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카드뮴의 Salmonella typhimurium 변이균주 및 랫드 간장 상피세포에서의 유전독성
정상희,조명행,조준형,Jeong, Sang-hee,Cho, Myung-haing,Cho, Joon-hyoung 대한수의학회 1998 大韓獸醫學會誌 Vol.38 No.3
Cadmium is one of the well-known environmental toxicants and induces cancer in rodents and human, but its carcinogenic mechanism has not been well demonstrated until now. Genotoxic effects of cadmium in Salmonella typhimurium TA98, TA100 and TA1535/pSK1002 or in WB-F344 rat liver epithelial cells were investigated to elucidate the tumor initiating effects of cadmium. TA98, TA100 and TA1535/pSK1002 tester strains were used to detect frameshift mutation, base-pair mutation and SOS repair response, respectively, in Salmonella mutation test. Reverse mutations from histidine to $histidin^+$ of Salmonella typhimurium TA98 and TA100 by $CdCl_2$ were not significantly different from control up to the maximum doses ($100{\mu}M$ and $200{\mu}M$ in TA98 and TA100, respectively) at which non-cytotoxicity was observed. DNA SOS repair responses(${\beta}$-galactosidase activity) generally did not show significant increases compared to control in both of the conditions with or without metabolic activation in Salmonella typhimurium TA1535/pSK1002 by $CdCl_2$. But the activities of ${\beta}$-galactosidase by $400{\mu}M$ of $CdCl_2$ in metabolic activation condition and by 130 and $400{\mu}M$ of $CdCl_2$ in non-metabolic activation condition were more decreased than those of control. DNA single strand breaks for 4hrs were observed only in WB-F344 rat liver epithelial cells treated with $200{\mu}M$ of $CdCl_2$. As a conclusion, $CdCl_2$ did not induce gene mutation in microbials but induce DNA single strand breaks in rat liver epithelial cells.
Staurosporine 전처치에 의한 항암 화학요법으로부터 정상 세포의 선택적 보호 역할
정상희 ( Jeong Sang Hui ),권문기 ( Kwon Mun Gi ),조윤성 ( Jo Yun Seong ),송민경 ( Song Min Gyeong ),류기성 ( Lyu Gi Seong ),나종구 ( Na Jong Gu ),한구택 ( Han Gu Taeg ) 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.9
배경 : 악성 종양에 대한 항암 화학요법에서 정상 조직에 대한 세포독성이 가장 큰 문제점으로 대두되고 있다. 목적 : 정상세포와 악성 종양세포 사이에 세포주기의 G1 점검점에 작용하는 약제에 대한 감수성의 차이를 이용함으로써, 정상적으로 증식하고 있는 세포들을 항암화학 요법제로부터 보호할 수 있는지를 알아보고자 본 연구를 시행하였다. 연구 방법 : 정상인의 혈액으로부터 분리한 말초혈액 단핵구와 OVCAR-3 및 SKOV-3 난소암 세포주를 RPMI 배양 Objective : A major limiting factor in human cancer chemotherapy is toxicity in normal cells and tissues. Our goal was to determine whether normal proliferating cells could be protected from chemotherapeutic agents by taking advantage of the differential
정상희(Sang Hee Jeong) 사단법인 한국언어학회 2021 언어학 Vol.- No.91
This study aims to describe the phonological, morphological and syntactic phenomena of the repetitive construction of malta and explain them in the basis of plural-event structure. The three main arguments are made: Firstly, collective reading which is defined by two semantic features, [±individuated] and [±bounded] is intermediate between distributive and group reading. [±Individuated] is involved in the individuality of a partial events, and [±bounded] is involved in the formation of the collective event consists of the partial events. Second, it is hard to consider that linguistic phenomena of the repetitive construction of malta are mainly related to main verb malta. Rather, it is better understood in its collective meaning. Third, many examples which can be explained as a collective event are easily found besides the repetitive construction of malta.