내동정맥루 조성술에 대한 임상적 경험

정성후,조백환,유희철,조래혁 대한혈관외과학회 1998 Vascular Specialist International Vol.14 No.2

Backgrounds: Hemodialysis remains the most important support for patients with end stage renal disease, and reliable vascular access is an essential component for their life. The internal arteriovenous fistula (AVF) fulfills nearly all of the criteria for an optimal access for chronic hemodialysis, such as long-term patency rate, low complication rate. Objective: This retrospective study is to review our experience and to evaluate the patency rate and the influencing factors of graft failure of the AVF. Material and Methods: From May 1988 through January 1997, 251 fistulas were created of 243 patients in Chonbuk National University Hospital. Only 119 cases were able to follow up survey. The statistical analysis used by Chi-square and Kaplan-Meier method. Results: The male versus female ratio was 1.3 :1 and the age distribution was occurred on from 3rd decade to 7th decade (93%). The most common cause of renal failure was hypertension and diabetes (54 cases, 45.4%). Among the 119 cases, the autogenous graft fistulas were performed in 106 cases (wrist/snuff box/antecubital fossa, 94/7/5), PTFE graft fistulas were 13 cases. The autogenous graft failures were 28 cases (early/late 15/13), PTFE graft failures were 8 cases (early/late 5/3). Overall failures, the most common cause was thrombosis or stricture (41.6%), and then dysfunction, infection, dysperfusion, rupture, and aneurysm in order of frequency. Early failures were occurred in 20 patients (male/female, 15/5) and late failures in 16 patients (male/female, 3/13). Older age (over 50 years old) and PTFE graft were more higher failure rate than younger age and autogenous fistula. 12, 24, 36 months accumulated patency rates were 70, 62, 55%, retrospectively. Conclusions: The results suggest that early failure was more frequent in male, and late failure was more frequent in female. The significant influencing factors of graft failures were age and material, one is PTFE graft and the other is over 50 years old were higher failure rate.

갑상선 분화암 수술 후 저용량 방사성 옥소(I-131)요법

정성후,정연준,유희철,강남부,Sung Hoo Jung,M,D,Yeon Jun Jeong,M,D,Hee Chul Yu,M,D,and Nam Poo Kang,M,D 대한갑상선-내분비외과학회 2001 The Koreran journal of Endocrine Surgery Vol.1 No.1

Purpose: To assess the effectiveness of low-dose (30 mCi) I-131 ablation therapy for remnant thyroid tissue following total thyroidectomy for differentiated thyroid cancer. Methods: Between March 1995 and December 1997, 48 patients were given ablative doses (30 mCi) of I-131 following total thyroidectomy for differentiated thyroid cancer in the presence of I-131 uptake in remnant thyroid tissue. The effective ablation of remnant thyroid tissue was determined using a subsequent I-131 whole body scan. If any remnant thyroid tissue remained, we repeated the same management protocol at 6-month intervals. Results: Thirty-eight (79.1%) patients displayed papillary, 8 (16.7%) follicular, 1 (2.1%) medullary and 1 (2.1%) Hurthle cell type cancer. Forty-eight patients underwent total thyroidectomy, 35 cases of which underwent central neck dissection, and 14 cases modified radical neck dissection. Postoperative complication developed in 8 cases, including 4 cases of transient hypoparathyroidism, 1 case of permanent hypoparathyroidism, 2 cases of transient recurrent laryngeal nerve palsy, and 1 case of wound hematoma. There was significant remnant thyroid tissue detected in 46 cases (95.8%) following total thyroidectomy, which were able to be ablated by low dose (30 mCi) I-131. There was no statistical difference between the operative procedures or the numbers of treatment of I-131. Conclusion: This data suggests that low-dose (30 mCi) I- 131 therapy is effective for the ablation of remnant thyroid tissue following total thyroidectomy for differentiated thyroid cancer. (Korean J Endocrine Surg 2001;1:98-103)

