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      • KCI등재

        Morphological classification, anatomical variations, innervation patterns, musculocutaneous nerve relation of the coracobrachialis muscle: anatomical study and clinical significance

        Ashraf Youssef Nasr,Rawan Ashraf Youssef 대한해부학회 2024 Anatomy & Cell Biology Vol.57 No.2

        The anatomical variations of coracobrachialis muscle (CBM) are of great clinical importance. This study aimed to elucidate the morphological variations, innervation patterns and musculocutaneous nerve (MCN) relation to CBM. Upper limbs of fifty cadavers (30 males and 20 females) were examined for proximal and distal attachments, innervation pattern of CBM and its relation to MCN. Four morphological types of CBM were identified according to number of its heads. The commonest type was the two-headed (63.0%) followed by the single belly (22.0%), three-headed (12.0%) and lastly four headed (3.0%) type. Moreover, an abnormal insertion of CBM was observed in four left limbs (4.0%); one inserting into the medial humeral epicondyle, the second into the upper third of humeral shaft, the third one in the common tendon of biceps, and the fourth one showing a bifurcated insertion. Also, four different innervation patterns of CBM were identified including MCN (80.0%), lateral cord (14.0%), lateral root of median nerve (4.0%), and median nerve itself (2.0%). The course of MCN was superficial to the single belly CBM (19.0%) and in-between the heads in the other types (71.0%). Measurements of the length and original distance of CBM muscular branches originating from MCN revealed no sex or side significant difference. Awareness of the anatomic variations, innervation patterns, and MCN relation of CBM is imperative in recent diagnostic and surgical procedures to obtain definite diagnosis, effective management and good outcome.

      • KCI등재

        Fungal biopriming increases the resistance of wheat to abiotic stress

        Ashraf S. A. El-Sayed,Hanan E. Dief,El-Sayed A. Hashem,Ahmed M. Desouky,Zamarud Shah,Salwa Fawzan 한국식물생명공학회 2022 JOURNAL OF PLANT BIOTECHNOLOGY Vol.49 No.2

        Increasing soil salinity is one of the global challenges that the agriculture sector in Egypt has been facing; 33% of the cultivated land in Egypt, which includes merely 3% of the entire land area, is already salinized. The present review sheds light on the role of fungal biopriming, a technique in which hydrated seeds are inoculated with beneficial fungal flora, in mitigating the deleterious influence of NaCl tension. Endophytic fungi were recognized to be able to interact with several plant species, markedly contributing to the mitigation of NaCl stress in these plants, such that some plants get impoverished to their absent associated microbes under stressful conditions

      • SCIESCOPUSKCI등재

        Production, Isolation, and Puri6cation of L-Asparaginase from Pseudomonas Aeruginosa 50071 Using Solid-state Fermentation

        ( Ashraf A. El-Bessoumy ),( Mohamed Sarhan ),( Jehan Mansour ) 생화학분자생물학회 2004 BMB Reports Vol.37 No.4

        The L-asparaginase (E. C. 3.5.1.1) enzyme was purified to homogeneity from Pseudomonas aeruginosa 50071 cells that were grown on solid-state fermentation. Different purification steps (including ammonium sulfate fractionation followed by separation on Sephadex G-100 gel filtration and CM-Sephadex C50) were applied to the crude culture filtrate to obtain a pure enzyme preparation. The enzyme was purified 106-fold and showed a final specific activity of 1900 IU/mg with a 43% yield. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDSPAGE) of the purified enzyme revealed it was one peptide chain with M, of 160 kDa. A Lineweaver-Burk analysis showed a K. value of 0.147 mM and of V_(max) 35.7 IU. The enzyme showed maximum activity at pH 9 when incubated at 37˚ for 30 min. The amino acid composition of the purified enzyme was also determined.

      • KCI등재후보

        Cytoprotective and antioxidant effects of aged garlic extract against adriamycin-induced cardiotoxicity in adult male rats

        Ashraf Youssef Nasr,Rasha A,Alshali 대한해부학회 2020 Anatomy & Cell Biology Vol.53 No.2

        Adriamycin (ADR) efficacy in cancer chemotherapy is well-established. However, ADR-induced cardiotoxicity remains a significant challenge. Aged garlic extract (AGE) is a natural polyphenol with high antioxidant potential. This study was planned to determine the cytoprotective and antioxidant actions of AGE against the cardiotoxic effect of ADR in rats. Six equal groups, control, ADR-treated (single dose of 10 mg/kg on day 8); AGE-treated (one dose of 250 mg/kg for 14 days); AGE plus ADR-treated (one dose of 250 mg/kg AGE for one week plus ADR injection of 10 mg/kg on day 8); ADR plus AGE-treated (single ADR injection of 10 mg/kg on day 8 plus AGE of 250 mg/kg once from 8th to 14th day); combined AGE plus ADR plus AGE-treated (one dose of 250 mg/kg AGE for 14 days plus single ADR injection of 10 mg/kg on day 8). Sera and cardiac samples were collected on day 15 and prepared for histological, ultrastructural and biochemical study. Disorganization, focal degeneration and necrosis with apoptotic changes of the cardiac myofibrils were observed in ADR-treated rats. Also, reduction in level of total creatine kinase, lactic dehydrogenase, alkaline phosphatase enzymes, glutathione, glutathione- peroxidase, superoxide dismutase, and catalase activities and elevation in malondialdehyde concentration were detected in ADR-treated rats. However, combination of AGE attenuated most of the histopathological, ultrastructural, and biochemical changes induced by ADR. Combination of AGE attenuated the cardiotoxic effects-induced by ADR through its antioxidant and cytoprotective potentials. Therefore, AGE can use as adjunct during administration of ADR in cancer therapy.

