Anti-Oxidant Activities of Acanthopanax senticosus Stems and Their Lignan Components

이상현,Dongwook Son,Jiyoung Ryu,이연실,정상훈,Jungil Kang,Sang Yun Lee,김현수,Kuk Hyun Shin 대한약학회 2004 Archives of Pharmacal Research Vol.27 No.1

The antioxidant activities of Acanthopanax senticosus stems were evaluated in CCl4-intoxicated rats. The n-butanol fraction from the water extract of the stems, when pretreated orally at 200 mg/kg/day for 7 consecutive days in rats, was demonstrated to exhibit significant increases in antioxidant enzyme activities such as hepatic cytosolic superoxide dismutase, catalase and glutathione peroxidase by 30.31, 19.82 and 155%, respectively. The n-butanol fraction whereas showed a significant inhibition of serum GPT activity (65.79% inhibition) elevated with hepatic damage induced by CCl4-intoxication. Eleutheroside B, a lignan component, isolated from the n-butanol fraction was found to cause a moderate free radical scavenging effect on DPPH, its scavenging potency as indicated in IC50 value, being 58.5 mM. These results suggested that the stems of A. senticosus possess not only antioxidant but also hepatoprotective activities.

Antitumor and Immunostimulating Activities of Acanthopanax sessiliflorus Fruits

이상현,Yeon Sil Lee,Sang Hoon Jung,Jun Ji,Kuk Hyun Shin,Bak-Kwang Kim,강삼식 한국생약학회 2003 Natural Product Sciences Vol.9 No.2

The antitumor and immunostimulating activities of Acanthopanax sessiliflorus fruits were investigated. Polysaccharide isolated from this plant, when administered consecutively for 9 days at 50 and 100 mg/kg i.p. in mice, caused a significant increase in the life span and a significant decrease in the tumor weight and volume in mice inoculated with Sarcoma-180 tumor cells. Polysaccharide was also demonstrated to exhibit phagocytosis-enhancing activity as measured by the carbon clearance in mice. Polysaccharide, when administered i.p. at 50 and 100 mg/kg/day for 3 consecutive days, exhibited a significant RCtr/RCc [the rate of regression coefficient of the animals teated (RCtr) to that of the control (RCc)], being 1.44 (PI = 1), 1.52 (PI = 2) which was approximately the same with that of enhancement of phagocytosis, its potency as expressed by the regression coefficient ratio of zymosan (RCtr/RCc = 1.55, PI = 2), a typical phagocytosis enhancer. Polysaccharide also caused a significant increase in the acid phosphatase activity representing lysosomal enzymes in macrophages at 1-100 ig/ml in vitro in compliance with in vivo results. These results suggest that the antitumor activity of polysaccharide might be related to the immunostimulating function.

Sol-gel법에 의한 박막태양전지용 CuInS₂ 박막의 증착과 특성

이상현,이승엽,박병옥,Lee, Sang-Hyun,Lee, Seung-Yup,Park, Byung-Ok 한국결정성장학회 2011 한국결정성장학회지 Vol.21 No.4

박막 태양전지의 저가 고효율화를 실현하기 위해 넓은 면적의 기판 위에 코팅이 가능하며 진공의 유자가 필요 없기 때문에 장치가 간단하고 고순도의 균질한 박막을 얻을 수 있고 박막의 조성을 쉽게 조절할 수 있는 Sol-Gel법을 이용 하였다. Se보다 저가이며 독성이 없고 풍부한 원료인 S로 치환하여 사용하며 Cu/In비 값을 조절하고 tetragonal chalcopyrite $CuInS_2$의 열처리 온도에 따른 박막의 구조적, 광학적 특성에 미치는 변수들의 영향을 알아보았다. XRD pattern을 관찰한 결과 Cu/In비가 1.0일 때 $2{\theta}=27.9^{\circ}$에서 주피크가 가장 강하게 나타났으며 (112) 방향의 배향성을 가진 chalcopyrite상임을 확언 할 수 있었다. 열처리 온도가 증가할수록 (112) 면의 강도가 커지며 $500^{\circ}C$에서 열처리를 한 $CuInS_2$ 박막은 tetragonal 구조의 화학량론적 $CuInS_2$ 특징을 나타내고 본 실험의 샘플의 격자상수를 측정한 값이 a = 5.5032, c = 11.1064 ${\AA}$이며 JCPDS(Joint Committee on Powder Diffraction Standards)에 보고된 데이터 a = 5.523, c = 11.14 ${\AA}$과 거의 일치하였다. 광학적 특성을 알아보기 위해 측정한 광투과율은 가시광선 영역(380~770 nm)에서 전체적으로 30% 이하로 나타났다. $CuInS_2$ thin films were prepared using a sol-gel spin-coating method. That makes large scale substrate coating, simple equipment, easy composition control available. The structural and optical properties of $CuInS_2$ thin films that include less toxic materials (S) instead of Se, tetragonal chalcopyrite structure. Copper acetate monohydrate ($Cu(CH_3COO)_2{\cdot}H2O$) and indium acetate ($In(CH_3COO)_3$) were dissolved into 2-propanol and l-propanol, respectively. The two solutions were mixed into a starting solution. The solution was dropped onto glass substrate, rotated at 3000 rpm, and dried at $300^{\circ}C$ for Cu-In as-grown films. The as-grown films were sulfurized inside a graphite container box and chalcopyrite phase of $CuInS_2$ was observed. To determine the optical properties measured optical transmittance of visible light region (380~770 nm) were less than 30 % in the overall. The XRD pattern shows that main peak was observed at Cu/In ratio 1.0 and its orientation was (112). As annealing temperature increases, the intensity of (112) plane increases. The unit cell constant are a = 5.5032 and c = 11.1064 $\AA$, and this was well matched with JCPDS card. The optical transmittance of visible region was below than 30 %.

