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- 저자 : ( Sang-yeop Lee ) (검색결과 960 건)
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Sung-Soo Park,Hee-Je Kim,Tong Yoon Kim,Joon yeop Lee,Jong Hyuk Lee,Gi June Min,Silvia Park,Jae-Ho Yoon,Sung-Eun Lee,Byung-Sik Cho,Ki-Seong Eom,Yoo-Jin Kim,Seok Lee,Dong-Wook Kim 대한혈액학회 2021 Blood Research Vol.56 No.3
Background Allogeneic hematopoietic stem cell transplantation (alloSCT) is a potentially curative treatment option for acute leukemia. We aimed to identify the comorbidity factors affecting survival outcomes after alloSCT and develop a new comorbidity index tool for predicting overall survival (OS). Methods A Korean nationwide cohort of 3,809 adults with acute leukemia treated with alloSCT between January 2002 and December 2018 was analyzed as the development cohort. A retrospective cohort comprising 313 consecutive adults with acute leukemia who underwent alloSCT between January 2019 and April 2020 was analyzed as the validation cohort. Results In the development cohort, advanced age, male sex, and comorbidities such as previous non-hematologic malignancy, hypertension, and coronary or cerebral vascular disease were significantly related to poor OS. Subsequently, a new comorbidity scoring system was developed, and risk groups were created, which included the low-risk (score ≤0.17), intermediate-risk (0.17< score ≤0.4), high-risk (0.4< score ≤0.55), and very high-risk (score >0.55) groups. The 1-year OS rates were discriminatively estimated at 73.5%, 66.2%, 61.9%, and 50.9% in the low-risk, intermediate-risk, high-risk, and very high-risk groups in the development cohort, respectively (P<0.001). The developed scoring system yielded discriminatively different 1-year OS rates and 1-year incidence of non-relapse mortality according to the risk group (P=0.085 and P=0.018, respectively). Furthermore, the developed model showed an acceptable performance for predicting 1-year non-relapse mortality with an area under the curve of 0.715. Conclusion The newly developed predictive scoring system could be a simple and reliable tool helping clinicians to assess risk of alloSCT in adults with acute leukemia.
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Lee, Su-Jun,Jung, Il-Sun,Jung, Eun-Ji,Choi, Ji-Yeop,Yeo, Chang-Woo,Cho, Doo-Yeoun,Kim, Yang-Weon,Lee, Sang-Seop,Shin, Jae-Gook Elsevier 2011 Thrombosis research Vol.127 No.3
<P><B>Abstract</B></P><P><B>Introduction</B></P><P>Although P2Y12 has a significant role in normal hemostasis and thrombosis, no genetic study has been described about the association between P2Y12 variants and the extent of ADP-induced platelet activation in the Korean population.</P><P><B>Materials and Methods</B></P><P>The expression levels of two reference sequences of <I>P2Y12</I> mRNA transcripts (variants 1 and 2) were examined in the whole blood before direct DNA sequencing. The subjects were screened for single-nucleotide polymorphisms (SNPs) in <I>P2Y12</I> by direct DNA sequencing (n=50). Frequencies of <I>P2Y12</I> single nucleotide polymorphisms (SNPs), linkage disequilibrium blocks, haplotype structures, and haplotype-tagging SNPs were determined. The effects of genetic variation in the <I>P2Y12</I> gene on the extent of ADP-induced platelet aggregation were studied in healthy Korean men (n=40).</P><P><B>Results</B></P><P>Variant 2 (NM 176876.1) was the predominantly expressed form in all subjects, but variant 1 was also weakly expressed in all cases (n=10). A total of 20 SNPs were identified: 2 in exons, 5 in introns, and 8 and 5 in the 5’-untranslated regions of the known <I>P2Y12</I> RNA variants 1 and 2, respectively. Genetic analysis of the <I>P2Y12</I> SNPs and haplotypes revealed a statistically significant association between <I>P2Y12</I> haplotype, denoted H3, and an increase in the ADP-induced platelet aggregation response relative to that for the reference haplotype H1 (<I>P</I>=0.01).</P><P><B>Conclusions</B></P><P>Application of these findings to the development of a multivariate model might be useful in explaining the variable outcome of antiplatelet drug therapy in Asian populations.</P>
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Lee Hye Young,Park Young-Joon,Yu Mi,Park Hanul,Lee Ji Joo,Choi Jihyun,Park Hee Seok,Kim Jun Yeop,Moon Jun Young,Lee Sang-Eun 대한감염학회 2023 Infection and Chemotherapy Vol.55 No.4
Background: The number of confirmed cases of individuals with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection increased rapidly due to the Omicron variant. Correctional facilities are vulnerable to infectious diseases, and they introduced rapid antigen tests (RATs) to allow for early detection and rapid response. We aimed to evaluate the diagnostic performance and usefulness of SARS-CoV-2 RATs in newly incarcerated people. Materials and Methods: We conducted a cross-sectional study at correctional facilities in Korea from 9 March to 22 May 2022. The study population was newly incarcerated people who were divided into two groups. In one group, 799 paired SARS-CoV-2 RATs and real-time polymerase chain reaction (RT-PCR) were conducted simultaneously in 522 individuals in March 2022. In the other group, 4,034 paired RATs and RT-PCR consecutively in 4,034 participants; only individuals with negative RATs results underwent RT-PCR from April to May 2022. We analyzed data using descriptive statistics and a logistic regression model. Results: Among the 799 specimens in March, RT-PCR was positive in 72 (9.0%), and among the 4,034 specimens in April - May 2022, RT-PCR was positive in 40 (1.0%). Overall, the RATs had a sensitivity of 58.3%, specificity of 100.0%, positive predictive value (PPV) of 100.0%, and negative predictive value (NPV) of 96.0%. Asymptomatic individuals constituted 98.2% of the study group, and symptomatic individuals 1.8%. In asymptomatic cases, the sensitivity of RATs was 52.5%, specificity was 100.0%, PPV was 100.0%, and NPV was 96.3%. In symptomatic cases, the sensitivity of RATs was 84.6%, specificity was 100.0%, PPV was 100.0%, and NPV was 33.3%. Sensitivity (P = 0.034) and NPV (P = 0.004) differed significantly according to the presence and absence of symptoms, and the F1 score was the highest at 0.9 in symptomatic individuals in March. There was a positive linear trend in the proportion of false-negative RATs in newly incarcerated people following the weekly incidence of SARS-CoV-2 (P = 0.033). The best-associated predictors of RATs for SARS-CoV-2 infection involved symptoms, timing of sample collection, and repeat testing. Conclusion: Sensitivity and NPV significantly depend on whether symptoms are present, and the percentage of false negatives is correlated with the incidence. Thus, using RATs should be adjusted according to the presence or absence of symptoms and the incidence of SARS-CoV-2 infection in the community. RATs could be a useful screening tool as an effective first-line countermeasure because they can rapidly identify infectious patients and minimize SARS-CoV-2 transmission in correctional facilities.
