221. 췌장의 유두상 낭성 종양

조창원,이광수,권오정,권성준,정파종,곽진영,전규영,원치규 대한외과학회 1998 대한외과학회 학술대회 초록집 Vol.1998 No.5

과학 선행학습의 실태와 그 효과에 대한 연구

조창원,구민주,박종근 국제문화기술진흥원 2020 The Journal of the Convergence on Culture Technolo Vol.6 No.4

Considering the fact that many students and parents spend a considerable amount of time and economic power on prior learning and that the environments of internet-based society change rapidly, it is worth examining the status and effectiveness of prior learning. In response, the study surveyed 186 first-year students of A high school in Changwon on the basic status of science prior learning. By the analysis results for the status, 39.8% of the students surveyed said they had experience in prior learning in science. Among the students experienced, 56 students who started science prior learning after the start of winter vacation in the third grade of middle school were analyzed the specific status of science prior learning and the impact of science prior learning on science achievements. As a result of the survey on the effect of science prior learning, 71.4% of the students who experienced science prior learning showed positive scientific achievement.

가토 뇌피질 혈관에서 국소 Nimodipine Plus Its Solvent(Nimotop) 및 Solvent의 효과

조창원,이영우 대한신경외과학회 1992 Journal of Korean neurosurgical society Vol.21 No.10

Nimodipine과 ethanol을 포함하는 solvent(nimodipine plus solvent, nimotop), ethanol을 포함하는solvent(the solvent) 그리고 생리적 식염수를 각각 가토 뇌연막 동맥과 정맥 표면에 임의로 도포하여 나타나는 동맥과 정맥의 변화를 연구하였다. 이 반응을 개두술하에 관찰했다. 생리학적 변수 즉 PaO₂, PaCO₂, 혈액 pH 및 수축기 혈압은 전 실험중 의의 있는 변화는 없었다(p>0.05). 90 동맥과 76정맥의 직접 변화를 수술현미경의 oculus에 micrometer eyepiece를 부착시켜 관찰했다. 1) 2.4×10^(-5) M nimodipine plus solvent의 뇌연막 도포시 10분에 동맥확장은 최고치에 도달했는데 대동맥 및 소동맥 평균 확장은 22%인데 소동맥에서는 23% 이고 대동맥에서 21% 이었으며(p<0.01), 이는 solvent만의 도포시에 나타나는 동맥 확장보다 상당히 의의있는 변화이었다(p<0.01). 그러나 소동맥 직경은 계속하여 확장되어 있었다(p<0.05). Solvent만을 뇌국소 도포시는 대동맥 및 소동맥 평균확장은 6%인데 비해 소동맥 확장은 평균 9%이고 대동맥 평균확장은 4%이었으며, 수분후 안정상태에 도달했다(p<0.05). 소동맥의 직경의 확장은 생리적 식염수 경우에 비해 계속하여 의의있는 확장을 볼 수 있었다(p<0.05). 그리고 생리적 식염수 도포시에 동맥은 안정상태와 비교하여 의의있는 변화를 보여주지 않았다(p>0.05). 2) Nimodipine plus solvent의 뇌연막 도포시 정맥직경의 변화는 사소하였다. 그리고 대정맥의 직경의 확장은 약물투여후 5%이고 소정맥에서는 8.5%였다. 대정맥과 소정맥 직경 변화는 solvent만 투여시 및 생리적 식염수 도포시에 비해 전체적으로 의의있는 변화는 없었다(p>0.05). 물론 생리적 식염수 투여 경우에는 안정상태와 비교하여 의의있는 변화는 없었다(p>0.05). 이상의 결과를 보아 대뇌연막 동맥에 nimodipine plus solvent 확장 효과는 주로 nimodipine에 의해 일어나는 것으로 판단된다. Nimodipine and its solvent containing ethanol, the solvent containing ethanol(the solvent alone) and normal saline alone were tested in a randomized in vivo study by local administration to the outer vessel wall surface of pial arteries and veins in rabbits. Reactions were studied through a craniectomized area. Physioloical parameters(PaO₂, PaCO₂, blood pH and systolic blood pressure) were not significantly changed during all experiments. Diameter variations of 90 arterial and 76 venous vessel segments were continuously analyzed using micrometer eyepiece on operating microscope. 1) 2.4×10^(-5)M nimodipine plus solvent induced 22% pial arterial dilatation(p<0.01). 23% in small and 21.0% in large arteries : dilatation induced by nimodipine plus solvent was significantly greater than dilatation by the solvent alone(p<0.01). After ceasing topical administration, ateries remained dilated by some 10%. The solvent alone caused minor though statistically significant(p<0.05) 6% dilatation, 9% in small and 4% in large arteries, which retured to their resting state. 2) Pial veins exhibited only minor reaction, i.e. 5%(statistically n.s.) dilatation of large veins during topical application of nimodipine plus its solvent and 8.5% dilatation of small veins 20 minutes. Pial veins were not significantly dilated by topical administration of the solvent alone. Of course normal saline did not significantly change the diameters of pial arterial and venous vessel segments in all experiments. Thus it might be concluded that the dilator effect on the investigated compound on pial arteries is predominantly due to nimodipine.

