Both endurance- and resistance-type exercise prevents neurodegeneration and cognitive decline in mice with impaired glucose tolerance

Jinhee,Woo,Ki-Ok,Shin,Chan-Ho,Park,Byung-Kon,Yoon,Do-Yeon,Kim,Ju-Yong,Bae,Yul-Hyo,Lee,Kangeun,Ko,Hee-Tae,Roh 한국응용과학기술학회 (구.한국유화학회) 2019 한국응용과학기술학회지 Vol.36 No.3

The purpose of this study was to investigate the effects of different types of exercise training on neurodegeneration and cognitive function in mice with impaired glucose tolerance (IGT). Thirty-six male C57BL/6 mice were randomly assigned to the control (CO, n = 9) and impaired glucose tolerance (IGT, n = 27) groups. The IGT group consumed 45% high fat diet for 4 weeks and received 40 mg/kg of streptozotocin twice in the lower abdomen to induce IGT. After the IGT induction period, the IGT group was subdivided into IGT + sedentary (IGT, n = 9), IGT + endurance exercise (IGTE, n = 9), and IGT + resistance exercise (IGTR, n = 9). The IGTE and IGTR groups performed treadmill and ladder climbing exercises 5 times per week for 8 weeks, respectively. Fasting glucose and glycated hemoglobin (HbA1c) levels were significantly higher in IGT group than in CO, IGTE, and IGTR groups ( p < 0.05). HOMA-IR was significantly higher in IGT group than CO group ( p < 0.05). Hippocampal catalase (CAT) was significantly lower in IGT group than in CO group ( p < 0.05), while beta-amyloid (Aβ) was significantly higher in IGT group than in CO group ( p < 0.05). Hippocampal tau was significantly higher in IGT group than in CO, IGTE, and IGTR groups ( p < 0.05). The Y-maze test performance for cognitive function was significantly lower in IGT group than in CO, IGTE, and IGTR groups ( p <0.05). These results suggest that IGT induces neurodegeneration and negatively affects cognitive function, while regular exercise may be effective in alleviating neurodegeneration and cognitive decline regardless of exercise type.

Weak Coordination Bond of Chloromethane: A Unique Way to Activate Metal Node Within an Unstable Metal–Organic Framework DUT-34

Bae Jinhee,Lee Chang Yeon,Jeong Nak Cheon 대한화학회 2021 Bulletin of the Korean Chemical Society Vol.42 No.4

Activation of metal nodes in metal–organic frameworks (MOFs) has been viewed as an essential step prior to their use for various potential applications. So far, a thermal method has been most commonly employed for the activation despite its negative influence on the structural integrity of MOFs. Meanwhile, DUT-34 has been considered as an ideal platform for the above applications due to its open-metal sites (OMSs) at the Cu node. However, the activation of DUT-34 has not been successful because of its fragile characteristics. In this article, we report the coordination-chemistry-controlled activation, namely chemical route activation, using chloromethanes. By monitoring the coordination exchangeability of chloromethanes, we demonstrate that the chloromethanes can weakly coordinate at the OMSs. Further, we demonstrate that this coordination exchange is a safe activation method to retain the framework structure of DUT-34, based on the observation that the DUT-34 placed in TCM remained intact over 2 months.

Metal coordination and metal activation abilities of commonly unreactive chloromethanes toward metal-organic frameworks

Bae, Jinhee,Lee, Eun Ji,Jeong, Nak Cheon The Royal Society of Chemistry 2018 Chemical communications Vol.54 No.50

