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Clinical effect of a polysaccharide-rich extract of Acanthopanax senticosus on alcohol hangover.
Bang, Joon Seok,Chung, Yoon Hee,Chung, Su Jin,Lee, Ho Sung,Song, Eun Ho,Shin, Yong Kyoo,Lee, Yu Jeung,Kim, Hyoung-Chun,Nam, Yunsung,Jeong, Ji Hoon GOVI VERLAG GMBH 2015 PHARMAZIE Vol.70 No.4
<P>The present study aimed to examine the effects polysaccharide-rich extract of Acanthopanax senticosus (PEA) on blood alcohol concentration (BAC) and hangover as well as blood lab parameters. A randomized, placebo-controlled, double-blind crossover trial was conducted. The PEA was orally administered before and after consuming alcohol 1.75 g/kg of pure alcohol. After alcohol consumption, BAC was measured for evaluation of alcohol pharmacokinetics. In the second day morning, subjects were asked to complete the Acute Hangover Scale (AHS) questionnarie. BAC results showed little difference between placebo and PEA groups, indicating that PEA does not have an effect on the pharmacokinetics of alcohol. However, several AHS items (i.e., tired, headache, dizziness, stomachache and nausea) and AHS total score were significantly improved by PEA. Blood lab parameters were significantly altered by alcohol in the placebo group. The alteration by alcohol of glucose and C-reactive protein (CRP) level was significantly attenuated by PEA. Therefore, PEA may have potential to reduce the severity of the alcohol hangover by inhibiting the alcohol-induced hypoglycemia and inflammatory response.</P>
Chang Seok Bang,Moon Kyung Joo,Byung-Wook Kim,Joon Sung Kim,Chan Hyuk Park,Ji Yong Ahn,Jeong Hoon Lee,Bong Eun Lee,Hyo-Joon Yang,Yu Kyung Cho,Jae Myung Park,Beom Jin Kim,Hye-Kyung Jung,대한상부위장관. 헬리코박터학 거트앤리버 소화기연관학회협의회 2020 Gut and Liver Vol.14 No.1
Background/Aims: Although acid suppressants are widely used for the prevention or treatment of drug-induced upper gastrointestinal bleeding (GIB), evidence regarding the prevention of anticoagulant-related GIB is scarce. The aim of this study was to evaluate the protective effect of acid suppressants against anticoagulant-related GIB. Methods: A systematic review was conducted of studies that evaluated the protective effect of acid suppressants against anticoagulant-related GIB found in PubMed, the Cochrane library, Embase, and KoreaMed from the date of database inception to April 2018. Random effect model meta-analyses with sensitivity analyses were conducted. The methodological quality of each included publication was evaluated using the Risk of Bias Assessment Tool for Nonrandomized Studies. Publication bias was assessed. Results: In total, six nested case-control or cohort studies were identified and analyzed. Proton-pump inhibitors (PPI) had a protective effect against upper GIB in patients on dicumarinics (risk ratio [RR], 0.56; 95% confidence interval [CI], 0.38 to 0.83; I2, 0%); however, the histamine-2 receptor antagonist did not have the same effect (RR, 0.97; 95% CI, 0.52 to 1.81; I2, 0%). Acid suppressants did not have a protective effect against GIB in patients on dabigatran (hazard ratio, 0.78; 95% CI, 0.44 to 1.37; I2, 81.8%). Conclusions: The protective effect of PPIs against dicumarinics-related upper GIB was clear, while there was no evidence supporting the protective effect of acid suppressants against dabigatran-related GIB. However, in the absence of randomized trials demonstrating a lack of bias, solid conclusions cannot be drawn.
