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이경성과 크리에이티브 바키(Creative VaQi)의 연극은 희곡의 재현이 아니라 `공간`에 대한 질문에서 출발한다. 광화문이나 문화역 서울과 같은 일상적 공간 속에서 행해졌던 그의 작업은 이들 공간으로부터 고유의 장소성, 즉 그 공간에 축적된 역사적, 사회적 맥락을 드러냈다. 이후 그들은 일상적 공간으로부터 극장이라는 제도적 공간으로 중심을 옮겨 극장의 장소성에 대해 근본적인 질문을 던지는데, 이것은 연극이 무엇인가에 대한 자기질문이기도 하다. 이로써 이경성과 바키의 연극은 예의 그 `장소특정적 공연`의 카테고리를 벗어나 보다 더 미학적 지평을 확장해가고 있다. 그 과정에서 우리는 그들의 작업을 공간과 함께, 좀더 시각을 달리하여 공간을 점유한 몸의 문제를 근거로 새롭게 논의할 수 있는 단초를 얻게 된다. 사실 공간에 대한 질문에서 출발한 바키의 작업은 애초부터 그 공간을 점유하고 있는 배우의 몸을 배제하고는 논의할 수가 없는 것이었다. 본 논문은 크리에이티브 바키의 연극을 배우, 배우의 몸으로부터 새롭게 논의하고자 한다. 통상적 연극과 다르게 그들은 연출과 배우 모두가 직접 공연 전 과정을 이끌면서 관련 자료를 조사하고 인터뷰하며, 여러 번의 발제와 토론 등의 과정을 거쳐 공연의 틀을 잡아간다. 이런 작업과정에서 배우는 어떻게 대상을 체험하는지, 그리고 체화된 감각을 바탕으로 무대를 그들 연극의 주요 화두인 공간과 시간, 더 나아가 타자에 대한 감각의 장소로 발생시키는지를 살펴보고자 한다. 무대 위의 배우의 몸은 공간을 점유한 몸으로서 `여기`에 대해 질문하기도 하고, 시간을 점유하고 `지금`에 대해 묻는다. 그런가하면 보이지 않는 타자의 고통을 감각하는 몸으로서, 기억에 대해 묻기도 한다. 배우의 몸에 기반한 이경성의 연출미학을 풀어내는 이론적 근거는 몸과 지각의 문제를 중심에 둔 현상학에서 가져왔으며, 구체적인 사례들은 최근 2년 동안 발표된 이들의 작품들에서 찾아보았다. Lee Kyung-Sung and the theatergroup `Creative VaQi) have made their theaters focusing on space discourses. But for about last two years, most of their works have been performed not only in everyday spaces but also in various instituional theaterspaces. This is why the research about their theater aesthetics should be conducted from different perspectives. This study examines several recent works that Lee Kyung Sung and his VaQi have performed in institutional theatrical spaces. Actor`s bodies that occupy the space have been their theatrical interest that they have focused on from the beginning. What they emphasize is not how they make actors represent their drama roles. They see actors not as tools of theater but as productive subjects. Actors in their theaters stand on stage as themselves with their own identities. In other words, they reveal themselves on stages as persons who have their own thoughts about the world. This is due to their unique working style that are completed through thorough collaborative work, from data research to interviews, presentations and discussions. Of course, actors are the center of all these processes. They constantly interact with objects and build their own viewpoint on them. The body itself is a performing body that creates events and forms the framework of perception and experience. This way of working is closely linked to the phenomenological point of view. Based on this phenomenological point of view, this paper examines how actor`s body is posing new questions about space and time. It tries also to look at how actor`s body occurs as a place of sensation for the other.
