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- 저자 : 최정호(Jung-ho Choi) (검색결과 152 건)
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Case Reports : A Case of Eosinophilic Polymyositis Treated with Immunosuppressants
최정호 ( Jung Ho Choi ),강지현 ( Ji Hyoun Kang ),온리휘 ( Lihui Wen ),이정원 ( Jeong Won Lee ),이경은 ( Kyung Eun Lee ),박동진 ( Dong Jin Park ),박용욱 ( Yong Wook Park ),김태종 ( Tae Jong Kim ),이신석 ( Shin Seok Lee ) 대한류마티스학회 2015 대한류마티스학회지 Vol.22 No.5
Eosinophilic polymyositis is a rare form of inflammatory muscle disease associated with peripheral blood and/or tissue eosinophilia. Most patients respond to glucocorticoids, however some show poor prognosis, leading to mortality. A 28-year-old female was admitted to our hospital because of myalgia and motor weakness of the upper and lower extremities. Laboratory findings showed significantly elevated levels of muscle enzymes and inflammatory lesions in both thigh muscles were demonstrated on magnetic resonance imaging. A diagnosis of eosinophilic polymyositis was based on histological findings, which showed diffuse eosinophilic infiltration into perivascular spaces in the endomysium and perimysium, and necrosis of myofibers. High-dose methylprednisolone treatment improved the clinical symptoms and muscle enzymes. However, on tapering the glucocorticoid dose, clinical and laboratory findings were exacerbated. After the addition of methotrexate and azathioprine, the symptoms and muscle enzymes recovered without relapse. Here, we report on a case of eosinophilic polymyositis, which responded to immunosuppressants. (J Rheum Dis 2015;22:308-312)
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최정호 ( Jung Ho Choi ),임덕빈 ( Deog Bin Lim ),이영종 ( Young Jong Lee ) 대한본초학회 2004 大韓本草學會誌 Vol.19 No.2
N/A Objective : Malvae Fructus and Abutili Semen come from different plants and medical purpose is different. Even though Abutili Semen(Abutilon theophrasti Medicus) is often used as Malvae Fructus(Malva verticillata Linne). Therefore, In order to distinguish morphological characteristics of Malvae Fructus and Abutili Semen were collected, and their external, internal, and flour states were observed via microscopic examination. Method : The slice of the tested material made by paraffin section technique was colored with Safranine Malachite Green contrast methods, and the flour of it was mounted by the liquid made by the same ratio of each of glycerin, acetic acid, and water, and then observed and photographed by olymphus-BHT. Results : 1. The external form, Malvae Fructus looks like a disk. The surface is bright or dark yellow with a prominent thin pattern, while Abutili Semen is triangular egg shape with dark brown surface and a little fluffy hair on it. 2. The internal form, Malvae Fructus had the following morphological characteristics. Palisade cells are constituted of one row in a shape of long column with very thick cell wall. The brilliant belt is located on the outer fourth of the transverse section. The pigment layer is constituted of cell of one row and filled with yellowish brown or violet matters. Abutili Semen is mostly similar to Malvae Fructus but pigment layer is constituted of cell of 4-5 row. 3. In the flour form, pericarp of Malvae Fructus could be classified square crystals of calcuim oxalate. Some of seed coat epidermis cells of Abutili Semen were cell layer and fibrous layer. These cell layer and fibrous layer have differentiated into unicellular non-glandular hair. Conclusion : There were differences in external, internal, and flour states between Malvae Fructus and Abutili Semen, so that microscope can be used to distinguish between these two.
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보증산업의 발전을 위한 보증공제조합의 문제점 분석 및 개선방안
최정호 ( Jung Ho Choi ),양성은 ( Sung Eun Yang ) 한국보험학회 2013 保險學會誌 Vol.95 No.-
본 연구에서는 보증보험과 손해보험 그리고 공제조합을 비교?분석함으로써 보증산업의 건전한 육성과 발전을 위한 금융정책적 지원방안을 마련하고자 하였다. 우선, 손해율자료를 이용하여 보증보험의 손해율이 일반 손해보험의 손해율과는 다른 특성이 있음을 실증적으로 분석하였다. 이를 통해 보증보험의 손해율이 상대적으로 경기에 더 민감하며, 이로 인해 손실이 동시다발적으로 발생할 수 있음을 확인하였다. 이러한 실증분석의 결과는 보증보험을 취급하고 있는 기관들에 대하여 일반 손해보험보다 더욱 엄격한 관리?감독기준이 마련되어야 함을 의미한다고 하겠다. 다음으로, 국내보증시장에 참여하고 있는 다수의 공제조합들의 현황과 영위 실태를 분석함으로써 이들 공제조합들의 문제점을 파악하였다. 현재 공제조합들은 체계적이고 일원화된 관리?감독 기준의 마련 없이 경쟁적으로 보증업무 취급하고 있어 상이한 규제, 준비금 적립, 관리?감독체계 등에서 잠재적인 문제점들이 나타 났다. 따라서 본 연구에서는 보증산업의 건전한 육성과 발전을 위해 첫째, 보증공제 전체를 규율할 수 있는 근거의 마련이 필요하고, 둘째, 준비금 적립 등 재무건전성 및 자본적정성에 관하여 보증보험과 동일한 기준이 적용되어야 하며, 마지막으로, 보증산업 전반에 대한 일관성 있는 금융정책 및 시장의 안정을 도모하기 위하여 동일한 감독기관과 기준을 적용하여 보증영업을 영위할 필요가 있음을 제시하였다. This study aims to find out alternatives of financial policy for solvent guarantee industry through analyzing markets of guarantee insurance, cooperatives and non-life insurance. First, we analyzed loss ratio of guarantee insurance and non-life insurance and recognized that guarantee insurance is more prone to be affected by volatile economic environment and huge probable loss can be occurred due to the correlation among losses. These findings connote that more stringent supervisory system is necessary for guarantee insurance. Second, we look into cooperatives in guarantee market by examining present business operation and management. Potential problems related to regulation, reserves, and supervision were found. Finally, this paper cogently suggests three alternatives for solvent development and growth of guarantee industry as follows. First, enactment which can regulate all guaranty players is needed. Second, identical guideline should be applied for financial solvency and capital adequacy. Third, identical supervisory system should be established for promoting consistent financial policy and stable guarantee market.
