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청소년의 경계선 성격장애 성향이 사이버폭력 가해 행동에 미치는 영향: 정신화 능력의 매개효과
황나리 ( Nari Hwang ),송현주 ( Hyunjoo Song ) 사단법인 아시아문화학술원 2021 인문사회 21 Vol.12 No.3
본 연구는 청소년의 경계선 성격장애 성향과 사이버폭력의 가해 행동의 관계에서 정신화 능력의 매개효과를 검증하고자 하였다. 이를 위해 서울 소재의 고등학교에 재학 중인 450명의 청소년을 대상으로 경계선 성격특성 척도, 정신화 능력 척도, 사이버폭력 척도를 사용하여 설문을 실시하였다. 분석 방법으로는 중다회귀분석과 매개효과분석을 적용하였고 결과는 다음과 같다. 청소년의 경계선 성격장애 성향은 사이버폭력에 유의한 영향을 미치는 것으로 나타났고, 경계선 성격장애 성향과 사이버폭력의 관계를 정신화 능력이 부분 매개하는 것으로 나타났다. 본 연구는 청소년을 대상으로 하는 심리치료 장면에서 정신화 능력의 중요성을 제고하고 사이버폭력의 감소를 다루는 프로그램을 개발하는데 기초자료를 제공할 수 있을 것으로 기대한다. This study aimed to examine mediating effects of mentalization on the relation between BPD features and cyberbullying in adolescent. Data were collected 450 student’s response from a high school in Seoul to the PAI-BOR Features Scale, MZQ and the survey of cyberbullying. Stepwise regression and the mediating effect testing as the analysis. As a results, BPD features had a significant effect on cyberbullying and mentalization partially mediated the relation. This study supports professionals in developing programs and interventions preventing cyberbullying.
황나래,권민영,차재봉,정수월,우제문 대한안과학회 2016 Korean Journal of Ophthalmology Vol.30 No.6
Purpose: To investigate the production of long pentraxin 3 (PTX3) in response to tunicamycin-induced endoplasmicreticulum (ER) stress and its role in ER stress-associated cell death, PTX3 expression was evaluatedin the human retinal pigment epithelial cell line, ARPE-19. Methods: PTX3 production in ARPE-19 cells was analyzed in the absence or presence of tunicamycin treatmentby enzyme-linked immunosorbent assay. PTX3 protein and mRNA levels were estimated using western blotanalysis and real-time reverse transcription-polymerase chain reaction, respectively. Protein and mRNA levelsof CCAAT-enhancer-binding protein homologous protein (CHOP) and ARPE-19 cell viability were measuredin the presence of tunicamycin-induced ER stress in control or PTX3 small hairpin RNA (shRNA)-transfectedARPE-19 cells. Results: The protein and mRNA levels of PTX3 were found to be significantly increased by tunicamycin treatment. PTX3 production was significantly decreased in inositol-requiring enzyme 1α shRNA-transfected ARPE-19 cells compared to control shRNA-transfected cells. Furthermore, pretreatment with the NF-kB inhibitorabolished tunicamycin-induced PTX3 production. Decreased cell viability and prolonged protein and mRNAexpression of CHOP were observed under tunicamycin-induced ER stress in PTX3 shRNA transfected ARPE-19 cells. Conclusions: These results suggest that PTX3 production increased in the presence of tunicamycin-inducedER stress. Therefore, PTX3 could be an important protector of ER stress-induced cell death in human retinalpigment epithelial cells. Inositol-requiring enzyme 1α and the NF-kB signaling pathway may serve as potentialtargets for regulation of PTX3 expression in the retina. Therefore, their role in PTX3 expression needs to befurther investigated.
