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정지안 ( Ji Ann Jung ),손가현 ( Ga Hyun Son ),이미경 ( Mi Kyung Lee ),김영한 ( Young Han Kim ),박용원 ( Yong Won Park ),권자영 ( Ja Young Kwon ) 대한산부인과학회 2010 Obstetrics & Gynecology Science Vol.53 No.2
Estimated incidence of round ligament varicosities in pregnancy is not known and often times it is confused with inguinal hernia due to their clinical similarities. When a patient is presented with inguinal mass especially in association with varicosity in the genital region or lower extremity, round ligament varicosity must be considered as a plausible diagnosis. Depiction of bag of worms on color Doppler ultrasonography is diagnostic of the round ligament varicosity and it is known to resolve spontaneously following delivery. We report a case of round ligament varicosities that was diagnosed at 29 weeks of gestation with a brief review of the literatures.
임상 ; 초극소 미숙아에서 조기 장관영양의 임상적 효과
정지미 ( Ji Mi Jung ),한성우 ( Seong Woo Han ),구수현 ( Mi Lim Chung ),정미림 ( Soo Hyun Koo ),전가원 ( Ga Won Jeon ),신종범 ( Jong Beom Sin ) 대한주산의학회 2011 Perinatology Vol.22 No.2
목적: 초극소 미숙아에서 조기 장관영양이 장점막의 위축을 방지하고 장운동을 성숙시킨다는 연구는 많지만 이로 인한 괴사성 장염, 패혈증 등의 우려로 실제로 환자에게 적용하기는 어렵다. 이에 초극소 미숙아에서 조기장관영양이 이들의 예후에 미치는 영향에 대해 알아보았다. 방법: 2007년 1월부터 2009년 10월까지 부산백병원 신생아 집중치료실에 입원한 출생체중 1,000 g 미만의 초극소저출생체중아 61명의 의무기록을 후향적으로 분석하였다. 2008년 4월부터 조기장관영양을 시작하여 2007년 1월부터 2008년 3월까지를 대조군, 2008년 4월부터 2009년 10월까지 조기장관영양군으로 나누었다. 결과: 재태연령과 출생체중은 두군간의 차이가 없었고, 장관영양 시작시기와 완전장관영양 도달시기는 대조군과 조기영양군에서 각각7±2일, 2±1일과 68±6일, 22±2일로 조기장관영양군에서 유의하게 빨랐다(P<0.05). 정맥영양 시행기간은 대조군 58±6일, 조기장관영양군 22±2일로 조기장관영양군에서 유의하게 짧았고, 28병일째 체중증가율은 조기장관영양군에서 의미있게 높았다. 괴사성 장염과 패혈증의 발생빈도는 두군간의 차이가 없었고, 담즙정체증(대조군; 44%, 조기장관영양군; 7%)과 중등도 이상의 기관지폐이형성증(대조군; 78%, 조기장관영양군; 24%)은 조기장관영양군에서 유의하게 감소하였다. 결론: 초극소 미숙아에서 조기 장관영양은 괴사성 장염이나 패혈증의 증가 없이 완전장관영양에 빨리 도달하게 하였으며 기관지폐이형성증, 담즙정체증을 의미있게 감소시켰다. Purpose: This study investigated the effects of early enteral feeding on the morbidities of extremely low birth weight infants (ELBWI) weighing less than 1,000 g. Methods: We conducted a retrospective review of the medical records of sixty one ELBWI who were admitted to the neonatal intensive care unit of Inje University Busan Paik Hospital from January 2007 to October 2009. ELBWI were divided into two groups; the control group included ELBWI from January 2007 to March 2008, for whom enteral feeding was started beyond 3 days and the early feeding group included ELBWI from April 2008 to October 2009, for whom enteral feeding was started within 3 days. Results: Gestational age and birth weight did not differ between the two groups. In the early feeding group, start day of enteral feeding (control group vs. early feeding group; 7±2days vs. 2±1days), time to achieve full enteral feeding (68±6 days vs. 22±2 days), and the duration of parenteral nutrition (58±6 days vs. 22±2 days) were significantly shorter, and weight gain at postnatal day 28 was significantly higher than that of the control group (P<0.001). No differences were observed in the incidence of sepsis and necrotizing enterocolitis and duration of hospitalization; however, the incidence of total parenteral nutrition induced cholestasis (44% vs. 7%) and bronchopulmonary dysplsia (78% vs. 24%) was significantly lower in the early feeding group. Conclusion: Early enteral feeding in ELBWI shortened the time to achieve full enteral feeding, improved weight gain, and decreased the incidence of brochopulmonay dysplasia and cholestasis.
