The Role of the SLC Transporters Protein in the Neurodegenerative Disorders

Asli Aykaç,Ahmet Özer Şehirli 대한정신약물학회 2020 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.18 No.2

The solute carrier (SLC) superfamily is one of the major sub-groups of membrane proteins in mammalian cells. The solute carrier proteins include more than 400 different membrane-spanning solute carriers organized with 65 families in the human. In solute carrier family neurons, neurotransmitter is considered to be a pharmacological target of neuropsychiatric drugs because of their important role in the recovery of neurotransmitters such as GABA, glutamate, serotonin, dopamine and noradrenaline and regulation of their concentration in synaptic regions. Therefore, solute carrier transporters play vital and different roles in neurodegenerative disorders. In this article, the role of solute carrier transporters in neurodegenerative disorders such as Alzheimer disease, amyotrophic lateral sclerosis, Huntington disease, Parkinson’s diseases, depression, post-traumatic stress disorder, dementia, schizophrenia, and Epilepsy reviewed and discussed to see how defects or absences in SLC transporter cause neurodegenerative disorders. In this review, we try to summarize what is known about solute carriers with respect to brain distribution and expression. The review summarizes current knowledge on the roles of solute carrier transporters in neurodegenerative disorders.

Faun Tail Nevus and Spinal Dysraphism: Cosmetic Improvement with Alexandrite Laser Epilation

Asli Feride Kaptanoglu,Erkan Kaptanoglu 대한피부과학회 2011 Annals of Dermatology Vol.23 No.-

Faun-tail presents as an abnormal lumbosacral hypertrischosis and may be associated with spinal dysrasphism. In addition to the problems due to spinal anomalies, patient’s physico-social life may also be affected. Here, we report a case of 13 years old female patient with Faun-tail in association with sypinal dysraphism, in which cosmetic improvement was achieved with the help of Alexandrite laser. Alexandrite laser can be the method of choice for permanent hair removal method due to its safe, effective and easy to apply properties. (Ann Dermatol 23(S3) S296∼S298,2011)

Severe Posterior Reversible Encephalopathy in Pheochromocytoma: Importance of Susceptibility-Weighted MRI

Asli Serter,Alpay Alkan,Ayse Aralasmak,Ercan Kocakoc 대한영상의학회 2013 Korean Journal of Radiology Vol.14 No.5

Pheochromocytoma is a rare cause of hypertension in children. Hypertension is one of the common reasons of posterior reversible encephalopathy. Intracerebral hemorrhage is a serious and unexpected complication of hypertensive encephalopathy due to pheochromocytoma, and very rarely seen in the childhood. Intracerebral hemorrhages should be searched if there are hypertensive reversible signal changes on the brain. Susceptibility weighted imaging (SWI) is a more sensitive method than conventional MRI when demonstrating cerebral microhemorrhagic foci. This is the first report of SWI findings on intracerebral hemorrhages in basal ganglia, brain stem and periventricular white matter due to hypertensive encephalopathy in a child with pheochromocytoma.

Case Reports : Faun Tail Nevus and Spinal Dysraphism: Cosmetic Improvement with Alexandrite Laser Epilation

( Asli Feride Kaptanoglu ),( Erkan Kaptanoglu ) 대한피부과학회 2011 Annals of Dermatology Vol.23 No.3s

Faun-tail presents as an abnormal lumbosacral hypertrischosis and may be associated with spinal dysrasphism. In addition to the problems due to spinal anomalies, patient`s physico-social life may also be affected. Here, we report a case of 13 years old female patient with Faun-tail in association with sypinal dysraphism, in which cosmetic improvement was achieved with the help of Alexandrite laser. Alexandrite laser can be the method of choice for permanent hair removal method due to its safe, effective and easy to apply properties. (Ann Dermatol 23(S3) S296~S298, 2011)

Fermented Extracts of Tenebrio molitors larvae Replacement for Casein Alters Hepatic Proteomic Profiles in Type 2 Diabetic Mice