입력전류 파형 개선형 단상 정류기의 토폴로지

이상현(Sang-Hyun Lee),박진민(Jin-Min Park),문상필(Sang-Pil Mun),서기영(Ki-Young Suh) 한국조명·전기설비학회 2003 한국조명·전기설비학회 학술대회논문집 Vol.2003 No.-

For small capacity rectifier circuits such as these for consumer electronics and appliances, capacitor input type rectifier circuits are generally used. Consequently, various harmonics generated within the power system become a serious problem. Various studies of this effect have been presented previously. However, most of these employ switching devices, such as FETs and the like. The absence of switching devices makes systems more tolerant to over-load, and brings low radio noise benefits. We propose a power factor correction scheme using a LC resonant in commercial frequency without switching devices. In this method, it makes a sinusoidal wave by widening conduction period using the current resonance in commercial frequency, Hence the harmonic characteristics can be significantly improved, where the lower order harmonics, such as the fifth and seventh order are much reduced. The result are confirmed by the theoretical and experiment implementations.

방약합편(方藥合編) 상통(上統) 처방(處方)에 대한 방제학적(方劑學的) 고찰(考察)

이상현,Lee, Sang-Hyun 대한한의학방제학회 2009 大韓韓醫學方劑學會誌 Vol.17 No.1

This report describes the studies as follows through the research of Basic-prescriptions about 123 prescriptions in high-chepter(上統) from Bang-Yak-Hap-Pyun(方藥合編). There are 24 Basic-prescriptions including Sagunja-tang(四君子湯), Samul-tang(四物湯), Sogeonjung-tang(小建中湯), lijung-tang(理中湯), Dangguibohyul-tang(當歸補血湯), Yijin-tang(二陳湯), Gauwon-chun(擧元煎), Jeongweon-eum(貞元飮), and Yukmichiwhang-won(六味地黃元), etc. about 123 prescriptions in high-chepter(上統) from Bang-Yak-Hap-Pyun(方藥合編). There were many cases compounding the Basic-prescriptions each other. So I investigated those cases. The results were the other typed (blended) Basic-prescriptions including Palmul-tang(八物湯), Sipjeondaebo-tang(十全大補湯), Yukgunja-tang(六君子湯), Bojungyikkee-tang(補中益氣湯), SsangHwa-tang(雙和湯), and Gwibitang(歸脾湯). And I investigated about pathologies in connection with these Basic-prescriptions. Oriental Medical Pathology applied with these Basic-prescriptions were Giheo(氣虛), hyulheo(血虛), Gihyulguheo(氣血俱虛), Biheohan(脾虛寒), Giheo-dameum(氣虛痰飮), Giheohaham(氣虛下陷), Sineumheo(腎陰虛), etc. These results indicated that 123 prescriptions in high-chepter from Bang-Yak-Hap-Pyun are composed of Bojei(補劑) to treatment against many kinds of Infirmity and promote physiological function.