<P>Over the last two decades, metal-organic frameworks (MOFs) have received particular attention because of their attractive properties such as permanent nanoporosity and the extraordinary functionality of open coordination sites (OCSs) at metal nodes. In particular, MOFs with open-state OCSs have shown potential in applications such as chemical separation, molecular sorption, catalysis, ionic conduction, and sensing. Thus, the activation of OCSs, <I>i.e.</I>, the removal of coordinated solvent to produce open-state OCSs, has been viewed as an essential step that must be performed prior to the use of the MOFs in the aforementioned applications. This Feature Article focuses on the chemical functions of the commonly unreactive chloromethanes, <I>i.e.</I>, dichloromethane (DCM) and trichloromethane (TCM), including their coordination to OCSs and activation of OCSs. Treatment with a chloromethane is a chemical route to activate OCSs that does not require an additional supply of external thermal energy. Importantly, a plausible mechanism for the chemical process, in which DCM and TCM weakly coordinate to the OCSs and then spontaneously dissociate in an intermediate step, which is proposed based on the results obtained from Raman studies will be discussed. Possible applications of chloromethane treatment to activate large-area MOF films and MOF-polymer mixed matrices, which can be propagated in molecular capture, will also be described.</P>

Interaction of T-Type Calcium Channel CaV3.3 with the β-Subunit

Jinhee Bae,Eui Jin Suh,이철주 한국분자세포생물학회 2010 Molecules and cells Vol.30 No.3

The β-subunit of high-voltage-activated (HVA) calcium channels is essential for the regulation of expression and gating. On the other hand, various reports have suggested that β subunits play no role in the regulation of lowvoltage-activated T-type channels. In addition there has been no clear demonstration of a physical interaction between the α-subunit of T-type channel with β-subunit. In this study, we systematically investigated the interaction between CaVα and CaVβ. The four CaVβ isoforms were expressed in a bacterial system and purified into homogeneity,whereas the t en t ypes of CaVα alpha interaction domain (AID) peptides were chemically synthesized. All possible combinations of CaVα and CaVβ were then tested for by in vitro immunoassays. We describe here the identification of a new interaction between CaV3.3 and CaVβ proteins. This interaction is of low affinity compared to that between the AID of the HVA α-subunit and the alpha-binding pocket (ABP) site of the β-subunit. The AID peptide of HVA channel exerted no effect on the CaV3.3-CaVβ interaction, thus demonstrating that another site not in the ABP of CaVβprotein played a role in binding with CaV3.3. This is the first demonstration of an α-β subunit interaction in a T-type calcium channel.

Multiple Coordination Exchanges for Room-Temperature Activation of Open-Metal Sites in Metal–Organic Frameworks

Bae, Jinhee,Choi, Jae Sun,Hwang, Sunhyun,Yun, Won Seok,Song, Dahae,Lee, JaeDong,Jeong, Nak Cheon American Chemical Society 2017 ACS APPLIED MATERIALS & INTERFACES Vol.9 No.29

<P>The activation of open coordination sites (OCSs) in metal organic frameworks (MOFs), i.e., the removal of solvent molecules coordinated at the OCSs, is an essential step that is required prior to the use of MOFs in potential applications such as gas chemisorption; separation, and catalysis because OCSs often Serve as key sites in these applications. Recently, we developed a 'chemical activation' method involving dichloromethane (DCM) treatment at room temperature, which is considered to be a promising alternative to conventional thermal activation (TA), because it does not require the application of external thermal energy, thereby preserving the structural integrity of the MOFs. However, strongly coordinating solvents such as N,N-dimethylformamide (DMF), N,N-diethylformamide (DEF), and dimethyl sulfoxide (DMSO) are difficult to remove solely with the DCM treatment. In this report, we demonstriate a multiple coordination exchange (CE) process executed initially with acetonitrile (MeCN), methanol (MeOH), or ethanol (EtOH) and subsequently with DCM to achieve the complete activation of OCSs that possess strong extracoordination. Thus, this process can serve as an effective 'chemical route' to activation at room temperature that does not require applying heat, To the best of our knowledge, no previous study has demonstrated the activation of OCSs using this multiple CE process, although MeOH and/or DCM has been popularly used in pretreatment steps prior to the TA process. Using MOF-74(Ni), we demonstrate that this multiple CE process can safely activate a thermally unstable MOF without inflicting structural damage. Furthermore, on the basis of in situ H-1 nuclear magnetic resonance (1H NMR) and Raman studies, we propose a plausible mechanism for the activation behavior of multiple CE.</P>