<P><B>Abstract</B></P><P>This is the first report that L(3)mbt-like 2 (L3MBTL2) specifically interacts with the histone deacetylase domain of histone deacetylase 3 (HDAC3) via its MBT domain. Here, we show that L3MBTL2 selectively interacts with HDAC3, but not other class I HDACs. An in vitro peptide-binding assay demonstrated the specific association of HDAC3 with methylated histone-K20 tail and L3MBTL2. Furthermore, depletion of HDAC3 resulted in a decrease of methylated K20-H4, as well as an increase in acetylated histone H3. Consequently, HDAC3 knock-down selectively suppressed L3MBTL2-mediated transcriptional repression. Taken together, our results reveal the concerted action of both HDAC3 and L3MBTL2 in histone deacetylation and methylation-dependent transcriptional repression.</P><P><B>Structured summary</B></P><P>MINT-7719975: <I>L3MBTL2</I> (uniprotkb:Q969R5) and <I>HDAC3</I> (uniprotkb:O15379) <I>colocalize</I> (MI:0403) by <I>fluorescence microscopy</I> (MI:0416)</P><P>MINT-7719941, MINT-7719921: <I>L3MBTL2</I> (uniprotkb:Q969R5) <I>binds</I> (MI:0407) to <I>HDAC3</I> (uniprotkb:O15379) by <I>pull down</I> (MI:0096)</P><P>MINT-7719991: <I>HDAC3</I> (uniprotkb:O15379) <I>physically interacts</I> (MI:0915) with <I>L3MBTL2</I> (uniprotkb:Q969R5) by <I>anti bait coimmunoprecipitation</I> (MI:0006)</P><P>MINT-7719958: <I>L3MBTL2</I> (uniprotkb:Q969R5) <I>physically interacts</I> (MI:0915) with <I>HDAC3</I> (uniprotkb:O15379) by <I>anti tag coimmunoprecipitation</I> (MI:0007)</P><P>MINT-7719897: <I>HDAC3</I> (uniprotkb:O15379) <I>physically interacts</I> (MI:0915) with <I>L3MBTL2</I> (uniprotkb:Q969R5) by <I>two hybrid</I> (MI:0018)</P>
The purpose of this study is to identify the perception, the future and images, and prejudice toward old people. And to examine difference the group of gerontological education (educated group) with the non-educated group. 189 students in K university were participated in this study. The educated group was composed 101 students who enrolled liberal arts course that learned this title. Data were collected from May to June, 2002. The results are as follows; 1) Many students perceived the elderly that was started 60~64 years. 2) The perception, the future and images, and prejudice of both groups were some positively. 3) Each variables were not significantly difference. But the mean level of the educated group were more higher. 4) The educated group was found significantly related to the perception and prejudice(r=.303, p=.002). The non-educated group was found significantly related to the perception and the future and image(r=.421, p=.000), the perception and prejudice(r=.321, p=.003), the future, image and prejudice(r=.272, p=.012).
Background : The relative frequency and clinicopathologic characteristics of lymphomas vary according to geography and race. Data on the features of cutaneous lymphoma in Korea we limited. Objective : The aim of this study was to document the relative occurrence, the clinical and histopathological features of cutaneous lymphomas in Korea. Methods : The Korean Dermatopathology Research Group conducted a review of nationwide collection of 80 cutaneous lymphomas, diagnosed at 23 institutes over recent 3-year period. Clinical records and pathology slides of the patients were reviewed retrospectively. Results and Conclusion : 1. Korea has a higher rate of T-cell lymphoma and NK/T cell lymphoma and a much lower rate of cutaneous B cell lymphoma. 2. The relative frequency of the major diagnostic group according to WHO classification was as follows mycosis fungoides/Sezary syndrome, 42.5%; anaplastic large cell lymphoma, 19%; nasal and nasal type NK/T cell lymphoma, 15%; subcutaneous panniculitis-like T cell lymphoma, 11%; peripheral T cell lymphoma, unspecified, 7.5%; follicular lymphoma, 3%; marginal zone Iymphorna, 1%; angioimmunoblastic lymphadenopathy, 1%. 3. Compared with Western countries, the rate of nasal and nasal-type NK/T cell lymphoma and subcutaneous panniculitis-like T cell lymphoma were much higher. Therefore, The EORTC classification is not effective in dealing with Korean cases of cutaneous lymphoma. We consider the principles of the WHO classification are applicable to the Korean cases of cutaneous lymphoma. (Korean J Dermatol 2003;41(1) : 48∼57)
Liposomes have been long used in cancer therapy with great expectations that they can improve efficacy mainly through enhanced permeation and retention (EPR) effect and reduce toxicity related to un-encapsulated anticancer agents. However, the advantage of liposomal formulations has not been prominent as anticipated in clinical cancer treatment in contrast to preclinical results and this has led nanomedicine field to review the experiences of liposomal anticancer products so far to pursue better strategies. The aim of this review is to look for answers to the questions whether liposomes really increase efficacy and reduce toxicity of encapsulated drugs in humans by consulting recent several meta-analyses. Based on the metaanalyses, liposomal formulations have shown comparable or modestly superior clinical efficacy compared to non-liposomal conventional formulations. Besides, drug-related toxicity, for example, cardiotoxicity of doxorubicin, has been clearly reduced by encapsulation of cytotoxic agents into liposomes despite carrier-related adverse events are newly occurred. In conclusion, liposomes are clinically useful in cancer therapy and their value can be raised by applying more advanced and elaborate strategies through understanding tumor microenvironment.
