황련 추출물의 아토피피부염 유발 생쥐에서 피부손상 완화 효과

정아람(A Ram Jung),안상현(Sang Hyun Ahn),정한솔(Han Sol Jeong),김기봉(Ki Bong Kim) 한의병리학회 2019 동의생리병리학회지 Vol.33 No.2

환아 보호자 대상으로 실시한 한약 용기 선호도 조사

정아람,이혜윤,천진홍,김기봉,Jeong, A Ram,Lee, Hye Yoon,Cheon, Jin Hong,Kim, Ki Bong 대한한방소아과학회 2014 대한한방소아과학회지 Vol.28 No.4

Objectives The aim of this study is to investigate preferred herbal medicine packaging. Methods The study used questionnaires for the caregivers, who have administered their children herbal and western medicine. 106 of them were visited the Department of Pediatrics, the Oriental Medicine Hospital of ${\bigcirc}{\bigcirc}$ University, during the period between in 2014. We used PASW Stastics 18.0 to analyze different dosing methods, and preferred packaging and drug formulations. Results 1. 77.4% answered that they use cups to administer medications, 9.4% transferred it to other plastic bottles, 8.5% used straw to drink from the pouch, 4.7% drank as it is inside the pouch. Method of taking it was not very significant depending on the age. 2. Compare to pills and capsules, 48 responders answered that pills and capsules are easier to take, 11 answered herbal medication is easier to take. 32 answered that there were no significant difference. 3. 45.3% reported vinyl pouch was preferable, 44.3% answered spout pouch was preferred, 5.7% answered bottles are convenient, and another 5.7% responders thought cup was fine. Others include syrup bottles had 1 person. These varying preferences were not depending on the age variations. 4. 56.3% answered that price was the main reason why they prefer one over the other. Others 29.2% stated convenience, 12.5% reported safety, and 10.4% people answered ease of administration as their main reason for their preferences. Conclusions Based on this study, numbers of parents felt inconvenient administering herbal medicine as a vinyl pouch, and felt necessary to improve this. However, price and other reasons made vinyl pouch still more preferable option. Vinyl pouch that we are using today didn't show any safety issues. Therefore, it is recommended to still use vinyl pouch, but with caps on top to improve administration and distinguishing issues.

영아 상완신경총 손상 치험 1례

정아람,김기봉,천진홍,Jeong, A Ram,Kim, Ki-Bong,Cheon, Jin-Hong 대한한방소아과학회 2014 대한한방소아과학회지 Vol.28 No.1

Objectives The objective of this study is to report the effects of acupuncture on neonatal brachial plexus palsy (neonatal brachial plexopathy). Methods We treated the patient with acupuncture for 4 months. Acupuncture was performed on the infant with flaccid paresis of a lower extremity. The effects of neonatal brachial plexus injury were measured by the active movement scale and the electromyographic test. Results 1. In electromyographic test, conduction velocity in left median nerve was elevated. 2. Active movement scale score was increased from 6 to 27 during the 4 months of treatment. 3. Grasping power of the patient's left hand was 60% stronger than the first medical examination. Conclusions This study showed that acupuncture was effective in treating the symptoms of brachial plexopathy. The further studies might be also needed.

문화다양성 가치실현을 위한 공공기관 경영의 쟁점 분석

정보람(Jeong, Bo-Ram),황아람(Hwang, A-Ram) 한국문화산업학회 2020 문화산업연구 Vol.20 No.4

본 연구는 문화다양성과 유사하게 국제사회의 요구에 의해 구체화되는 과정에서 공공기관 경영과 연계하여 CSR(사회적 책임경영), 인권경영, 윤리경영 등이 형성된데 비해, 논의가 부족했던 문화다양성 경영을 개념화하고자 진행되었다. 연구에서는 CSR, 윤리경영, 인권경영 등과 문화다양성 경영의 영역을 확인하고, 문화다양성 경영 쟁점별 분석을 통해 문화다양성 경영을 현장에서 구체화할 수 있는 방안을 모색하였다. 주요 결과를 살펴보면 공공기관의 문화다양성 경영 영역은 공공성, 사회형평성(소수에 대한 배려), 공정성과 윤리를 요구한다는 점에서 현재 공공기관에 적용되고 있는 CSR이 지향하는 바와 중첩되고, 소외·소멸 문화상품을 보호하는 영역은 독립적인 영역이라 할 수 있다. 측정함에 있어서 문화다양성 경영의 실효성을 고려하며 포괄적 지침보다 적절한 세부적 요구사항 제시가 필요한데, 이는 문화다양성을 저해하는 이슈 해결 관점에서 구체적인 조건이자 적극적인 요구사항으로 제안되어야 한다. 또한 소수, 소외, 소멸과 같은 대상에 대한 낙인, 역차별이 논란되지 않게 대상을 특정하는 방식이 아닌 상황에 대한 이해와 관용수준을 높이는 방식이 중요하다. 마지막으로 문화다양성 경영은 공공기관의 자발적 참여와 스스로 기관에 맞는 문화다양성 이슈 발굴과 해결 노력이 중요하지만 현실에서 순수한 자발성을 기대하기 어려우므로, 자발적 형식이지만 책임을 부각하여 강력한 유인책이 되는 방식 채택을 제안하였다. This study set out to conceptualize cultural diversity management because there is a shortage of its discussions. This study checked the domain of cultural diversity management along with CSR, ethical management and human rights-based management and analyzed cultural diversity management by issue to search for ways to make it specific in the field. The major findings were as follows: the domain of cultural diversity management in public institutions overlaps with the orientation of CSR currently applied to public institutions in that it demands publicness, social equality, fairness, and ethics. Its domain is independent in the protection of cultural products that are becoming extinct or alienated. Given the effectiveness of cultural diversity management in its measurement, there should be proper, detailed requirements rather than comprehensive guidelines and should be proposed as specific conditions and active requirements in the viewpoint of solving issues hindering cultural diversity. In addition, it is important to increase the understanding and tolerance level for situations instead of specifying an object so that stigmas and reverse discrimination will not be controversial for the subjects of minority, alienation, and extinction. Finally, public institutions" voluntary participation is important in cultural diversity management along with their effort to identify and solve cultural diversity issues fit for them, but in reality, it is difficult to expect pure volunteering from them. Powerful incentives need to be employed that highlight their responsibility even in a voluntary format.

