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조윤미,김태민,김대훈,김동희,정성환,권오주 생화학분자생물학회 2016 Experimental and molecular medicine Vol.48 No.-
Wnt10b, an endogenous inhibitor of adipogenesis, maintains preadipocytes in an undifferentiated state by suppressing adipogenic transcription factors. We have previously demonstrated that Wnt10b transcription during adipogenesis is negatively regulated by X-box-binding protein 1 (XBP1), an important transcription factor of the unfolded protein response. In this report, we demonstrate that XBP1s can directly induce the transcription of microRNA-148a, which in turn mediates the silencing of Wnt10b mRNA during adipogenic differentiation of 3T3-L1 cells. Stability of Wnt10b mRNA was found to be significantly increased by knockdown of XBP1s. Using computational algorithms, a set of microRNAs was predicted to bind Wnt10b mRNA, of which microRNA-148a was selected as a potential target for XBP1s. Our results revealed that microRNA-148a could bind to the 3′UTR of Wnt10b mRNA. Its ectopic expression significantly suppressed both Wnt10b expression and β-catenin activity. When we altered the expression of XBP1 in 3T3-L1 cells, microRNA-148a levels changed accordingly. A potential XBP1 response element was found in the promoter region of microRNA-148a, and XBP1s directly bound to this response element as shown by point mutation analysis and chromatin immunoprecipitation assay. In addition, a microRNA-148a mimic significantly restored adipogenic potential in XBP1-deficient 3T3-L1 cells. These findings provide the first evidence that XBP1s can regulate Wnt10b by a post-transcriptional mechanism through directly inducing microRNA-148a.
부모-자녀 의사소통 시간과 유형에 따른 청소년의 자기효능감
조윤미,이숙 전남대학교 생활과학연구소 2007 生活科學硏究 Vol.17 No.-
The purpose of this study was to analyse the difference of adolescent's self-efficacy according to parentsadolescent communication time and communication styles. The samples were 285 adolescents from Kwangju City. For statistical analysis, Cronbach'α, t-test, one-way ANOVA, Scheffe's multiple Comparison Analysis, and LSD method were used. The results were summarized as follow: First, there were significant differences in the degree of adolescent's self-efficacy according to parents-adolescent communication time and communication styles. Second, father's open communication style showed a significant difference on adolescent's self-efficacy.
조윤미,손민,안영미,서민희,이상미,정소영 한국보건간호학회 2023 韓國保健看護學會誌 Vol.37 No.2
Purpose: This study aimed to examine the injury prevention behaviors of school-age children using the Theory of Planned Behavior (TPB) and sought to identify the associated factors. Methods: A sample of 199 students in Grades 3 to 6 and their parents participated in the study. Measures were used to assess injury prevention behaviors, intentions, and parental influence. The data were analyzed using logistic regression analysis. Results: The findings showed that a stronger intention toward injury prevention behavior, living in an urban area, and higher involvement of parent's to prevent injuries were significantly associated with higher levels of injury prevention behaviors among the children. Conclusion: This study highlights the importance of intention, parental influence, and urban residence in promoting injury prevention behaviors among school-age children. The findings suggest the need for tailored interventions targeting these factors to promote prevention of injuries among children. Further research is needed to develop comprehensive strategies to prevent injuries in this population.
조윤미,김동희,이경혜,정성환,권오주 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
The peroxisome proliferator-activated receptor-γ (PPARγ) improves whole-body insulin sensitivity by regulating the adipogenic and metabolic functions of mature adipocytes. We have previously demonstrated that an active splice variant of X-box binding protein 1 (XBP1s) enhances PPARγ expression during adipogenesis. In this study, we investigated the role of XBP1s, particularly with respect to PPARγ, in the mechanisms underlying insulin sensitivity in mature adipocytes. Insulin was able to stimulate XBP1s generation by activating inositol-requiring enzyme 1 (IRE1) α and was also able to increase its transcriptional activity by inducing nuclear translocation. XBP1s also upregulated the levels of phosphorylated IRS1 and AKT, demonstrating a positive feedback regulatory mechanism linking insulin and XBP1s. XBP1s enhanced the expression of fibroblast growth factor 21 and, in turn, increased PPARγ activity, translocation of GLUT4 to the cell surface, and glucose uptake rate in adipocytes. In addition, XBP1s abolished palmitate-induced insulin resistance in adipocytes by increasing adiponectin secretion, repressing the secretion of proinflammatory adipokines such as leptin, monocyte chemoattractant protein 1, and tumor necrosis factor α, and decreasing fatty acid release. These findings provide a novel mechanism by which XBP1s stimulate insulin sensitivity in adipocytes through fibroblast growth factor 21 induction and PPARγ activation.
조윤미 대한어린이교육협회 2004 어린이교육 Vol.- No.6
놀이는 재미가 있어서 하는 거으로, 인간의 유희 본능과 모방 본능에서 발생했다고 한다. 본능이 원시 종교의 제사 의식과 결부되면서 각종 놀이로 표현되었고, 생활의 변화에 따라 여가를 즐기는 방법으로 인식되어 전해져 내려오고 있다. 전통적으로 우리의 영,유아기 교육의 근간을 이룬것은'놀이'이다. 영아기에는 부모나 주변의 성인과 함께 한 도리도리,잼잼,짝짜쿵 등 영아와의 상호 작용 놀이가 있고, 유아기는 두껍아 두껍아, 어깨동무 내동무, 고무줄 노래, 별 헤는 노래 등의 또래 집단 놀이가 있다.