Enhancing Electrical Properties of N-type Bismuth Telluride Alloys through Graphene Oxide Incorporation in Extrusion 3D Printing

Jinhee Bae,Seungki Jo,Kyung Tae Kim 한국분말재료학회(구 한국분말야금학회) 2023 한국분말재료학회지 (KPMI) Vol.30 No.4

The thermoelectric effect, which converts waste heat into electricity, holds promise as a renewable energy technology. Recently, bismuth telluride (Bi2Te3)-based alloys are being recognized as important materials for practical applications in the temperature range from room temperature to 500 K. However, conventional sintering processes impose limitations on shape-changeable and tailorable Bi2Te3 materials. To overcome these issues, three-dimensional (3D) printing (additive manufacturing) is being adopted. Although some research results have been reported, relatively few studies on 3D printed thermoelectric materials are being carried out. In this study, we utilize extrusion 3D printing to manufacture n-type Bi1.7Sb0.3Te3 (N-BST). The ink is produced without using organic binders, which could negatively influence its thermoelectric properties. Furthermore, we introduce graphene oxide (GO) at the crystal interface to enhance the electrical properties. The formed N-BST composites exhibit significantly improved electrical conductivity and a higher Seebeck coefficient as the GO content increases. Therefore, we propose that the combination of the extrusion 3D printing process (Direct Ink Writing, DIW) and the incorporation of GO into N-BST offers a convenient and effective approach for achieving higher thermoelectric efficiency.

청소년 자기효능감, 사회적지지, 박물관 직업체험활동 만족도가 진로성숙도에 미치는 영향

배진희 ( Bae Jinhee ) 국립중앙박물관 2017 동원학술논문집 Vol.18 No.-

One of the most important challenges that a person faces as he or she grows into adulthood is finding a goal in life and developing the skills required to realize that goal. That is, the challenge lies in discovering one's aptitudes and interests, then deciding on one's career path. A person's career path can be affected by many factors. Thus, how one decides on one's career path is a very important matter. In Korea, much criticism has been leveled at its educational system because of its almost exclusive focus on entrance examinations and the fact that it compels students to make decisions about their career path based on examination scores. It has been suggested that the country needs to set up a career path educational program that can teach students about the fast changing world of professions and prepare them to make career decisions based on their talents and aptitudes. In recent years, emphasis has been placed on career path education and, consequently, work experience programs are gaining popularity as one approach to achieving such educational objectives. However, for realistic reasons, there are practical limits to operating such work experience programs as part of a school curriculum. Instead, to run such programs efficiently, regional organizations are jumping on the bandwagon to develop and run work experience programs of various kinds. Against this backdrop of growing priority being accorded to teenager education, we undertook this research, in which we conducted a multiple regression analysis and then carried out an empirical analysis of the effects of self-efficacy, social support, and museum work experience satisfaction on career path maturity, one of the most important variables in a person’s teenage years. For this study, we collected survey responses from 466 middle school students who had participated in teenager museum work experience programs in Seoul, Daegu, and Jinju. Of these, 425 valid responses were selected for use in the analysis. The analysis first showed that 64.7% of the respondents were male, if the responses were sorted according to demographics. Also, 28.2% of the respondents stated they had never taken part in a similar work experience program in the past. If family monthly income levels were classified into upper, upper median, median, lower median and lower groups, the median group had the highest proportion of respondents in this survey. Office worker and housewife” were the most common answers to the questions about the occupations of the respondents’ father and mother. Second, the results of the multiple regression analysis indicated that career path maturity increased in line with increases in self-efficacy and social support, but that museum work experience satisfaction had no bearing on career path maturity. These results are attributable to the lack of advanced studies on the relationship between career path maturity and work experience programs, the inadequate work experience of the 1st grade middle school students who participated in the survey and the immature survey responses given by the students. The results of this study showed that museum work experience satisfaction is not related to career path maturity in any statistically significant way. This is not an appraisement of the degree of satisfaction itself, but rather a result of analyzing the relationship between two variables. On the basis of this finding, follow-up studies must come up with a basic material that can be used in career path education for teenagers. In follow-up studies, teenagers must be made aware of the importance of work experience activities so that career path education can be promoted in the process. The studies must also contribute toward raising the quality of education and the implications thereof must be derived. Furthermore, a work experience program must not end as a one-off event, but should be preceded by preliminary education and succeeded by follow-up education. This is to make sure that the short-term and long-term benefits of career path education can be realized. However, as the conditions for implementing preliminary and follow-up education cannot be met with the current personnel, what is required is not a onetime, temporary work experience program but a program with clear educational benefits that can be operated continuously. The school educational course must also be set up in a systematic way, and cooperation will be required with organizations that can carry out the education.