요막관 잔류이상에 대한 임상적 고찰

조창원,이종인,정풍만,Cho, Chang-Weon,Lee, Jong-In,Jung, Poong-Man 대한소아외과학회 1998 소아외과 Vol.4 No.2

The embryological and anatomical features of urachal anomalies have been well defined. Because of the variable clinical presentation, uniform guideline for evaluation and treatment are lacking. Although urachal remnants are rarely observed clinically, they often give rise to a number of problems such as infection and late malignant changes. Therefore, a total assessment of the disease with a particular focus on embryology, anatomy, clinical symptoms, as well as the most advisable management, is necessary. Twenty six patients with urachal remnants were treated at the Department of Pediatric Surgery from August 1980 to June 1998. Of these 26, 9 were classified as patent urachus 11 as urachal sinus, 4 as urachal cyst, 1 as urachal diverticulum and 1 as an alternating sinus. The group consisted of 11 males and 15 females. The age distribution was 20 neonates, 3 infants, 2 preschoolers and 1 adult. Infection was the most frequent complication and Staph. aureus was the predominant causative microorganism. Fistulogram was performed in 4 cases and ultrasound examination disclosed cysts or sinus in 7 cases. Excision was performed in 24 patients and incision and draniage in 2 cases as a primary treatment. There was no postopreative complication or recurrence.

유방에서 발생한 Peripheral Neuroectodermal Tumor 1예

조창원,정파종,정태준,조무식 대한외과학회 1997 대한외과학회 학술대회 초록집 Vol.1997 No.5

나환자의 결핵 감염 상태

조창원 대한결핵 및 호흡기학회 1965 춘계학술대회 초록집 Vol.20 No.-

Mycobacterium tuberculosis와 Mycobacterium Leprosy 혼합배양에 관하여

조창원 대한결핵 및 호흡기학회 1966 춘계학술대회 초록집 Vol.22 No.-

지방종을 동반한 요부 지주막하강내 호흡상피성 낭종 : 증례보고 및 발생기전에 대한 고찰 Case Report and Review of the Pathogenesis

조창원,최창화,장병조,이영우 대한신경외과학회 1992 Journal of Korean neurosurgical society Vol.21 No.11

The authors report a case of the respiratory epithelial cyst of lumbar subarachnoid space associated with lipoma. A 22-year-old woman presented with three month history of hyperalgesia and tingling sensation of right sole. Plain X-ray of lumbar spine revealed spinal dysraphism. Myelogram and computed tomogram revealed the mass lesion of the lumbar subarachnoid space of left side at the level of L1 and L2. At operation. lipoma and two discrete cystic lesions adherent with cauda equina at the level of conus medullaris were found and carefully removed Histological examination using light microscopy disclosed the cystic lesion to be lined by pseudostratified ciliated columnar epithelia with goblet cells. which contained mucus that was positive on PAS and D-PAS staining. Other characteristic light microscopic findings were basal cells, continuous basement membrane, and squamous metaplasia. These are typical findings of respiratory epithelia. It might be postulated that the cyst of this case arose from respiratory epithelium and endodermal origin by neurenteric adhesion.

國軍結核 患者및中高等學生 PPD反應 檢査成績

趙昌源,申泰聖 육군의무장교단 1957 육군의무장교단잡지 Vol.4 No.3

기초 : 뇌종양에서 진단적 지표로서의 Telomerase의 활성과 그 조절 기전에 관한 연구

조창원 ( Chang Weon Cho ),최창화 ( Chang Hwa Choi ),차승헌 ( Seung Heon Cha ),김철민 ( Cheol Min Kim ) 대한뇌종양학회 2005 대한뇌종양학회지 Vol.4 No.2

Objective￡ºTelomerase is the ribonucleoprotein complex which elongates telomeric repeats(TTAGGG)n and appears to play an important role in cellular immortalization. The almost exclusive expression of telomerase in tumor cells, and not in most normal cells, offers an exciting opportunity for therapy by inhibiting its function. In order to know the possibility of telomerase activity as a diagnostic marker for prediction of prognosis in brain tumors, telomerase activity was investigated in and cell lines. Patients and Methods￡ºThe surgical specimens from 34 patients with of brain tumors were analyzed by TRAP assay for access telomerase activity. And the mechanism of regulation on telomerase activity in brain tumor was investigated by RT-PCR analysis of catalytic subunit of telomerase gene, hTERT, and c-myc oncogene in five cell lines. To investigate more factors involved in carcinogenosis in malignant brain tumors, gene expression analysis with Atlas human cDNA expression array was conducted in two glioblastoma cell lines, A172 and U373MG. Results￡ºMalignant brain tumors have high activity of telomerase. This means telomerase activity can be used as a marker for malignant brain tumor. The catalytic subunit of telomerase, hTERT, were coamplified with c-myc oncogene in brain tumors with high activity of telomerase. This finding suggest the possibility of c-myc as a regulatory factor on telomerase function. Atlas human cDNA expression array profiles of two cell lines showed common expression of 27 genes which were known as genes involve during carcinogenesis. Among 27 genes, there were four genes of cell cycle or growth regulators, one intermediate filament marker, three genes for apoptosis, two genes for DNA damage repair, three receptor genes, four genes for cell adhesion and motility, one gene for angiogenesis, one genes of invasion regulators, one gene belong to Rho family of GTPases, and seven genes of growth factors and cytokines. Conclusion￡ºThis study suggest that c-myc might be a possibile upstream regulator of telomerase activity in brain tumors and that 27 genes might involve the carcinogenosis of malinant brain tumor especially in glioblastoma.