재래식 메주에서 분리한 유산균들의 각종 효소활성 및 기능성
정지강(Ji-Kang Jeong),정연비(Yanfei Zheng),최혜선(Hye-Sun Choi),한귀정(Gwi-Jung Han),박건영(Kun-Young Park) 한국식품영양과학회 2010 한국식품영양과학회지 Vol.39 No.12
전통 재래식 메주 3종을 수집하여 호기성 생균수, 유산균 수, 효모 및 곰팡이의 수를 측정한 결과 각각 10?~10? CFU/g, 106~108 CFU/g, 107~108 CFU/g의 분포를 나타내었고, 일반적으로 메주의 발효에 가장 크게 관여하고 있는 효모 및 곰팡이이 외에도 유산균 역시 메주의 발효에 깊이 관여하고 있는 주요 균주인 것으로 나타났다. 재래식 메주로부터 몇 종의 유산균을 분리한 후, 3종의 우수균주를 선별하여 동정을 실시한 결과, Leuconostoc mesenteroides, Lactobacillus plantarum, Lactococcus lactis로 밝혀졌으며, 이들을 각각 Lm-SMm, Lp-SMm, Ll-GAm로 명명하였다. 3종 유산균의 효소 활성을 측정한 결과, 모두 protease, lipase, α-amylase 활성을 나타내었고 특히 Ll-GAm이 상대적으로 높은 효소 활성을 나타내었다. DPPH를 이용하여 항산화 효과를 측정한 결과, Lm-SMm, Lp-SMm, Ll-GAm은 각각 45%, 48%, 60%의 free radical 소거 효과를 나타내었고, MTT assay를 이용하여 HT-29 인체 결장암 세포 성장억제 효과를 측정한 결과 각각 45%, 67%, 70%의 성장억제 효과를 나타내었다. 따라서 전통메주로부터 분리한 우수한 유산균은 장류제조 산업에 있어서 적용성이 있을 것으로 생각되어지며, 메주 제조에 있어서 스타터로 사용되었을 때 장류제품의 품질을 향상시킬 수 있을 것으로 기대된다. Three kinds of Korean traditional Meju were selected and the counts of microorganisms in these Meju were determined. The counts of total aerobic bacteria, lactic acid bacteria and yeasts and molds were 10?~10?, 10?~108 and 10?~10? cfu/g, respectively in three Meju and lactic acid bacteria were important microorganisms in the fermentation of Meju. Therefore, we isolated three kinds of dominant lactic acid bacteria from these Meju. They were identified as Leuconostoc mesenteroides (98%, Lm-SMm), Lactobacillus plantarum (99%, Lp-SMm) and Lactococcus lactis (98%, Ll-GAm). Then, enzyme activities and physiological functionalities of three lactic acid bacteria were investigated. Protease, lipase and α-amylase activities were detected in three lactic acid bacteria, Ll-GAm showed relatively higher activities than other two lactic acid bacteria. Lm-SMm, Lp-SMm and Ll-GAm showed 45, 48 and 60% of antioxidative activity to 1,1-diphenyl-2-picryhydrazyl (DPPH), and exhibited 45, 67 and 70% of inhibitory effects in HT-29 human colon cancer cells, respectively. These results indicate that three lactic acid bacteria isolated from traditional Meju, especially Ll-GAm are applicable to Meju preparation for soybean paste industry.
