http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
다양한 친수성 고분자를 이용한 삼중층 정제의 니페디핀 서방화 및 특성분석
이천중(Cheon Jung Lee),하현정(Hyun Jung Ha),김수영(Su Young Kim),박진영(Jin Young Park),장나금(Na Keum Jang),송정은(Jeong Eun Song),강길선(Gilson Khang) 한국고분자학회 2015 폴리머 Vol.39 No.5
니페디핀은 고혈압 치료제로 쓰이는 약물로 난용성이기 때문에 용출률의 개선이 필요한 약물이다. 또한 반감기가 1.5~2시간 정도로 짧기 때문에 약물방출을 서방화시킬 필요성이 있다. 본 연구에서는 니페디핀의 약물 방출을 조절하기 위하여 다중층 정제를 통한 24시간 방출제어를 목표로 하였다. 다중층 정제는 윗층과 아래층 그리고 가운데층의 세층으로 이루어지며 윗층과 아래층은 gel-forming 고분자를 이용하여 방출조절을 시도하였다. 가운데 층은 니페디핀의 용출률 향상을 위해 니페디핀과 폴리비닐프롤리돈 K30의 고체분산체를 제조하여 사용하였다. 고체분산체 분석을 위한 SEM, XRD 그리고 DSC분석을 실시하였으며, 인공장액(pH 6.8)에서 생체 외 용출거동을 24시간동안 실시하였다. 실험 결과, 여러 종류의 친수성 고분자 종류 중 하이드록시프로필 메틸셀룰로스 K15M을 사용한 니페디핀 삼중층 제형이 가장 좋은 서방형 패턴과 용출률을 확인할 수 있었다. 이를 통해 니페디핀의 서방화 가능성을 확인할 수 있었다. Nifedipine is mainly used for treatment of antianginal (especially in Prinzmetal’s angina) and antihypertensive. However, it is needed to improve the dissolution rate because it is poorly water-soluble drug. Nifedipine needs the sustained release formulation due to its short half-life of 1.5~2 h. Therefore, the purpose of this study is to control the burst release of nifedipine through the multi-layer as three layers formulation for 24 h. Upper and bottom layers consisted of gel-forming polymers as release controlling agent, and the middle layer was prepared by nifedipin-PVP K30 solid dispersion. The prepared solid dispersion was analyzed by SEM, XRD and DSC. The prepared multi-layer tablet was characterized by swelling assays. The release behavior of nifedipine from the multi-layer tablet was confirmed through in vitro assay (pH 6.8). It was confirmed that the nifedipine three-layered tablet using hydroxypropylmethyl cellulose (HPMC) K15M showed the best of sustained pattern and dissolution behavior.
변동비반영 발전경쟁시장에서 LNG-복합 화력발전소의 경제성 분석에 관한 연구
李天豪(Cheon-Ho Lee),韓錫萬(Seok-Man Han),鄭求亨(Koo-Hyung Chung),姜東周(Dong-Ju Kang),金發鎬(Balho H. Kim) 대한전기학회 2008 전기학회논문지 Vol.57 No.8
Since Cost Based Pool markets has been continued to power markets, Genco. needs economic analysis about investment in power plants. Particularly most Private Genco.s have presently a construction plan about LNG combined cycle thermal power plants. In this paper, we propose a economic analysis method of LNG combined cycle thermal power plants using Economic Dispatch and Optimal Power Flow in CBP markets. Also we develope computation model using it for decision making to build a plant. This method can consider a variation of power facility like power plants and transmission lines in CBP markets. Finally, this dissertation provides a relevant case study to confirm the effect of cost factor to economical efficiency.
2009년 12월 11일 한양대학교 법학연구소 학술대회 : 「주요법 개정의 현황과 문제점」-민법, 형법, 상법, 개정의 쟁점과 관련하여- ; 재산범죄 분야의 개정에 관한 소고
이천현 ( Cheon Hyun Lee ) 한양대학교 법학연구소 2010 법학논총 Vol.27 No.1
Korean Criminal Law was revised eight times so far this year since it was established in 1953. Criminal Law Revisions in the field of crimes against property were three times: the third revision (1995), the fifth revision (2002) and the seventh revision (2005). In this way, it`s rare to revise crimes against property in Criminal Law. The object of this study is the field of crimes against property in Particulars of Criminal Law. But, in order to limit the range of the discussion, it is not be studied all regulations of the field of crimes against property individually but be studied only some regulations that intimately connected to one another in the field of crimes against property. This study considers the trend of the Criminal Law revision(Ⅱ) and proposes developmental strategies of the Criminal Law revision from now on(Ⅲ). The efforts for the total revision of the Criminal Law still exists. The government (Ministry of Justice) and the relevant academic societies pull out all the stops to revise the Criminal Law. It is expected to be proposed Criminal Law Revision Draft(a government bill) that is the fruit of their efforts before long.
제3차 대한간학회 춘계학술대회 초록집 : Holmium-166 macroaggregate의 경피적 종양내주입에 의한 원발성 간암의 치료
이천균 ( Lee Cheon Gyun ),한광협 ( Han Gwang Hyeob ),이종태 ( Lee Jong Tae ),최원 ( Choe Won ),이관식 ( Lee Gwan Sig ),전재윤 ( Jeon Jae Yun ),문영명 ( Mun Yeong Myeong ),박경배 ( Park Gyeong Bae ) 대한간학회 1997 Clinical and Molecular Hepatology(대한간학회지) Vol.3 No.2(S)