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      • Surface potential measurement of As‐doped homojunction ZnO nanorods by Kelvin probe force microscopy

        Ben, Chu Van,Cho, Hak Dong,Kang, Tae Won,Yang, Woochul John Wiley Sons, Ltd 2012 Surface and interface analysis Vol.44 No.6

        <P>In this study, we demonstrate the electronic properties of As‐doped homojunction ZnO nanorods by Kelvin probe force microscopy (KPFM). The self‐assembled undoped/As‐doped homojunction ZnO nanorods were grown on Si (111) substrates by using vapor phase transport. Individual nanorods were transferred onto Au films grown on Si substrates. The morphology and surface potentials of the ZnO nanorods were simultaneously measured by KPFM. For the homojunction nanorods with ~200 nm in diameter, the KPFM images show obviously doping transition across the junction region, indicating local doping types. Also, the surface potential difference across the junction was measured to be ~85 mV, which could be the result from the work function difference between undoped and As‐doped region. It is in good agreement with the work function difference of ~95 meV between the As‐doped p‐type and intrinsic n‐type nanorods in the same measurement condition. The work function of the doped ZnO nanorods measured by KPFM is discussed in terms of surface band bending induced by surface states of ZnO. Copyright © 2011 John Wiley & Sons, Ltd.</P>

      • KCI등재

        Complete occlusion of the right middle cerebral artery associated with Mycoplasma pneumoniae pneumonia

        Ben Kang,Dong Hyun Kim,Young Jin Hong,Byong Kwan Son,임명관,Yon Ho Choe,권영세 대한소아청소년과학회 2016 Clinical and Experimental Pediatrics (CEP) Vol.59 No.3

        the initiation of fever and respiratory symptoms due to pneumonia. Chest radiography, conducted upon admission, showed pneumonic infiltration and pleural effusion in the left lung field. Brain magnetic resonance imaging showed acute ischemic infarction in the right middle cerebral artery territory. Brain magnetic resonance angiography and transfemoral cerebral angiography revealed complete occlusion of the right middle cerebral artery. Mycoplasma pneumoniae infection was identified by a 4-fold increase in IgG antibodies to M. pneumoniae between acute and convalescent sera by enzyme-linked immunosorbent assay. Fibrinogen and D-dimer levels were elevated, while laboratory exams in order to identify other predisposing factors of pediatric stroke were all negative. This is the first reported pediatric case in English literature of a M. pneumoniae-associated cerebral infarction involving complete occlusion of the right middle cerebral artery.

      • KCI등재
      • KCI등재

        Efficient Surface Display of L-glutamate Oxidase and L-amino Acid Oxidase on Pichia pastoris Using Multi-copy Expression Strains

        Rao Ben,Zhou Ronghua,Dong Qing,Liao Xianqing,Liu Fang,Chen Wei,Liu Xiaoyan,Min Yong,Wang YaPing 한국생물공학회 2020 Biotechnology and Bioprocess Engineering Vol.25 No.4

        L-glutamate oxidase (GLOD) and L-amino acid oxidase (AAO) were reported to be capable of convert L-glutamic acid to α-aketoglutaric acid (α-KG). These two enzymes gene have been successfully expressed by using pHBM905BDM in Pichia pastoris to produce α-aketoglutaric acid from L-glutamic acid in our previous studies. Here these two enzymes were displayed on P. pastoris to achieve the conversion. We constructed multi-copy expression plasmids using plasmid pHBM905BDM. By using this plasmid, multi-copy strains were constructed and named as PGLOD(1-3)-AGα1 and PAAO(1-3)-AGα1, respectively. The following results showed that expression of GLOD(1-3)- AGα1 and AAO(1-3)-AGα1 in multi-copy strains increased as designed and strain PGLOD3-AGα1 and PAAO3-AGα1 was chosen for high-density fermentation and enzyme activity experiments. By using a multi-copy expression approach and high-density fermentation, we achieved a GLOD expression yield of 688.5 U/g dry cell weight and AAO expression yield of 626.7 U/g dry cell weight. By using displayed GLOD, the average production rate of L-glutamic acid to α-KG was 6.22 g/L/h and the highest α-KG titer (124.5 g/L) was converted from 135 g/L L-glutamic acid. By using displayed AAO, the average production rate of L-glutamic acid to α-KG was 5.78 g/L/h and the highest α-KG titer (115.6 g/L) was converted from 135 g/L L-glutamic acid. It showed that displaying enzymes on P. pastoris are suitable for use in industrial applications.

