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파라쿼트 중독 환자에서 deferoxamine의 치료 효과
허진원 ( Jin Won Huh ),제갈양진 ( Yang Jin Jegal ),홍상범 ( Sang Bum Hong ),오연목 ( Yeon Mok Oh ),심태선 ( Tae Sun Shim ),임채만 ( Chae Man Lim ),이상도 ( Sang Do Lee ),김우성 ( Woo Sung Kim ),김동순 ( Dong Soon Kim ),김원동 ( Won 대한결핵 및 호흡기학회 2007 Tuberculosis and Respiratory Diseases Vol.62 No.2
연구배경: 파라쿼트 중독은 다발성 장기부전과 폐섬유화를 유발하여 높은 사망률을 초래한다. 폐섬유화의 약화를 위해 여러 종류의 면역억제제가 사용되었으나 그 치료효과는 다양하다. 철은 파라쿼트로 유발된 산화 스트레스에 의한 폐손상에 중요한 역할은 한다. 본 연구는 파라쿼트 중독의 치료시 철 킬레이트 제제인 deferoxamine의 효과를 보고자 시행되었다. 방법: 2001년 10월부터 2005년 4월까지 파라쿼트 중독으로 내과계중환자실에 입원한 37명 중 28명이 본 연구에 포함되었다. 환자들은 서울아산병원의 파라쿼트 치료 프로토콜에 따라서 치료되었다. 이 중 12명이 추가로 deferoxamine 투여군으로 무작위 분류되었다. 결과: 두 군간의 성별, 나이, 파라쿼트 중독의 정도, 섭취 후 병원까지의 도착 시간 등은 유의한 차이를 보이지 않았다. 파라쿼트 섭취 후 간기능과 신기능의 변화도 유의한 차이를 보이지 않았다. 전체 사망률은 두 군 간의 차이는 없었으나 deferoxamine 투여군에서 대조군과 비교시 호흡부전의 빈도가 높았다(4/7 versus 0/9, p=0.019). 결론: 파라쿼트 중독 시 본 연구에서 적용된 용량과 기간의 deferoxamine (100mg/kg during 24h)은 치료효과가 없을 것으로 사료된다. Background: Paraquat is known to induce oxidant injury that results in multiorgan failure and lung fibrosis. Iron has been considered to play a key role in paraquat-induced oxidant lung injury. This study examined the effect of deferoxamine, an iron-chelating agent, in the treatment of paraquat poisoning. Methods: From September, 2001 to April, 2005, 28 patients with paraquat poisoning who were admitted at a medical intensive care unit of a University-affiliated hospital, were enrolled in this study. Sixteen patients were treated according to the paraquat poisoning treatment guidelines and 12 received an intravenous infusion of deferoxamine in addition to the treatment guidelines. Results: There were no differences between the two groups in terms of age, gender, severity of paraquat poisoning, and the time elapsed from ingestion to presentation at hospital. There was no difference in overall mortality between the two groups but the incidence of respiratory failure in the deferoxamine group was higher than in the conventional group(4/7 versus 0/9, p=0.019). Conclusion: Deferoxamine seems to have no clinical benefit compared with the conventional treatment. (Tuberc Respir Dis 2007; 62: 113-118)
Ceftizoxime 투약 후 면역용혈빈혈 및 다발장기부전
허진영 ( Jin-young Huh ),안아리 ( Ari Ahn ),김형석 ( Hyungsuk Kim ),권석운 ( Seog-woon Kwon ),안수종 ( Sujong An ),이재용 ( Jae Yong Lee ),권병수 ( Byoung Soo Kwon ),오은혜 ( Eun Hye Oh ),박도현 ( Do Hyun Park ),허진원 ( Jin Won H 영남대학교 의과대학 2017 Yeungnam University Journal of Medicine Vol.34 No.1
Drug-induced immune hemolytic anemia (DIIHA) is a rare side effect of drugs. DIIHA may cause a systemic inflammatory response that results in acute multi-organ failure and death. Ceftizoxime belongs to the class of third generation cephalosporins, which are the most common drugs associated with DIIHA. Herein, we present a case of a 66-year-old man who developed fatal DIIHA after receiving a second dose of ceftizoxime. He was admitted to receive photodynamic therapy. He had a history of a single parenteral dose of ceftizoxime 3 months prior to admission. On the day of the procedure ― shortly after the infusion of ceftizoxime ― the patient`s mental status was altered. The blood test results revealed hemolysis. Oliguric acute kidney injury developed, and continuous renal replacement therapy had to be applied. On the suspicion of DIIHA, the patient underwent plasmapheresis. Diagnosis was confirmed by a detection of drug-dependent antibody with immune complex formation. Although his hemolysis improved, his liver failure did not improve. He was eventually discharged to palliative care, and subsequently died.
