디지털 기억과 바쿠의 <마할라 프로젝트>: 노스탤지어와 스펙타클을 넘어

황기은 한국슬라브․유라시아학회 2023 슬라브학보 Vol.38 No.4

본고는 21세기 바쿠 스펙타클이 만든 환상과 폭력에 맞서 일상의 기억을 보존하고 새로운 도시를 재창조하는 <마할라 프로젝트>를 살펴보고, 스펙타클에 대한 저항 가능성을 탐구해보고자 한다.<마할라 프로젝트>는 바쿠의 일상적 풍경과 네트워크를 기록한 디지털 스토리텔링 프로젝트로, 디지털 매핑 기술과 인터랙티브 디자인을 활용하여, 노스탤지어나 폐허의 미학을 넘어 사용자가 장소에 대한 기억을 나열하고 재창조하는 데 적극적으로 참여하도록 유도한다. 이를 통해 국가의 폭력적인 사업 하에 동질화된 도시 바쿠 공간을 사회적으로, 미학적으로, 정치적으로 재고하고 디지털 공간에서의 도시 기억의 보존에 대해 논의하고자 하며, 탈소비에트 도시의 역사와 기억의 형태에 하나의 대안을 제시한다.

microRNA-144 expression overcomes resistance to EGFR-tyrosine kinase inhibitors in EGFR mutant lung cancer cells by targeting survivin

황기은,조경화,김학렬,정은택 대한결핵 및 호흡기학회 2015 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.120 No.-

Objectives: The emergence of drug resistance in cancer patients limits the success rate of clinical chemotherapy. MicroRNAs may play a role in chemoresistance and may be involved in modulating some drug resistance-related pathways in cancer cells. In this study, we hypothesized that microRNA-survivin interaction was involved in resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in non-small cell lung cancer (NSCLC) cells. We focused on the effect of altered expression of microRNAs on EGFR-TKI resistance in EGFR-TKI-resistant cell lines. Methods: We performed a microarray analysis to identify microRNAs whose expression level was altered in EGFR-TKI-resistant cells. We confirmed the altered expression of miR144-3p, which was predicted to target survivin, in EGFR-TKI-resistant cells by quantitative real-time PCR, using the HCC827, HCC827GR, and H1975 NSCLC cell lines. Results: Expression of miR144-3p in EGFR-TKI-resistant cell lines reversed EGFR-TKI chemoresistance through enhancing apoptosis by modulating survivin expression. Luciferase reporters containing the 3`` untranslated region of survivin mRNA were used to demonstrate that miR144-3p could directly target survivin. We observed an inverse correlation between the expression levels of miR144-3p and survivin mRNA. Conclusions: Targeting the miR144-3p/survivin interaction is a potential strategy for reversing chemoresistance in NSCLC.

Automatic Pulmonary Nodule Detection using Mobility Characteristics and Area Pattern via Pixel Object Tracking

황기은,조경화,김학렬,정은택,이진석 대한결핵 및 호흡기학회 2015 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.120 No.-

Objectives: A mobility and shape pattern analysis with successive chest CT image slices is proposed to automatically detect pulmonary nodules or masses as objects. Our target is to detect the objects corresponding to nodules or masses with the size between 3-30mm from each slice of lung CT. Methods: The nodule/mass object detection algorithm is applied to each slice of CT images and each detected object is assigned with different ID. The detected objects are profiled with mobility and shape and tracked in the next slices with the ID assignment. From the three steps of mobility, cross-correlation and TPR (Turning Point Ratio), the nodule/mass is finally chosen. Results: In 58 CT images, we have totally detected 50,023 objects (134 nodules, 49889 non-nodules). By applying mobility characteristic and area pattern algorithm, we detected 133 nodules and 127 non-nodules (false positives) as nodule candidates. We achieved 99.25% sensitivity with only 2.19 false positives per scan based on the Lung Image Database Consortium (LIDC). Conclusions: Our proposed method shows significantly high sensitivity with reduce false positives.

