Red Cell Distribution Width as a Predictor of Prostate Cancer Progression

Albayrak, Sebahattin,Zengin, Kursad,Tanik, Serhat,Bakirtas, Hasan,Imamoglu, Abdurrahim,Gurdal, Mesut Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.18

Background: The aims of this study were to investigate the utility of red blood cell distribution width (RDW) as a simple and readily available marker in prostate cancer, as well as to evaluate RDW as a predictor of progression in prostate cancer patients. Materials and Methods: We evaluated 62 newly diagnosed prostate cancer patients who underwent transrectal ultrasound (TRUS)-guided biopsy and 62 healthy controls of mean age 64 (range, 45-75) years at the Urology Clinic of Bozok University Hospital. Data collection was performed using our laboratory information system database to retrieve findings regarding RDW, hemoglobin, prostatespecific antigen (PSA), and age. The RDW values were compared between the healthy control group and prostate cancer patients. A high risk of progression as defined as a Gleason score (GS) >6, total number of cores positive for cancer >33%, each core containing >50% cancer cells, and a prostate-specific antigen (PSA) level >10 ng/mL. Patients were classified according to risk of progression, as well as divided into subgroups according to the RDW quartile. Results: The mean RDW value of prostate cancer patients was 14.6, compared with 13.7 in the healthy control group (p=0.001). A higher RDW was associated with an increased risk of progression, whereas a lower RDW value was correlated with a low risk of progression. Conclusions: RDW is an easily derived measure that might, in combination with other markers, help predict prostate cancer risk and progression. We suggest that RDW may be used in combination with other parameters in the assessment of prostate cancer.

The Crystal Field Effects in the Spin-1 ising Model with FM/AFM Interactions on a Two-layer Bethe Lattice

Erhan Albayrak,Seyma Akkaya 한국물리학회 2009 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.55 No.4

The exact recursion equations in a pair-wise approach are used to study the phase transitions on a two-layer Bethe lattice with crystal field (D) and external magnetic field (H) acting on the layers. The ferromagnetic (FM) and the antiferromagnetic (AFM) interactions for the spins of the upper and the lower layers, respectively, and either a FM- or an AFM-type interaction between the adjacent spins of the layers are assumed. The ground state (GS) phase diagrams of the model are calculated on the (J2/J1, J3/qJ1) planes for given system parameters, and thirteen distinct GS configurations are obtained. With the GS phase diagrams, the temperature-dependent phase diagrams of the model are obtained by studying the thermal behaviors of the order parameters and the response functions. The model was found to exhibit first- and second-order phase transitions for the coordination numbers q = 3, 4, and 6; hence, tricritical points are also observed. A reentrant behavior is also found whenever the model displays two N´eel temperatures. The exact recursion equations in a pair-wise approach are used to study the phase transitions on a two-layer Bethe lattice with crystal field (D) and external magnetic field (H) acting on the layers. The ferromagnetic (FM) and the antiferromagnetic (AFM) interactions for the spins of the upper and the lower layers, respectively, and either a FM- or an AFM-type interaction between the adjacent spins of the layers are assumed. The ground state (GS) phase diagrams of the model are calculated on the (J2/J1, J3/qJ1) planes for given system parameters, and thirteen distinct GS configurations are obtained. With the GS phase diagrams, the temperature-dependent phase diagrams of the model are obtained by studying the thermal behaviors of the order parameters and the response functions. The model was found to exhibit first- and second-order phase transitions for the coordination numbers q = 3, 4, and 6; hence, tricritical points are also observed. A reentrant behavior is also found whenever the model displays two N´eel temperatures.

Is conventional radiofrequency ablation of the superolateral branch, one of the three genicular nerves targeted as standard, necessary or not? A non-inferiority randomized controlled trial

Osman Albayrak,Canan Sanal Toprak,Osman Hakan Gunduz,Savas Sencan 대한통증학회 2024 The Korean Journal of Pain Vol.37 No.3

