인두편도염 환자와 보균자에서 분리한 Streptococcus pyogenes의 T-protein serotyping 및 항균제 감수성

이영희,황규잠,주영란,박강수,이광준,엄영길,배송미,차성호 국립보건연구원 1998 국립보건원보 Vol.35 No.-

Various supercritical carbon dioxide cycle layouts study for molten carbonate fuel cell application

Bae, S.J.,Ahn, Y.,Lee, J.,Lee, J.I. Elsevier Sequoia 2014 Journal of Power Sources Vol.270 No.-

Various supercritical carbon dioxide (S-CO<SUB>2</SUB>) cycles for a power conversion system of a Molten Carbonate Fuel Cell (MCFC) hybrid system are studied in this paper. Re-Compressing Brayton (RCB) cycle, Simple Recuperated Brayton (SRB) cycle and Simple Recuperated Transcritical (SRT) cycle layouts were selected as candidates for this study. In addition, a novel concept of S-CO<SUB>2</SUB> cycle which combines Brayton cycle and Rankine cycle is proposed and intensively studied with other S-CO<SUB>2</SUB> layouts. A parametric study is performed to optimize the total system to be compact and to achieve wider operating range. Performances of each S-CO<SUB>2</SUB> cycle are compared in terms of the thermal efficiency, net electricity of the MCFC hybrid system and approximate total volumes of each S-CO<SUB>2</SUB> cycle. As a result, performance and total physical size of S-CO<SUB>2</SUB> cycle can be better understood for MCFC S-CO<SUB>2</SUB> hybrid system and especially, newly suggested S-CO<SUB>2</SUB> cycle shows some success.

CK2α/CSNK2A1 Phosphorylates SIRT6 and Is Involved in the Progression of Breast Carcinoma and Predicts Shorter Survival of Diagnosed Patients

Bae, J.S.,Park, S.H.,Jamiyandorj, U.,Kim, K.M.,Noh, S.J.,Kim, J.R.,Park, H.J.,Kwon, K.S.,Jung, S.H.,Park, H.S.,Park, B.H.,Lee, H.,Moon, W.S.,Sylvester, K.G.,Jang, K.Y. American Association of Pathologists and Bacteriol 2016 The American journal of pathology Vol.186 No.12

<P>Recently, the roles of sirtuins (SIRTs) in tumorigenesis have been of interest to oncologists, and protein kinase CK2 alpha 1 (CSNK2A1) has been shown to be involved in tumorigenesis by phosphorylating various proteins, including SIRT1. Therefore, we evaluated the roles of CSNK2A1, SIRT6, and phosphorylated SIRT6 and their relationships in breast carcinoma. Nuclear expression of CSNK2A1 and SIRT6 predicted shorter overall survival and relapse-free survival by multivariate analysis. Inhibition of CSNK2A1 decreased the proliferative and invasive activity of cancer cells. In addition, CSNK2A1 was bound to SIRT6 and phosphorylated SIRT6; evidence for this is provided from immunofluorescence staining, co-immunoprecipitation of CSNK2A1 and SIRT6, a glutathione S-transferase pull-down assay, an in vitro kinase assay, and transfection of mutant CSNK2A1. Knockdown of SIRT6 decreased the proliferation and invasiveness of cancer cells. Overexpression of SIRT6 increased proliferation, but mutation at the Ser338 phosphorylation site of SIRT6 inhibited the proliferation of MCF7 cells. Moreover, both knockdown of SIRT6 and a mutation at the phosphorylation site of SIRT6 decreased expression of matrix metallopeptidase 9, beta-catenin, cyclin D1, and NF-kappa B. Especially, SIRT6 expression was associated with the nuclear localization of B-catenin. This study demonstrates that CSNK2A1 and SIRT6 are indicators of poor prognosis for breast carcinomas and that CSNK2A1-mediated phosphorylation of SIRT6 might be involved in the progression of breast carcinoma.</P>

S6K1 Phosphorylation of H2B Mediates EZH2 Trimethylation of H3: A Determinant of Early Adipogenesis