      • 韓國 스포오츠科學의 實態와 그 改善策에 대한 硏究

        金東希,卞鎬光 건국대학교 1972 學術誌 Vol.13 No.1

        In the 20th century, the progress and advance in both of sports skill and records has been watched with great expectation. Such cause and effect depend upon continuance of human volition and laborious work. Since 1975. Korean sports have attained remarkable improvement both in terms of techniques and education through consistent efforts of sports experts and physical education professors. Some sports events have reached the world top level however, there are many events in which Korea is far behind other countries. Specially in foreign cuntries the achieved development of sports skill is not merely by the hard training, but also by study of skills based on the scientific therory and practice along with adoptation application of the scientific method Although we are cognizant of the world developments in the sports science, we have been pouring our utmost efforts in the development of new scientific training methods. Through the scientific study peculiar to our own fundamental conditions. In this paper, the following factors essential to the process of training of players have been investigated : 1.Study of sports science 2.Selection of representative player. 3.Management of representative players physical strength. 4.Management of representative players daily life. 5.Training of representative players. This study has been made with the object of improvement, at the same time, the investigation of present circumstances of sports in Korea, and how to treat sports with scientific theory and practice.

      • SCOPUSKCI등재

        Complete occlusion of the right middle cerebral artery associated with Mycoplasma pneumoniae pneumonia

        Kang, Ben,Kim, Dong Hyun,Hong, Young Jin,Son, Byong Kwan,Lim, Myung Kwan,Choe, Yon Ho,Kwon, Young Se The Korean Pediatric Society 2016 Clinical and Experimental Pediatrics (CEP) Vol.59 No.3

        We report a case of a 5-year-old girl who developed left hemiparesis and left facial palsy, 6 days after the initiation of fever and respiratory symptoms due to pneumonia. Chest radiography, conducted upon admission, showed pneumonic infiltration and pleural effusion in the left lung field. Brain magnetic resonance imaging showed acute ischemic infarction in the right middle cerebral artery territory. Brain magnetic resonance angiography and transfemoral cerebral angiography revealed complete occlusion of the right middle cerebral artery. Mycoplasma pneumoniae infection was identified by a 4-fold increase in IgG antibodies to M. pneumoniae between acute and convalescent sera by enzyme-linked immunosorbent assay. Fibrinogen and D-dimer levels were elevated, while laboratory exams in order to identify other predisposing factors of pediatric stroke were all negative. This is the first reported pediatric case in English literature of a M. pneumoniae-associated cerebral infarction involving complete occlusion of the right middle cerebral artery.

      • KCI등재

        Effects of Black Raspberry Supplementation on Methylation Pathways in Vav-cre Asxl1fl/fl Tet2fl/fl Double Knockout Mice with Early-stage Myelodysplastic Syndrome

        Athena Dong,Yi-Wen Huang,Ben Niu,Ruiling Liu,Weijie Wu,Haiyan Gao,Jianhua Yu 대한암예방학회 2023 Journal of cancer prevention Vol.28 No.4

        Myelodysplastic syndromes (MDS) are a subset of myeloid malignancies defined by clonality of immature hematopoietic stem cells that leads to faulty blood cell development. These syndromes can lead to an increased risk of infection and may transform into acute myeloid leukemia, making it critical to determine effective treatments for the condition. While hypomethylating agents such as azacitidine and decitabine, as well as stem cell transplants, have been delineated as favored treatments for MDS, not all patients are physiologically receptive to these treatments. However, black raspberries (BRBs) have been shown to exert hypomethylating effects in various malignancies, with minimal adverse effects and thus a broader range of potential candidacies. This study aimed to investigate the potential of BRBs to exert such effects on MDS using Addition of Sex Combs Like/Tet Methylcytosine Dioxygenase 2 (Asxl1/Tet2) double knockout mice (Vav-cre Asxl1fl/fl Tet2fl/fl), which typically manifest symptoms around 25 weeks of age, mirroring genetic mutations found in humans with MDS. Following a 12-week dietary supplementation of Vav-cre Asxl1fl/fl Tet2fl/fl mice with 5% BRBs, we observed both hyper- and hypomethylation at multiple transcription start sites and intragenic locations linked to critical pathways, including hematopoiesis. This methylation profile may have implications for delaying the onset of MDS, prompting a need for in-depth investigation. Our results emphasize the importance of exploring whether an extended BRB intervention can effectively alter MDS risk and elucidate the relationship between BRB-induced methylation changes, thus further unlocking the potential benefits of BRBs for MDS patients.

