively (t=-4.060, p<0.001; t=-3.977, p<0.001; t=-4.293, p<0.001; t=-3.499, p=0.001). Among psychopath scale, each score of schizophrenia and paranoia subscales were not statistically different between two groups (t=-1.669, p=0.096; t=-2.012, p=0.045). Conclusion According to MPI results, we can confirm that SS or OSA patients may appear feature such as anxiety, depression, somatization and personality tendency (introversion or impulsivity) than the control group.

군신체검사 대상자 중 기면증이 있는 남성의 성격 특성

이한준 ( Hanjun Lee ),남범우 ( Beomwoo Nam ),서정석 ( Jeong Seok Seo ),김태 ( Tae Kim ),노수림 ( Soo Rim Noh ),이제정 ( Je Jung Lee ),오근 ( Keun Oh ),서희영 ( Hee Young Seo ),김태 ( Tae Kim ),이종국 ( Jonggook Lee ) 한국정신병리진단분류학회 2021 精神病理學 Vol.25 No.2

Objectives The purpose of this study was to quantitatively assess multiphasic personality inventory results of narcolepsy affecting mental health using military personality inventory in Korea. Method We registered the 19-year-old men who visited the Military Manpower Administration from February 2010 to January 2013. Results Among demographic characteristics, both narcolepsy and control groups are 19-year-old male. Education level and socioeconomic status are higher(χ2=4.23, p=0.04 ; χ2=17.94, p=0.001) in control group. BMI is higher(t=-3.10, p=0.002) in narcolepsy group. Parents relationship showed no difference between control and narcolepsy groups(χ2=7.57, p=0.06). Among validity scales, score of faking good subscale was higher(t=4.368, p<0.001) in control group, of faking bad subscale was higher(t=-2.497, p=0.013) in narcolepsy group, of infrequency subscale showed no difference(t=-0.466, p=0.642) between control and narcolepsy groups. Among neurosis scales, the score of somatization, depression, anxiety, and personality disorder subscales were higher in narcolepsy group, respectively(t=-4.721, p<0.001 ; t=-5.189, p<0.001 ; t=-6.068, p<0.001 ; t=-2.161, p=0.032). Among psychopath scales, the score of paranoia subscale was higher in narcolepsy group(t=-2.795, p=0.006), of schizophrenia subscale showed no difference (t=-0.687, p=0.493). Conclusion According to MPI results, we suggest that narcolepsy patients are more concerned with their somatic symptoms, more depressive and anxious, have more introverted or impulsive tendency and paranoid traits.

혈중 알코올 농도와 호흡기 알코올 농도 상관성: 한국인 남성

이승환,남범우,서정석,Yi, SeungHwan,Nam, BeomWoo,Seo, JeongSeok 한국자동차안전학회 2015 자동차안전학회지 Vol.7 No.4

The relationship between BAC(Blood Alcohol Concentrations) and BrACs(Breath Alcohol Concentrations) and also partition ratio of healthy Korean adult males (96 males) are researched in this paper and its dependency is described according to TBW (total body water), BMI (body mass index), BFM (body fat mass), and PBF (percentage of body fat). Among the above four variables, TBW affects significantly to the partition ratio compared to the other variables. The partition ratio of Korean healthy males showed 1,913 (95 % Confidence Interval (C.I.) from 1,889 to 1,937) for the whole time intervals. However, when Q was averaged after 60 minutes later, its values was 2,011 (95 % C.I. from 1,982 to 2,040). Bland-Altman plots showed the compatibility of measurement methods of multi-gas analyzer, and the biases according to the partition ratios (Q=2,100 and Q=1,913) gave -0.0052 % (95 % CI from -0.0059 to -0.0045%) and -0.0004 % (95 % CI from -0.0011 to +0.0003%), respectively.

한국 성인 여성의 혈중 알코올 농도와 알코올의 약동학적 특징 및 영향 요인

유전원(Jeonwon Yu),이보람(Boram Lee),안민철(Minchoul Ahn),남범우(Beomwoo Nam),이상호(Sangho Lee),이승환(SeungHwan Yi),서정석(Jeong Seok Seo) 한국중독정신의학회 2015 중독정신의학 Vol.19 No.2

