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최준배 대한동의병리학회 1995 동의생리병리학회지 Vol.9 No.2
연구배경 : 지금의 傷寒論 강의는 中國式 辨證에 의한 六經의 분류를 기초로, 湯證과 條文解析에 의지하고 있는 바, 원래 本意를 벗어나 단지 外感病의 轉變과정으로만 생각하고 있는 오류를 범하고 있는 바, 이에 저자는 傷寒論의 三陰三陽을 보다 와벽한 인식을 통한 개념을 정확히 파악하고자 함. 연구방법 : 河圖와 洛書의 이치, 三陰三陽의 各稱과 分析등을 통하여 三陰三陽의 形成背景을 알아보고, 內徑에서의 三陰三陽에 관한 부분을 정리 분석하고, 經絡의 三陰三陽, 運氣의 三陰三陽, 三陰三陽과 六氣와의 관계, 三陰三陽의 氣血多少, 三陰三陽의 標本中, 三陰三陽의 開闔樞, 三陰三陽의 從氣, 傷寒論의 治療槪念등을 제 문헌을 통하여 비교 검토함. 결론 : 지금의 傷寒論은 단지 傷寒의 감기병을 고치는 처방서로만 인식하고 있고 이를 교과목에서 폐지하려는 망상을 가지고 있는 실정은 이를 內徑과 같이 한의학의 근본으로 생각하지 아니하는 우매한 결과인 것이다. 이를 한의학의 임상의 기초로 삼아 질병을 분석하고 이론 및 처방을 발전시키는 것이 지금 한의학을 연구하는 이의 책임이라 여겨진다.
알츠하이머 치매 환자에서의 추체외로 증상과 영역별 인지기능의 연관성
최준배(Junbae Choi),명우재(Woojae Myung),송지혜(Jihye Song),김상하(Sang Ha Kim),윤혜연(Hyeyeon Yoon),강효신(Hyo Shin Kang),나덕렬(Duk L. Na),김성윤(Seong Yoon Kim),이재홍(Jae-Hong Lee),한설희(Seol-Heui Han),최성혜(Seong Hye Choi),김상윤 대한노인정신의학회 2013 노인정신의학 Vol.17 No.1
Objectives:We aimed to investigate the prevalence of Extrapyramidal signs (EPS) and the associations between EPS and cognitive subdomains in patients with Alzheimer disease (AD). Methods:We recruited 1,324 patients with AD from the Clinical Research of Dementia of South Korea (CREDOS), a hospital based cohort study with fifty-six participating hospitals. We estimated cognitive subdomain using the Seoul Neuropsychological Screening Battery-Dementia version (SNSB-D). Dementia severity was measured by Clinical Dementia Rating Sum of Boxes (CDR- SB) and Korean version of Mini-Mental Status Examination (K-MMSE). The EPS group was defined by the presence of at least one EPS based on a focused neurologic examination. Results:The prevalence of patients with EPS was 11%. These had higher CDR-SB scores than non-EPS group. After controlling for demographic, radiological, and dementia severity (CDR-SB) factors, EPS group showed lower cognitive ability in the subdomains for visuospatial and frontal-executive function than non-EPS group. The patients with EPS were showed significantly higher scores in the subdomain for memory function. Conclusion:The presence of EPSs in patients with AD was associated with lower visuospatial, frontal-executive function and higher memory function.
윤혜연,명우재,송지혜,최준배,강효신,나덕렬,김성윤,이재홍,한설희,최성혜,김상윤,김도관 대한신경정신의학회 2013 신경정신의학 Vol.52 No.1
Objectives The aim of this study was to identify the association between insight and neuropsychiatric symptoms in patients with Alzheimer’s dementia (AD). Methods We examined 2607 patients with AD in the Clinical Research Center for Dementia of South Korea study and designed a cross-sectional study. Each patient underwent psychiatric,neurological, and medical examination, interview for caregivers, laboratory tests, neuropsychological tests, and brain MRI. Cognitive function was measured using the Korean version of the Mini-Mental State Examination, Global Deterioration Scale, and Clinical Dementia Rating. Behavioral and psychological symptoms were measured using the Korean version of the Neuropsychiatric Inventory. Daily Living was measured using the Barthel Index for daily living activities and Seoul-Instrumental Activities of Daily Living. Insight was classified according to ‘with insight’,‘partial insight’, and ‘without insight’ by interview with caregivers. Results Among the 2607 patients, 990 were included in the ‘with insight’ group, 1191 were included in the ‘Partial insight’ group, and the ‘without insight’ group included 426 patients. The ‘without insight’ group had a significantly higher aggression level than the ‘with insight’ group, but not the ‘partial insight’ group [odds ratio (OR)=1.46, 95% confidence interval (CI) : 1,14-1.88]. A significantly lower prevalence of depression was observed in the ‘Partial insight’ group and the ‘without insight’ group, compared to the ‘with insight’ group (OR=0.51, 95% CI : 0.43-0.61/OR=0.61, 95% CI : 0.48-0.78). The ‘partial insight’ group showed a lower anxiety level than the ‘with insight’ group (OR=0.63, 95% CI : 0.53-0.75). Conclusion Findings of this study confirmed that insight level was associated with aggression,depression, and anxiety in patients with Alzheimer’ dementia.
경도인지장애에서 추체외로 증상과 영역별 인지기능 저하 :A Clinical Research Center for Dementia of South Korea (CREDOS) Study
박진홍(Jin Hong Park),명우재(Woojae Myung),최준배(Junbae Choi),김상하(Sangha Kim),강효신(Hyo Shin Kang),나덕렬(Duk L. Na),김성윤(Seong Yoon Kim),이재홍(Jae-Hong Lee),한설희(Seol-Heui Han),최성혜(Seong Hye Choi),김상윤(SangYun Kim),김도 대한노인정신의학회 2015 노인정신의학 Vol.19 No.2
Objective:This study investigated the association between extrapyramidal signs (EPS) and five cognitive sub-domains in a large number of patients with mild cognitive impairment (MCI). Methods:Our analyses considered 1,943 patients with MCI drawn from the nationwide Clinical Research of Dementia of South Korea study. EPS were defined as presence in patients with at least 1 of 11 operationally specified features. We assessed five cognitive sub-domains : attention, language, visuospatial function, memory, and frontal/executive function using the Seoul Neuro-psychological Screening Battery-Dementia version. The associations of EPS with each cognitive sub-domain were analyzed with a multiple linear regression model after controlling for confounding factors : sex, age, education years, diabetes, hypertension, sever-ity of global function, depressive symptoms, and white matter hyperintensities (WMH). Results:138 MCI patients (7.1%) had EPS. This group had more global cognitive deterioration and severe WMH. MCI pa-tients with EPS showed lower performance compared to those without EPS in 3 cognitive sub-domains: attention (p=0.05), vi-suospatial function (p=0.02), and frontal/executive function (p<0.0001). The language sub-domain and the memory sub-domain did not differ between the EPS positive and the EPS negative groups. Conclusion:EPS in MCI are associated with greater cognitive impairment in specific functional sub-domains rather than with global greater cognitive deterioration.