암종으로 오진하였던 모기질종의 세침흡인 세포학적 소견 - 1예 보고 -
정지한,김영신,이교영,강창석,심상인,Jung, Ji-Han,Kim, Young-Shin,Lee, Kyo-Young,Kang, Chang-Suk,Shim, Sang-In 대한세포병리학회 1999 대한세포병리학회지 Vol.10 No.1
Sometimes a pilomatrixoma on upper neck can be misdiagnosed as primary salivary gland tumor, skin adnexal tumor or metastatic carcinoma. On fine needle aspiration cytology(FNAC), characteristic features are ghost cells, basaloid cells, and calcium deposits, among which presence of ghost cells seems to be the key to recognize it. Here we present a cytologically misdiagnosed case of pilomatrixoma. A 32-year-old man presented a subcutaneous mass on the right posterior neck. It has grown slowly for 1 year, and was nontender, well circumscribed, hard, and movable mass. An Initial FNAC yielded only monomorphic population of highly mitotic basaloid cells, without anucleated ghost cells, chronic inflammatory cells or foreign-body giant cells, suggestive of a poorly differentiated carcinoma. However, that was inconsistent with patient's clinical findings. For further correct diagnosis, FNAC was repeated, which yielded the basaloid cells and foreign-body giant cells. The diagnosis of pilomatrixoma could be made and the mass was excised. This case demonstrates that the pilomatrixoma should be considered in the differential diagnosis of subcutaneous aspirates containing not ghost cells but a dominant population of basaloid cells.
A Case of Metastatic Eccrine Porocarcinoma with a Review of the Literatures
Jung Hwan Lee(이정환),Joo Han Lim(임주한),Lucia Kim(김루시아),Chul Soo Kim(김철수),Hyeon Gyu Yi(이현규),So Yun Nah(나소연),Seong Hyun Kim(김성현),Ji Joong Jeong(정지중),Myung Dong Lee(이명동),Jea Ho Ye(예재호),Moon Hee Lee(이문희) 대한두경부종양학회 2011 대한두경부 종양학회지 Vol.27 No.2
에크린 한공암종은 흔하지 않으며, 전이성 에크린 한공암종은 매우 드문 암이다. 에크린 한공암종은 표피내 한관에서 기원하는 피부 부속기 악성 종양으로, 대부분 에크린 한공암종은 항암치료와 방사선치료에 효과가 없으며, 따라서 유일한 치료방법은 전이되기 전에 국소 및 광범위 절제술을 시행하여야 한다. 본 환자는 두피에 발생한 에크린 한공암종이 점점 진행하여 피부, 림프절, 폐 등으로 전이하였고, 다수의 광범위 절제술에 이어 항암치료와 방사선치료를 받았지만, 결국 폐전이가 악화되어 사망하였다. 본 저자들은 항암치료와 방사선치료에 불응한 에크린 한공암종 1예를 치료에 대한 문헌고찰과 더불어 보고하는 바이다.
갑상선의 원주세포형 유두상 암종의 세침흡인 세포학적 소견 - 1예 보고 -
정지한,강창석,심상인,김병기,이교영,Jung, Ji-Han,Kang, Chang-Suk,Shim, Sang-In,Kim, Byung-Kee,Lee, Kyo-Young 대한세포병리학회 1999 대한세포병리학회지 Vol.10 No.2
The columnar cell variant of papillary carcinoma is a rare tumor of the thyroid, associated with aggressive behavior, early metastasis, and a rapidly fatal course. We present the fine needle aspiration cytologic(FNAC) findings of columnar ceil variant of papillary carcinoma with cytohistologic correlation. In the smears, the tumor fragments showed mainly papillary pattern and a few scattered individual cells were present around the papillary fragments. The tumor cells were columnar or cuboidal and exhibited pseudostratification of the nuclei. The nuclei were oval to elongated with finely stippled chromatin and inconspicous nucleoli. Neither nuclear grooves nor intracytoplasmic inclusion was found. The FNAC diagnosis was consistent with papillary carcinoma. Total thyroidectomy was done and the histologic finding of the mass showed a predominantly papillary and focal solid proliferation of columar cells with marked nuclear pseudostratification. The unique histopathologic features and highly aggressive nature of columnar ceil variant of papillary carcinoma require that this variant should be differeniated from common papillary carcinoma of the thyroid.