임금 근로 여성 가구주 가구의 경제적 지위에 영향을 미치는 요인

배진희(Bae, Jinhee) 연세대학교 사회복지연구소 2010 한국사회복지조사연구 Vol.24 No.-

본 연구의 목적은 임금 근로 여성 가구주의 경제적 지위 정도와 인적자원, 가족환경, 노동 환경의 특성을 살펴보고 이러한 특성이 경제적 지위에 미치는 영향을 살펴보는 것이다. 이를 위해 여성가족패널 제 1차 조사 자료 중 임금 근로 여성 가구주에 해당하는 377사례를 분석에 활용하였다. 분석결과 임금 근로 여성 가구주 가구 소득이 기초생계비 이하인 가구가 15.0%였고, 근로빈곤층 분류 기준으로 사용되고 있는 기초생계비 150%이하인 가구는 32.2%에 달했다. 여성 가구주의 월 급여만을 기준으로 할 경우 26.1%가 기초생계비 이하의 수준이었고 기초생계비 150%이하인 경우는 43.4%에 달했다. 그리고 임금 근로 여성 가구주의 연령, 학력, 돌봄노동 부담, 사업장의 가족친화정책이 경제적 지위에 영향을 미치는 것으로 나타났다. 이러한 결과를 기초로 정책적 실천적 함의를 제안하였다. The aim of this study is to empirically examine the human capital, household characteristics, labor market status factors affecting the poverty status of female household head workers. I used the Korean Longitudinal Survey of Women & Families(KLoWF) data. Major Finding of this study are as follow. First, The percentage of the household that the income of female-headed household is lower than the absolute poverty thresholds is 15%. And the percentage of the household that the income of female-headed household is lower than the absolute poverty thresholds 150% is 32.2%. Second, age, education, burden of caring and family-friendly policies influence the poverty status of female-headed households. On the basis of these result, implications are suggested for improving the chances of escaping the poverty.

메타인지 정확성의 발달 차이 연구

배진희(Jinhee Bae),조혜승(Hye-seung Cho),김경일(Kyungil Kim) 한국인지과학회 2015 인지과학 Vol.26 No.1