저온 냉각이 원유의 품질에 끼치는 영향에 관한 연구

정아람 ( A Ram Jeong ),한송이 ( Song Ee Han ),김명희 ( Myeong Hee Kim ),김송희 ( Song Hee Kim ),박은주 ( Eun Ju Park ),윤여창 ( Yoh Chang Yoon ) 한국유가공기술과학회 2011 한국유가공기술과학회지 Vol.29 No.1

This study was carried out to investigate the change of components which raw milk has during cold storage. General component content of raw milk (fat, protein, lactose, total solids) was decreased in proportion to the length of cold storage. The pH of raw milk was decreased in according to the length of cold storage. In electrophoresis images, β-casein which was one of the composition of raw milk was decreased as the period of cold storage extended on the other hand, the content of Ca and P in the serum casein was increased in accordance with the length of cold storage.

국내 대학부속 한방병원 한약 포장팩의 사용 현황 및 효용성 연구

정아람,이혜윤,천진홍,김기봉,Jeong, A Ram,Lee, Hye Yoon,Cheon, Jin Hong,Kim, Ki Bong 대한한방소아과학회 2013 대한한방소아과학회지 Vol.27 No.1

Objectives The purpose of this study is to know the present uses of pre-packed herbal medicine and their usefulness in Korean University Oriental Medicine Hospitals. Methods We selected 29 university hospitals to survey by using telephone and by mail. Results 1. The kind of packages that 29 hospitals uses were 2 layers, 3 layers and 3 layers with aluminum as the component layer, standing or non-standing pouch. 2. Total 24.1% hospitals are using 3 layers patch with aluminum because of their merits. The merits are preserving the quality of packaged drugs, blocking sun lights and beautiful looking, gas barrier properties and an opening convenience. 3. However, the 3 layers with aluminum packages were little bit more expensive and it can't be used in the microwaves. Conclusions This study revealed that 3 layers with aluminum packages were superior to any other packages because it can keep original flavor and properties, block sun light, and an easy opening convenience. Thus, aluminum contained 3 layer packages are better to preserve herbal medicines.

금은화 추출물의 항산화, 항염증 효과가 Dextran Sulfate Sodium으로 유도된 생쥐의 궤양성 대장염에 미치는 영향

차호열,정아람,천진홍,안상현,박선영,김기봉,Cha, Ho Yeol,Jeong, A Ram,Cheon, Jin Hong,Ahn, Sang Hyun,Park, Sun Young,Kim, Ki Bong 대한한방소아과학회 2015 대한한방소아과학회지 Vol.29 No.3

Objectives : This study was to investigate the anti-oxidative and anti-inflammatory effect of Lonicera japonica water extracts (LE) on Ulcerative Colitis Induced by DSS (Dextran Sulfate Sodium) in Mice. Methods : Colitis was induced by DSS in Balb/c mice. The sample group was divided into three. The mice in control group were not inflammation-induced. The pathological group was composed of untreated colitis elicited mice. The experimental group was administered Lonicera japonica water extracts (LE) after colitis elicitation. The effects on ulcerative colitis were evaluated the anti-oxidant effect, inhibition of COX-2 mRNA expression, the morphological change of colonic mucosa, decrease effect of HSP 70 and COX-2 in mucosa. Results : The SOD ability of LE was dose-dependently increased and the LPS-induced COX-2 mRNA expression of LE was dose-dependently decreased. LE showed the protective effects on DSS-induced experimental colitis. LE inhibited shortening of colon length, the hemorrhagic erosion in colonic mucosa. LE also showed the decrease effect for HSP70 and COX-2 in mucosa. Conclusions : The current results demonstrate the clinical utility of LE in traditional medicine and indicate the possible treatments for ulcerative colitis from natural products. Further investigations for exact mechanisms will be needed.