Augmented Quantum Yield of a 2D Monolayer Photodetector by Surface Plasmon Coupling
Bang, Seungho,Duong, Ngoc Thanh,Lee, Jubok,Cho, Yoo Hyun,Oh, Hye Min,Kim, Hyun,Yun, Seok Joon,Park, Chulho,Kwon, Min-Ki,Kim, Ja-Yeon,Kim, Jeongyong,Jeong, Mun Seok American Chemical Society 2018 NANO LETTERS Vol.18 No.4
<P>Monolayer (1L) transition metal dichalcogenides (TMDCs) are promising materials for nanoscale optoelectronic devices because of their direct band gap and wide absorption range (ultraviolet to infrared). However, 1L-TMDCs cannot be easily utilized for practical optoelectronic device applications (e.g., photodetectors, solar cells, and light-emitting diodes) because of their extremely low optical quantum yields (QYs). In this investigation, a high-gain 1L-MoS<SUB>2</SUB> photodetector was successfully realized, based on the surface plasmon (SP) of the Ag nanowire (NW) network. Through systematic optical characterization of the hybrid structure consisting of a 1L-MoS<SUB>2</SUB> and the Ag NW network, it was determined that a strong SP and strain relaxation effect influenced a greatly enhanced optical QY. The photoluminescence (PL) emission was drastically increased by a factor of 560, and the main peak was shifted to the neutral exciton of 1L-MoS<SUB>2</SUB>. Consequently, the overall photocurrent of the hybrid 1L-MoS<SUB>2</SUB> photodetector was observed to be 250 times better than that of the pristine 1L-MoS<SUB>2</SUB> photodetector. In addition, the photoresponsivity and photodetectivity of the hybrid photodetector were effectively improved by a factor of ∼1000. This study provides a new approach for realizing highly efficient optoelectronic devices based on TMDCs.</P> [FIG OMISSION]</BR>
Bang, Jongchul,Bae, Sung-Hun,Park, Chin-Ju,Lee, Joon-Hwa,Choi, Byong-Seok American Chemical Society 2008 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.130 No.52
<P>Methylation of DNA plays a regulatory role in DNA metabolism. The Escherichia coli DNA adenine methyltransferase methylates the N6 positions of adenines in the sequence 5'-GATC-3', which exists in the fully methylated state during most of the cell cycle. Just after DNA replication, however, the GATC sites transiently become hemimethylated, a condition that is indispensable for various cellular processes, such as negative modulation of replication initiation at oriC by SeqA. The lack of structural and dynamic information on DNA duplexes that contain fully methylated GATC sites makes it difficult to explain how hemimethylated GATC sites are recognized in vivo by proteins in a sea of fully methylated ones. Here, we used NMR spectroscopy to characterize the solution structure of a dodecamer DNA duplex that contained a fully methylated GATC site and the dynamics of the unmethylated, hemimethylated, and fully methylated GATC duplexes. Only the hemimethylated GATC duplex displays a unique major groove conformation, which is optimized for entrance into the cleft structure of SeqA. The apparent equilibrium constants for base-pair opening of the three differentially methylated GATC duplexes revealed that N6-methylation of the adenine residue affects the thermodynamics and kinetics of its own and neighboring base pairs. The equilibrium constants for base-pair opening of three GATC duplexes were determined using proton exchange catalyzed by TRIS. The two G.C base pairs of the hemimethylated GATC duplex displayed a faster base-pair opening rate and required less energy for the base-pair opening reaction than did those of the fully methylated one.</P>
Chang Seok Bang,So Hyung Hong,Ki Tae Suk,Jin Bong Kim,Sang Hak Han,Hotaik Sung,Eun Ji Kim,Myoung Jo Kim,Moon Young Kim,Soon Koo Baik,Dong Joon Kim 고려인삼학회 2014 Journal of Ginseng Research Vol.38 No.3
Background: Roles of immune reaction and toll-like receptor-4 (TLR-4) have widely been established in the pathogenesis of alcoholic liver disease (ALD). Methods: We evaluated the biologic efficacy of Korean Red Ginseng (KRG), urushiol, and probiotics (Lactobacillus rhamnosus R0011 and Lactobacillus acidophilus R0052) in mouse models of ALD. Sixty C57BL/6 mice were equally divided into six feeding groups for 10 weeks: normal diet, alcohol, control, alcohol + KRG, alcohol + urushiol, and alcohol + probiotics. Alcohol was administered via a LiebereDeCarli liquid diet containing 10% alcohol. TLR-4 expression, proinflammatory cytokines, and histology, as well as the results of liver function tests were evaluated and compared. Results: No between-group differences were observed with regard to liver function. TLR-4 levels were significantly lower in the KRG, urushiol, and probiotics groups than in the alcohol group (0.37±0.06 ng/ mL, 0.39±0.12 ng/mL, and 0.33±0.07 ng/mL, respectively, vs. 0.88± 0.31 ng/mL; p < 0.05). Interleukin- 1b levels in liver tissues were decreased among the probiotics and KRG groups. The tumor necrosis factor-a level of liver tissue was decreased in the KRG group. Conclusion: The pathological findings showed that alcohol-induced steatosis was significantly reduced by KRG and urushiol. As these agents improve immunologic capacity, they may be considered in potential anti-ALD treatments.