유방암 진단방법의 효율성에 대한 고찰

정성후,김종훈,황용 의과학연구소 1998 全北醫大論文集 Vol.22 No.1

Background : Palpable breast tumors have traditionally been diagnosed with open biopsy. We propose physical examination, fine needle aspiration(FNA) cytology, mammography and ultrasonography as a relia-ble, safe and cost saving initial diagnostic procedure in these patients. Methods : We performed 248 FNA cytology of breast tumors, among which 106 cases were histologically examined during the period of from jan. 1994 to Dec. 1997at the Department of Surgery, Chonbuk Natio-nal University Hospital. Results : Manin clinical symptom was palpable mass on breast at the time she visited the hospital. Clini-cal diagnosis based on symptoms and physical examination had 96.9% of sensitivity, 57.5%of specificity. Based on definite histologic diagnosis, the sensitivity of FNA cytology was 96.9%, specificity 91.7%, diagno-stic accuracy 93.5%, respectively. 86.1% of cytologic malignancy were proven as malignant histologically, and 100% of cytologically benign cases turned out hitologically benign. Mammography was performed in 96 cases and the results were as follows; sensitivity 89.3%, specificity 84%, accuracy 86.8%. Ultrasonography in 73 cases showed 93.5% sensitivity, 51.4% specificity, 74.6% accuracy Conclusion : A combination of physical examination, mammography, ultrasonography and FNA cytology of solid palpable breast lesions shoud be diagnostic procedure of choice for those patients classified clinically as probably bening or clinically as malignant. (Key Words : Breast tumor, FNA, Mammography, Ultrasonography)

白鼠의 腦內 Opiate 受用體의 日中變動에 미치는 Hemicholinium의 影響

정성후,배철,김기원,조문환,조규박 의과학연구소 1987 全北醫大論文集 Vol.11 No.3

To investigate the influence of hemicholinium on the diurnal variation of opiate receptor binding, the amount of specifically bound (3H)-morphine and content of β-endorphin were measured in the midbrain of rats at 4-hr intervals in a day. Animals were housed and adapted to a controlled light-dark cycle(L:D, 12:12). After 3 weeks of adaptation, 0.5㎖ of physiological saline or hemicholinium(4㎍/㎏/day) were administered intraperitoneally twice a day for 2 weeks. Highly significant rhythms of opiate receptor binding and β-endorphin content were found with peak at 22-hr and 6-hr in the control group. In the hemicholinium-treated group, these rhythms were modified in shape, phase and amplitude as well as in timing of peak and nadir. In this group, 24-hr mean of opiate receptor binding was significantly increased and β-endorphin content was significantly decreased. However, Kd values (affinity index of antagonist) were not changed in all experimental groups, indicating that the differences in binding were due not to change in affinity but to changes in the number of binding sites. Statistical analysis of regression lines revealed that changes in opiate receptor binding were inversely correlated with the changes in β-endorphin content. These results indicate that hemicholinium may affect the djurnal rhythm of opiate receptor binding and influence the action of opiate by changing the number of opiate receptor in central nervous system.

분화성 갑상선암의 임상적 평가

정성후,Sung Hoo Jung,M,D 대한갑상선-내분비외과학회 2002 The Koreran journal of Endocrine Surgery Vol.2 No.1

Purpose: Thyroid cancer is the most common endocrine malignancy, and it has a wide spectrum of biologic behavior, histologic appearance, and management. This study reviewed various aspects of the clinical features of differentiated thyroid cancer. Methods: We retrospectively reviewed the clinical characteristics of 114 patients who had undergone surgical management for differentiated thyroid cancer at the Chonbuk National University Hospital from September 1989 to December 1997. Results: The most prevalent age group was in the 5th decade (29 cases, 25.4%). The male-to-female ratio was 1 to 5.7. The most common initial symptom was a palpable mass on the anterior or the lateral portion of the neck (110 cases, 96.5%). The most common duration of illness from the appearance of the symptom to the treatment was below 3 months (38 cases, 34.5%). The primary tumors were located on the right lobe (49 cases, 43.0%), the left lobe (38 cases, 33.3%), both lobes (22 cases, 19.3%), and the isthmus (5 cases, 4.4%). In the histopathologic study, the common type was a papillary carcinoma (102 cases, 89.5%). The common surgical procedures were a total thyroidectomy (66 cases, 57.8%) and a near total thyroidectomy (24 cases, 21.0%). Seventy-five patients (65.8%) received a lymph-noe dissection, and there was cervical lymph-node metastasis in 43 cases (57.3%) of this group. Postoperative complications occurred in 11 cases (9.3%). The common complications were hemorrhage or seroma (5 cases, 4.4%), hoarseness (5 cases, 4.4%) and wound infection (1 cases, 0.9%). Although hypoparathyroidism was predicted, the predominant symptoms did not appear. Regional recurrence or distant metastases were present in 13 cases (11.4%) during four years. Conclusion: Thyroid cancer has a wide sectrum of biological behavior and also problems including the lack of reliable prognostic factors and objective assessments of therapeutic modalities. Appropriate and aggressive management should be recommended because most of differentiated thyroid cancer has a favorable prognosis. (Korean J Endocrine Surg 2002;2:19-24)