한의학 관련 특허 중 소아 관련 특허동향 연구 - 국내 등록 특허를 중심으로 -

천진홍,김기봉,정아람,Hong, Cheon Jin,Kim, Ki Bong,Ram, Jeong A 대한예방한의학회 2014 대한예방한의학회지 Vol.18 No.2

Objective : The purpose of this study is to analyze for the patent application tendency in Korean Oriental Pediatric Medicine. Recently, many studies are published in Korean Oriental Pediatric Medicine. However, in the patent area, the research results are few. Method : For patent analysis, we searched the database kipris (http://www.kipris.or.kr) which managed in the Korean Intellectual Property Office by keywords about Korean Oriental Pediatrics. They are technically analysed by year and IPC, patent's contents, main applicant and organization. Results : 1. Patents by year have been on the rise 2 in 1997 to 32 in 2011. 2. Our findings are Section A61;182, A23;46 in IPC analysis 3. In classification of content, 'application-food' is 67 cases, 'application-functional cosmetic' is 18 cases, 'application-clothes' is 5 cases. 4. Korea Institute of Oriental Medicine have 14 patent cases, that is the most patent agency in possession. Main applicants are person > company > university > laboratory > state or local government. Conclusion : This study shows that it has high frequency of daily necessity in patent cases about oriental pediatrics. The results are more distributed 'applied' field than 'treatment' field. The patent information should be connected research achievement results in Korean Oriental Medicine.

황련-감초 추출물을 이용한 하태독법이 NC/Nga 생쥐에서 유발된 아토피 유사 피부염에 미치는 항염증 효과

차호열,안상현,정아람,천진홍,박선영,최준용,김기봉,Cha, Ho-yeol,Ahn, Sang-hyun,Jeong, A-ram,Cheon, Jin-hong,Park, Sun-young,Choi, Jun-yong,Kim, Ki-bong 대한한방내과학회 2015 大韓韓方內科學會誌 Vol.36 No.4

Objectives Hataedock is an orally administered herbal extract treatment for newborn babies that dispels toxic heat and meconium gathered by the fetus. The purpose of this study was to evaluate whether Hataedock alleviates inflammatory skin damage in AD (Atopic Dermatitis)-induced NC/Nga mice through regulating and maintaining the skin barrier and anti-inflammation effects.Methods We established an AD model in three-week-old NC/Nga mice through the repeated application of DNFB (dinitrochlorobenzene) on days 28, 35, and 42 after Hataedock treatment was orally administered. We identified changes in the skin barrier and anti-inflammation effects through the histological and immunohistochemical changes of TNF- α, NF-κB p65, iNOS, COX-2, and apoptotic bodies.Results Skin damage and angiogenesis were mitigated in the HT (Hataedock) group. Damage to the intercellular space of the stratum corneum as well as hyperplasia, edema, the infiltration of lymphocytes, and the increase of capillaries decreased in the HT group. Our results suggest that Hataedock treatment significantly down-regulated levels of TNF- α by 38% (p<0.001) and of NF-κB p65 by 70% (p<0.001). But Hataedock up-regulated apoptosis by 183% in dermatitis-induced skin.Conclusions These results suggest that Hataedock alleviates AD through diminishing the various inflammatory cytokines in skin lesions that are involved in the initial steps of AD development. It might have potential applications for the prevention and treatment of atopic dermatitis.

하태독법 중 황련감초법이 DNFB로 유발된 NC/Nga 생쥐의 아토피 피부염에 미치는 영향

차호열,안상현,정아람,천진홍,박선영,김기봉,Cha, Ho Yeol,Ahn, Sang Hyun,Jeong, A Ram,Cheon, Jin Hong,Park, Sun Young,Kim, Ki Bong 대한한방소아과학회 2015 대한한방소아과학회지 Vol.29 No.4

Objectives Hataedock is the treatment that dispels toxic heat and meconium gathered at the fetus for the new born baby by orally administered herbal extracts. The purpose of this study was to evaluate whether Hataedock alleviate inflammatory skin damages in AD-induced NC/Nga mice through regulating of skin barrier maintain and Th2 differentiation. Methods We established an AD model in the 3-week-old NC/Nga mice through the repeated application of DNFB (dinitrochlorobenzene) on days 28, 35, 42 after Hataedock treatment which was orally administered. We identified the changes of skin barrier and Th2 differentiation through the histological and immunohistochemical changes of protein kinase C (PKC), interleukin (IL)-4, degranulated mast cell, Substance P and MMP-9. Results Our results suggested that Hataedock treatment significantly down-regulated levels of PKC by 82% (p < 0.001), as well as IL-4 by 56% (p < 0.001). Hataedock also suppressed mast cell infiltration, ear edema formation. and Substance P in the tissue of NC/Nga mice were decreased by 57% (p < 0.001), and MMP-9 by 55% (p < 0.001). Conclusions These results suggest that Hataedock alleviates AD through the down-regulation of PKC and Th2 cytokines, which are involved in the initial steps of AD development. Hataedock have potential application for the treatment of AD.