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최정호(Jung Ho Choi),김지수(Chi Soo Kim) 한국경영학회 1996 經營學硏究 Vol.25 No.3
This study empirically examines the effect of corporate capital expenditures decisions on the market value of firm. Specifically, this study focuses on whether the announcement of capital expenditures plans will change the stock price and what factors, if any, might influence their relationship. Both traditional event study method and multiple regression analysis have been employed in order to answer this questions. The results of this study report that the announcement of capital expenditures plans is associated with significant positive excess stock returns. However, the effect of the information could be observed during 4 or 5 days before it was actually announced to the market. This evidence implies that managers convey signal to the market that they have private information about future demand and costs through their investment decisions and the signal is regarded as favorable to the evaluation of firm value by investor. This study also provides evidence that operation income and manager`s ownership ratios positively influence the relationship between capital expenditures and firm value. The higher operating income firm achieved after capital expenditures and the more shares managers have in the firm, the greater was the value assigned to the firm by investor.
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최정호(Jung-Ho Choi),신광순(Kwang-Soon Shin) 한국식품영양과학회 2011 한국식품영양과학회지 Vol.40 No.2
천년초에 존재하는 점질다당의 새로운 이용방안을 모색하기 위해 천년초로부터 다당을 분리하여 항전이 활성을 평가하고 구조 분석을 행하였다. B16BL6 종양세포를 이용한 폐암 전이모델에서 천년초 조다당 CNC-0는 농도 의존적으로 높은 항전이 활성을 나타냈다. 천년초 조다당 CNC-0는 DEAE-Sepharose FF 및 Sephadex G-75를 이용한 연속적 chromatography를 행하여 CNC-Ia으로 정제하고 이들의 구조적 특성을 검토하였다. CNC-Ia는 분자량 약 700 kDa의 다당체로 구성당 조성을 확인한 결과, arabinose, galactose 및 xylose를 높은 비율로 함유하고 있었으며 rhamnose와 fucose를 미량 함유하고 있었다. 본 당쇄의 결합양식을 규명하기 위해 methylation analysis를 행한 결과 CNC-Ia은 terminal Ara f, 5-linked Ara f, 4-linked Gal p, terminal Xyl p와를 포함한 총 18종의 결합으로 구성되어 있었으며 full branched Ara f, 3,4,6-branched Gal p및 full branched Gal p와 같은 3종의 CNC-Ia 고유의 특징적 결합을 포함하고 있었다. 또한 CNC-Ia의 미세구조를 규명하기 위해 exo-α-Larabinofuranosidase와 endo-β-1,4-D-galactanase를 이용한 연속 가수분해 및 해석도 행하였다. 이상의 결과로부터 천년초 유래 다당 CNC-Ia는 β-(1→4)-galactan 주쇄에 arabinose oligo당이 측쇄로 분지된 Type I arabinogalactan으로 판단되었으며 주쇄 및 측쇄 모두 고도로 분지된 특징이 있음을 알 수 있었다. To examine the new practical utilization of mucilages in Opuntia humifusa, polysaccharides were isolated from O. humifusa and their anti-metastatic activity and structural analysis were carried out. In experimental lung metastasis of B16BL6 melanoma cells, prophylactically intravenous (i.v.) administration of the crude polysaccharide (CNC-0) from O. humifusa significantly inhibited lung metastasis in a dose-dependant manner. The main polysaccharide, CNC-Ia was purified to homogeneity from CNC-0 by two successive column chromatographies using DEAE-Sepharose FF and Sephadex G-100 and its structure was characterized. Molecular mass of CNC-Ia was estimated to be 700 kDa and it mainly consisted of arabinose, galactose and xylose in addition to two minor sugars such as rhamnose and fucose. Methylation analysis indicated that CNC-Ia comprised at least 18 different glycosyl linkages such as terminal Ara f, 5-linked Ara f, 4-linked Gal p and terminal Xyl p in addition to three characteristic linkages such as full branched Ara f, 3,4,6-branched Gal p and full branched Gal p. To analyze the fine structure of CNC-Ia, it was sequentially digested by exo-α-L-arabinofuranosidase and endo-β-1,4-D-galactanase. These analyses suggested that CNC-Ia belongs to be a highly branched Type I arabinogalactan which has a (1→4)-β-galactan backbone with arabinosyl oligosaccharide side chains.
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