한국인 외과영역 환자에 대한 Ceftezole 임상효과

정성후,이승렬,황용 전북대학교 의과학연구소 1986 全北醫大論文集 Vol.10 No.3

To investigate the overall clinical effect of Ceftezole, a new cephalosporin C derivative, we administered Ceftezole into 30 patients with infection during the period of May, 1986 to August, 1986. The results were as follows: 1) The clinical effect: 8cases were excellent, 12 cases were good, 5 cases were slightly good, 3 cases were poor, and 2 cases were unkown. The clinical effective rate is 83%. 2) The bacteriological effect:bacterial clonies were eradicated in 12 cases, decreased in 10 cases, persisted in 3 cases, changed in 3 cases, and 2 cases were unkown. The bacteriological effective rate is 73%. 3) The overall clinical effect: 7 cases were excellent, 15 cases were good, 5 cases were slightly good, 1 case was poor, and 2 cases were unkown. The overall clinical effective rate is 90%. 4) There were no specific side effects.

A Study for Expression and Biological Function of N-myc Downstream Regulated Gene 2 in Breast Cancer

정성후 한국유방암학회 2007 Journal of breast cancer Vol.10 No.3

Purpose: It is important to identify a potential tumor marker that is associated with pathophysiologic processes of breast cancer. N-Myc downstream regulated genes (NDRG) are composed of four subtypes (NDRG 1-4) and NDRG2 gene has been reported as a specifically expressed gene in the human solid tumor including breast cancer. Although NDRG2 inhibits cell proliferation and promote differentiation, the molecular basis of the tumor-suppressor activity of NDRG2 in breast cancer is unknown. Herein, we tried to reveal the correlations between the expression of NDRG2 and the various clinicopathologic prognostic factors and evaluate its functional and pathophysiological roles in tumorigenesis of breast cancer. Methods: We were obtained the 67 breast cancers and paired normal tissue samples from patients who operated for breast cancer between June 2002 and June 2004. The expression of NDRG2 were measured with immmunohistochemistry using monoclonal antibody and it was used eukaryotic transfection to manipulate the expression in MDAMB-231 breast cancer cell line. Cell proliferation analysis were evaluated with trypan blue stain and status of differentially-expressed genes by NDRG2 overexpression were investigated with oligo microarray chip analysis. Results: Significant difference of NDRG2 mRNA expression between breast cancer and normal tissue was not detected. However, NDRG2 was significantly down-regulated in breast cancer tissue, compared to normal tissue (p<0.0001). It was a inverse-correlation between the NDRG2 expression and tumor size, histologic grade although other clinicopathological parameters such as axillary lymph node metastasis were not correlated. Overexpression of NDRG2 in MDA-MB-231 cell showed a decrease of cell proliferation compared with Mock control. Of the 24,000 genes, 64 genes were increased in expression while 256 genes including cyclin D1 were repressed by NDRG2 overexpression. Conclusion: Our results suggest that NDRG2 can function as a regulator of cell differentiation and cell cycle (as a tumor suppressor gene) in the early stage of breast cancer. In addition, NDRG2 protein indicates a prognostic tumor marker for breast cancer.