F-71 SRSF5: a novel marker for small-cell lung cancer and pleural metastatic cancer

황기은,김학렬,박도심,조재삼,정은택 대한결핵 및 호흡기학회 2016 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.121 No.-

Background: We evaluated SRSF 5-7 protein levels in lung cancer (LC) and their diagnostic potential for cancer cells in lung and pleural effusion (PE) and, for the dysregulated SRSFs, investigated their neutralization effect on LC. Methods: SRSF 5-7 levels in lung tissue and PE cell lysate samples (n = 453) were compared with the results of conventional tumor markers. Knockdown of SRSF gene expression was performed using siRNAs on small-cell LC (SCLC) cell lines. Results: In lung tissue analysis, SRSF 5-7 levels were up-regulated in LC samples compared with non-tumoral lung tissue samples; they were markedly higher in SCLC than in adenocarcinoma or squamous cell carcinoma. SRSF5 showed the highest detection accuracy (89%) for total LC, and it was superior to that (74%) of CEA, NSCLC marker. Notably, the detection accuracies of the three SRSFs for SCLC were all 100% and higher than that (69%) of pro-GRP, SCLC marker. In PE cell analysis, the detection accuracy (86%) of SRSF5 for malignant cells was highest among SRSFs and comparable to that (83%) of CEA. SRSF5 additionally detected 70% of CEA-missed non-NSCLC cases. Down-regulation of the SRSFs induced mild (SRSF5 andSRSF7) to remarkably (SRSF6) reduced cell proliferation. Conclusions: The up-regulated expression of SRSF 5-7 proteins in LC with much more profound up-regulation in SCLC than in NSCLC and suggest that up-regulation of the SRSFs is related to SCLC proliferation. Moreover,we identified SRSF5 as a novel detection marker for SCLC and pleural metastatic cancer cells.

Diagnostic Value of YKL-40 and YKL-39 Levels in Tuberculous Pleural Effusion

황기은,김학렬,김휘정,정은택 대한결핵 및 호흡기학회 2011 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.112 No.-

TP-33 : Thematic Poster ; Absolute Eosinophils Count as a Marker of Mortality in Patients Admitted to Intensive Care Unit

황기은,정은택,김학렬 대한결핵 및 호흡기학회 2013 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.116 No.-

Background: Inflammatory markers may have a role in predicting severity of illness of intensive care unit (ICU) patients. The reduction in the number of eosinophils may be linked to the action of inflammatory cytokine. The aim of the study was to evaluate the absolute eosinophils count as a marker of mortality in patients admitted to intensive care unit. Methods: We retrospectively evaluated 28-day mortality and identified risk factors for 28-day mortality in consecutive patients admitted to the ICU. Daily eosinophils count and C-reactive protein (CRP) in all patients was analyzed. Results: A total of 122 patients were included in the study. The median age was 69.2 years. Overall 28-day mortality was 27.8% (n=34). At discharge, the significant differences were found in eosinophils count collected between survivors and nonsurvivors (260 vs 55, p<0.05). When the eosinophils counts at discharge was assessed, an area under the curve (AUC) of 0.41 (95% confidence interval, 0.30-0.51 was observed. However, CRP at discharge showed an AUC of 0.78 (95% confidence interval, 0.69-0.86). Conclusion: Eosinophils count were lower in nonsurvivors admitted to ICU, but its clinical usefulness seems limited in comparison with CRP.Background: Inflammatory markers may have a role in predicting severity of illness of intensive care unit (ICU) patients. The reduction in the number of eosinophils may be linked to the action of inflammatory cytokine. The aim of the study was to evaluate the absolute eosinophils count as a marker of mortality in patients admitted to intensive care unit. Methods: We retrospectively evaluated 28-day mortality and identified risk factors for 28-day mortality in consecutive patients admitted to the ICU. Daily eosinophils count and C-reactive protein (CRP) in all patients was analyzed. Results: A total of 122 patients were included in the study. The median age was 69.2 years. Overall 28-day mortality was 27.8% (n=34). At discharge, the significant differences were found in eosinophils count collected between survivors and nonsurvivors (260 vs 55, p<0.05). When the eosinophils counts at discharge was assessed, an area under the curve (AUC) of 0.41 (95% confidence interval, 0.30-0.51 was observed. However, CRP at discharge showed an AUC of 0.78 (95% confidence interval, 0.69-0.86). Conclusion: Eosinophils count were lower in nonsurvivors admitted to ICU, but its clinical usefulness seems limited in comparison with CRP.