      • KCI등재

        Phenol Removal Performance and Mechanism Using Catalytic Ozonation with the Catalyst of Cobalt-doped α-MnO2

        Jie Zhang,Ben Dong,Ying Han,Xiaocui Zhan,Sijie Ge,Shilong He 대한환경공학회 2023 Environmental Engineering Research Vol.28 No.3

        In this paper, Cobalt-doped α-MnO2 (i.e., Co-α-MnO2) were synthesized through hydrothermal method. Phenol was employed as targeted pollutants to investigate the catalytic ozonation performance of Co-α-MnO2. Results showed that Co-α-MnO2 significantly improved the phenol removal increased to 97.47 % after 40 min, which was 16.46 %, 38.92 % higher than that of α-MnO2 catalytic ozonation and single ozonation without catalyst. Additionally, the physicochemical properties of α-MnO2 and Co-α-MnO2 were analyzed using technologies such as XRD, TEM, BET and XPS. Compared to α-MnO2, Co-α-MnO2 has larger specific surface area (79.496 m2/g) and pore volume (0.0396 cm3/g), higher Mn3+ relative content (41.16 %) and adsorbed oxygen content (18.99 %). Also, the oxygen vacancy content, lattice defect content and surface hydroxyl content of Co-α-MnO2 are higher than that of α-MnO2, which could result in higher catalytic oxidation performance of Co-α-MnO2. The influence of masking agent showed that surface hydroxyl group, •OH and •O2− were involved in the catalytic ozonation of phenol. This study could help recognize the role of surface hydroxyl groups and active free radicals and demonstrate the contribution of reactive oxygen species on phenol removal in Co-α-MnO2 systems.

      • SCOPUSKCI등재

        Removal efficiency and mechanism of bio-treated coking wastewater by catalytic ozonation using MnO₂ modified with anionic precursors

        Jie Zhang,Ben Dong,Ding Ding,Shilong He,Sijie Ge 대한환경공학회 2021 Environmental Engineering Research Vol.26 No.5

        In this paper, MnO₂ catalyst were firstly prepared and modified by four kinds of anionic precursors (i.e., NO₃⁻, AC⁻, SO₄<SUP>2-</SUP> and Cl-) through redox precipitation method. After that, bio-treated coking wastewater (BTCW) was prepared and employed as targeted pollutants to investigate the catalytic ozonation performance of prepared-MnO₂ catalyst was investigated and characterized by the removal efficiencies and mechanism of the prepared bio-treated coking wastewater (BTCW), which was employed as the targeted pollutants. Specifically, the effects of specific surface area, crystal structure, valence state of Mn element and lattice oxygen content on catalytic activity of MnO₂ materials were characterized by BET, XRD and XPS, respectively. Results showed that COD of BTCW could be removed 47.39% under MnO₂-NO₃⁻ catalyst with 2 h reaction time, which was much higher than that of MnO₂-AC⁻ (3.94%), MnO₂-SO₄<SUP>2-</SUP> (12.42%), MnO₂-Cl⁻ (12.94%) and pure O₃ without catalyst (21.51%), respectively. So, MnO₂-NO₃⁻ presented the highest catalytic performance among these catalysts. The reason may be attributed to a series of better physiochemical properties including the smaller average grain, the larger specific surface area and active groups, more crystal defect and oxygen vacancy, higher relative content of Mn<SUP>3+</SUP> and adsorbed oxygen (Oads) than that of another three catalysts.

      • KCI등재

        Time-resolved photoluminescence study of an aggregation-induced emissive chromophore

        이명희,Yongqiang Dong,Ben Zhong Tang,도석 김 한국물리학회 2004 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.45 No.2

        The photophysical properties associated with the aggregation-induced emission of hexaphenylsilole (silole) in an acetone/water mixture were studied by using a uorescence decay lifetime measurements. The uorescence decay lifetime of silole in a pure acetone solution was very short and was barely resolved from the instrumental response function (150 ps) of the time-correlated single photon counting system. When water as a poor solvent was added to the silole solution, the photoluminescence (PL) intensity was signicantly enhanced above 60 % of the water fraction compared to the pure acetone solution, and the PL decay lifetime increased up to a value of 4 ns. These results conrmed the formation of silole nanoparticles in the solution of water mixture, which restricted the intramolecular rotational motion of the phenyl rings linked to silole center, reduced the nonradiative decay process of silole chromophore, and led to an increase in the PL decay lifetime and the quantum efficiency.

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