Asli Turkyilmaz,Hae-In Lee,Mi-Kyung Lee 한국식품영양과학회 2022 한국식품영양과학회 학술대회발표집 Vol.2022 No.10

Comparison of three different orthodontic wires for bonded lingual retainer fabrication

Asli Baysal,Tancan Uysal,Nisa Gul,Melike Busra Alan,Sabri Ilhan Ramoglu 대한치과교정학회 2012 대한치과교정학회지 Vol.42 No.1

Objective: We evaluated the detachment force, amount of deformation, fracture mode, and pull-out force of 3 different wires used for bonded lingual retainer fabrication. Methods: We tested 0.0215-inch five-stranded wire (PentaOne, Masel; group I), 0.016 × 0.022-inch dead-soft eight-braided wire (Bond-ABraid, Reliance; group II), and 0.0195-inch dead-soft coaxial wire (Respond, Ormco; group III). To test detachment force, deformation, and fracture mode, we embedded 94 lower incisor teeth in acrylic blocks in pairs. Retainer wires were bonded to the teeth and vertically directed force was applied to the wire. To test pull-out force, wires were embedded in composite that was placed in a hole at the center of an acrylic block. Tensile force was applied along the long axis of the wire. Results: Detachment force and mode of fracture were not different between groups. Deformation was significantly higher in groups II and III than in group I (p < 0.001). Mean pull-out force was significantly higher for group I compared to groups II and III (p < 0.001). Conclusions: Detachment force and fracture mode were similar for all wires, but greater deformations were seen in dead-soft wires. Wire pull-out force was significantly higher for five-stranded coaxial wire than for the other wires tested. Five-stranded coaxial wires are suggested for use in bonded lingual retainers.

Evaluation of alveolar bone loss following rapid maxillary expansion using cone-beam computed tomography

Asli Baysal,Tancan Uysal,Ilknur Veli,Torun Ozer,Irfan Karadede,Seyit Hekimoglu 대한치과교정학회 2013 대한치과교정학회지 Vol.43 No.2

Objective: To evaluate the changes in cortical bone thickness, alveolar bone height, and the incidence of dehiscence and fenestration in the surrounding alveolar bone of posterior teeth after rapid maxillary expansion (RME) treatment using cone-beam computed tomography (CBCT). Methods: The CBCT records of 20 subjects (9 boys, mean age: 13.97 ± 1.17 years; 11 girls, mean age: 13.53 ± 2.12 year) that underwent RME were selected from the archives. CBCT scans had been taken before (T1) and after (T2) the RME. Moreover, 10 of the subjects had 6-month retention (T3) records. We used the CBCT data to evaluate the buccal and palatal aspects of the canines, first and second premolars, and the first molars at 3 vertical levels. The cortical bone thickness and alveolar bone height at T1 and T2 were evaluated with the paired-samples t-test or the Wilcoxon signed-rank test. Repeated measure ANOVA or the Friedman test was used to evaluate the statistical significance at T1, T2, and T3. Statistical significance was set at p < 0.05. Results: The buccal cortical bone thickness decreased gradually from baseline to the end of the retention period. After expansion, the buccal alveolar bone height was reduced significantly; however, this change was not statistically significant after the 6-month retention period. During the course of the treatment, the incidence of dehiscence and fenestration increased and decreased, respectively. Conclusions: RME may have detrimental effects on the supporting alveolar bone, since the thickness and height of the buccal alveolar bone decreased during the retention period.