급성호흡곤란증후군 환자에서 Soluble Triggering Receptor Expressed on Myeloid Cells-1의 예후인자로서의 유용성
허진원 ( Jin Won Huh ),정훈 ( Hoon Jung ),임채만 ( Chae Man Lim ),고윤석 ( Youn Suck Koh ),홍상범 ( Sang Bum Hong ) 대한결핵 및 호흡기학회 2008 Tuberculosis and Respiratory Diseases Vol.65 No.4
연구배경: Triggering receptor expressed on myeloid cells-1 (TREM-1)은 호중구와 단핵구의 표면에 표현되는 수용체로 호중구가 자극되면 표면에서 떨어져 수용체인 sTREM-1으로 존재하며 염증반응을 증폭시킨다. 본 연구는 호중구의 활성화가 중요한 병인인 급성호흡곤란증후군 환자의 기관지폐포세척액과 혈청에서 측정한 sTREM-1의 농도가 예후인자로서 유용성이 있는지 확인하고자 시행되었다. 방법: 32명의 급성호흡곤란증후군 환자가 포함되었고 이 중 15명이 생존군, 17명이 사망군으로 분류되었다. 중증도 지표로 APACHE II score, Clinical Pulmonary Infection Score (CPIS)를 측정하였고, 기관지폐포세척액과 혈청에서 sTREM-1 농도를 측정하였고 중환자실 사망여부를 확인하였다. 결과: 진단 시 급성호흡곤란증후군 환자의 혈청 내 sTREM-1의 농도는 사망군에서 생존군 보다 유의하게 상승되어 있었으나 (54.3±10.3 pg/ml vs. 22.7±2.3 pg/ml, p<0.05) 기관지폐포세척액 내의 sTREM-1의 농도는 차이가 없었다. 혈청 내 sTREM-1의 농도는 급성호흡곤란증후군 환자의 예후를 예측할 수 있는 독립적인 인자(OR: 22.051, 95% CI: 1.780∼273.146, p=0.016)이었고, 33pg/ml 경계로 분류 시 중환자실 사망률을 예측하는데 71%의 민감도와 93%의 특이도를 보였다. 결론: 급성호흡곤란증후군 환자의 진단 당시 측정한 혈청 sTREM-1의 농도는 중요한 예후 인자로서 유용성이 있을 것으로 생각된다. Background: The triggering receptor expressed on myeloid cells-1 (TREM-1) is an activating receptor that is expressed on the surface of neutrophils and mature monocytes when stimulated with several microbial components, which can amplify the inflammatory response. This study analyzed the prognostic value of the sTREM-1 levels in patients with acute respiratory distress syndrome (ARDS). Methods: The bronchoalveolar lavage (BAL) fluid and blood was collected prospectively from 32 patients with ARDS, 15 survivors and 17 nonsurvivors. An enzyme-linked immunosorbent assay was performed to measure the sTREM-1. The following data was obtained: APACHE II score, Clinical Pulmonary Infection Score (CPIS), BAL fluid analysis, C-reative protein. Mortality in the ICU was defined as the end point. Results: The serum sTREM-1 level was significantly higher in the nonsurvivors than survivors (54.3±10.3 pg/ml vs. 22.7±2.3 pg/ml, p<0.05). The sTREM-1 level in the serum, but not in the BAL fluid, was an independent predictor of the ICU mortality (OR: 22.051, 95% CI: 1.780∼273.148, p<0.016), and a cut-off value of ≥33 pg/ml yielded a diagnostic sensitivity of 71% and specificity of 93%. Conclusion: The serum sTREM-1 level may be a useful predictor of the outcome of ARDS patients. (Tuberc Respir Dis 2008;65:301-307)
호흡부전환자의 재택산소치료 실태: 한 대학병원에서의 관찰