Yi, S.,Um, S.,Lee, J.,Yoo, J.,Bang, S.,Park, E.,Lee, M.,Nam, K.,Jeon, Y.,Park, J.,You, J.,Lee, S.J.,Bae, G.U.,Rhie, J.,Kozma, Sara C.,Thomas, G.,Han, J.W. Cell Press 2016 Molecular Cell Vol.62 No.3

S6K1 has been implicated in a number of key metabolic responses, which contribute to obesity. Critical among these is the control of a transcriptional program required for the commitment of mesenchymal stem cells to the adipocytic lineage. However, in contrast to its role in the cytosol, the functions and targets of nuclear S6K1 are unknown. Here, we show that adipogenic stimuli trigger nuclear translocation of S6K1, leading to H2BS36 phosphorylation and recruitment of EZH2 to H3, which mediates H3K27 trimethylation. This blocks Wnt gene expression, inducing the upregulation of PPARγ and Cebpa and driving increased adipogenesis. Consistent with this finding, white adipose tissue from S6K1-deficient mice exhibits no detectable H2BS36 phosphorylation or H3K27 trimethylation, whereas both responses are highly elevated in obese humans or in mice fed a high-fat diet. These findings define an S6K1-dependent mechanism in early adipogenesis, contributing to the promotion of obesity.

Prediction of stone-free status and complication rates after tubeless percutaneous nephrolithotomy: a comparative and retrospective study using three stone-scoring systems and preoperative parameters

Choi, S. W.,Bae, W. J.,Ha, U. S.,Hong, S. H.,Lee, J. Y.,Kim, S. W.,Cho, H. J. Springer Science + Business Media 2017 World journal of urology Vol.35 No.3

<P>To investigate the factors predictive of surgical outcomes of tubeless percutaneous nephrolithotomy (TPCNL) and to compare the predictability and accuracy of the Guy's stone score, S.T.O.N.E. nephrolithometry, and CROES nomogram. We reviewed retrospectively the surgical outcomes recorded consecutively and imaging data of preoperative computed tomography scans of 141 patients who had undergone TPCNL from June 2012 to October 2015. Guy's, S.T.O.N.E., and CROES stone-scoring systems (SSSs) and other prognostic factors were assessed using univariate and multivariate statistical analyses. The initial stone-free and complication rates after TPCNL were 78.7 (111/141) and 17.0 % (24/141). On univariate analysis, all three scoring systems were identified as significant factors in terms of stone-free rate (SFR). The multivariate logistic regression analysis showed that the Guy's stone score and stone burden 385 mm(2) had significant correlations with stone-free status [odds ratios (OR) = 3.220, p = 0.001 and OR = 6.451, p = 0.002, respectively]. Guy's stone score (OR = 1.879, p = 0.013) was an independent risk factor for the development of complications. The area under the receiver operating characteristic (ROC) curves for the Guy's, S.T.O.N.E., and CROES SSSs and stone burden showed good results (0.821, 0.816, 0.820, and 0.800, respectively). Pairwise comparison of ROC curves showed that there was no significant difference between each final score and stone burden. Of the three scoring systems, Guy's stone score was the only significant predictive factor for SFR and complication rates after TPCNL in the multivariate logistic regression analysis. Stone burden was significantly associated with a postoperative stone-free status (SFS).</P>

