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RISS 인기검색어
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- 저자 : 현진해(Jin Hai Hyum) (검색결과 4 건)
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송치욱(Chi Wook song),구양서(Yang Suh Koo),이홍식(Hong Sik Lee),이상우(Sang Woo Lee),최재현(Jai Hyun Choi),김창덕(Chang Duck Kim),류호상(Ho Sang Ryu),현진해(Jin Hai Hyum) 대한소화기학회 1995 대한소화기학회지 Vol.27 No.4
N/A Background/Aims: Recently the esophagus is considered a major source of recurrent noncardiac chest pain to patients in whom exercise stress test and/or cardiac catheterization have excluded a cardiac etiology. To investigate the esophageal origin of noncardiac chest pain, esophageal motility tests including manometry, provocation test, and radioisotope esophahgeal transit study(RETS) were studied in patients with noncardiac chest pain. Methods: A total of l26 patients with noncardiac chest pain were assessed;they included 41 patients with normal coronary angiogram and 85 patients with normal noninvasive cardiac tests such as echocardiogram and exercise stress test done in Korea University Hospital from Feb. l993 to Aug. 1994. Results: 56 out of 126 patients(44.4%) with noncardiac chest pain had abnormal manometric findings which included 20(35.7%) nonspecific esophageal motility disorder, 17(30.4%) hypertensive lower esophageal sphincter, 9(16.1%) hypo- tensive lower esophageal sphincter, and 2(3.6%) nutcracker esophagus. Thirty eight out of 126(30.1 %) patients had abnormal manometric findings but no reproducible chest pain by provocation test and were considered to have a probable esophageal chest pain. When patients having positives for both provocation tests are counted as a single positive, 39 out of l26(3l /o) patients had their chest pain reproduced and were considered to have a defini(e esophageal chest pain. The combination of patients with definite esophageal chest pain(31%) and probable(30.17c) gave an overall diagnostic yield of 61.1% for our esophageal laboratory. There was no significant difference between invasive cardiac test group and noninvasive cardiac test group in the results of esophageal motility tests. RETS merely reflected the peristaltic abnonnalities with no more informations for esophageal chest pain. Conclusions: These results reveal that esophagus is considered a source of noncardiac chest pain in 61.1%. Provocation test complements esophageal manometry alone and increases diagnostic yield. RETS can be used in diagnosis of noncardiac chest pain accompanied by peristaltic abnormality of the esophagus. (Korean J Gastroenterol 1995;27:381-387)
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Oddi 괄약근 운동기능에 대한 5 - Hydroxytryptamine Type 3 수용체 길항제의 영향
김창덕,진윤태,류호상,현진해 대한소화기학회 1998 대한소화기학회지 Vol.31 No.4
Background/Aims: The sphincter of Oddi motor activity is modulated by multifactorial and various neural and hormonal factors. However, it has not been studied whether 5-HT3 receptor antagonist modulate the sphincter of Oddi motor activity. The aim of this study was to confirm the presence of 5-HT on the sphincter of Oddi and to investigate the role of 5-HT3 receptor antagonist in the regulation of motor activity of the sphincter of Oddi in human using ERCP manometry. Methods: The motor activity of sphincter of Oddi was examined using ERCP manometry before and after intravenous bolus injection of a selective 5-HT3 receptor antagonist (Ondansetron), 8 mg, in 30 study subjects. To confirm the presence of 5-HT in sphincter of Oddi, immunohistochemical stain was done using resected specimen of ampulla of Vater. Results: On immunohistochemical staining, we confirm the expression of 5-HT in the normal duodenal mucosa (16 cells/HPF). Ampullary mucosa showed weakly positive stain for 5-HT using anti 5-HT (1.4 cell/HPF). Basal pressure of the sphincter of Oddi was significantly reduced by injection of ondansetron from 10.7±0.8 to 8.8±0.7 mmHg. Amplitude of phasic contraction was also significantly reduced from 82.9±10.9 to 65.4±10.5 mmHg. Although frequency of phasic contraction was slightly reduced from 3.1±0.6 to 2.5±0.4/min, it was not statistically significant. Conclusions: These findings suggest that 5-HT3 receptor antagonist has inhibitory effects on the sphincter of Oddi motor activity.
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소화성 궤양에서 저용량 Clarithromycin 삼제요법의 Helicobacter pylori 박멸률
이상우,권오상,이구,이홍식,김창덕,진윤태,최재현,엄순호,류호상,전훈재,송치욱,허병원,김광희,현진해 대한소화기학회 1999 대한소화기학회지 Vol.34 No.1
Background/Aims: A clear therapeutic regimen for the optimal treatment of Helicobacter pylori (H. pylori) infection has not emerged. We evaluated the eradication rate and side effects of triple regimen with low-dose clarithromycin (0.5 g/day). Methods: One hundred and one patients with duodenal ulcer (n=72), gastric ulcer (n=19), or combined duodenal and gastric ulcer (n=10) were enrolled. H. pylori infection was assessed by histology and rapid urease test before therapy and 4-6 weeks after finishing the treatment of triple regimen. Patients were treated either with omeprazole 20 mg b.d., amoxicillin 1.0 g b.d. and clarithromycin 250 mg b.d. (OAC; n=66) or with omeprazole 20 mg b.d., metronidazole 500 mg b.d. and clarithromycin 250 mg b.d. (OMC; n=35) for 2 weeks. Follow-up endoscopy was performed on 60 patients (OAC; n=41, OMC; n=19). Side effects were evaluated after completion of therapy. Results: Eradication rate of OAC group was 85.4% and that of OMC group was 78.9%. Side effects were observed in 18.2% of the OAC group and 17.1% of the OMC group. Conclusions: Both triple regimens have low rates of side effects. OAC regimen with low-dose clarithromycin shows slightly higher eradication rate of H. pylori than OMC regimen.
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