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술후 통증조절을 위한 새로운 대안으로서의 Oxycodone
최병문,Choi, Byung Moon 대한치과마취과학회 2013 Journal of Dental Anesthesia and Pain Medicine Vol.13 No.4
Oxycodone is a semi-synthetic opioid synthesized from poppy-derived thebaine. It is a narcotic analgesic generally indicated for relief of moderate to severe pain. Although developed in an attempt to improve on the existing opioids, the adverse effects of oxycodone are those that are typically found in opioids. In recent years, the use of the opioid oxycodone has increased markedly and replacing morphine as the first line choice of opioid in several countries. There are formulations for oral immediate, oral extended release and intravenous use. In 2013, intravenous oxycodone was approved for marketing by Ministry of Food and Drug Safety (MFDS), with the indication of postoperative intravenous patient-controlled analgesia (IV PAC). Simulation study of oxycodone demonstrated that minimum effective analgesic concentration (MEAC) of oxycodone was most quickly reached with higher loading dose and IV PCA with background infusion, which may reduce the necessity of rescue analgesics during immediate postoperative period. Previous studies for postoperative pain management with intravenous oxycodone are limited in sample size, mostly less than 100 patients, which may not be large enough to assess safety of intravenous oxycodone. The effectiveness and tolerability of IV PCA with oxycodone should, therefore, be evaluated in large scale clinical trials in Korean populations.
최병문 ( Byung Moon Choi ),진지현 ( Ji Hyun Chin ),김영국 ( Young Kug Kim ),함경돈 ( Kyung Don Hahm ),심지연 ( Ji Yeon Sim ),최인철 ( In Cheol Choi ),황규삼 ( Gyu Sam Hwang ),한성민 ( Sung Min Han ) 대한마취과학회 2006 Korean Journal of Anesthesiology Vol.51 No.2
An inguinal hernia shows that the protruding viscus exits from the endoabdominal fascial sac through the internal inguinal ring. Because an inguinal hernia is usually associated with incarceration, obstruction and even strangulation, it must be quickly treated whenever observed. Although there are several predisposing factors of the development of inguinal hernia, relatively little is a case report of the inguinal hernia developed by the increased intra-abdominal pressure during general anesthesia. In this case, we report a patient who developed the unexpected recurrence of left inguinal hernia following lumbar spinal surgery in prone position by increasing intra-abdominal pressure. After manual reduction was performed promptly by general surgeon, the patient was discharged without any complication on the eighth postoperative day. (Korean J Anesthesiol 2006; 51: 239~42)
실험연구 : Propofol 미세유탁액을 지속정주하여 진정된 비글견에서 집단 약동력학적 모형화
최병문 ( Byung Moon Choi ),정성문 ( Sung Moon Jung ),배균섭 ( Kyun Seop Bae ),노규정 ( Gyu Jeong Noh ) 대한마취과학회 2006 Korean Journal of Anesthesiology Vol.50 No.6
Background: Aquafol(R) is a microemulsion formulation of propofol. This study was designed to investigate the population pharmacokinetic and pharmacodynamic modeling in beagle dogs sedated by Aquafol(R). Methods: Electroencephalogram was recorded and venous blood was sampled at preset times in 15 beagle dogs during 3 hours of infusion of Aquafol(R) and subsequently during 3 hours of recovery. Venous blood was sampled at 0, 2, 10, 30, 60, 120, 180, 190, 240 and 360 minutes after infusion. We evaluated the effect of propofol on electroencephalogram by calculating SEF90. In the preliminary analysis, two compartment model best described all data from all subjects. The pharmacodynamics were best described using an effect compartment model and ke0, a first-order elimination rate constant characterizing the effect-site equivalent to estimate the apparent effect-site concentrations. The relationship between propofol effect-site concentration and SEF90 was analyzed using an inhibitory sigmoid Emax model. Results: The final pharmacokinetic model was best described with the followings: V1 = 18.5e0.114*BWT, k10 = 1.86 min-1, k12 = 0.6 min-1, k21 = 0.684 min-1. The final pharmacodynamic model was best described with the followings: t1/2ke0 = 0.62 min, Ce50 = 32.2 ng/ml, Eo = 31.3 Hz, Emax = 20.9 Hz, γ = 1.28. Conclusions: The propofol microemulsion shows different pharmacokinetics and pharmacodynamics compared with the propofol lipid emulsion. (Korean J Anesthesiol 2006; 50: 689~97)
임상연구 : 수술 후 환자에서 기계식 통증자가조절기의 안전성 및 유효성에 관한 임상연구
정용보 ( Yong Bo Jeong ),이무송 ( Moo Song Lee ),최병문 ( Byung Moon Choi ),진지현 ( Ji Hyun Chin ),노규정 ( Gyu Jeong Noh ) 대한마취과학회 2007 Korean Journal of Anesthesiology Vol.52 No.2
Background: The disposable patient-controlled analgesia (PCA) devices are convenient for portability and management. An ideal PCA can be developed as an electronic device with various functions of safety and control. Recently, Accumate 1000(R). was developed as an electronic pump in Korea, and has passed the relevant laboratory criteria of safety and efficacy. We conducted a clinical study on the safety and efficacy when the device is applied to patients. Methods: Fentanyl 1,500μg, ketorolac 180 mg, and ondansetron 8 mg were used for PCA. Continuous infusion rate, bolus dose, and lockout time were set at 1 ml/h, 1 ml, and 15 min, respectively. Fifty patients were monitored for 48 h. The safety of Accumate 1000(R). was evaluated by backflow and siphonage, auto-clamp function, and lockout time intraoperatively. The efficacy was evaluated by the accuracy of bolus and total infused dose, and the satisfaction rates of patients and users. Results: Backflow and siphonage did not occur, and the auto-clamp function was excellent. There was no bolus infusion during lockout time, and the bolus dose was infused accurately after lockout time. For the accuracy of the total infused dose, the mean and median value of performance error between the infused and target doses were -0.55%, and -0.29%, respectively. Noise, button sense, and convenience of cable were rated as satisfactory by 90%, 78%, and 84%, of patients respectively. Conclusions: The safety and efficacy of Accumate 1000(R) were established by clinical trial. We can provide patients with the more precise and optimal analgesia. The history of drug infusion can be used as research data. (Korean J Anesthesiol 2007; 52: 161~5)