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정용준,이대용,최기백,안혜지,김필한,박지호,김유천 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.48 No.-
In this study, a novel oral insulin delivery system was prepared by combining two different artificialpolypeptides with insulin. Negatively charged poly(L-glutamate-co-N-3-L-glutamylsulfanilic acid)(PLGS), cationic alpha helical peptide poly-L-lysine (PLL), and insulin formed polyelectrolyte complexes(PCs) were characterized. The property of the PCs was examined by an in vitro study. A significantly higheramount of the loaded FITC insulin was released in the intestinal condition, suggesting the controlledrelease of the PCs to protect insulin in the acidic stomach condition while releasing it in the smallintestine. The in vitro cellular uptake study with Caco-2 cells also revealed the improved penetration ofthe loaded FITC labeled insulin. By virtue of the cell penetration enhancing ability of PLL, the permeationof insulin in the small intestine was notably augmented. Furthermore, the feasibility of the PCs wasconfirmed through an in vivo hypoglycemic effect study. The PCs showed an improved hypoglycemiceffect suggesting the success of the delivery and penetration of the loaded insulin. The blood glucose levelwas lowered to 80% of its initial value after the oral administration of the PCs, and the hypoglycemialasted for more than 14 h. The long lasting hypoglycemic effect of the PCs can reduce the number ofadministrations, and it will contribute to improving the quality of patients’ lives. The PCs providedreasonable results as a competitive candidate for oral insulin delivery. The introduction of the PCs willpromote the oral delivery of charged proteins or drugs.
실측 데이터를 이용한 고무류 화생방 물자의 저장수명 예측 연구
정용준,이해연,서지영,이남례 한국산학기술학회 2022 한국산학기술학회논문지 Vol.23 No.9
In this study, the shelf-life of rubber CBRN materials was predicted using tensile strength test results. Unlike other fields, including ASRP, no studies have been conducted on the shelf-life of protective clothing, which is one of the most important items in CSRP. Therefore, in this study, the shelf-lives of gloves and footwear-covers were predicted using tensile strength test results performed in DTaQ from 2007 to 2021. Shelf- life predictions were made by organizing tensile strength values by storage period and performing regression analysis. In addition, the lower limits of prediction intervals were used to predict shelf-lives using stricter standards. As a result of regression analysis, the shelf-life of gloves was predicted to be about 57 years, and those of the upper and sole of footwear-covers were predicted to be 115 and 721 years, respectively. Shelf-lives based on lower limits of prediction intervals were lower, and shelf-lives predicted by the two methods were similarly derived for the upper footwear-cover, for which the correlation between storage period and tensile strength was straightforward. Based on actual data, this study is the first to predict the shelf-life of rubber CBRN materials and should contribute to setting future shelf-life standards for rubber materials. 본 연구에서는 인장강도 시험 결과을 이용하여 고무류 화생방 물자의 저장수명을 예측하였다. ASRP를 포함한 여타 분야와는 달리 그간 CSRP에서는 저장수명 예측에 관한 충분한 연구가 수행되지 못하였다. 특히 신체 보호에 직접적인 영향을 미치는 보호의류에서는 수명 예측에 관한 연구가 전무한 실정이다. 이에 본 연구에서는 2007년부터 2021년까지 국방기술품질원에서 수행한 인장강도 시험 결과를 바탕으로 장갑과 덧신의 저장수명을 예측하였다. 수명 예측은 저장 기간에 따른 인장강도 값을 정리하고 회귀분석을 수행하는 방식으로 이루어졌다. 또한, 보다 엄격한 기준으로 수명을 예측하고자 예측구간 하한값에 따른 저장수명도 산출하였다. 회귀분석 수행 결과 장갑의 저장수명은 약 57년으로 예측되었으며 덧신의 갑피와 밑창은 각각 115년과 721년으로 예측되었다. 예측구간 하한값에 따른 저장수명은 이보다 낮았으며 저장 기간과 인장강도의 상관관계가 비교적 명확한 덧신 갑피에서는 두 가지 방식으로 예측한 수명이 유사하게 도출되었다. 본 연구는 실제 데이터를 바탕으로 고무류 화생방 물자의 저장수명을 예측한 첫 연구이며 향후 고무류의 저장수명 설정에 기여할 수 있을 것으로 기대된다.