도금슬러지 시멘트고형화에서의 강도 및 안정화 증진

윤현식,강민성,이두진,신응배,배우근,유도윤 漢陽大學校 環境工學硏究所 1997 環境科學論文集 Vol.18 No.-

본 연구에서는 도금폐수처리공정에서 발생하는 실 슬러지를 대상으로 현장에서 적용이 가능한 시멘트고형화 및 안정화효율 증진방안을 찾기 위하여 실내 실험을 통해 1) 슬러지내의 수분이 시멘트의 수화반응에 미치는 영향, 2) 교반시간증가에 의한 고화체의 강도향상 및 용출억제효과, 그리고 3) 첨가제를 이용한 고형화효율 증대를 중점적으로 살펴 보았다. 실슬러지의(습윤슬러지) 자체가 함유한 수분이 시멘트수화반응에 미치는 영향을 살펴보기 위하여 슬러지를 건조시킨 후 물을 첨가하여 시멘트모르터내에 자유수를 증가시킨 결과 습윤슬러지를 그대로 고형화 한 경우보다 동일한 수분에서 2배정도의 높은강도를 얻을 수 있었다. 교반시간을 증가시킬수록 강도와 용출성이 점차 향상되어 10분정도의 교반시간에서 우수한 결과를 얻었으며, 특히 습윤슬러지의 경우 그 효과가 두드러지게 나타났다. 첨가제사용에 따른 효율평가 실험은 Silica fume, 황산반토, Zeolite, EDTA를 대상으로 실시하였으며 이중 Silica fume이 강도와 용출억제면에서 가장 효과가 좋았다. 최적배합비는 습윤슬러지의 경우 첨가비(첨가제/시멘트)0.25∼0.5에서 가장 우수하였고, 0.05∼0.1에서 가장 좋은 용출효과를 나타내었다. 이는 Silica fume이 중금속에 의한 시멘트수화 방해작용을 억제하고 중금속이온을 불용성의 화합물로 고정하기 때문으로 사료된다. The Solidification /Stabilization (S/S) using the cement as a binder is widely used because of its stability and low cost. For cement-based S/S, however, the S/S efficiency in terms of strength and contaminant immobilization varies significantly according to the treated waste types and operational conditions. In this research real planting sludges were choosen for the S/S experiments in order to increase the applicability of the results in the actual site. Especially, the study focused on the effects of 1) the moisture of sludge on the hydration-reaction of cements, 2) the increased mixing time on the enhancement of the strength and immobilization, and 3) using the binder additives on the S/S efficiency. The compressive strength and leachability of the heavy metals (CU, Cd, Pb, Cr, and Zn) from the solidified materials were measured for evaluating the S/S efficiency. Drying the sludge and putting water, keeping the moisture content the same as the original sludge, into the cement mortar for supplying free-water increased the compressive strength of the solidified material by appoximately two times. Prolonged mixing of the sludge-cement mixture increased, particually in the wet sludges, the strength of the solidified material and retarded the mobility of heavy metals from the sludge. Good results obtained at ten minutes of mixing. In the experiments using the additives, silica fume gave superior results with the strength and immobilization to other additives (Al₂(SO₄)₃Zeolite, EDTA) tested. In the wet sludges, the optimum additive/cement ratio was 0.25-0.5 for strength and 0.05-0.1 for immobilization. It was suspected that the silica fume prevented the interference of heavy metals on the hydration reaction of cement and fixed the heavy metal ions into insoluble complexes.

Phase I/II study of S-1 combined with weekly docetaxel in patients with metastatic gastric carcinoma

Park, S R,Kim, H K,Kim, C G,Choi, I J,Lee, J S,Lee, J H,Ryu, K W,Kim, Y-W,Bae, J-M,Kim, N K Cancer Research UK 2008 The British journal of cancer Vol.98 No.8

We designed a phase I/II trial of S-1 combined with weekly docetaxel to determine the maximum tolerated dose (MTD) and recommended dose (RD) and to evaluate the efficacy and toxicity in metastatic gastric carcinoma (MGC). Patients with measurable disease received S-1 orally b.i.d. on days 1–14 and docetaxel intravenously on days 1 and 8 every 3 weeks. In phase I (n=30), each cohort received escalating doses of S-1 (30–45 mg m<SUP>−2</SUP> b.i.d.) and docetaxel (25–40 mg m<SUP>−2</SUP>); MTD was 45 mg m<SUP>−2</SUP> b.i.d. S-1/35 mg m<SUP>−2</SUP> docetaxel and RD was 40 mg m<SUP>−2</SUP> b.i.d. S-1/35 mg m<SUP>−2</SUP> docetaxel. Dose-limiting toxicities included grade 3 elevated liver enzymes, gastric perforation, grade 3 diarrhoea/fatigue, febrile neutropenia with grade 3 anorexia/fatigue, and neutropenic infection with grade 3 stomatitis/anorexia. In phase II (n=52), the overall response rate was 66.7% (95% confidence interval (CI): 53.8–79.6%) and the median time to progression and overall survival were 6.5 months (95% CI: 4.9–8.1) and 13.7 months (95% CI: 9.9–17.5), respectively. The most common grade 3/4 toxicity was neutropenia (29.4%), and febrile neutropenia/neutropenic infection occurred in 19.6% of patients. Non-haematological toxicities were generally mild. There was one treatment-related death due to pneumonitis. S-1 combined with weekly docetaxel is active in MGC with moderate toxicities.British Journal of Cancer (2008) 98, 1305–1311. doi:10.1038/sj.bjc.6604312 www.bjcancer.com Published online 25 March 2008