Fresh attention is being paid to lifestyle brands offering differentiated contents and value such that the 21st century is now being called the age of global lifestyle. Recently national income has been increasing and a broad lifestyle culture has been established. Thus, brands with Scandinavian (Sweden, Denmark, or Norway), culture sensitivity, and design have deeply permeated the domestic market which has led to a domestic consumers' lifestyle trend (Chung& Park, 2004; Kwon, 2013; Magnus & Chrystin, 2003). In particular, such global lifestyle brands as Marimekko (Finland), CathKidston (UK), and Muji (Japan) have secured competitiveness in the global market as textile products which reflect its country's cultural identity (Lee& Park, 2014). Meanwhile, a new word, Hanban (韓版)which refers to Korean brands or products that were created from the Korean wave (韓流), which refers to Korean dramas or songs. Korean culture has been commercialized and grafted into various industries. In particular, a strong wind of Hanban in fashion cultural products not only has spread the Korean lifestyle to the world, but has enhanced its influence on related industries as well as fashion. Although certain major Korean companies launched lifestyle brands such as Jaju, Modern House, Butter, and Pum to help realize a Korean lifestyle brand business, most products sold in Korean lifestyle brands focus on overseas imported goods,so it is difficult to find Korean images on these products(Bang, 2004; Lee & Chung, 2013). The size of the lifestyle market is growing as a high value-added industry that can lead consumers' lifestyle trends, and there is a growing interest for Korean fashion cultural products. Therefore, the purpose of this study is to attempt to develop textile designs for Korean-made high value-added products with the improvement of Korean brand values. For study methodology, the status of lifestyle brands at home and abroad was examined and textile designs were developed for lifestyle brand B. For the development of the textile designs, demand required by brand B was researched and a textile design concept was established based on fashion and interior decoration trends. Then, a textile was designed using a motive that can effectively represent the identity of brand B and the Korean image. Adobe Photoshop 6.0 and Adobe Illustrator CC programs were used for the standardized textile design motif, pattern development, and colorway. The results were as follows. First, global lifestyle brands such as Marimekko, CathKidston, and Muji sell differentiated lifestyle products from other brands by applying motifs and colors which symbolize their country's and city's cultural image on textile products and displaying their own identity and peculiarity. On the other hand, Korean lifestyle brands such as Casamia, Hanssem, Kosney, and Art Box do not plan or produce their own design, but will import and sell foreign textile fabric or textile products with high recognition, or copy imported fabric. Thus, their textile design is unsatisfactory to express their own identity and satisfy consumers' needs. Second, as to the development direction required by brand B, a Korean lifestyle brand, the focus was to first, 'design American and European products using colors and techniques which reflect Korean image trends', Second, to create a 'design with Scandinavia's peculiar simplified line and sensitive color', and finally, to make a 'flower pattern design with good sustainable market feasibility'. Based on the direction and 2015 S/S color and textile trends, three concepts were established: Global Tribe, Bunny in the Wonderland, and Beyond Nature. Global Tribe is a folk paintin g(Minhwa) representing the Korean image well, and was reinterpreted in a modern sense. Bunny in the Wonderland is a modern Scandinavian style design using a rabbit, a symbol of brand B, as the main motif. Beyond Nature used a flower motif in various expression techniques and images. A textile design was developed by extracting from a folk painting, a rabbit, and a flower motif and standardizing a motif in watercolor, pen, and graphic techniques. It was digitalized by a scanner and a pattern was made via the steps of color adjustment and repetition. Three kinds of textile designs were developed according to three concepts and four kinds of colorways were made for each design. This study attempted to develop a textile design as Korean-made high value-added textile products. It is meaningful to suggest textile design with Korean cultural images and brand identity. Further study will focus on the development of fashion cultural products and DIY products to commercialize developed textile design.
