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흰 쥐 해마에서 Midazolam 및 Propofol에 의한 GABA성 전류(GABAergic Currents)에 대한 비교
천상우 ( Sang Woo Chun ),손용 ( Yong Son ) 대한마취과학회 2009 Korean Journal of Anesthesiology Vol.56 No.6
Background: γ-Aminobutyric acid (GABA), the principal inhibitory neurotransmitter, activates persistent low amplitude tonic currents in several brain regions, in addition to conventional synaptic currents. Tonic conductance is highly sensitive to low concentrations of volatile anesthetics and therefore might contribute to amnestic properties. We compared the properties of GABAergic tonic currents mediated by sedative-amnestic midazolam and anesthetic propofol in rat hippocampal neurons. Methods: Patch clamp techniques were used to characterize the GABAergic currents recorded in CA1 pyramidal neurons in rat hippocampal slices. The amplitude of the tonic currents and the decay of miniature inhibitory postsynaptic currents (mIPSCs) were measured after administration of midazolam or propofol. Results: Both midazolam and propofol caused concentration dependent increases in the tonic currents. The enhancement of the tonic currents by midazolam concentrations of greater than 0.5 μM caused no further increase in current amplitude. Propofol continued to increase with concentrations over the range tested (0.1-10 μM). Low concentrations of midazolam 0.01 μM and propofol 0.5 μM selectively enhanced the tonic currents but failed to alter mIPSCs. Conclusions: Low concentrations of midazolam and propofol selectively enhanced the tonic currents but not synaptic currents of rat hippocampal pyramidal neurons. Unlike midazolam, the response to propofol did not become saturated and had a greater effect on the tonic currents. (Korean J Anesthesiol 2009; 56: 675~80)
TNBS 유발 대장염(大腸炎)에 의한 체중 및 혈액상 변화에 대한 인삼(人蔘) 약침(藥鍼)의 효과
김종성 ( Jong Sung Kim ),천상우 ( Sang Woo Chun ),박상연 ( Sang Yeon Park ),박성익 ( Sung Ik Park ),김경식 ( Kyung Sik Kim ),김재효 ( Jae Hyo Kim ),구성태 ( Sung Tae Koo ),손인철 ( In Chul Sohn ) 대한경락경혈학회 2006 Korean Journal of Acupuncture Vol.23 No.4
Objectives: The purpose of the present study is to evaluate the effects of herbal acupuncture with Ginseng Radix for the treatment to intestinal disease in the rat with 2, 4, 6-trinitrobenzenesulfonic acid (TNBS) induced colitis. Methods: All animals were subjected to the injection of saline (300 ㎕, 500 ㎕) for a study control or TNBS (300 ㎕, 500 ㎕) into the Lumen of the colon, 8cm proximal to the anus through the intestine. Ginseng Radix herbal acupuncture (20 ㎎/㎖, 0.4 ㎖) were injected to the both Hapgok (LI4) acupoints at the 2nd injection of TNBS in rats. Thus, the body weight, RBC count, WBC count, total protein, IgG Levels and IgM Levels were observed to study the effects of Ginseng Radix herbal acupuncture. Results: Ginseng Radix herbal acupuncture on Hapgok (LI4) for TNBS-induced colitis inhibited the body weight Loss rate but did not affect RBC and WBC counts. Furthermore, it inhibited the reduction of total protein concentration and serum IgG and IgM Levels in TNBS induced colitis were recovered. Conclusions: Herbal acupuncture with Ginseng Radix helps recover the TNBS-induced colonic damage and may be an important method for treatment of the colitis.
척수 아교질 세포의 흥분성과 세포내 칼슘농도에 대한 활성산소의 영향에대한 연구
이해인 ( Hae In Lee ),천상우 ( Sang Woo Chun ) 조선대학교 치의학연구원 2011 Oral Biology Research (Oral Biol Res) Vol.35 No.1
Substantia gelatinosa (SG) neurons, lamina II of the spinal dorsal horn, receive sensory informations from peripheral neurons directly and send the informations to upper brain regions. In recent studies, it is reported that reactive oxygen species (ROS) takes part in generation and transmission of pain, but these are the results from behavioral test and immunohistochemical study. In the present study, we recorded neuronal excitability to investigate the effects of tert-buthyl hydroperoxide (t-BuOOH), a kind of ROS, on transmission of pain in SG using the patch clamp technique. We also used calcium imaging technique to measure the changes of intracellular calcium concentration. Depolarization and action potential were evoked by perfusion of t-BuOOH, and these are suppressed by phenyl-N-tert-buthylnitrone, an antioxidant. When we treated t-BuOOH, intracellular calcium concentration was increased, but it was rather decreased in extracellular calcium free solution and on the condition of pretreated 2-aminoethoxydiphenylbolate, ruthenium red, and thapsigargin. We confirmed that t-BuOOH activates excitability of neurons in SG suggesting that ROS boosts nociception through central sensitization. This result is induced by increase of intracellular calcium, and the sources of calcium are from extracellular fluid and endoplasmic reticulum in neurons.
흰쥐 삼차신경 척수감각핵의 미측소핵 세포의 전압의존성 소디움통로와 포타슘통로에 대한 전기생리학적 연구
천상우,최정희,김권수,유용묵,김종구,이동근 대한악안면성형재건외과학회 2002 Maxillofacial Plastic Reconstructive Surgery Vol.24 No.1
The caudal subnucleus of the spinal trigeminal nucleus (medullary dorsal horn ; MDH) receives direct inputs from unmyelinated and thinly myelinated, small diameter primary afferent fibers. Thus, the MDH is implicated in the processing of nociceptive information in the orofacial region. In this study, the types and characteristics of voltage-dependent ion currents were investigated in acutely isolated MDH neurons of postnatal rats by means of the whole cell patch clamp techniques. Coronal slice (400㎛) of the trigeminal caudal subnucleus region was sequentially treated with pronase 0.2㎎/㎖. then single neurons were mechanically dissociated. Voltage-dependent sodium currents showed that the half-maximum activation potential was -41.8±1.8mV and half-maximum inactivation potential was -62.4±3.0mV. And the currents were blocked totally by application of 100nM tetrodotoxin. In a Ca^2+ free solution, low-threshold transient (I_A) and high-threshold sustained (I_K) currents were recorded. The half-maximum activation and inactivation potential of I_K were 2.5±1.9mV and -37.1±2.3mV, respectively. I_A was activated and inactivated more rapidly than I_K. The half-maximum activation and inactivation potential were -21.6±6.3mV and -84.5±5.0mV, respectively. When a 4-aminopyridine of 5mM was applied, I_A was almost totally blocked. These results reveal that MDH neurons express a variety of voltage-dependent ionic currents with distinct physiological and pharmacological properties, and they play an essential role in the transmission and modulation of sensation, especially pain, from trigeminal region.