Background: Radiofrequency ablation is an effective treatment modality in the symptomatic treatment of knee osteoarthritis. Our aim was to compare the efficacy of radiofrequency ablation of the superomedial and inferomedial genicular nerves (2 branches) with the superolateral, superomedial, and inferomedial genicular nerves (3 branches) and to show whether the 2-branch procedure is inferior to the 3-branch procedure. Methods: This study is a prospective, randomized, single-blind clinical study. Eligible participants were randomized into 2 groups: group A, which applied the procedure to the superomedial and inferomedial genicular nerves, and group B, which applied it to the superomedial, superolateral and inferomedial genicular nerves. Pain was evaluated with the numerical rating scale, quality of life with the Short Form-36 (SF-36), and disability with the Western Ontario and McMaster Universities (WOMAC) Osteoarthritis Index before, and at 1 and 3 months after the procedure. Results: A total of 41 patients were included. There were no differences between the groups except for the SF- 36 physical health sub-score at baseline. A significant improvement was seen in the numeric rating scale (NRS) score, SF-36 sub-scores, WOMAC Index total, as well as pain and physical function scores in both groups, though no significant difference was detected between the groups during follow-up. Conclusions: Although we were unable to establish the noninferiority of conventional radiofrequency ablation (CRFA) applied to 2 branches to CRFA applied to 3 branches, in this trial, significant and similar improvement was observed in NRS, WOMAC total, pain, and physical function and SF-36 scores in both groups.

CASE REPORT : A rare cause of dysphagia: compression of the esophagus by an anterior cervical osteophyte due to ankylosing spondylitis

( ?lknur Albayrak ),( Sinan Bagcacı ),( Ali Sallı ),( Sami Kucuksen ),( Hatice Ugurlu ) 대한내과학회 2013 The Korean Journal of Internal Medicine Vol.28 No.5

Ankylosing spondylitis (AS) is a chronic inflammatory rheumatological disease affecting the axial skeleton with various extra-articular complications. Dysphagia due to a giant anterior osteophyte of the cervical spine in AS is extremely rare. We present a 48-year-old male with AS suffering from progressive dysphagia to soft foods and liquids. Esophagography showed an anterior osteophyte at C5-C6 resulting in esophageal compression. The patient refused surgical resection of the osteophyte and received conservative therapy. However, after 6 months there was no improvement in dysphagia. This case illustrates that a large cervical osteophyte may be the cause of dysphagia in patients with AS and should be included in the diagnostic workup in early stages of the disease.

Benefical Effects of Sigma-1 Agonist Fluvoxamine for Tardive Dyskinesia and Tardive Akathisia in Patients with Schizophrenia: Report of Three Cases

Yakup Albayrak,갠지하시모토 대한신경정신의학회 2013 PSYCHIATRY INVESTIGATION Vol.10 No.4

Fluvoxamine is a selective serotonin reuptake inhibitor that is approved for psychiatric disorders such as major depressive episodes and obsessive-compulsive disorder. Beside inhibition of serotonin reuptake, fluvoxamine is also a potent agonist of endoplasmic reticulum (ER) protein sigma-1 receptors, which play a role in the pathophysiology of a number of psychiatric and neurodegenerative disorders. This report presents beneficial effects of sigma-1 agonist fluvoxamine on hyperkinetic movement disorders such as tardive dyskinesia and tardive akathisia. Fluvoxamine might be a novel treatmet approach in the treatment of hyperkinetic movement disorders.

A Report of Rabbit Syndrome Who Benefited from Sigma 1 Agonist Fluvoxamine

Yakup Albayrak,Murat Beyazyüz,Özlem Abbak,Ece Altındağ 대한정신약물학회 2019 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.17 No.1

Rabbit Syndrome is an uncommon side effect of antipsychotic treatment. Although it is usually associated with typical antipsychotics, it can also be related to atypical antipsychotics. Anticholinergics are the most accepted treatment approach in treating Rabbit Syndrome. Fluvoxamine is a member of selective serotonin reuptake inhibitors and it is a potent agonist of sigma 1 receptors. In this article, we report a Rabbit Syndrome case who has benefited from fluvoxamine, in terms of both depressive disorder and Rabbit Syndrome; and present the data on the effects of sigma 1 agonist fluvoxamine on numerous movement disorders.