Alveolar bone thickness and lower incisor position in skeletal Class I and Class II malocclusionsassessed with cone-beam computed tomography

Asli Baysal,Faruk Izzet Ucar,Suleyman Kutalmis Buyuk,Torun Ozer,Tancan Uysal 대한치과교정학회 2013 대한치과교정학회지 Vol.43 No.3

Objective: To evaluate lower incisor position and bony support between patients with Class II average- and high-angle malocclusions and compare with the patients presenting Class I malocclusions. Methods: CBCT records of 79 patients were divided into 2 groups according to sagittal jaw relationships: Class I and II. Each group was further divided into average- and high-angle subgroups. Six angular and 6 linear measurements were performed. Independent samples t-test, Kruskal?Wallis, and Dunn post-hoc tests were performed for statistical comparisons. Results: Labial alveolar bone thickness was significantly higher in Class I group compared to Class II group (p = 0.003). Lingual alveolar bone angle (p = 0.004), lower incisor protrusion (p = 0.007) and proclination (p = 0.046) were greatest in Class II average-angle patients. Spongious bone was thinner (p = 0.016) and root apex was closer to the labial cortex in high-angle subgroups when compared to the Class II average-angle subgroup (p = 0.004). Conclusions: Mandibular anterior bony support and lower incisor position were different between average- and high-angle Class II patients. Clinicians should be aware that the range of lower incisor movement in high-angle Class II patients is limited compared to average- angle Class II patients.

Changes in mandibular transversal arch dimensions after rapid maxillary expansion procedure assessed through cone-beam computed tomography

Asli Baysal,Ilknur Veli,Faruk Izzet Ucar,Murat Eruz,Torun Ozer,Tancan Uysal 대한치과교정학회 2011 대한치과교정학회지 Vol.41 No.3

Objective: This study aimed at evaluating the changes in mandibular arch widths and buccolingual inclinations of mandibular posterior teeth after rapid maxillary expansion (RME). Methods: Baseline and post-expansion cone-beam computed tomographic (CBCT) images of patients who initially had bilateral posterior cross-bite and underwent RME with a banded-type expander were assessed in this study. The patients included 9 boys (mean age: 13.97 ± 1.17 years) and 11 girls (mean age: 13.53 ± 2.12 years). Images obtained 6 months after retention were available for 10 of these patients. Eighteen angular and 43 linear measurements were performed for the maxilla and mandible. The measurements were performed on frontally clipped images at the following time points; before expansion (T1), after expansion (T2), and after retention (T3). Statistical significance was assessed with paired sample t-test at p < 0.05. Results: T1-T2 comparisons showed statistically significant post-RME increases for all measurements; similarly, T2-T1 and T3-T1 comparisons showed statistically significant changes. The maxillary linear and angular measurements showed decreases after expansion, and mandibular linear and angular measurements increased after retention. Conclusion: All mandibular arch widths increased and mandibular posterior teeth were uprighted after RME procedure.

A comparison of destructive behaviors of distilled water, salty water, sulfuric acid and heat on glass/vinyl ester composites

Asli, S.A.,Shokrieh, M.M.,Kamangar, M.A. Techno-Press 2021 Composite materials and engineering Vol.3 No.3

In the present paper, the destructive behavior of distilled water, salty water, sulfuric acid, and heat on glass/vinyl ester composites was investigated by experimental methods. Hetron 922 vinyl ester resin and two types of mat and woven glass fibers as the reinforcements were used to fabricate composite test samples. All samples were immersed in distilled water, salty water, and sulfuric acid with three different concentrations. The tests were performed at 20℃ and 70℃ for the exposure duration of 1, 2, 4, and 8 weeks. Bending tests were performed after aging for all composite samples to check the degradation of the bending modulus and strength. The results show that the effect of distilled water, in comparison with salty water, on the degradation of composite samples was significant. On the other hand, almost non-sensitivity of concentrations of salty water on the weight gain of specimens has been observed. In addition, it was also observed that the degradation of samples at 70℃ temperature is much more than that of at 20℃. Also, it was observed that the flexural modulus of virgin specimens exposed to salty water (2% concentration) has been recovered just after two weeks of immersion. Furthermore, in some cases, composite samples under the sulfuric acid solution have lost almost 80% of their mechanical properties.