허진원 ( Jin Won Huh ),이정연 ( Jung Yeon Lee ),홍상범 ( Sang Bum Hong ),오연목 ( Yeon Mok Oh ),심태선 ( Tae Sun Shim ),임채만 ( Chae Man Lim ),이상도 ( Sang Do Lee ),김우성 ( Woo Sung Kim ),김동순 ( Dong Soon Kim ),김원동 ( Won D 대한결핵 및 호흡기학회 2005 Tuberculosis and Respiratory Diseases Vol.58 No.2
연구배경 : 최근 국내에서도 만성폐질환을 가진 저산소증 환자에게 재택산소요법이 증가하고 있으나 그 실태는 잘 알려져 있지 않다. 이에 한 대학병원 호흡기내과에서 재택산소요법을 처방 받은 환자들의 실태를 알아보고자 하였다. 방법 : 2000년 1월부터 2003년 8월까지 서울아산병원 호흡기내과에서 재택산소요법을 처방 받은 환자들을 대상으로 의무기록 검토와 설문조사를 시행하였다. 산소를 중단한 4명의 환자는 제외하였다. 결과 : 총 86명의 환자가 산소요법 Background : Although home oxygen therapy in hypoxemic patients with chronic lung disease has been increasing over the decade in Korea, the present state has not been known well. This study was done to know the situation of home oxygen therapy in a Korean
배구선수의 학교급과 경기력 수준에 따른 체력, 유·무산소성 능력 및 배구기능의 비교
허진원(Huh, Jin-Won),정원상(Jung, Won-Sang),이만균(Lee, Man-Gyoon) 한국체육과학회 2017 한국체육과학회지 Vol.26 No.5
This study were designed not only to compare physical fitness, aerobic/anaerobic capacity, and volleyball skills according school level and performance level in volleyball players, but also to aim at providing basic data on necessary and supplementary elements for developing non-excellent athletes into excellent athletes. The subjects of the study consisted of 15 excellent and 11 non-excellent high school volleyball players and 14 excellent and 14 non-excellent collegiate volleyball players. Main results obtained in the present study were as follows: 1) There were significant differences in height, body weight, body mass index, skeletal muscle mass, and percent body fat by school level, but no significant differences by performance level. Chest size did not significantly differ between school levels. 2) Standing long jumps significantly differed between school levels, and sargent jumps significantly differed between performance levels. 3) There were no significant differences in aerobic/anaerobic capacity between school levels except for the power decline index. 4) There were significant differences in volleyball skills between performance levels except for the serve, and significant differences did appear in the serve depending on performance level. The results suggested that high school athletes must improve their body composition, muscular power, aerobic/anaerobic capacity, and over and under pass skills when advancing into collegiate volleyball players, and that non-excellent athletes must improve their sargent jump and volleyball skills in order to develop into excellent athletes.