Erratum - Influence of various metal oxides on mechanical and physical properties of heat-cured polymethyl methacrylate denture base resins

Ilser Turkyilmaz,Turan Korkmaz,Hai Albayrak,Neset Volkan Asar 대한치과보철학회 2013 The Journal of Advanced Prosthodontics Vol.5 No.4

Reliability and Validity Study of the Turkish Version of Child and Adolescent Social Support Scale for Healthy Behaviors

Sevil Albayrak,Biriz Çakır,Fatma Nisancı Kılınç,Ozge Vergili,Yurdagül Erdem 한국간호과학회 2018 Asian Nursing Research Vol.12 No.4

Purpose: The purpose of this study is to investigate adaptation, validity, and reliability of the Turkish version of the Child and Adolescent Social Support Scale for Healthy Behaviors (CASSS-HB). Methods: The CASSS-HB was translated using translation and back-translation. This was a methodological study conducted with 860 students (11-14 years old). Content and construct validity were assessed to test the validity of the CASSS-HB. Exploratory and confirmatory factor analysis of the scale was performed and the reliability of the scale over time (the test-retest method) was examined. Results: Psychometric analyses of the Turkish version of the CASSS-HB indicate high reliability and good content and construct validity. Conclusions: It can be seen that the items comprising the scale appear to be acceptably capable of measuring the variable of social support in terms of healthy behavior in children and adolescents. Healthcare professionals can thus use the scale for determining the degree of social support students of the ages 11-14 receive in terms of developing healthy behavior.

Determination of biological activities of essential oil and extract obtained from Achillea coarctata Poir.

Sevil Albayrak,Nurcan Silahtarlıoğlu 경희대학교 융합한의과학연구소 2020 Oriental Pharmacy and Experimental Medicine Vol.20 No.1

In this study evaluated the phenolic, flavonoid contents, antioxidant, antimicrobial and cytotoxic activities of Achillea coarctata extract. Also, chemical compositions of the extract and essential oil were analyzed by HPLC and GC–MS. The antioxidant activity of the extract was determined with phosphomolybdenum, DPPH (2,2-diphenyl-1-picrylhydrazyl radical scavenging), hydrogen peroxide scavenging, β-carotene bleaching activity, Fe+2-ion reducing power (FRAP) and cupric ion (Cu2+) reducing antioxidant capacity (CUPRAC) assays. The extract and essential oil were investigated for antimicrobial activities against 15 species of microorganisms. The extract has been only found to be effective against Klebsiella pneumoniae, while essential oil was effective against Listeria monocytogenes, K. pneumoniae, Bacillus cereus, Streptococcus pneumoniae and Candida albicans. The cytotoxic activity of the extract on MCF7 (human breast cancer cell line, ATCC HTB-22) and NIH/3T3 (mouse embryo fibroblast cells, ATCC CRL-1658) was studied by MTT assay. The extract showed cytotoxic activity on MCF-7 cell line.

Effects of Epinephrine and Cortisol on the Analgesic Activity of Metyrosine in Rats

Yavuz Albayrak,Mustafa Bahadir Saglam,Kadir Yildirim,Saliha Karatay,Beyzagul Polat,Turan Uslu,Fatih Akcay,Halis Suleyman 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.9

Some endogenous hormones (epinephrine and cortisol) can change an individual’s pain threshold. Propranolol is a non-selective β adrenergic receptor blocker which antagonises the antiinflammatory effect of non-steroidal anti-inflammatory drugs via the β1 and β2 adrenergic receptors. The roles of epinephrine and cortisol were investigated in the analgesic activity of metyrosine in rats with reduced epinephrine levels induced by metyrosine. Pain threshold measurement was performed using an analgesimeter with different doses and the single or combined usage of metyrosine, prednisolone, metyrapone and propranolol in rats. Epinephrine and corticosterone levels were measured by high-performance liquid chromatography in metyrosine-administered rats. Metyrosine reduces the epinephrine levels without affecting the corticosterone levels, thereby creating an analgesic effect. It was determined that prednisolone did not have an analgesic effect in rats with normal epinephrine levels, but its analgesic activity increased with a parallel decrease in the epinephrine levels. Similarly, the combined use of prednisolone and metyrosine provided a stronger analgesic effect than that rendered by metyrosine alone. The strongest analgesic effect, however, was observed in the group of rats with the lowest epinephrine level in whom the metyrosine + prednisolone combination was administered. The findings of this study may be useful in severe pain cases in which the available analgesics are unable to relieve the individual’s pain.