멘토링 활동 참여 경험에서의 멘토의 성장과 도전 : H대학교 멘토링 프로그램의 평가 사례를 중심으로

배진형,안정선,방진희 이화여자대학교 사회복지연구소 2014 사회복지 실천과 연구 Vol.11 No.-

본 연구는 2013년도 실시 된 보건복지부 휴먼네트워크 사업의 일환인 멘토링 프로그램에 참여한 H대학교 대학생 멘토들을 대상으로 양적, 질적 방법을 통해 프로그램 경험에 있어서의 성장과 도전에 대해 평가하고, 이를 지역 내 취약계층 아동청소년을 대상으로 하는 대학생 멘토링 활동프로그램의 질 향상을 위한 기초자료로서 활용하고자 하는 목적을 가진다. 이를 위한 연구 방법으로, 먼저 양적 평가는 20명의 멘토링 참여자 전원을 대상으로 프로그램 평가 설문을 통하여 실시되었고, 질적 평가는 6명의 멘토링 참여자를 대상으로 포커스집단 인터뷰를 통해 진행되었다. 자료의 분석은, 양적 자료에 대한 분석으로 SPSS Ver. 20.0 패키지를 활용하였고, 포커스집단 인터뷰를 통한 질적 자료는 근거이론의 초기단계인 개방 코딩을 통한 지속적 비교분석방법을 활용하여 분석하고 범주화 하였다. 양적 평가 결과, 먼저, 멘토의 성장과 관련하여, 개별목표성취도가 5점 만점에 평균 4.26으로 높게 나타났다. 프로그램평가 설문 결과, 멘토 전체 집단목표성취도에 있어서 5점 만점에 평균 4.27로 높게 나타났고, 특별히 팀워크 능력향상, 멘티에 대한 이해도 향상, 인간관계 능력향상 및 성취감과 성공을 느끼는 기회가 됨 영역이 상대적으로 높게 나타났다. 멘토링 활동에 대한 전반적 만족도는 5점 만점에 4.45점으로 높게 나타났다. 멘토 본인의 참여도는 5점 만점에 4.38로 비교적 높았고, 구체적으로 조별활동 보다는 개별멘토링 활동의 참여도가 높았다. 세부활동 만족도에 있어서는 중간평가회가 4.63으로 가장 높았고, 운영 만족도에 있어서는 활동을 위한 교육과 슈퍼비전의 만족도가 4.3점으로 가장 높았다. 멘토의 도전과 관련하여서는 활동 장소 만족도가 3.1로 가장 낮아 환경요인과 연결성이 있었다. 질적 평가 인터뷰 자료 분석결과, 먼저 멘토링 경험에서의 성장영역은 동기부여된 시작 자체에서 오는 성장, 또 다른 나 자신과의 만남과 전문적 역량의 증진, 팀활동과 멘티를 통한 역량 강화, 자신의 현재와 미래 삶의 의미를 발견함이라는 5가지 범주로 분석되었다. 또한 멘토링 경험에서의 도전영역은 지지적이지 않았던 환경요인들, 부족한 개인적 역량에 대한 부담, 시기적절한 행정적 지원의 불충분이라는 3가지 범주로 분석되었다. 차후 멘토링 프로그램 발전을 위해 멘토 및 멘티 주도형 활동 기획 강화, 멘토링 활동을 통한 소속감과 팀웍 증진 지원, 전공 연계의 실천적 적용과 관련된 슈퍼비전 체계 강화, 다양한 환경적 요인 및 행정적 지원의 체계화를 제언하였다. This study aims to evaluate mentoring program experience through both quantitative and qualitative methods and to be the base study for developing more qualified mentoring program by college student mentors. To achieve this purpose, quantitative study was implemented through survey that examines program evaluation with 20 mentors, and qualitative study was taken as focus group interview with 6 mentors. The quantitative data were analyzed by SPSS PC+ package, and the interview data was categorized by constant comparison in open coding of grounded theory. As the quantitative evaluation result, relating to mentor's growth, the individual goal achievement level showed pretty high as 4.26 in 5 as full score. Program evaluation area showed that 4.27 point was for group goal achievement level, comparatively higher in the areas of understanding/practical skill development, human relationship improvement, and feeling achievement/success. Results showed 4.5 in general satisfaction of the program, 4.38 in individual participation (highest in individual mentoring participation). Specific activity satisfaction was 4.63 for mid-term evaluation conference, and 4.3 for administration evaluation in education/supervision. Relating to challenges, location factor involving long distance factor was the lowest as 3.1. As the qualitative analysis results, the growth part was categorized with 5 different areas; growth from the motivated starting, finding unrecognized sides in themselves, professional capacities developed, strengthened abilities through team activities and their mentees, and finding the meaning in their own life both for the present and the future. In the area of challenges, not supportive factors in the environment, feeling of burden from insufficient capacities, need for timely support from the administrative agency. Based on the research findings, strengthening the mentor-mentee self-led activity/planning, development of belonging/teamwork, improving supervision system for connecting social work major, and environmental/administrative support were suggested.