High-resolution electrohydrodynamic inkjet printing of stretchable metal oxide semiconductor transistors with high performance

Kim, S.-Y.,Kim, K.,Hwang, Y. H.,Park, J.,Jang, J.,Nam, Y.,Kang, Y.,Kim, M.,Park, H. J.,Lee, Z.,Choi, J.,Kim, Y.,Jeong, S.,Bae, B.-S.,Park, J.-U. The Royal Society of Chemistry 2016 Nanoscale Vol.8 No.39

<P>As demands for high pixel densities and wearable forms of displays increase, high-resolution printing technologies to achieve high performance transistors beyond current amorphous silicon levels and to allow low-temperature solution processability for plastic substrates have been explored as key processes in emerging flexible electronics. This study describes electrohydrodynamic inkjet (e-jet) technology for direct printing of oxide semiconductor thin film transistors (TFTs) with high resolution (minimum line width: 2 mu m) and superb performance, including high mobility (similar to 230 cm(2) V-1 s(-1)). Logic operations of the amplifier circuits composed of these e-jet-printed metal oxide semiconductor (MOS) TFTs demonstrate their high performance. Printed In2O TFTs with e-jet printing-assisted high-resolution S/D electrodes were prepared, and the direct printing of passivation layers on these channels enhanced their gate-bias stabilities significantly. Moreover, low process temperatures (<250 degrees C) enable the use of thin plastic substrates; highly flexible and stretchable TFT arrays have been demonstrated, suggesting promise for next-generation printed electronics.</P>

수험생활 중 경주 및 포항 지진 경험

김선주,김유영,김은주,박솔민,배지윤,이민영,이유진,정재원,Li Keying,Wuyingjinzhu,신수진,도지영 이화여자대학교 간호과학대학 2019 이화간호학회지 Vol.- No.53

Purpose: The purpose of this study was to understand the experiences of Gyeongju and Pohang earthquakes during the examinees’ life. Methods: This study applied Colaizzis’s Phenomenological method. The Data was collected through in-depth interviews with a total 8 students of university in Seoul. Results: On the analysis of the interviews, their experience can be expressed as ‘Feeling embarrassed and frightened by earthquakes’, ‘Reduced susceptibility to earthquake hazards due to heavy exam pressure’, ‘Increased exam stress due to earthquake’, ‘Feeling the inadequacy of examinees' earthquake related safety measures in retrospect’. Conclusion: This study was meaningful in deeply understanding of their experiences and revealing that the examinees were more focused on studying rather than actively coping with the disaster. Furthermore, it reconsider the social climate surrounding college admission exams. This study meaningfully discovered that examinees could not stably prepare for both the exam and the earthquake evacuation procedures due to the timing of the earthquake in relation to their upcoming college admission test. Therefore, this study highlighted the examinees’ difficulties due to the earthquakes and increased the necessity of acute phase nursing intervention in relation to the seismic safety education system.

서울대학교 保健大學院 博士課程 敎育프로그램의 評價的 硏究

김정순,김성옥,문용,박은옥,박태진,배은영,정인숙 서울大學校 保健大學院 國民保健硏究所 1997 國民保健硏究所 硏究論叢 Vol.7 No.2