Background and Objectives : The aim of this study was to evaluate alcohol pharmacokinetics, such as blood alcohol concentration and alcohol elimination rate, and to identify the cor-relations between various alcohol metabolism factors in healthy Korean female adults. Materials and Methods : Ninety-one subjects were randomly divided into two groups. One group was provided as much as 0.35 mg/mL/kg of alcohol and the other as much as 0.70 mg/mL/kg, and blood alcohol concentration was measured 15, 30, 45, 60, 90, 120, 180, and 240 min af-ter the women finished drinking. Results : The subjects’ mean alcohol elimination rate (β) was -0.002379 mg/100 mL·h, and there was no statistically significant difference in elimination rate between the two groups. The mean time to reach maxi-mum blood alcohol concentration was 45 minutes, alcohol ab-sorption rate was 0.1123±0.1799 g/L/min, and the area under the concentration curve was 109.15±62.95. Among the factors that correlated with alcohol metabolism, alcohol absorption rate and follicle-stimulating hormone were statistically significant, but age, body mass index, and body fat percentage were not significantly correlated with alcohol metabolism. Conclusion : These results suggest that the β values for healthy Korean females can differ from the cut-offs that are currently used in Korea, which suggests that the legal limit for driving under intoxication should be adjusted.

Screening with the Korean Version of the Mood Disorder Questionnaire for Bipolar Disorders in Adolescents: Korean Validity and Reliability Study

Se-Hoon Shim,Jong-Hun Lee,Jye-Heon Song,Beomwoo Nam,Bo-Hyun Yoon,Ha-young Jin,Hyung-Mo Sung,Jong Hyun Jeong,Sae-Heon Jang,Duk-In Jon,Young Sup Woo,Won-Myong Bahk 대한정신약물학회 2018 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.16 No.3

Objective: This study aimed to evaluate the validity and reliability of a Korean version of the Mood Disorder Questionnaire-Adolescent version (K-MDQ-A) as a screening instrument for bipolar disorders in adolescents. Methods: One hundred two adolescents with bipolar disorders and their parents were recruited from November 2014 to November 2016 at 7 training hospitals. One hundred six controls were recruited from each middle school in two cities of South Korea. The parent version of the original MDQ-A was translated into Korean. The parents of all participants completed the K-MDQ-A. The diagnoses of bipolar disorders were determined based on the Korean version of K-SADS-PL. The test-retest reliability with a 10-month interval was investigated in 33 bipolar adolescents. Results: K-MDQ-A yielded a sensitivity of 0.90 and a specificity of 0.92 when using a cut-off score of endorsement of 5 items, indicating that symptoms occurred in the same time period and caused moderate or serious problems. The internal consistency of the K-MDQ-A was good. The correlations between each item and the total score ranged from 0.40 to 0.76 and were all statistically significant. Factor analysis revealed 3 factors that explained 61.25% of the total variance. The mean total score was significantly higher in bipolar adolescents (7.29) than in controls (1.32). The Pearson correlation coefficient for the total test-retest score was 0.59 (p<0.001). Conclusion: The K-MDQ-A completed by parents showed the excellent validity and reliability and may be a useful screening tool for adolescents with bipolar disorders attending in- and outpatient psychiatric clinics.

Validation of the Korean Version of the Depression in Old Age Scale and Comparison with Other Depression Screening Questionnaires Used in Elderly Patients in Medical Settings

Young-Eun Jung,Moon Doo Kim,Won-Myong Bahk,Young Sup Woo,Beomwoo Nam,Jeong Seok Seo,Sae-Heon Jang,Hyung-Mo Sung,In Hee Shim,Bo-Hyun Yoon,Ji Sun Kim,Young Joon Kwon 대한정신약물학회 2019 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.17 No.3

Objective: The Depression in Old Age Scale (DIA-S) is a new screening tool for assessing depression in the elderly. The primary aims of this study were to describe the validation of the Korean version of the DIA-S (K-DIA-S) and to compare its validity with that of other depression screening questionnaires used in elderly outpatients in medical settings. Methods: A total of 385 elderly outpatients completed the K-DIA-S and underwent the Mini International Neuropsychiatric Interview to diagnose depressive disorders. Other measures included the 15-item short form of the Geriatric Depression Scale (SGDS), the 9-item depression module of the Patient Health Questionnaire (PHQ-9), and the Montgomery–Asberg Depression Rating Scale (MADRS). Reliability and validity tests, an optimal cutoff point estimate, and receiver operating characteristic curve analysis were performed to investigate the diagnostic validity of the K-DIA-S. Areas under the curves (AUCs) for the K-DIA-S, SGDS, and PHQ-9 were compared statistically. Results: The K-DIA-S showed good internal consistency and strong correlations with the SGDS (r = 0.853), PHQ-9 (r = 0.739), and MADRS (r = 0.772). The cut-off point of the K-DIA-S that can be recommended for screening depressive symptoms was a score of 4. For “any depressive disorder”, the AUC (standard error) for the K-DIA-S was 0.896 (0.015), which was significantly larger than that for the PHQ-9 (p = 0.033). Conclusion: The present findings suggest that the K-DIA-S has good psychometric properties and is a valid and reliable tool for assessing depressive symptoms in elderly populations and medically ill patients.