Determination of Fucosterol in the Marine Algae Pelvetia siliquosa by Gas Chromatography

이상현,이연실,Sang Hoon Jung,Hye Seung Lee,Sam sik Kang,Kuk Hyun Shin 한국생약학회 2004 Natural Product Sciences Vol.10 No.1

A new method for the quantitative determination of fucosterol in the marine algae Pelvetia siliquosa by gas chromatography was established. A HP-1 column programmed as 200oC (5 min) → 5/min → 280oC (10min) was developed. The analysis of fucosterol in P. siliquosa was successfully carried out within 30 min.

쌀 생산 및 소비에 따른 지역 간 청색 가상수 흐름 추정을 통한 지역 수자원의 기여도 분석

이상현,최진용,유승환,김윤형,Lee, Sang-Hyun,Choi, Jin-Yong,Yoo, Seung-Hwan,Kim, Yoon Hyung 한국농공학회 2016 한국농공학회논문집 Vol.58 No.1

The aim of this study is to analyze the contribution of regional water resources through the gap between water used for rice production and water used for consumption. The blue water use for rice production and for consumption was quantified and the regional blue water flows were estimated using the virtual water concept from 1995 to 2010. About $1134.4Mm^3/yr$ of blue water flowed among the provinces and metropolises of Korea, and about 28.5 % of total blue water flows came from Jeonnam province. In addition, blue water usage for rice was classified into three categories: water for production, internal consumption, and overproduction in each region. In Jeonnam, $633.8Mm^3/yr$ of blue water totally used for rice production, and 50.9 % and 15.5 % were used for external and internal rice consumption, respectively. The other 33.6 % was used for over production of rice for food security. This study assumed the blue water flows depended on the gap between virtual water use for rice production and consumption. However, the analysis of regional blue water usage and flows might show the importance of other region's water resources, and make policy decision-makers aware of the integrated water management among the regions.

평균역학고도장과 인공위성고도계 자료를 이용한 동해 표층해류 추산

이상현,변도성,최병주,이은일,Lee, Sang-Hyun,Byun, Do-Seong,Choi, Byoung-Ju,Lee, Eun-Il 한국해양학회 2009 바다 Vol.14 No.4

인공위성 고도계로 측정한 해수면 높이 자료를 사용하여 준 실시간 동해 표층해류를 추정하기 위해, 세 가지 방법으로 평균 역학지형(또는 평균 해류장)을 계산하고 각각의 특징들을 살펴보았다. 프랑스 AVISO(Archiviing, Validation and Interpretation of Satellite Oceanographic data)는 인공위성 고도계 자료와 수치모델을 이용하여 전 지구 해양에 대하여 수평적으로 $0.25^{\circ}$의 해상도를 갖는 평균 역학지형을 계산하고 지형류 방정식을 적용하여 평균 해류장을 만들어 제공하고 있다. 동해에서 장기간 관측한 수온과 염분 자료를 사용하여 500 dbar를 기준면으로 사용한 역학적 해면(steric height)을 계산하고 이를 평균 여각지형으로 환산하였다. 또한 14년 동안 동행의 표층을 이동한 표층뜰개들(ARGOS)의 궤적을 이용하여 평균 해류장을 구하였다. 인공위성 고도계로 관측한 해수면 편차와 세 가지 평균 역학지형을 합하여 절대 역학지형을 얻고, 각각의 절대 역학지형에 지형류 방정식을 적용하여 세 가지 표층해류를 추정하였다. 각 방법으로 추정된 표층해류를 2005년에 동해 남서부 해역에서 선박장착 초음파 해류계(ADCP)로 관측한 해류 자료와 정량적으로 비교하였다. 육지에서 50 km 이상 떨어진 해역에서는 인공위성 고도계로 측정한 해수면 자료에 지형류 방정식을 적용하여 구한 표층해류와 현장 관측 해류의 상관계수(R)가 0.58~0.73이며 두 자료의 제곱 평균 제곱근 편차(Root Mean Square Deviation, RMSD)는 $17.1{\sim}21.8cm\;s^{-1}$이다. 육지에서 50 km 이내의 연안에서 두자료의 R이 0.06~0.46로 상대적으로 낮고 RMSD는 $15.5{\sim}28.0cm\;s^{-1}$이다. 이처럼 연안에서는 인공위성 고도계로 관측한 해수면 높이 자료의 오차가 크므로 향후 연안에 대해서는 새로운 표층해류 추정 방법에 대한 추가 연구가 필요하다. In order to estimate sea surface current fields in the East Sea, we examined characteristics of mean dynamic topography (MDT) fields (or mean surface current field, MSC) generated from three different methods. This preliminary investigation evaluates the accuracy of surface currents estimated from satellite-derived sea level anomaly (SLA) data and three MDT fields in the East Sea. AVISO (Archiving, Validation and Interpretation of Satellite Oceanographic data) provides a MDT field derived from satellite observation and numerical models with $0.25^{\circ}$ horizontal resolution. Steric height field relative to 500 dbar from temperature and salinity profiles in the East Sea supplies another MDT field. Trajectory data of surface drifters (ARGOS) in the East Sea for 14 years provide another MSC field. Absolute dynamic topography (ADT) field is calculated by adding SLA to each MDT. Application of geostrophic equation to three different ADT fields yields three surface geostrophic current fields. Comparisons were made between the estimated surface currents from the three different methods and in-situ current measurements from a ship-mounted ADCP (Acoustic Doppler Current Profiler) in the southwestern East Sea in 2005. For offshore areas more than 50 km away from the land, the correlation coefficients (R) between the estimated versus the measured currents range from 0.58 to 0.73, with 17.1 to $21.7\;cm\;s^{-1}$ root mean square deviation (RMSD). For coastal ocean within 50 km from the land, however, R ranges from 0.06 to 0.46 and RMSD ranges from 15.5 to $28.0\;cm\;s^{-1}$. Results from this study reveal that a new approach in producing MDT and SLA is required to improve the accuracy of surface current estimations for the shallow costal zones of the East Sea.