프로선수 및 일반인의 승마 운동시, 회복시의 심박수 변화 비교
황나리(Hwang, Na-Ri),황영식(Hwang, Young-Shik),최대혁(Choi, Dai-Hyuk),소위영(So, Wi-Young) 한국체육과학회 2017 한국체육과학회지 Vol.26 No.3
This study investigated the change in heart rate during exercise and the recovery phase after horseriding exercise. Additionally, it provides basic data for exercise prescriptions by analyzing the difference between professional and amateur horse riders. The subjects of this study included 21 participants (11 professional and 10 amateur horse riders). The heart rate was measured 11 times for 1-minute durations at rest 1, 2, 3, 4, and 5 minutes of horse-riding, and 1, 2, 3, 4, and 5 minutes of recovery phase. In statistical analysis, repeated measure analysis of variance and independent t-test were conducted. The level of significance was set at 0.05. Both professional and amateur horse riders, in time effect, showed a significant increase in heart rate for 5 minutes of horse-riding every minute, and showed a significant decrease during the recovery phase (F=29.923, p<.001). However, there was no significant group effect difference of the overall pattern of change between professional and amateur horse riders (F=1.006, p=.497). Nevertheless, there was a significant difference between professional and amateur horse riders in interaction effect (time x group) (F=8.204, p=.009). The result of the post-hoc test is as follows. There was no significant difference in resting heart rate before horse-riding between professional and amateur horse riders (t=.458, p=.652). However, amateur horse riders showed a statistically higher heart rate compared with professional riders from 5 minutes of the exercise phase to 1 minute of recovery phase (p<.05). There was no significant difference in heart rate between professional and amateur horse riders from 2 minutes of recovery phase to the 5 minutes of recovery phase (termination of experiment) (p>.05). In conclusion, it is assumed that the change of heart rate results from the psychological tension rather than from the exercise itself, leading to rapid decrease of heart rate within 5 minutes after finishing horse-riding, as the effect of psychological tension is removed. We hope that more systematic studies about the intensity of horse-riding exercise are followed.
Leukemic Pleural Effusion in Acute Promyelocytic Leukemia: A Case Report
황나래,노숭기,함지연,서장수 대한진단검사의학회 2018 Laboratory Medicine Online Vol.8 No.1
In patients with acute myeloid leukemia (AML), pleural effusion may be attributed to various factors, including infection, hypoalbuminemia, and renal failure. However, leukemic infiltration of the pleural fluid is rarely reported and poorly understood. Extramedullary diseases have been reported with increasing frequency as the survival rates of patients with AML have increased. However, the reported prognostic effects of leukemic pleural effusion in patients with AML range from none to a worse prognosis. Here, we report a case of acute promyelocytic leukemia (APL) in a patient exhibiting leukemic pleural effusion with fluorescence in situ hybridization (FISH) results indicating the presence of the PML-RARA fusion gene. A 52-year-old man presented with pancytopenia, dyspnea, and fever. He had a medical history of hypertension, end-stage renal disease, and hepatitis B virus-related liver cirrhosis. A peripheral blood smear revealed the presence of multiple abnormally hypergranular promyelocytes. White blood cell differential counts were not performed due to severe pancytopenia. A bone marrow examination, immunophenotyping analysis, and cytogenetic and molecular studies revealed APL. The patient was treated with all-trans retinoic acid immediately after abnormal promyelocytes were observed in the peripheral blood smear, but induction chemotherapy was delayed because of his poor condition. His persistent dyspnea and abdominal discomfort led to a thoracentesis and the observation of abnormal promyelocytes that were positive for PML-RARA fusion gene by FISH. To our knowledge, this is the first report of leukemic pleural infiltration with PML-RARA fusion gene-positivity via FISH.
황나래,김유경,서장수 대한진단검사의학회 2019 Laboratory Medicine Online Vol.9 No.3
Background: Here we investigated the clinical utilities of blast suspect, large unstained cell (LUC), delta neutrophil index ll (DN ll), and delta neutrophil index l (DN l), analyzed in peripheral blood samples with automated hematology analyzers to predict the relapse of acute leukemia. Methods: We retrospectively reviewed the medical records of 112 patients, including 56 patients with acute leukemia relapse and 56 controls. Blast suspect, LUC, DN ll, and DN l were compared between the control and leukemia relapse groups. Results: Significant differences in blast suspect (P<0.001), LUC (P<0.001), DN ll (P<0.001), and DN l (P=0.002) were observed between the leukemia relapse and control groups. The areas under the curve (AUC) value was 0.927 for blast suspect (95% confidence interval [CI]: 0.8750.978, P<0.001), 0.868 for LUC (95% CI: 0.794–0.941, P<0.001), and 0.900 for DN ll (95% CI: 0.841–0.960, P<0.001). Logistic regression analysis for the prediction of leukemia relapse revealed odds ratio values of 1.52 (95% CI: 1.26–1.96, P=0.0002) for blast suspect, 1.66 (95% CI: 1.27–2.42, P=0.0019) for LUC, 1.16 (95% CI: 1.08–1.29, P=0.0014) for DN ll, and 1.05 (95% CI: 1.01–1.13, P=0.0845) for DN l. Conclusions: Multiple parameters provided by automated blood cell analyzers may serve as powerful ancillary tools for the prediction and diagnosis of leukemia relapse.