Switching Antipsychotics to Blonanserin in Patients with Schizophrenia: An Open-label, Prospective, Multicenter Study

Young Sup Woo,Bo-Hyun Yoon,Bong-Hee Jeon,Jeong Seok Seo,Beomwoo Nam,Sang-Yeol Lee,Young-Myo Jae,Sae-Heon Jang,Hun-Jeong Eun,Seunghee Won,Kwang Hun Lee,Jong Hun Lee,Won-Myong Bahk 대한정신약물학회 2019 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.17 No.3

Objective: This study was performed to investigate the efficacy and tolerability of blonanserin in schizophrenic patients who were previously treated with other antipsychotics but, due to insufficient response, were switched to blonanserin. Methods: A total of 52 patients with schizophrenia who were unresponsive to treatment with antipsychotic monotherapy or combination therapy were recruited into this 12-week, open-label, prospective, multicenter study. Patients were switched to blonanserin from their existing antipsychotics over a maximum 2-week tapering-off period. Efficacy was primarily evaluated using the 18-item Brief Psychiatric Rating Scale (BPRS). Assessments were performed at baseline, and at weeks 1, 2, 4, 8, and 12. Results: Switching to blonanserin resulted in a significant decrease in the mean total score on the BPRS from baseline (56.8 ± 9.4) to week 12 (42.1 ± 13.8, p < 0.001). The most common adverse events were extrapyramidal symptoms (n = 12, 23.1%), insomnia (n = 10, 19.2%), and emotional arousal (n = 6, 11.5%). Overweight or obese patients (body mass index ≥ 23 kg/m2, n = 33) who switched to blonanserin exhibited significant weight loss from 75.2 ± 9.3 kg at baseline to 73.5 ± 9.2 kg at week 12 (p = 0.006). The total cholesterol (baseline, 236.1 ± 47.6 mg/dl; endpoint [week 12], 209.9 ± 28.0 mg/dl; p = 0.005) and prolactin levels (baseline, 80.0 ± 85.2 ng/ml; endpoint [week 12], 63.2 ± 88.9 ng/ml; p = 0.003) were also significantly improved in patients with hypercholesterolemia or hyperprolactinemia. Conclusion: The results of the present study suggest that switching to blonanserin may be an effective strategy for schizophrenic patients unresponsive to other antipsychotic treatments.

The Changes of Blood Glucose Control and Lipid Profiles after Short-Term Smoking Cessation in Healthy Males

SeongSu Lee,JeongSeok Seo,SungRae Kim,JoEun Jeong,BeomWoo Nam,JuYul Lee,HeeJin Lee,Chul Lee,ChangUk Lee,InHo Paik,JeongHo Chae,SookHee Chai,SoonJib Yoo,WangYoun Won,DaiJin Kim 대한신경정신의학회 2011 PSYCHIATRY INVESTIGATION Vol.8 No.2

Objective-Our aim was to evaluate the changes in blood glucose control and lipid profiles after 2-months of smoking cessation in healthy males. Methods-Smoking abstinence was evaluated through self-report and urine cotinine levels. 12 individuals who succeeded in quitting smoking were analyzed. Fasting values of glucose and insulin were used to estimate the β-cell activity and insulin resistance was evaluated using the Homeostasis Model Assessment (HOMA) and Quantitative Insulin Sensitivity Check Index (QUICKI). Results-The data showed that the subjects had a significant increase in weight, body mass index and fasting plasma glucose levels after smoking cessation. The HOMA-Insulin Resistance and the HOMA β-cell function increased significantly (p=0.005, p=0.047 respectively). The QUICKI showed a significant decrease (p=0.005). In addition, the low-density lipoprotein cholesterol levels decreased significantly (p=0.028); however, changes in the high-density lipoprotein cholesterol, the triglyceride and total cholesterol levels were not significant (p=0.284, p=0.445 respectively). Conclusion-During the initial stage of smoking abstinence, insulin resistance increased and insulin sensitivity decreased due to elevated body weight and fat composition. Therefore, it is important to educate individuals that stop smoking about the necessity of weight control during smoking cessation programs.