Background : Malignant melanoma in Korea has been increasing as in other countries, but there is no nationwide survey of malignant melanoma in Korea. Objective : The aim of this study was to document the clinical and histopathological features of cutaneous melanoma in Korea. Methods : The Dermatopathology Research Group conducted a review of nationwide collection of109 primary cutaneous melanomas, diagnosed at 23 institutes over a recent 3-year period. Clinical records and pathology slides of the patients were reviewed retrospectively. Results and Conclusion : 1. The peak age was the 7th decade with the mean age of 58.1 years. Korea has a higher rate of acral melanoma and much lower rate of lentigo maligna melanoma. 2. Major component tumor cell was spindle cell type. 3. Clark level of tumor was Ⅲ or more and Breslow depth was 2 ㎜ or more at the time of the first diagnosis in many cases (62%). 4. Pre-existing melanocytic nevus was present in a few cases (3 cases). 5. All these features suggest that the racial difference between the Korean and the Caucasian is evident. We also suggest that an early detection program is very important to cure this malignant tumor. (Korean J Dermatol 2003;41(1) 43∼47)
본 연구는 직업관련 극 놀이 활동이 유아의 진로인식 및 자아개념 향상에 효과적인지를 확인하는데 목적을 두었다. 이에 따라 서울 소재 B, Y 국공립 어린이집 2개 반에서 만 5세유아 40명을 무선 선정하여 실험집단과 통제집단에 각각 20명씩 배정하였다. 실험집단 유아들을 대상으로 직업관련 극 놀이 활동을 12회 실시하였고, 통제집단 유아들에게는 누리과정활동을 하였다. 본 연구에서 사용한 검사 도구는 유아의 진로인식 검사(임연정, 2011)와 유아용 자아개념검사(이경화, 고진영, 2014)를 사용하였다. 수집된 자료는 SPSS WIN 22.0 프로그램을 사용하여 사전, 사후간 독립표본 t-test를 실시하였다. 연구결과, 직업관련 극 놀이 활동을 실시한 실험집단이 일반누리과정을 실시한 통제집단보다 진로인식과 자아개념에 있어서 더 향상이 나타나 실험이 효과적이었음이 확인되었다. 이러한 연구결과를 통해 유아교육현장에서 유아의 진로인식과 자아개념향상을 돕기 위한 교수학습방법으로 직업관련 극 놀이활동이 활용될 수 있음을 시사한다. The purpose of this research was to identify how job-related dramatic play affect career-awareness and self-concept of young children. For this research 20 children in each experimental group and control group, total 40 children were selected. They were 5-year-old children going to 2 classes of B and Y public kindergarten located in Seoul. 12 times of dramatic play activity were played for children in experimental group and for control group they had Nuri curriculum which has no special treatment. In terms of research tool used in this study, career-awareness test of children (Yim Yun-jeong, 2011) and self-concept test for children (Lee Kyung-hwa & Goh Jin-young, 2014, unpublished) were used. The collected data was analyzed by using SPSS WIN 22.0 program and t-test for pre and post independent samples was implemented. As a result of this research children in experimental group who had gone through job-related dramatic play activity had positive influence on improvement of their career-awareness and self-concept compared to ones in control group who had gone through general Nuri curriculum. This conclusion implies that job-related dramatic play activity can be a meaningful teaching tool for developing children’s career-awareness and self-concept.
이 연구에서는 서울·경기지역 특수학교에 재학 중인 중도 뇌성마비학생 4명을 대상으로 중재학습경험전략을 적용한 이야기책 읽기가 어휘력과 읽기이해력에 어떠한 효과가 있는가를 알아보았다. 연구의 결과, 첫째, 중재학습경험전략은 중도 뇌성마비학생의 어휘력 증진에 효과적이었다. 즉, 학습자에 맞게 과제를 조정, 선택, 변화시켜 제공하는 중재학습경험전략은 중도 뇌성마비 학생의 어휘습득에 긍정적인 영향을 주었다. 둘째, 중재학습경험전략은 중도 뇌성마비학생의 사실적 읽기이해력 및 추론적 읽기이해력에 긍정적인 효과를 가져왔다. 이는 중재자가 학생과의 상호작용 관계에서 자극을 학생의 인지적 수준에 맞게 변형시켜 제공한 결과이다. 이상의 결과들을 종합해 볼 때, 중재학습경험전략은 중도 뇌성마비학생의 어휘력 및 읽기이해력 향상에 효과적인 전략이라고 하겠다. The primary purpose of this study was to find out how storybook reading by using mediated learning experiences affect vocabulary acquisition, reading comprehension of four students with severe cerebral palsy who attended a special school in Seoul and the Kyung-gi providence. The multiple probe design was employed as a study design. The results of study were as follow. First, the mediated learning experience showed positive effects on acquisition of vocabulary by adjusting, selecting, and changing tasks could be understand and appropriate to the students learning level. Second, the students showed better performances on factual reading and inferential reading tests. That is because there was a modification of stimulus based on the participants` cognitive abilities in their social interactions. In conclusion, the mediated learning experience could be an effective strategy on improving reading ability of students with severe cerebral palsy. It is possible to recommend that continuous reading interventions are necessary to improve their reading ability, access curriculum contents and maintain their independent living in the future.