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제연진,윤영훈 대한상부위장관ㆍ헬리코박터학회 2022 Korean Journal of Helicobacter Upper Gastrointesti Vol.22 No.4
Non-ampullary duodenal tumors refer to duodenal lesions that originate at sites other than the ampulla of Vater. They differ from ampullary duodenal tumors, which are typically associated with obstructive symptoms. Non-ampullary duodenal tumors are rare; therefore, standardized clinical management, including diagnostic and therapeutic modalities and the follow-up strategy remain unclear. An increase in the numbers of patients undergoing endoscopy during medical checkups and technological advances in endoscopic procedures, including high-resolution and image-enhanced endoscopy have led to an increase in detection rates of duodenal tumors recently. Currently, endoscopic resection of duodenal tumors is widely used and is a preferred therapeutic alternative to surgical excision. Some duodenal tumors of high malignant potential are associated with poor prognosis; therefore, accurate diagnosis and timely management are important. In this article, we review the current knowledge regarding non-ampullary duodenal tumors and the therapeutic approaches to these lesions.
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The First Case Series of Cryopyrin-Associated Periodic Syndrome in Korea
한종희,제연진,윤현제,안종균,이진성,박정원,박혜정 대한천식알레르기학회 2019 Allergy, Asthma & Immunology Research Vol.11 No.4
Cryopyrin-associated periodic syndrome (CAPS) is a hereditary autoinflammatory syndrome caused by mutations in NLRP3 (encoding cryopyrin), which presents with fever, fatigue and arthralgia. Thus far, however there have been no reports of CAPS in Korea. Herein, we report 3 cases of CAPS for the first time in Korea. The first case, a 28-year-old man with recurrent urticaria, arthralgia and fever induced by cold, all of which were observed in his father, showed elevated erythrocyte sedimentation rate and C-reactive protein. He exhibited a p.Gly303Asp variant of the NLPR3 gene. The second case, a 2-year-old girl who had recurrent urticaria, arthritis and oral and genital ulcers, was positive for HLA B51 and a p.Glu569Lys mutation in exon 3 of the NLRP3 gene. Administration of anakinra greatly improved her symptoms. The third case, a 4-year-old boy who presented with recurrent urticaria, arthralgia, and fever, exhibited a p.Val72Met mutation in exon 1 of the NLRP3 gene. Administration of tocilizumab improved all of his symptoms. This small case series suggests that clinicians consider CAPS and conduct genetic studies when arthralgia and fever are accompanied by urticaria in Korea.
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CNT 첨가에 따른 유리섬유/섬유 복합재 제작 및 특성 평가
김형태,이도현,안우진,오창환,제연진,이동박,조규철,박준홍,Kim, Hyeongtae,Lee, Do-Hyeon,An, Woo-Jin,Oh, Chang-Hwan,Je, Yeonjin,Lee, Dong-Park,Cho, Kyuchul,Park, Jun Hong 한국결정성장학회 2021 한국결정성장학회지 Vol.31 No.4
The fiber composites have been investigated as lightweight structure material platforms for aerospace applications because their strength can be enhanced by adding reinforcement without a significant increase in weight. In this study, the fabrication and characterization of carbon nanotube (CNT) reinforced glass fiber composites are demonstrated to enhance the tensile strength of longitudinal direction along the glass fibers. Due to the reinforcement of CNT in epoxy layers, the yield strength of fiber/epoxy composites is enhanced by about 10 %. Furthermore, using scanning electron microscopy, analysis of fracture surfaces shows that mixed CNT in epoxy layers acts as necking agents between fractured surfaces of fiber/epoxy; thereby, initiation and evolution of crack across fiber composite can be suppressed by CNT necking between fractured surfaces. 본 연구에서는 CNT 첨가에 따른 유리섬유/에폭시의 강도 변화를 관찰하기 위해서 에폭시 기지 상에 CNT를 분산 시켜 유리섬유 표면에 도포하였다. 제작된 유리섬유/에폭시/CNT 복합재의 특성을 강도 측정기를 이용해 평가하고, 파괴 메커니즘을 분석하기 위해서, 원자힘현미경과 전자현미경을 활용하여 분석하였다. 원자힘현미경 이미지들을 기반으로 line trace 분석을 통해 CNT 소재의 굵기 및 길이를 분석한 결과, 대부분의 CNT는 약 10 ㎛ 이상의 길이와 평균적으로 47.72 ± 4.0 nm의 두께를 가진것으로 확인되었다. 3 wt%로 혼합한 유리섬유/에폭시/CNT 복합재의 경우 대조 시편인 유리섬유/에폭시와 비교 시, 740.17 ± 111.05 N/mm<sup>2</sup>에서 816.56 ± 200.26 N/mm<sup>2</sup>로 약 10 % 이상의 인장 강도 향상이 관측되었다. 전자 현미경을 이용한 파단면 분석 결과, 에폭시 기지 층에 분산된 CNT가 복합재의 길이 방향으로 배열되어 있음이 관찰되었으며, 유리섬유/에폭시/CNT에 하중 인가 시, 에폭시 층에서 생성된 크랙들의 성장을 에폭시 수지상에 분산된 CNT들이 넥킹 역할을 하면서, 복합재의 인장 강도 향상이 되었다고 판단된다.
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