      • KCI등재

        Quality of Life among Iranian Infertile Women in Postmenopausal Period: A Cross-sectional Study

        ( Ashraf Direkvand-moghadam ),( Ali Delpisheh ),( Ali Montazeri ),( Kourosh Sayehmiri ) 대한폐경학회 2016 대한폐경학회지 Vol.22 No.2

        Objective: Infertility has a significant impact on a women``s quality of life (QOL). Infertile women face with physical and mental challenges during their postmenopausal period. Therefore, the present study aimed to evaluate the QOL among Iranian infertile women in the postmenopausal period using a valid and reliable instrument. Methods: In this cross-sectional study both snowball and social networking methods were used for sampling. Two demographic and QOL questionnaire were used for data collection. The QOL questionnaire includes 41 items which measure the QOL in five dimensions: socioeconomic, mental health, religiousness, physical health and future imagining. Data analyzed was carried out in IBM SPSS ver. 20.0 using descriptive statistic, x² test, and Fisher test. A P value of 0.01 or less was considered significant. Results: Overall 211 eligible participants were studied. Some participants obtained full score on socioeconomic, religiousness, physical health and future imagining dimensions of QOL but none on the mental health dimension of the QOL. Only, 6.6% of study participants have a good QOL. There was a significant relationship between age and financial provider whit status of QOL. Conclusion: Most Iranian infertile women in the postmenopausal period have poor or moderate QOL. Therefore, improving the QOL among these women should be considered. (J Menopausal Med 2016;22:108-113)

      • KCI등재

        Characterization of the Heavy Metals Contaminating the River Nile at El-Giza Governorate, Egypt and Their Relative Bioaccumulations in Tilapia nilotica

        Ashraf M. Morgan,Ho-Chul Shin,A.M. Abd El Aty 한국독성학회 2008 Toxicological Research Vol.24 No.4

        This study was carried out to measure the concentration of heavy metals (Pb, Mn, Cr, Cd, Ni, Zn, and Cu) in water and Bolti fish (Tilapia nilotica) samples collected from Rasheed branch of River Nile, north of El-Giza Governorate, Egypt by atomic absorption spectrophotometry. The investigated districts through which the branch passes include El-Manashi, Gezzaya, El Katta, Abo Ghaleb and Wardan. Based on WHO and FAO safety reference standards, the results of the current study showed that water and fish tissues were found to contain heavy metals at significantly variable concentration levels among the investigated districts. They were polluted with respect to all the metals tested at Gezzaya district. However, the levels of analyzed metals in water and fish tissues were found lower than legal limits in other districts. The heavy metals showed differential bioaccumulation in fish tissues of the different districts as the accumulation pattern (as total heavy metal residues) was district dependant as follow: Gezzaya >Wardan > El Katta > Abo Ghaleb > El Manashi.

      • Dynamic Clustering and User Association in Wireless Small-Cell Networks With Social Considerations

        Ashraf, Muhammad Ikram,Bennis, Mehdi,Saad, Walid,Katz, Marcos,Hong, Choong-Seon IEEE 2017 IEEE TRANSACTIONS ON VEHICULAR TECHNOLOGY Vol.66 No.7

        <P>In this paper, a novel social network-aware user association in wireless small cell networks with underlaid device-to-device (D2D) communication is investigated. The proposed approach exploits strategic social relationships between user equipments (UEs) and their physical proximity to optimize the overall network performance. This problem is formulated as a matching game between UEs and their serving nodes (SNs) in which, an SN can be a small cell base station (SCBS) or an important UE with D2D capabilities. The problem is cast as a many-to-one matching game in which UEs and SNs rank one another using preference relations that capture both the wireless aspects (i.e., received signal strength, traffic load, etc.) and users' social ties (e.g., UE proximity and social distance). Due to the combinatorial nature of the network-wide UE-SN matching, the problem is decomposed into a dynamic clustering problem in which SCBSs are grouped into disjoint clusters based on mutual interference. Subsequently, an UE-SN matching game is carried out per cluster. The game under consideration is shown to belong to a class of matching games with externalities arising from interference and peer effects due to users social distance, enabling UEs and SNs to interact with one another until reaching a stable matching. Simulation results show that the proposed social-aware user association approach yields significant performance gains, reaching up to 26%, 24%, and 31% for 5th, 50th, and 95th percentiles for UE throughputs, respectively, as compared to the classical social-unaware baseline.</P>

      • KCI등재

        Benzylamides from Salvadora persica

        Ashraf Taha Khalil 대한약학회 2006 Archives of Pharmacal Research Vol.29 No.11

        A phytochemical investigation of stems from Salvadora persica resulted in the first isolation of four benzylamides from a natural source. The isolated compounds were identified as butanediamide, N1,N4-bis(phenylmethyl)-2(S)-hydroxy-butanediamide (1), N-benzyl-2-phenylacetamide (2), N-benzylbenzamide (3) and benzylurea (4). The structure elucidation was accomplished using spectroscopic methods, especially 2D NMR and HREIMS. Compound 2 revealed a significant inhibitory effect on human collagen-induced platelet aggregation, and a moderate antibacterial activity against Escherichia coli.

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