Peroxisome proliferator-activated receptor gamma activator inhibits cell growth of MDA-MB-231 breast cancer cells through induction of apoptosis

정성후 한국유방암학회 2006 Journal of breast cancer Vol.9 No.4

Purpose: Peroxisome proliferator-activated receptor gamma (PPARγ) has become a potential target for the prevention and treatment of human cancers. PPARγligands inhibit cell proliferation of estrogen receptorα(ERα)-positive breast cancer cells. However, it has recently been shown that ERα-negatively inhibits PPARγsignaling in breast cancer cells, indicating that PPARγligand may be more useful for treating ERα-negative breast cancer cells compared to ERα-positive breast cancer cells. In this study, we attempted to elucidate the role of PPARg in ERα-negative breast cancer cells. Methods: The effect of PPARγligand on the growth of MDA-MB-231 cells was measured by MTT assay and flow cytometric analysis. TUNEL staining and Hoechst 33342 fluorescent staining were used to observe the effects of PPARγligand on cell apoptosis. The regulatory proteins of the cell cycle were measured by Western blot. Results: The treatment of MDA-MB-231 human breast cancer cells with the PPARγligand, trgoglitazone, was shown to induce inhibition of cell growth in a dose-dependent manner. Cell cycle analysis showed a G1 arrest in MDA-MB-231 cells exposed to troglitazone. The apoptotic effect by troglitazone demonstrated that apoptotic cells were elevated from 2.5-fold of the control level at 10 mM, to 3.1-fold at 50μM and to 3.5-fold at 75 mM of troglitazone. Moreover, troglitazone treatment dose-dependently caused a marked decrease in the pRb, cyclin D1, cyclin D2, cyclin D3, cdk2, Cdk4 and Cdk6 expressions and there was a significant increase in the p21 and p27 expressions. Conclusion: These results indicate that trgoglitazone induces cell-cycle G1 arrest and apoptosis in ER α-negative MDA-MB-231 breast cancer cells. Collectively, this paper shows that PPARγligand is an important player as a member of the chemotherapeutic candidates for treating ERα-negative breast cancer.

Electrochemical characterization of highly conductive RuO2 coated LiNi0.5Mn1.5O4 for Li-ion batteries

정성후,김동현,이혜연,하회진,김석구,정윤석 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.0

리튬이온전지는 에너지밀도와 출력밀도의 지속적인 향상이 요구되고 있다. 높은 전위에서 작동할 수 있는 스피넬 구조의 양극 활물질인 LiNi0.5Mn1.5O4는 고에너지밀도를 만족할 수 있는 차세대 양극물질로 각광 받고 있다. 그러나 높은 전위에서의 전극-전해질 계면에서의 부반응으로 인한 성능의 퇴화는 해결해야 할 난제이다. 게다가 LiNi0.5Mn1.5O4의 매우 낮은 전자전도도는 속도특성의 향상에 있어 걸림돌로 작용하고 있다. 본 발표에서는 RuO2이 습식코팅된 LiNi0.5Mn1.5O4의 결과를 보고할 것이다. RuO2의 코팅에 따른 전자전도도의 향상과 그에 따른 전기화학적인 거동의 결과에 대해 논의될 것이다.

AHP를 활용한 IP-CCTV 위험 결정 모델(클라우드 컴퓨팅 기반으로)

정성후,이경호 한국정보보호학회 2018 정보보호학회논문지 Vol.28 No.1

This paper analyzes the problems of existing CCTV and discusses cyber security problems of IP-CCTV in cloudcomputing environment. In order to reduce the risk of simply removing the risk associated with the provision of cloudservices, the risk analysis and counter-measures need to be carried out effectively. Therefore, the STRIDE model as theThreat Risk Modeling is used to analyze the risk factors, and Analytic Hierarchy Process(AHP) is used to measure riskpriorities based on the analyzed threats. 본 논문은 기존의 CCTV가 가진 문제점을 분석하고, 클라우드 컴퓨팅 환경에서의 IP-CCTV를 사용할 때, 보안문제점에 대하여 논한다. 클라우드 서비스 제공과 관련된 보안 위험을 단순히 위험 현상만 제거하는 실수를 줄이기위해서는 위험 분석과 조치에 대한 효과적인 수행 방법이 필요하다. 이에 따라, Threat Risk Modeling의STRIDE 모델을 통하여 위협 분석을 하고, 위협 분석된 내용을 토대로 Analytic Hierarchy Process(AHP) 방법론을 사용하여 위험 우선순위를 측정하였으며, 우선순위에 대한 적절한 해결방법이 무엇인지를 분석하였다.