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- 저자 : 최인준(IJ Choi) (검색결과 3 건)
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이봉구(BK Lee),최인준(IJ Choi),이유복(YB Lee),김동식(DS Kim) 대한산부인과학회 1975 Obstetrics & Gynecology Science Vol.18 No.7
자궁경부 및 질도말표본과 자궁경부생검을 병행한 총 88례를 분석하여 다음과 같은 결론을 얻었다. 1. 총 88례의 질환별 분포는 만성자궁경부염 34예, 경도, 중증도 및 고도의 상피이상증식증 각각 3예가 있었으며 상피내암 22례 및 침습암 33예가 있었고 침습암중 2례는 현미경적 침 습암이었다. 2. 상피이상증식증의 도말표본 특징은 비정상세포들이 거의 모두가 다각형이며 유리된 배열 소견을 볼수 있었고, 심한 염증 및 출혈의 배경소견은 많지 않았다. 3. 상피내암의 도말표본 특징은 비정상 세포들은 대부분 원형내지 타원형이었으며 유리된 배열이 많이 나타났으나 다수의 유합배열도 관찰되엇고 핵은 비정상세포의 67%가 균일한 굵은 과립상의 염색질 소견을 보였다. 4. 침습암의 도말표본 특징은 비정상세포들의 모양이 원형내지 타원형이 가장 많이 나타나 나 불규칙한 모양의 세포도 자주 볼수 있었고 유리 및 융합된 세포 배열을 관찰하였으며 심 한 염증 및 출혈소견을 지닌 배경이 많았다. 5. 상피내임을 소형 및 대형 세포암, 침습암을 비각화대형세포암, 각화세포암 및 소형세포암 으로 분류 검색한 결과 소형 및 대형 상피내암은 각각 2례, 및 20례가 잇었으며 비각화대형 및 각화세포침습암은 각각 71례 및 6례가 있었고 세포학적 검사로 15례 및 2례에서 검색이 가능하였다. 6. 세포학적 진단 및 조직학적 진단과의 일치율은 중등도 및 고도의 상피이상증식증 각 3례 (100%) 상피내암 22례중 21예(95%) 침습암 23례중 현미경학적 침습암 2례와 불량한 도말표 본 1례를 제외하면 20례(100%)이었으며 총체적으로는 51례중 47례로서 92%의 일치율을 보 였다. 이상의 결과를 종합분석하면 세포병리학적검사로 자궁경부병변 즉 상피이상증식증, 상피내 암 및 침습암 등을 진단하는데에도 정확율이 높으며 자궁경부암의 예후와 밀접한 관련이 있 다고 알려진 유형까지도 구별이 가능함으로 자궁경부암의 예방 조기진단 및 치료에 큰 도움 이 될 것으로 사료된다. 1. The cervical lesions of 88 cases consisted of 34 cases of chronic cervicitis, 9 cases of epithelial dysplasia 22 cases of carcinoma in situ and 23 cases of invasive carcinoma including 2 cases of microinvasion. 2. The characteistic of the smear in epithelial dysplasia were polyhedarl in shape, isolated in arrangement and uniformly finely granular in chromatin pattern (96%) without nucleoli. 3. The characteristics of the smear of carcinoma in situ were abnormal cells with round ot oval in shape and either isolated or syncytial in all arrangements . The abnormal cells of the smear had the nuclei with uniformly coarse chromatin in 67 percent of cells. 4. The characteristics of the invasive carcinoma in smear were round oval in shape, equal degrees of either isolated or syncytial in arraggements with frequent inflamatory and bloody background. The 55 percent of abnormal cells showed irreqularly coarse granular chromatine of nuclei with 6% of micronueleoli and 14 % of marconucleioli. 5. The 22 cases of carcinoma in situ consisted of 2 cases of small cell type and 20 cases of large cell type. The cytologic diagnosis was correct in 15 cases out of 17 cases of non-keratinizing large cell type and 2 cases out of 6 cases of keratinizing cell type. 6. The ratio of positive correlation between cytologic and histopathologic diagnoses was 100% in moderate to severe degree of dysplasia, 95% in caricinoma in situ, 100% in invasive carcinoma and 92% in total cases.
