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중증뇌성마비장애인의 장애정체감 및 대처효능감이 자립에 미치는 인과관계 연구
조재삼,송인욱,채현탁 한국장애인재활협회 2010 재활복지 Vol.14 No.3
This study is to address the causal relationship among disability identity, coping self-efficacy, and independence among people with severe cerebral palsy. Structural equation modeling was used to identify the relationships of the three factors. The result showed that the disability identity was not statistically significantly related to the independence of people with severe cerebral palsy. However, the coping self-efficacy was both directly and indirectly related to the independence of people with severe cerebral palsy. Hence, the coping self-efficacy mediated the relationship between the disability identity and the independence. In detail, the disability identity influenced on the coping self-efficacy that makes people with severe cerebral palsy to manage their current not-so-benign condition more positively. Also, the coping self-efficacy influenced on the independence. Thus, it is necessary to understand the role of the coping self-efficacy as a mediator to the independence among people with severe cerebral palsy. In addition, programs to promote the coping self-efficacy among people with severe cerebral palsy should be considered.
조재삼,김학렬,김영숙,오수진,황기은,정은택 대한결핵 및 호흡기학회 2017 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.124 No.-
Pemetrexed is a multitarget antifolate for the treatment of advanced non-squamous NSCLC. Although pemetrexed as a maintenance therapy after cisplatin-based doublet chemotherapy increases survival, development of acquired resistance is almost inevitable. Salinomycin has reported antitumor activity, but it is unknown whether salinomycin can decrease pemetrexed resistance. This study was designed to investigate overcoming pemetrexed resistance by inhibiting epithelial-mesenchymal transition (EMT) using salinomycin. We developed an in vitro model of acquired resistance to pemetrexed by continuously treating A549 and H460 with escalating doses. The effects of salinomycin on EMT and lung cancer migration and invasion in pemetrexed resistance (PR) cells were examined by western blotting and confocal microscopy. The anti-tumor effects of salinomycin on tumor growth in vivo also evaluated. Morphological changes that are persistent with the acquisition of the EMT phenotype showed in A549PR and H460PR cells. Addition of salinomycin to pemetrexed inhibited PR-induced EMT, as indicated by upregulation of E-cadherin, and downregulation of mesenchymal markers and transcriptional factors. Moreover, salinomycin could suppress migration and invasion of A549PR and H460PR cells. In vivo, salinomycin also augmented the inhibitory effects of pemetrexed on tumor growth of A549PR. Taken together, these results suggested that Salinomycin may overcome pemetrexed resistance in NSCLC via inhibiting EMT and suppressing lung cancer cell migration and invasion.
F-97 Computed Tomography Morphologic Features of Pulmonary Adenocarcinoma with Brain/bone Metastasis
조재삼,황기은,김학렬,정은택 대한결핵 및 호흡기학회 2016 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.121 No.-
Background: Brain and bone metastases are common in patients with lung cancer. The development of metastasis is associated with poor survival in lung cancer patients. We assessed morphologic features of pulmonary adenocarcinomas with brain/bone metastasis on computed tomography (CT) to identify related factors for metastasis and overall survival. Methods: We performed a retrospective analysis of initial chest CT findings (size, type of contour, percentage of necrosis, enhancement, presence or absence of calcification, and air cavity) from 2009-2010 of patients with brain or bone metastasis and compared the findings with those of patients without metastases. Results: In total, 128 patients were included (78 men, 52 women; mean age 69 years; range 36-87 years). Nineteen patients had brain metastases and 32 had bone metastases. Morphologic features associated with brain metastasis included size ≥ 50 mm (odds ratio [OR]: 3.37, 95% confidence interval [CI]: 1.24-9.17, p = 0.013), necrosis ≥ 30% (OR: 4.51, 95% CI: 1.62-12.55, p = 0.002), and presence of calcification (OR: 3.97, 95% CI: 1.16-13.55, p = 0.035). Morphologic features associated with bone metastasis included necrosis ≥ 30% (OR: 4.639, 95% CI: 1.98-10.82, p < 0.001) and T 3-4 stage (OR: 2.53, 95% CI: 1.07-6.00, p = 0.031). However, in this study, morphologic features were not related with overall survival. Conclusions: We found that necrosis ≥ 30% was associated with pulmonary adenocarcinoma with brain and bone metastasis at initial chest CT morphologic feature.
만성변비 환자에서 직장항문 기능검사의 진단적 응용 가치
조재삼,박웅채 대한소화기학회 1998 대한소화기학회지 Vol.31 No.3
Background/Aims: The pathophysiology of chronic constipation is more complex than just simple disorders of the pelvic floor muscle or colon. This study was designed to assess the diagnostic usefulness of physiologic investigation in patients with chronic constipation and to analyze the characteristics of physiologic findings of obtained diagnosis. Methods: Anal manometry (n=82), cinedefecography (n=106), anal EMG/PNTML (pudendal nerve terminal motor latency; n=27) and colonic transit time study (n=35) were performed on the patients with chronic constipation. Physiologic findings of patients who recieved at least two items of physiologic tests (n=106, 68 females and 38 males) were retrospectively evaluated. Age matched control data (n=33) in anal manometry and sex matched control data (n=20) were selected from volunteers. Results: Patients were categorized as rectocele (Group I: n=36), nonrelaxing puborectalis syndrome (Group II: n=14), anal dyschezia (Group III: n=14), rectoanal intussusception (Group IV: n=8), encopresis (Group V: n=7) and others (n=27). In anal manometry, the patients with group III showed higher mean and maximum resting pressures (p$lt;0.001) and higher mean squeeze pressures and maximal voluntary contraction (p$lt;0.01) than the patients with other groups. In cinedefecography, patients with group II showed smaller anorectal angle at strain (p$lt;0.001) and at dynamic change between rest and strain (p$lt;0.05) than the patients with other groups. In neurologic study, mean value of PNTML for all patients was 2.35±0.44 (range, 1.66-3.66) msec. The value of PNTML was increased in proportion to the ages of patients (r=0.46, p=0.003). Conclusions: These results suggest that anorectal physiologic studies are vital to the functional diagnosis for the patients with constipation. Current data provide the important diagnostic ramification, and can be used for clinical appraisal.