식품 소비 및 칼로리 공급 변화에 따른 가상수 소비량의 변화 분석

이상현,최진용,유승환,Lee, Sang-Hyun,Choi, Jin-Yong,Yoo, Seung-Hwan 한국농공학회 2015 한국농공학회논문집 Vol.57 No.3

The agricultural water management generally has focused on water resources for crop production but it could be affected by the food consumption pattern. The aim of this study is to estimate virtual water consumption for food consumption and calorie supply using the water footprint and virtual water concept. In addition, we estimated the virtual water requirements for increasing the food and calorie self-sufficiency adjusted by the government for food security. About $330.0m^3/cap/yr$ of virtual water was consumed for the main foods consumption in 1985, and it was increased to $450.0m^3/cap/yr$ in 2010. The rate of virtual water consumption by meats consumption was 28 % in 1985 but it was increased to 54 % in 2010. In other words, the total virtual water consumption by foods consumption was increased from 1985 to 2010 with the high rate of meats consumption. The average $1.29m^3$ of virtual water was consumed for supplying 1 calorie per capita in 2010 but about $10.1m^3/cal$ of virtual water was consumed by only bovine meats consumption. The food self-sufficiency is the main factor for food security in Korea. About $46.5Mm^3$ and $393.9Mm^3$ of virtual water were required in order to increase the food and calorie self-sufficiency of wheat by 1 % individually. This study showed the water consumption was related to food consumption and calorie supply pattern, and these results could be used as the indices for the agricultural water management considering the change of eating habit and food security.

한국의 축산물 물발자국 산정

이상현,최진용,유승환,김영득,신안국,Lee, Sang-Hyun,Choi, Jin-Yong,Yoo, Seung-Hwan,Kim, Young Deuk,Shin, Ankook 한국농공학회 2015 한국농공학회논문집 Vol.57 No.2

Since the consumption of the livestock products increased for the past 10 years in Korea, the water use for live animals has become more important in terms of water savings. Therefore, the index connecting water use and livestock products consumption should be required for sustainable water management, and water footprint concept could be suggested as the index. The aim of this study is to estimate the water footprint for livestock products; beef cattle, swine, and broiler chicken. The water footprint for livestock products is divided into direct and indirect water. The direct water includes the drinking and servicing water, and the indirect water includes the water for the cultivation of feed crops. The water footprint of beef cattle was calculated to $17,023.1m^3/ton$, and direct water was $91.2m^3/ton$, and indirect water was $16,931.9m^3/ton$. The water footprint of swine was calculated to $4,235.8m^3/ton$, and direct water was $129.7m^3/ton$, and indirect water was $4,106.0m^3/ton$. The water footprint of broiler chicken was calculated to $2,427.7m^3/ton$, and direct water was $7.6m^3/ton$, and indirect water was $2,420.1m^3/ton$. Also, we compared the water footprint to water demand of water vision 2020 which is the main report for national water management. The water vision 2020 reported only direct water for live animal, but the water footprint includes the direct and indirect water. Therefore, the water footprint could be applied to various fields relating water and food.