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항암제 Cisplatin ( cis-diamminedichloroplatinum II ) 이 백서 신장에 미치는 영향에 관한 연구
김재욱(JU Kim),곽현모(HM Kwak),이광길(KK Lee),최인준(IJ Choi) 대한산부인과학회 1985 Obstetrics & Gynecology Science Vol.28 No.6
Cisplatin (cis-diamminedichloroplatinum II) is a new anticancer drug containing a heavy metal, platinum. Cisplatin shows a broad spectrum of antitumor activities in certain human cancers including gynecologic malignancies such as ovarian carcinoma. The clinical trial with cisplatin has shown moderate therapeutic benefits but also has significant toxic effects. The major toxic effects are impairment of renal function, myelosuppression, hearing loss and gastrointestinal disturbance. Of which these toxic effects, the renal toxicity is most serious dose limiting factor in clinical use. The nephrotoxicity of cisplatin has been well documented clinically, but the renal pathologic findings in patients treated with this drug have been scarce and not well demonstrated in the literature. In this study, renal toxicity is investigated in rats following a single intraperitoneal injection of cisplatin 6mg/kg, as acute experimental group and repeated treatments with cisplatin(1mg/kg twice weekly and 2mg/kg twice weekly for 11 weeks) as chronic experimental group. The results are as follows: A. Acute experimental group. 1. The mean kidney to body weight ratio is significantly greater in experimental group than controls on day 7. 2. Serum levels of BUN and creatinine rise to peak level on the 5th day and uric acid on the 7th day. On the 10th day, serum levels of creatinine and uric acid decreased to control level, but those of BUN are still greater than controls. 3. Histologic changes are characteristically confined to the corticomedullary region, straight tubules of outer zones of the medulla. Necrosis of the tubular cells is maximal on the 5th day, tubular dilatation is mostly severe on the 7th day and regeneration begins on the 10th day. B. Chronic experimental group. 1. The kidney to body weight ratio is greater than controls. 2. In rats treated with 1mg/kg of cisplatin, the mean BUN values are 6-fold greater and mean creatinine and uric acid values are 2-fold greater than controls. 3. Massive tubular dilatation in the corticomedullary region and interstitial fibrosis are noted. In conclusion, chronic use of cisplatin in cancer patients could cause irreversible renal damage.
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최동희,김수녕,박찬규,박기현,최인준,이병석,정현주,양우익,박주영 대한산부인과학회 1990 Obstetrics & Gynecology Science Vol.33 No.2
저자들은 조기폐경 환자 21명을 대상으로 면역학적 요인을 규명해 보고자 환자의 혈청내 antiovarian antibody 등의 autoantibody 및 혈중내 면역 복합체를 조사하여 다음과 같은 결과를 얻었다. 1. 21명의 조기폐경 환자중 1가지 이상의 autoantibody가 발견된 환자는 6명(28.5%)으로서 antiovarian antibody가 3명(14.3%)에서,antinuclear antibody가 1명(4.7%), antimicrosomal antibody가 3명(14.3%), rheumatoid factor가 1명(4.7%)에서 관찰되었으며, antiadrenal antibody는 1예에서도 관찰되지 않았고, antiovarian antibody가 발견된 환자에서는 타내분비 질환이 동반되지 않았다. 2. 조기폐경과 동반된 타내분비질환은 21명중 4명(19.1%)으로서 Graves diease가 2명(9.5%), Addisons disease가 1명(4.7%), Myasthenia gravis 환자가 1명(4.7%)이었다. 3. 면역효소법을 이용한 혈중내 면역복합체를 조사하였으나 환자군에서는 28.65 ± 8.0ug/ml이었고 대조군은 29.59 ± 9.57ug/ml로서 대조군과 비교해 볼때 1예에서도 혈중내 면역 복합체는 증가하지 않았다. We investigated the circulating antiovarian antobodies and several kinds of autoantibodies in 21 patients with premature ovarian failure. One or more autoantibody was detected in 6 patients (28.6 %). Four patients (19.1 %) had clinically evident autoimmune disease: two had Graves disease, one had myasthenia gravis, one had addisons disease. The presence of antiovarian antibody in sera of woman was determined by indirect immunofluorescence using human ovarian tissue. Of 21 patients, 3 (14.3 %) had positive ovarian fluorescence, compared with zero of 26 normal cycling controls (P $lt; 0.025), and zero of 26 postmenopausal controls (P $lt; 0.025). Antiadrenal antibody using indirect immunofluorescene was negative in all patients. Other endocrine disorders were notpresented in the patients having circulating antiovarian antibodies. In the immunologic screening tests, 3 (14.3 %) had antimicrosomal antibody, 1 (4.8 %) had rheumatoid factor, and 1 (4.8 %) had antinuclear antibody. Circulating immune complex was not increased compared with 15 normal cycling women. This study suggests that in some but not all patients with POF have their disease caused by autoimmune mechanism.
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