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The Design and Implementation of Anomaly Traffic Analysis System using Data Mining
Lee, Se-Yul,Cho, Sang-Yeop,Kim, Yong-Soo Korean Institute of Intelligent Systems 2008 INTERNATIONAL JOURNAL of FUZZY LOGIC and INTELLIGE Vol.8 No.4
Advanced computer network technology enables computers to be connected in an open network environment. Despite the growing numbers of security threats to networks, most intrusion detection identifies security attacks mainly by detecting misuse using a set of rules based on past hacking patterns. This pattern matching has a high rate of false positives and can not detect new hacking patterns, which makes it vulnerable to previously unidentified attack patterns and variations in attack and increases false negatives. Intrusion detection and analysis technologies are thus required. This paper investigates the asymmetric costs of false errors to enhance the performances the detection systems. The proposed method utilizes the network model to consider the cost ratio of false errors. By comparing false positive errors with false negative errors, this scheme achieved better performance on the view point of both security and system performance objectives. The results of our empirical experiment show that the network model provides high accuracy in detection. In addition, the simulation results show that effectiveness of anomaly traffic detection is enhanced by considering the costs of false errors.
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( Sang Jun Eun ),( Jin Yong Lee ),( Do-yeop Kim ),( Hyun-sun Yoon ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2
Background: Previous epidemiologic studies of the natural course of urticaria mainly focused on chronic spontaneous urticaria and were conducted at hospitals. Objectives: We aimed to investigate the natural course of new-onset urticaria using the National Health Insurance Service-National Sample Cohort (NHIS-NSC) data. Methods: Patients with new-onset urticaria were identified from the NHIS-NSC data. Patients who had at least one visit for urticaria in 2002 and 2003 were excluded and the study cohort consisted of 1,027,620 subjects with no history of urticaria. We analyzed cumulative incidences of urticaria, chronic urticaria, and chronic urticaria remission using the life table estimation method from 2004 to 2013. Their association with related factors was analyzed using the Cox proportional hazards analysis. Results: From 2004 to 2013, a total of 49,129 patients with new-onset urticaria were identified. The 10-year cumulative incidence rate of urticaria for the general population was 4.9% and that of chronic urticaria among patients with new-onset urticaria was 7.8%. Remission rates of chronic urticaria were 52.6% at 1 year and 88.9% at 5 years. Age, sex, residential area, and autoimmune thyroid disease were significantly associated with urticaria or chronic urticaria, but not with chronic urticaria remission, after adjusting for covariates. Conclusion: During the 10-year follow-up period, only a small proportion of patients with new-onset urticaria developed chronic urticaria.
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Development of Welsh Onion Harvester for Tractor
( Sung Ha Hong ),( Kyou Seung Lee ),( Yong Jin Cho ),( Won Yeop Park ) 한국농업기계학회 2014 바이오시스템공학 Vol.39 No.4
Purpose: To ascertain the increase of the farm income that predominantly relies on human resources by mechanizing Welsh onion harvesting, a tractor-mounted Welsh onion harvester was developed in this study. Method: An experiment for evaluating harvesting performance was performed for the developed Welsh onion harvester in an actual Welsh onion farm. The harvest performance was evaluated at the tractor running speeds of 5.0 cm/s, 11.4 cm/s and 15.8 cm/s, by comparing the operating efficiency, harvest rate, and damage rate of the Welsh onion harvester. Results: The performance of the harvester was rated as very good, with a 100% harvest rate, regardless of tractor running speed. Furthermore, it is shown that work efficiency of the harvester is expected to increase as the running speed increases. Nonetheless, the damage rate of the harvested Welsh onions at running speeds 5.0 cm/s, 11.4 cm/s, and 15.8 cm/s, increased correspondingly and proportionally to speeds from 4.55% to 6.53% and to 11.29%. The residual amount of soil on the harvested Welsh onions was about 0.24% of their weight showing excellent soil-removal performance of the harvester. Conclusion: The developed Welsh onion harvester is believed to improve the labor productivity and cultivation environment of Welsh onion farmhouses by the mechanization of the harvesting process that is currently associated with the largest amount of labor hours.
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