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      • SCOPUSKCI등재

        고령자 담석증의 임상적 고찰

        차상우(Sang Woo Cha),천갑진(Gab Jin Chun),박용순(Yong Soon Park),송동화(Dong Hwa Song),조영덕(Young Deok Cho),김진오(Jin Oh Kim),봉형근(Hyung Keun Bong),조주영(Joo Young Cho),김연수(Yun Soo Kim),이준성(Joon Seong Lee),이문성(Moon Sun 대한소화기학회 1996 대한소화기학회지 Vol.28 No.2

        N/A Background/Aims: Gallstone is uncommon before adolescence, and its incidence increases v:ith age. In elderly patients, one of the important characteristics of the ga]lstone disease is that they often have bile duct stones causing acute obstructive cholangitis. Another is that they could be accompained by other diseases. Methods: We analyzed 2,154 patients surgical]y or radiologically proven gallstone patients at the Soon Chun Hyang University Hospita] from l984 to 1994 and compared the clinical characteristics of elderly patients group(over 60 years) with younger patients group(under 60 years). Results: The peak incidence of gallstone (fisease wos noted in the 6th decade and the mean age was 55 years. Elderly patients group were 40.6%(874 cases) and younger patients group were 59.4%(l,280 cases'). Male to female ratio of eler]y patients vras I:1.IO. The location of stones was gallbladder(GB) in l,395 cases(64.9%), multiple sites in 416 cases(19.3%), common bile duct(CBD) in 214 cases(9.9%) and intrahepatic duct(IHD) in 129 cases(5.9%). In elderly patients group, the ]ocation of stones was multiple sites in l86 cases(2l.3%)and CBD in 120 cases(l3.7%). Frequency of stones in multiple sites and GB was significontly higher in elderly patients group than younger patients group(pO.OJ). The prominent clinical manifestations were right upper quadrant abdominal pain(24.5%), epigastric pain(19.4%), and no symptoms(l0.8%). In elderly patients group, chilling and jaundice were significantly higher than younger patients group(p 0.01). The associated diseases were cardiac diseases(l3.7%), diabetes me]litus(8.1%), malignancy (7.3%), liver cirrhosis(6.4%), and hepatitis(5.2%). Cardiac diseases, respiratory diseases, diabetes rnellitus and malignancy were more frequently associated in elder]y patients group than in younger group(p0.01). The incidence of complication was 10.7%(230/2,154)and mortality rate was 1.1% (24/2,154). In elderly patients group, the incidence of complication* and mortality* was signifi- cantly higher than younger patients group(*: p0.01; **: p0.05). Conclusions: The incidence of stones in CBD and mutiple sites, complication and morta]ity rate were higher, and chilling and jaundice were more frequently noted in elderly patients group than younger patients group. Our results suggest that ear]y diagnosis and proper treatment migbt be necessary in elderly patients with the gallstone disease. (Korean J Gastroenterol 1996; 28:260-266)

      • SCOPUSKCI등재

        고도 이형성증을 동반한 식도 편평세포 유두종 1예

        김진오,이문성,이준성,진소영,차상우,심찬섭,유창범,조주영,정인섭,천갑진 대한소화기내시경학회 2000 Clinical Endoscopy Vol.21 No.6

        A squamous cell papilloma of esophagus is regarded as a rare tumor, and one of the distal esophagus is known to be not changed into a malignant neoplasm although squamous papilloma of the larynx, cervix and the upper esophagus may be associated with squamous cell carcinoma. We report the first case of a squamous papilloma associated with hig grade dysplasia at the lower esophagus. We think this case may have an important implication in the surveillance and management of esophageal papilloma found at endoscopy.

      • SCOPUSKCI등재

        위점막탈출증 환자에서의 식도내압검사 소견

        조주영,이준성,김진오,이문성,심찬섭,조영덕,홍수진,문종호,천갑진 대한소화기학회 1999 대한소화기학회지 Vol.34 No.4

        Background/Aims: The purpose of this study was to investigate the roles of the abnormalities of lower esophageal sphincter (LES) and esophageal body as a factor of gastric mucosal prolapse (GMP). Methods: Ninety-one patients were classified into the GMP group (n=51) and control group (n=40). They had a routine esophageal manometry. Fourteen patients of GMP group and 18 normal controls had a dynamic study to assess the effect of routine endoscopic premedication such as atropine sulfate and scopolamine butylbromide. Results: The mean pressure of LES in GMP group was similar to that in the control group (22.99±9.97 mmHg vs 25.46±7.92 mmHg). LES length of the GMP group was shorter than that of the control group (3.33±0.73 mm vs 3.88±0.78 mm, p$lt;0.05), but errors in measurement should be considered. Other parameters such as mean amplitude, duration and velocity of the peristaltic waves in esophageal body were not different in the both groups. By the findings of endoscopy and manometry, GMP was accompanied by reant gastric mucosa of fundus or upper body (51/51), hiatal hernia (9/51), nutcracker esophagus (2/51), hypertensive LES (1/51) and nonspecific esophageal motor disturbance (NEMD) (5/51). In the dynamic study, the mean basal pressures of LES were significantly decreased after premedication in both groups (p$lt;0.05), and the percentage of pressure reduction in both groups was similar (71.93±6.16% vs 73.56±10.61%). Conclusions: The pathogenesis of the gastric mucosal prolapse was not associated with a decrease of LES pressure and sensitivity for premedication. It may be caused mainly by redundancy of gastric mucosa, and partially by hiatal hernia.

      • SCOPUSKCI등재

        부분 간절제술로 급성간부전이 유도된 흰쥐에서 비장내 동종 간세포 이식

        조주영,이준성,김홍수,김진오,이문성,황성규,김연수,심찬섭,조영덕,홍수진,천갑진,윤익진 대한소화기학회 1998 대한소화기학회지 Vol.31 No.5

        Background/Aims: Various techniques of hepatocyte transplantation were actively studied as the alternatives to liver transplantation because of potential advantages including technical simplicity, low risk of operation and use of cells from a liver of single donor for multiple recipients, We investigated the effect of allogenic hepatocellular transplantation into spleen on the survival rate after 90% partial hepatectomy-induced acute hepatic failure in rats. Methods: Acute hepatic failure was induced by resection of all lobes except caudate lobe in Sprague-Dawley rats. Hepatocytes, isolated by collagenase perfusion of the liver via the portal vein, were transplanted into the spleen of rats after 90% partial hepatectomy (2.0×10^7 hepatocytes/rat). Results: There was significant difference in the survival rate between control group without treatment after 90% partial hepatectomy and transplanted group receiving intrasplenic allogenic hepatocellular transplantation after 90% partial hepatectomy. Engraftment and survival of transplanted hepatocytes were observed in spleen 2 days after transplantation. Conclusioas: We could observe significant improvernent of survival rate by intrasplenic hepatocellular transplantation in rats with 90% partial hepatectomy-induced acute liver failure. These results suggest that intrasplenic hepatocellular transplantation may be effective in the treatment of acute liver failure.

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