α-Lipoic acid 후처치가 내독소로 유발된 급성폐손상에 미치는 효과
허진원 ( Jin Won Huh ),홍상범 ( Sang Bum Hong ),김미정 ( Mi Jung Kim ),임채만 ( Chae Man Lim ),고윤석 ( Youn Suck Koh ) 대한결핵 및 호흡기학회 2007 Tuberculosis and Respiratory Diseases Vol.62 No.2
연구배경: 내독소로 유발된 급성폐손상의 발생기전에 산화스트레스가 중요한 역할은 한다. 본 실험은 LPS로 유발한 급성폐손상 모델에서 항산화제인 α-lipoic acid의 치료효과를 보고하였다. 방법: Sprague-Dawley 쥐를 대상으로 LPS (E.coli, 3mg/Kg)를 기도내 주입 후 α-lipoic acid를 복강 내 주입하였다. 2시간, 6시간 후에 폐포세척액에서 호중구수, CINC, 시토카인의 농도를 구하고 폐조직에서 MPO를 측정하였다. 결과: α-lipoic acid를 후처치한 군에서 LPS 단독군보다 2시간 뒤와 6시간 뒤에 총 세포수와 호중구의 수가 감소하였으나 단백질 농도는 차이가 없었다. 또한 염증성 인자인 TNF-α, IL-1ß, IL-6의 농도도 α-lipoic acid 처치군에서 유의한 감소를 보이지 못하였다. 결론: LPS로 급성폐손상 유도 모델에서 α-lipoic acid의 후처치는 폐장내로의 호중구의 침윤은 억제할 수 있지만 급성폐손상을 약화시키지는 못 하였다. Background: Oxidative stress may play an important role in the pathogenesis of endotoxin-induced acute lung injury (ALI). This study evaluated the therapeutic effect of α-lipoic acid, a nonenzymatic antioxidant, in a rat model of lipopolysaccharide (LPS) induced ALI. Materials and Methods: ALI was induced in Sprague-Dawley rats by instilling LPS (E.coli, 3mg/Kg) into the trachea. The rats were classified into the control, control+α-lipoic acid, LPS, and LPS+α-lipoic acid groups. The lung lavage neutrophil count, cytokine-induced neutrophil chemoattractant (CINC), lung myeloperoxidase (MPO), and cytokine concentrations (TNF-α, IL-1ß, IL-6 and IL-10) were measured at 2 h and 6 h after LPS administration. Results: The total cell and neutrophil counts of the LPS+α-lipoic acid groups were significantly lower than the LPS groups. The protein concentration in the BAL fluid was similar in the LPS groups and LPS+α-lipoic acid groups. The TNF-α, IL-1ß, and IL-6 concentrations in the BAL fluid were not decreased by the α-lipoic acid treatment in the LPS treated rats. Conclusions: Although α-lipoic acid decreased the level of LPS-induced neutrophil infiltration into the lung, it could not attenuate the LPS-induced ALI at the dose administered in this study. (Tuberc Respir Dis 2007; 62: 105-112)
좌측 주기관지 근위부에서 발생한 무기폐를 동반한 횡문근 육종의 수술 치료 -1례 보고-
김연수,장우익,허진원,박시영,장선희,박경택,김창영,류지윤,조성준,Kim, Yeon-Soo,Chang, Woo-Ik,Huh, Jin-Won,Park, See-Young,Chang, Sun-Hee,Park, Kyung-Taek,Kim, Chang-Young,Ryoo, Ji-Yoon,Cho, Seong-Joon 대한기관식도과학회 2007 大韓氣管食道科學會誌 Vol.13 No.2
Treatment choice for primary pulmonary sarcoma is complete surgical resection. A 69 year old man developed dyspnea due to left lung atelectasis. There was endobronchial tumor completely obstructing the left main bronchus. The tumor was resected completely by main bronchial resection via a left thoracotomy incision, and diagnosed as leiomyosarcoma. Bronchoscopy and computed tomography in 6 months after operation, there was no evidence of recurrence.
만성폐쇄성폐질환 환자에서 Beraprost sodium의 효과에 대한 연구: 이중 맹검 무작위 임상시험
이상도 ( Sang Do Lee ),서광원 ( Kwang Won Seo ),이정연 ( Jung Yeon Lee ),허진원 ( Jin Won Huh ),최익수 ( Ik Su Choi ),박재선 ( Jae Sun Park ),심태선 ( Tae Sun Shim ),오연목 ( Yeon Mok Oh ),박인원 ( In Won Park ),류왕성 ( Wang Seon 대한결핵 및 호흡기학회 2004 Tuberculosis and Respiratory Diseases Vol.57 No.4