1995년 제 34 차 대한소화기학회 추계학술대회 / 포스터전시 : 간 및 위장관계를 침범한 특발성 과호산구 증후군 1예

황기은,금주섭,박창영,김병익,김향,김명숙,정을순,이상종 대한소화기학회 1995 대한소화기학회 추계학술대회 Vol.1995 No.-

원발성 폐암 환자에서 항암제에 의해 발생한 위막성 대장염 1례

황기은,황의태,임윤혁,조향정,박정현,박성훈,김학렬,양세훈,정은택 대한결핵 및 호흡기학회 2006 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.103 No.-

Prognosis of Lung Cancer Patients Admitted to the Medical Intensive Care Unit

황기은,김학렬,정은택 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.-

Introduction: Lung cancer remains the leading cause of cancer mortality worldwide. Despite lung cancer`s poor prognosis, lung cancer patients are increasingly admitted to medical intensive care unit (MICU) for critical illness. The aim of the this study was to assess the outcome of lung cancer patients who admitted to a MICU and to identify the measurable predictors of their MICU outcome. Methods: We retrospectively evaluated MICU outcomes and identified risk factors for MICU mortality in consecutive patients with lung cancer admitted to the MICU between 2007 and 2012. A total of 105 lung cancer patients were included during the study period. The mean age±SD at MICU admission was 71.2±8.6 yrs (85% males, 15% females). Of 105 included patients, 78 had non-small cell lung cancer. Extensive disease (NSCLC stage III, IV, disseminated small cell lung cancer) was diagnosed in 98 patients (93%). The MICU mortality was 62% (64 patients). The main reasons for MICU admission were acute respiratory failure (60%). Results: The independent predictors of poor MICU outcome were: diabetes mellitus on past history (p=0.025); Acute Physiology And Chronic Health Evaluation III (p=0.012); the need for mechanical ventilation (p=0.012); the use of vasopressor (p=0.000); complication of ARF (p=0.003), presence of multiorgan failure (p=0.000). Conclusions: We found that MICU mortality was not influenced by the type and stage of lung cancer but increased with the severity of the organ failure at MICU admission.

F-96 Can be a prognostic factor in pulmonary adenocarcinoma by measuring attenuation change through CAD system?

황기은,김학렬,조재삼,정은택 대한결핵 및 호흡기학회 2016 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.121 No.-

Background: In this study, we proposed computer aided medical image diagnosis system (CAD) using the image segmentation, feature extraction and registration for CT image to detect and analyze the patient`s lung mass. We analyzed the prognostic significance of attenuation change through CAD system in overall survival (OS). Method: Pulmonary adenocarcinoma patients diagnosed in Wonkwang University Hospital were analyzed. All cases underwent lung mass detection both by the simple spiral CT scan and by the CAD system, respectively. We quantified attenuation change of lung mass through the CAD system. Results: Totally, 94 patients were analyzed. Median value of attenuation change was 67.2±18.19 % (range,15.2-98.1%). Attenuation change was significantly associated with advanced stage (p=0.02). Over the follow-up period, 75 patients (79.8%) died, and median OS was 13.0 months (95% CI, 9.1-16.8 months). Patients with attenuation change < 70% showed significantly poorer OS than patients with attenuation change ± 70% (8.3 vs. 15.1 months; p=0.031 by the log-rank test). Conclusions: Lower attenuation change through CAD system, was found to be associated with poor prognosis in patients with advanced adenocarcinoma. Furthermore, our findings suggest attenuation change could be used to better predict prognosis in advanced adenocarcinoma.